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Cu<sup>2+</sup>-Responsive Bimodal (Optical/MRI) Contrast Agent for Cellular Imaging
Jang, Joo Hee,Bhuniya, Sankarprasad,Kang, Jongeun,Yeom, Areum,Hong, Kwan Soo,Kim, Jong Seung American Chemical Society 2013 ORGANIC LETTERS Vol.15 No.18
<P>A water-soluble T<SUB>1</SUB> magnetic resonance imaging contrast agent (<B>1</B>) has been synthesized. The bimodal contrast agent <B>1</B> responds to the Cu<SUP>2+</SUP> ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2013/orlef7.2013.15.issue-18/ol4025293/production/images/medium/ol-2013-025293_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol4025293'>ACS Electronic Supporting Info</A></P>
Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist
Sugawara, Reiko,Lee, Eun-Jung,Jang, Min Seong,Jeun, Eun-Ji,Hong, Chun-Pyo,Kim, Jung-Hwan,Park, Areum,Yun, Chang Ho,Hong, Sung-Wook,Kim, You-Me,Seoh, Ju-Young,Jung, YunJae,Surh, Charles D.,Miyasaka, Ma The Rockefeller University Press 2016 The Journal of experimental medicine Vol.213 No.4
<▼1><P>Jang et al. show that eosinophils in the small intestine can suppress Th17 cell differentiation through the secretion of the IL-1 receptor antagonist.</P></▼1><▼2><P>Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the ΔdblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4<SUP>+</SUP> T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1β. Moreover, small intestinal eosinophils isolated from IL-1Ra−deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra.</P></▼2>
Knock sensing and imaging from structural bending waves
Sangyul Ha,Areum Jang,이경준,손성호 한국통신학회 2022 ICT Express Vol.8 No.4
This paper presents a novel knock imaging technique for human-to-things interfaces. It allows any object to use its own surface as an imaging sensor. The methodology is to sense the structural bending waves caused by the knock and reconstruct the intensity image through the beamforming of the wave signals. To verify this, we prepare a thin piezoelectric sensor array on a square plate. The performances are evaluated by measuring the beam peak, beamwidth, and sidelobe level in the reconstructed image. Finally, a real finger knock test is demonstrated, showing an image reconstruction that the position error is only 3 mm.