http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Bakht, Mohamadreza K.,Sadeghi, Mahdi,Ahmadi, Seyed J.,Sadjadi, Sodeh S.,Tenreiro, Claudio Lippincott Williams Wilkins, Inc. 2013 Nuclear medicine communications Vol.34 No.1
OBJECTIVE: Many studies have attempted to assess the significance of the use of the &bgr;-particle emitter praseodymium-142 (Pr) in cancer treatment. As praseodymium oxide (Pr2O3) powder is not water soluble, it was dissolved in HCl solution and the resultant solution had to be pH adjusted to be in an injectable radiopharmaceutical form. Moreover, it was shown that the nanosized neodymium oxide (Nd2O3) induced massive vacuolization and cell death in non-small-cell lung cancer. In this work, the production of Pr was studied and water-dispersible nanosized Pr2O3 was proposed to improve the application of Pr in nuclear medicine. MATERIALS AND METHODS: Data from different databases pertaining to the production of Pr were compared to evaluate the accuracy of the theoretical calculations. Water-dispersible nanosized Pr2O3 was prepared using a poly(ethylene glycol) (PEG) coating or PEGylation method as a successful mode of drug delivery. Radioactive Pr2O3 was produced via a Pr(n,&ggr;)Pr reaction by thermal neutron bombardment of the prepared sample. RESULTS: There was good agreement between the reported experimental data and the data based on nuclear model calculations. In addition, a small part of nano-Pr2O3 particles remained in suspension and most of them settled out of the water. Interestingly, the PEGylated Pr2O3 nanoparticles were water dispersible. After neutron bombardment of the sample, a stable colloidal Pr2O3 was formed. CONCLUSION: The radioactive Pr2O3 decays to the stable Nd2O3. The suggested colloidal Pr2O3 as a multifunctional therapeutic agent could have dual roles in cancer treatment as a radiotherapeutic agent using nanosized Pr2O3 and as an autophagy-inducing agent using nanosized Nd2O3.
Wind-induced response and loads for the Confederation Bridge -Part II: derivation of wind loads
Bakht, Bilal,King, J. Peter C.,Bartlett, F.M. Techno-Press 2013 Wind and Structures, An International Journal (WAS Vol.16 No.4
This paper uses ten years of on-site monitoring data for the Confederation Bridge to derive wind loads and investigate whether the bridge has experienced its design wind force effects since its completion in 1997. The load effects derived using loads from the on-site monitoring data are compared to the load effects derived using loads from the 1994 and 2009 wind tunnel aerodynamic model tests. The research shows, for the first time, that the aerodynamic model-based methodology originally developed in 1994 is a very accurate method for deriving wind loads for structural design. The research also confirms that the bridge has not experienced its specified (i.e., unfactored) wind force effects since it was opened to traffic in 1997, even during the most severe event that has occurred during this period.
Wind-induced response and loads for the Confederation Bridge -Part I: on-site monitoring data
Bakht, Bilal,King, J. Peter C.,Bartlett, F.M. Techno-Press 2013 Wind and Structures, An International Journal (WAS Vol.16 No.4
This is the first of two companion papers that analyse ten years of on-site monitoring data for the Confederation Bridge to determine the validity of the original wind speeds and wind loads predicted in 1994 when the bridge was being designed. The check of the original design values is warranted because the design wind speed at the middle of Northumberland Strait was derived from data collected at shore-based weather stations, and the design wind loads were based on tests of section and full-aeroelastic models in the wind tunnel. This first paper uses wind, tilt, and acceleration monitoring data to determine the static and dynamic responses of the bridge, which are then used in the second paper to derive the static and dynamic wind loads. It is shown that the design ten-minute mean wind speed with a 100-year return period is 1.5% less than the 1994 design value, and that the bridge has been subjected to this design event once on November 7, 2001. The dynamic characteristics of the instrumented spans of the bridge including frequencies, mode shapes and damping are in good agreement with published values reported by others. The on-site monitoring data show bridge response to be that of turbulent buffeting which is consistent with the response predicted at the design stage.
Ahtesham Bakht,Alam Nawaz,Moonyong Lee(이문용),Hyunsoo Lee(이현수) 한국지능시스템학회 2022 한국지능시스템학회논문지 Vol.32 No.3
본 연구는 산업폐수 처리프로세스 에서의 딥러닝 기법을 응용한 예측 프레임웍을 다룬다. 산업폐수 처리 및 분석은 프로세스 자체 및 데이터가 가지는 비선형성 및 처리시간 때문에 어렵다는 특징을 지닌다. 기존의 수학적 모델링 기반의 방법들은 이러한 데이터의 다상관성 때문에 그 예측이 어렵다는 한계를 나타내었다. 이를 극복하기 하기 위하여, 본 연구는 측정이 어려운 NO2 집중도를 예측하는 하이브리드 멀티스트림 딥러닝 프레임웍을 제안한다. 입력값으로서, 상대적으로 측정이 쉬운 산성도, 온도, 산소포화도, 용량등을 활용한다. 입력값은 심층신경망을 통과하며, 추가적으로 NO2집중도는 순환신경망을 통하여 특성값을 추출하고, 이를 심층신경망을 통해 학습한다. 제안된 프레임웍은 RMSE와 R² 관점에서 기존의 딥러닝 기반 방법론들보다 좋은 예측정확도를 나타낸다. This paper discusses a prediction framework of deep learning techniques for modeling nutrient discharge from wastewater treatment plants. Control of Biological Wastewater Treatment (BWWT) is difficult because of the time-consuming, non-linearity nature of the process. Traditional modeling methods are incapable of capturing long-term multivariate dependencies of data for forecasting. To address such concerns, this study proposes a hybrid multi-stream deep learning architecture to estimate a hard-to-measure nitrite (NO2) concentration. As input data, comparatively easily measurable elements such as pH, temperature, dissolved oxygen (DO), suspended solids, and volumes are used. The features are trained a deep learning structure and NO2 Concentration is trained using a recurrent neural network. The proposed hybrid multi-stream architecture performed much better than other existing unimodal deep learning architecture in terms of root mean square error (RMSE) and R².
Martin K. Bakht,오소원,윤혜원,천기정,곽철,강건욱 대한핵의학회 2017 핵의학 분자영상 Vol.51 No.3
Prostate-specific membrane antigen (PSMA) is an attractive target for both diagnosis and therapy because of its high expression in the vast majority of prostate cancers. Development of small molecules for targeting PSMA is important for molecular imaging and radionuclide therapy of prostate cancer. Recent evidence implies that androgendeprivation therapy increase PSMA-ligand uptake in some cases. The reported upregulations in PSMA-ligand uptake after exposure to second-generation antiandrogens such as enzalutamide and abiraterone might disturb PSMA-targeted imaging for staging and response monitoring of patients undergoing treatment with antiandrogen-based drugs. On the other hand, second-generation antiandrogens are emerging as potential endoradio-/chemosensitizers. Therefore, the enhancement of the therapeutic efficiency of PSMA-targeted theranostic methods can be listed as a new capability of antiandrogens. In this manuscript, we will present what is currently known about the mechanism of increasing PSMA uptake following exposure to antiandrogens. In addition, we will discuss whether these above-mentioned antiandrogens could play the role of endoradio-/chemosensitizers in combination with the well-established PSMA-targeted methods for pre-targeting of prostate cancer.