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Pyriminobac-methyl과 azimsulfuron 합제의 신규제형인 분산형 정제에 대한 독성 평가
백경진,이동연,이상훈,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
Dispersible tablets disintegrate either to form a stabilized suspension rapidly in water, or to disperse instantaneously in the rice field without the aid of water. In this study, the newly formulated dispersible tablet form of herbicidal combination, pyriminobac-methyl and azimsulfuron, was evaluated the safety for human and animals in the toxicological viewpoints. The LD_(50) value of dispersible tablet form for pyriminobac-methyl and azimsulfuron was above 2,500 mg/kg for the oral route and above 2,000 mg/kg for the dermal route. It is considered to have low acute oral and dermal toxicity based on the findings of the present studies. In addition, the combination of pyriminobac-methyl and azimsulfuron showed mild skin irritant under the conditions of this study and conjunctival redness and slight opacity on cornea appeared from 1 hour after application.
ActiveX와 Shockwave 技術을 利用한 電子商去來 System 構築에 關한 硏究
朴鐘憲, 白点錫 영남대학교 사회과학연구소 2000 社會科學硏究 Vol.20 No.1
인터넷이라는 시공을 초월하는 가상공간을 통해 전자쇼핑몰을 중심으로 활성화 된 전자상거래는 그 범위가 다양한 금융분야로 급속히 확산되고 있다. 이러한 배경하에 본 연구는 ActiveX와 Shockwave를 이용한 전자 상거래시스템의 프로토타입을 구축하여 그 유용성을 고찰하였다. 연구결과를 요약해보면 ActiveX와 Shockwave라는 신기술을 이용하여 전자쇼핑몰을 구축함에 있어 몇몇 문제점이 나타났지만, 이 기술을 이용하면 훨씬 동적이며 차별화 된 전자쇼핑몰이 구축이 가능하며, 짧은 쇼핑몰구축 기간, 서버의 불필요한 부하의 감소 등의 장점으로 인하여 그 만큼 서버에 투자되어야 할 비용과 개발비용을 줄일 수 있어 기업의 경제적인 측면에도 기여할 것이다.
한종현,백승화,김일광,한두석 圓光大學校 韓醫學硏究所 1993 원광한의학 Vol.3 No.1
In order to investigate the cytotoxicity of Lonicerae Flos extract, their extracts were dissolved in distilled water and methanol. All material diluted from 10^-3to 10^-7(㎎/㎖) with distilled water putted in each well of 24 multidish cultured rat fibroblast for 48hours. The cell number was calculated at 2 days and cell shape takes photographed by inverted microscope at same day. The results were as follows: 1. The rate of cell multiplication was the lowest in water extract from 10^-3 to 10^-7(㎎/㎖) concentration and the highest in ether and hexane extract at 10^-7(㎎/㎖) concentration. 2. Index of cytotoxicity was the highest with 3 score in water extract at 10^-3(㎎/㎖) concentration and the lowest with 1 score in ether, ethyl acetate or hexane extract at same concentration. 3. The degeneration of cell shape and number was the severest in water extract of 10&-4(㎎/㎖) concentration, but ether and hexane extracts in same concentration were weaker than water extract. These results indicate that the cytotoxicity of extracts by ether and hexane from same Lonicerae Flos was weaker then water extract.
접지된 유전체층 위의 유한한 주기적인 스트립격자에 의한 TM회절
이종익,백운석 東西大學校 1999 동서논문집 Vol.5 No.-
TM diffraction of a Gaussian beam wave by finite periodic conducting strip grating on a grounded dielectric slab is considered. The integro-differential equation for the induced strip currents is derived for the case that the spectural bandwidth of the incident Gaussian beam wave is narrow and solved numerically by use of the methid of moments. From results for the angular diffraction pattern, some similarity between scattering behaviours of the proposed finite periodic geometry and the infinite one is examined by observing the off-Bragg as well as Bragg blazing phenomena in the geometry.
신규개발된 제초제 metamifop 현탁농축액제에 대한 급성독성평가
이동연,이상훈,백경진,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
Metamifop, (R)-2-[4-[(6-chloro-2-benzoxazolyloxyphenoxy]-N-(2-fluorophenyl)-N-methyl propanamide, was newly developed by Dongbu Hannong Chemicals in Korea. In the present study we conducted acute oral toxicity and acute dermal toxicity test. The values of LD_(50) of metamifop was found to be over 5,000 mg/kg for ICR mice. On the other hand, metamifop showed no acute dermal toxicity to SD rats.
Carbosulfan의 피부자극성, 안점막 자극성 및 피부감작성등의 알러지성 효과에 관한 연구
이상훈,이동연,백경진,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
Many studies have been published on the human health effects of carbosulfan toxicity. Carbosulfan used as an insecticide can produce an irritating and allergenic effect when acting on the skin. In this study, a sensitization test on albino guinea pigs and intradermal reactivity and occular irritation test on albino rabbits were carried out with carbosulfan. Signs of acute skin inflammation appeared along with the clinical symptom of chronic dermatosis caused by the solution irritating characteristics. Moreover, carbosulfan showed severe eye irritation with conjuctival redness and severe opacity on cornea. Preventive measures should involve workers' obligatory instructions on the noxious impact on human skin and strict observance of industrial safety rules.
Baek, Seung Ho,Kim, Chulwon,Lee, Jong Hyun,Nam, Dongwoo,Lee, Junhee,Lee, Seok-Geun,Chung, Won-Seok,Jang, Hyeung-Jin,Kim, Sung-Hoon,Ahn, Kwang Seok Informa Healthcare USA, Inc. 2015 Immunopharmacology and immunotoxicology Vol.37 No.3
<P>Cinobufagin (CBG) is a cardiotoxic bufanolide steroid secreted by the skin and parotid venom glands of the Asiatic toad <I>Bufo bufo gargarizans</I> (called Chan-Su). Although CBG is known to exhibit anti-cancer activities, very little is known about its potential mechanism(s) of action. In this study, we investigated whether CBG mediates its effect through the modulation of the mitogen-activated protein kinases (MAPKs) signaling pathway in human multiple myeloma (MM) U266 cells. We found that CBG caused the significant activation of ERK, JNK and p38 MAPK in U266 cells. CBG showed much higher cytotoxicity against U266 cells as compared to peripheral blood mononuclear cells (PBMC). Induction of CBG increased reactive oxygen species (ROS) generation from mitochondria, which is associated with the induction of apoptosis as characterized by increased sub-G1 DNA contents of cell cycle, positive Annexin V binding, activation of caspase-3 and cleavage of PARP. Inhibition of ROS generation by <I>N</I>-acetyl-<SMALL>L</SMALL>-cysteine (NAC) significantly prevented CBG-induced ERK, JNK and p38 MAPK activation and apoptosis. CBG also down-regulated the expression of various downstream gene products that mediate cell proliferation, survival, angiogenesis and metastasis. Interestingly, ERK, JNK and p38MAPK pharmacological inhibitors blocked CBG-induced MAPKs activation and ERK inhibitor (PD98059) also prevented the CBG-induced caspase-3 activation and PARP cleavage in U266 cells. Taken together, these findings suggest that CBG can act as a potent anticancer agent against MM and possibly exerts its effects through the ROS-mediated activation of ERK, JNK and p38 MAPK leading to the activation of caspase-3 in U266 cells.</P>