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Psychometric Properties of the Hypomania Checklist-32 in Korean Patients with Mood Disorders
Bo-Hyun Yoon,Jules Angst,Won-Myong Bahk,Hee Ryung Wang,Seung-Oh Bae,Moon Doo Kim,Young-Eun Jung,Kyung Joon Min,Hwang-Bin Lee,Seunghee Won,Jeongwan Hong,Myong Su Choi,Duk-In Jon,Young Sup Woo 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.4
Objective: The aim of this study was to examine the validity of the Korean version of the Hypomania Checklist-32, second revision (HCL-32-R2) in mood disorder patients. Methods: A total of 454 patients who diagnosed as mood disorder according to Structured Clinical Interview for DSM-IV Axis I Disorders, clinician version (SCID-CV) (bipolar disorder [BD] I, n=190; BD-II, n=72; and major depressive disorder [MDD], n=192) completed the Korean module of the HCL-32-R2 (KHCL-32-R2). Results: The KHCL-32-R2 showed a three-factorial structure (eigenvalue >2) that accounted for 43.26% of the total variance. Factor 1 was labeled “active/elated” and included 16 items; factor 2, “irritable/distractible” and included 9 items; and factor 3 was labeled “risk-taking/indulging” and included 9 items. A score of 16 or more on the KHCL-32-R2 total scale score distinguished between BD and MDD, which yielded a sensitivity of 70% and a specificity of 70%. MDD and BD-II also could be differentiated at a cut-off of 15 with maximized sensitivity (0.67) and specificity (0.66). Cronbach’s alpha of KHCL-32-R2 and its subsets (factors 1, 2, and 3) were 0.91, 0.89, 0.81 and 0.79, respectively. Correlations between KHCL-32-R2 and Montgomery- Asberg Depression Rating Scale, Young Mania Rating Scale and Korean version of Mood Disorder Questionnaire were −0.66 ( p =0.41), −0.14 ( p =0.9), and 0.61 ( p <0.001), respectively. Conclusion: The KHCL-32-R2 may be a useful tool in distinguishing between bipolar and depressive patients in clinical settings.
3D8 scFv 형질전환 돼지 개발 및 PRRS 저항성 평가
이휘철 ( Hwi-cheul Lee ),이건섭 ( Gunsup Lee ),김지윤 ( Ji-yoon Kim ),양현 ( Hyeon Yang ),이보람 ( Bo Ram Lee ),박미령 ( Mi-ryung Park ),황인설 ( In-sul Hwang ),이풍연 ( Poongyeon Lee ),변승준 ( Sung-june Byun ),김원일 ( Won-il K 한국동물위생학회(구 한국가축위생학회) 2020 韓國家畜衛生學會誌 Vol.43 No.4
In this study, we have developed 3D8 scFv transgenic pig (TG) by microinjection of fertilized one-cell pig zygotes (2.17%). The effect of 3D8 scFv TG on porcine reproductive and respiratory syndrome virus (PRRSV) resistance were evaluated through PRRSV VR2332 (1×10 <sup>3</sup> TCID<sub>50</sub>/mL) challenge and transmission experiments. As a result, the average daily weight gain (ADWG) of TG increased compared to the wild type pigs (WT) in PRRSV challenge groups and the serum viremia levels of the TG was significantly lower than of WT on the 7 day and 21 day after infection, meaning that the viral shedding was suppressed by 3D8 scFv expression. These results suggest that the expression of 3D8 scFv in pig could suppress spreading of infected virus to pigs sharing a room.