Guest Editorial The Third Round of Migrant Incorporation in East Asia: An Introduction to the Special Issue on Friends and Foes of Multicultural East Asia

Asahina, Yuki,Higuchi, Naoto World Association for Triple Helix and Future Stra 2020 Journal of Contemporary Eastern Asia Vol.19 No.2

Trends toward an influx of new migrants have been pronounced in East Asia through a development we call the third round of migrant incorporation. At the same time, other features of East Asian societies, such as strong levels of ethnic nationalism, have changed little, posing challenges to multiculturalism. In this introduction to this special issue, we review the latest research trends broadly concerning multiculturalism, migrant groups that have received little attention, racism and xenophobia. We first discuss the state of migrant incorporation in East Asia and the limits of multiculturalism in this region, where various features of the developmental state persist. We then introduce research on voices opposing multiculturalism in East Asia. This introduction highlights what is peculiar―and ordinary―about migrant incorporation and the associated challenges in East Asia.

Review : The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration

Ingrid Lua,Kinji Asahina 대한소화기학회 2016 Gut and Liver Vol.10 No.2

기계적 합금화에 의한 비정질 Cu-Ta 분말의 제조 및 전자물성

Lee, Chung-Hyo,Asahina, Tadashi,Mizutani, Uichiro 한국재료학회 1994 한국재료학회지 Vol.4 No.6

자자들은 최근 비고용 Cu-Ta계의 기계적 합금화(Mechanical Alloying) 방법을 이용하여 이계에 있어서 비정질상의 형성에 대한 구조적 확인을 중성자 회절과 EXAFS(Extended X-ray Absorption Fine Structure)의 실험결과로 부터 얻었다. Cu-Ta계와 같이 혼합 엔탈피(Heat of Mixing: $\Delta$ Hmix)가 정인계에 있어서 비정질상 형성에 대한 연구는 구조적인 측면 뿐만 아니라. 시료의 전자물성에 대해서도 많은 연구가 되어야만 할 것으로 사료된다. 따라서 본 논문에서는 120시간 MA방법으로 제작한 시료에 대하여 초전도 천이온도 및 X선 광전자분광 실험에서 얻은 가전자대 구조의 전자물성을 측정하고, 그 결과로부터 이종원자 Cu와 Ta간의 결합은 화하결합에 의한 생성임을 확인하였는데, 이들 결과로부터 120시간 MA를 행하여 얻어진 시료는 확실하게 비정질 합금임을 알 수 있었다. We recently showed from the neutron diffraction and extended X-ray absorption fine structure studies the structural evidence for the formation of an amorphous phase in immiscible Cu-Ta system subjected to mechanical alloying. In a system with a positive heat of mixing like Cu-Ta, we consider it necessary to confirm the formation of an amorphous phase not only from the structural studies but also from a change in the electronic properties. We show the electronic evidence for the formation of the chemical bonding between the unlike atoms Cu and Ta for the 120 h-milling sample through changes in superconducting transition temperature and X-ray photoemission spectroscopy valence band structure.

Necessity of pharyngeal anesthesia during transoral gastrointestinal endoscopy: a randomized clinical trial

Tomoyuki Hayashi,Yoshiro Asahina,Yasuhito Takeda,Masaki Miyazawa,Hajime Takatori,Hidenori Kido,Jun Seishima,Noriho Iida,Kazuya Kitamura,Takeshi Terashima,Sakae Miyagi,Tadashi Toyama,Eishiro Mizukoshi 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.5

Background/Aims: The necessity for pharyngeal anesthesia during upper gastrointestinal endoscopy is controversial. This study aimedto compare the observation ability with and without pharyngeal anesthesia under midazolam sedation. Methods: This prospective, single-blinded, randomized study included 500 patients who underwent transoral upper gastrointestinalendoscopy under intravenous midazolam sedation. Patients were randomly allocated to pharyngeal anesthesia: PA+ or PA– groups (250patients/group). The endoscopists obtained 10 images of the oropharynx and hypopharynx. The primary outcome was the non-inferiorityof the PA- group in terms of the pharyngeal observation success rate. Results: The pharyngeal observation success rates in the pharyngeal anesthesia with and without (PA+ and PA–) groups were 84.0%and 72.0%, respectively. The PA– group was inferior (p=0.707, non-inferiority) to the PA+ group in terms of observable parts (8.33 vs. 8.86, p=0.006), time (67.2 vs. 58.2 seconds, p=0.001), and pain (1.21±2.37 vs. 0.68±1.78, p=0.004, 0–10 point visual analog scale). Suitablequality images of the posterior wall of the oropharynx, vocal fold, and pyriform sinus were inferior in the PA– group. Subgroupanalysis showed a higher sedation level (Ramsay score ≥5) with almost no differences in the pharyngeal observation success rate betweenthe groups. Conclusions: Non-pharyngeal anesthesia showed no non-inferiority in pharyngeal observation ability. Pharyngeal anesthesia may improvepharyngeal observation ability in the hypopharynx and reduce pain. However, deeper anesthesia may reduce this difference.

Detection of unexploded ordnance (UXO) using marine magnetic gradiometer data

Salem Ahmed,Hamada Toshio,Asahina Joseph Kiyoshi,Ushijima Keisuke Korean Society of Earth and Exploration Geophysici 2005 지구물리와 물리탐사 Vol.8 No.1

여러 센서들의 배열을 이용한 최근의 해양 자력구배 측정시스템의 개발을 통하여 넓은 오염지역의 조사를 빠르게 수행할 수 있게 되었다. 그러나 물밑의 UXO 는 조류에 의해 이동할 수 있으며 따라서 이런 환경에서의 복원과정은 정적이라기 보다는 동적이 되었다. 이는 곧 성공적인 복원을 위해서는 탐지가 거의 실시간으로 이루어져야 함을 말한다. 그러므로 해양 자력탐사자료로부터 물밑 물체의 신호를 빠르게 탐지할 수 있는 신속한 해석법이 필요하다. 이 논문에서는 물밑 UXO 의 위치 및 특성을 알아내는 신속한 방법을 소개하였다. 먼저 대상체의 정밀 탐지를 위해 자력구배자료의 해석기법(해석적 신호와 Euler 방법)을 이용하며, 반복적 선형 최소자승법을 이용해 대상체의 자기 특성을 얻어낸다. 이 방법은 알고 있는 대상체에 대해 무작위 잡음을 더한 이론적 해양 자력이상에 적용되었으며, 일본의 해양 자력구배탐사 자료를 이용하여 실질적인 유용성을 예시하였다.

Twelve Weeks of Ledipasvir/Sofosbuvir for Patients with Chronic Hepatitis C Genotype 2 Infection: Integrated Analysis of Three Clinical Studies

( Chung-feng Huang ),( Yasuhiro Asahina ),( Chun-jen Liu ),( Edward Gane ),( Yoshito Itoh ),( Norifumi Kawada ),( Yoshiyuki Ueno ),( Jin Youn ),( Chen-yu Wang ),( Joe Llewellyn ),( Anu Osinusi ),( Jen 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: HCV genotype (GT) 2 is the second most common genotype in several Asian countries including Taiwan and Korea. Treatment options for GT2 remain limited in these countries. The once-daily fixed-dose combination of ledipasvir/sofosbuvir (LDV/SOF) was evaluated for the treatment of GT 2, in patients with or without compensated cirrhosis, in three phase 2 and 3 studies. Methods: This was a retrospective analysis of subjects treated with LDV/SOF for 12 weeks in the GS-US-337-1655 (Taiwan), GS-US-337-1903 (Japan) and GS-US-1468 (New Zealand) studies. Subjects analyzed in this integrated analysis were either mono-infected with HCV GT2, or co-infected with HCV GT2 and HBV. The data was pooled and safety and efficacy were analyzed. Results: Overall 200 subjects were treated and analyzed; 88% of subjects were Asian, 46% male, 31% had prior treatment failure, 15% were cirrhotic, 25% were IL28B non-CC, 34% were 65 years or older and 22% (n=43) were co-infected with HBV. The overall SVR rate was 97% (194/200), and was 93% (27/29) among patients with cirrhosis and 97% (59/61) in patients who had failed previous therapy. Of the 197 patients with available testing; NS5A resistance-associated substitutions (RASs) were present in 86% (169/197) at baseline. SVR12 rate was 98% (165/169) in patients with baseline NS5A RASs compared with 100% (28/28) in patients without NS5A RASs. No new RASs emerged in patients with virologic failure. Treatment with LDV/SOF for 12 weeks was well tolerated. Overall the most common adverse events AEs were headache and nasopharyngitis. Few subjects experienced serious AEs, none of which were assessed as treatment related. One patient discontinued treatment due to AE. Conclusions: Treatment with LDV/SOF for 12 weeks is highly effective and well tolerated in patients with GT2 HCV infection, including patients who are treatment experienced and/or have compensated cirrhosis, baseline NS5A RASs and with HBV/HCV coinfection.

Diagnosing metabolic acidosis in chronic kidney disease: importance of blood pH and serum anion gap

Kaimori Jun-Ya,Sakaguchi Yusuke,Kajimoto Sachio,Asahina Yuta,Oka Tatsufumi,Hattori Koki,Doi Yohei,Isaka Yoshitaka 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Metabolic acidosis is one of the most common complications of chronic kidney disease (CKD). It is associated with the progression of CKD, and many other functional impairments. Until recently, only serum bicarbonate levels have been used to evaluate acid-base changes in patients with reduced kidney function. However, recent emerging evidence suggests that nephrologists should reevaluate the clinical approach for diagnosing metabolic acidosis in patients with CKD based on two perspectives; pH and anion gap. Biochemistry and physiology textbooks clearly indicate that blood pH is the most important acid-base parameter for cellular function. Therefore, it is important to determine if the prognostic impact of hypobicarbonatemia varies according to pH level. A recent cohort study of CKD patients showed that venous pH modified the association between a low bicarbonate level and the progression of CKD. Furthermore, acidosis with a high anion gap has recently been recognized as an important prognostic factor, because veverimer, a nonabsorbable hydrochloride-binding polymer, has been shown to improve kidney function and decrease the anion gap. Acidosis with high anion gap frequently develops in later stages of CKD. Therefore, the anion gap is a time-varying factor and renal function (estimated glomerular filtration rate) is a time-dependent confounder for the anion gap and renal outcomes. Recent analyses using marginal structural models showed that acidosis with a high anion gap was associated with a high risk of CKD. Based on these observations, reconsideration of the clinical approach to diagnosing and treating metabolic acidosis in CKD may be warranted.

Cell wall mechanical properties of closed-cell Al foam

Jeon, Insu,Katou, Kiyotaka,Sonoda, Tsutomu,Asahina, Tadashi,Kang, Ki-Ju Elsevier 2009 Mechanics of materials Vol.41 No.1

<P><B>Abstract</B></P><P>The mechanical properties of the cell wall, such as the elastic modulus, 0.2% offset yield stress and power-law hardening exponent of the closed-cell Al foam are determined using both experimental measurements and finite element analyses. A 6×6×12cm<SUP>3</SUP> ingot of the cell wall base material, which is sampled from melted Al-1.5wt.%Ca alloy before foaming, is prepared, and its mechanical properties are initially measured to set the limit values of the mechanical properties of the Al cell wall. Two 5×5×5mm<SUP>3</SUP> Al foam specimens of completely different structures are fabricated, and directly modeled for the finite element analysis by using a microfocus X-ray CT system, 3D reconstruction program, 3D scanned data processing software, and commercial mesh generation program. Subsequently, uniaxial compression tests are carried out on the specimens, and the numerical simulations of these tests are performed using the finite element models. For the simulations, various mechanical properties for the cell wall selected from the measured properties of the base material are used. Then, the Al cell wall mechanical properties are precisely determined by comparing the computed force–displacement curves with the measured ones. Finally, the effects of each mechanical property on the compressive behavior of the foam material are analyzed.</P>

해양 자력구배 탐사자료를 이용한 UXO 탐지

( Ahmed Salem ),빈전민부 ( Toshio Hamada ),조비내결 ( Joseph Kiyoshi Asahina ),우도혜보 ( Keisuke Ushijima ) 한국지구물리·물리탐사학회 2005 지구물리와 물리탐사 Vol.8 No.1

Pyrrole-Based Macrocyclic Small-Molecule Inhibitors That Target Oocyte Maturation

Gunasekaran, Pethaiah,Lee, So-Rim,Jeong, Seung-Min,Kwon, Jeong-Woo,Takei, Toshiki,Asahina, Yuya,Bang, Geul,Kim, Seongnyeon,Ahn, Mija,Ryu, Eun Kyung,Kim, Hak Nam,Nam, Ki-Yub,Shin, Song Yub,Hojo, Hirono Wiley - V C H Verlag GmbH & Co. KGaA 2017 CHEMMEDCHEM Vol.12 No.8

<P>Polo-like kinase1 (PLK1) plays crucial roles in various stages of oocyte maturation. Recently, we reported that the peptidomimetic compound AB103-8, which targets the polo box domain (PBD) of PLK1, affects oocyte meiotic maturation and the resumption of meiosis. However, to overcome the drawbacks of peptidic compounds, we designed and synthesized a series of pyrrole-based small-molecule inhibitors and tested them for their effects on the rates of porcine oocyte maturation. Among them, the macrocyclic compound (E/Z)-3-(2,16-dioxo-19-(4-phenylbutyl)-3,19-diazabicyclo[15.2.1]icosa-1(20),6,17-trien-3-yl)propyl dihydrogen phosphate (4) showed the highest inhibitory activity with enhanced inhibition against embryonic blastocyst formation. Furthermore, the addition of this compound to culture media efficiently blocked the maturation of porcine and mouse oocytes, indicating its ability to penetrate the zona pellucida and cell membrane. We investigated mouse oocytes treated with compound 4, and the resulting impairment of spindle formation confirmed PLK1 inhibition. Finally, molecular modeling studies with PLK1 PBD also confirmed the presence of significant interactions between compound 4 and PLK1 PBD binding pocket residues, including those in the phosphate, tyrosine-rich, and pyrrolidine binding pockets. Collectively, these results suggest that the macrocyclic compound 4 may serve as a promising template for the development of novel contraceptive agents.</P>