Cyber Threat Intelligence Traffic Through Black Widow Optimisation by Applying RNN-BiLSTM Recognition Model

Kanti Singh Sangher,Archana Singh,Hari Mohan Pandey International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.11

The darknet is frequently referred to as the hub of illicit online activity. In order to keep track of real-time applications and activities taking place on Darknet, traffic on that network must be analysed. It is without a doubt important to recognise network traffic tied to an unused Internet address in order to spot and investigate malicious online activity. Any observed network traffic is the result of mis-configuration from faked source addresses and another methods that monitor the unused space address because there are no genuine devices or hosts in an unused address block. Digital systems can now detect and identify darknet activity on their own thanks to recent advances in artificial intelligence. In this paper, offer a generalised method for deep learning-based detection and classification of darknet traffic. Furthermore, analyse a cutting-edge complicated dataset that contains a lot of information about darknet traffic. Next, examine various feature selection strategies to choose a best attribute for detecting and classifying darknet traffic. For the purpose of identifying threats using network properties acquired from darknet traffic, devised a hybrid deep learning (DL) approach that combines Recurrent Neural Network (RNN) and Bidirectional LSTM (BiLSTM). This probing technique can tell malicious traffic from legitimate traffic. The results show that the suggested strategy works better than the existing ways by producing the highest level of accuracy for categorising darknet traffic using the Black widow optimization algorithm as a feature selection approach and RNN-BiLSTM as a recognition model.

Expression profiling of mitogen-activated protein kinase genes from chickpea (Cicer arietinum L.) in response to Helicoverpa armigera, wounding and signaling compounds

Indrakant Kumar Singh,Sumit Kumar,Sujata Singh,Archana Singh 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.3

The Mitogen-activated Protein Kinase (MAPK) Cascades play a crucial role in the regulation of defense responses in plants. Herbivory- or wounding-related MAPKs, SA-induced protein kinase (SIPK) and wound-induced protein kinase (WIPK) have been identified to be associated with insect attack. However, function of MAPKs in crop plants in response to herbivory largely remains unknown. Here, we evaluated the expression patterns of fifteen MAPK genes from chickpea in response to infestation by a major pest, Helicoverpa armigera via quantitative realtime PCR (qPCR). Subsequently, we compared the expression patterns of CaMAPKs in response to two related but different processes i.e. insect attack and mechanical wounding. Signaling compounds such as Jasmonates, Salicylic acid and Ethylene also play crucial function in defense response. Therefore, we have also examined the expression profiles of H. armigera-inducible MAPK genes in response to these signaling compounds. Our results revealed that out of fifteen CaMAPKs, seven of the CaMAPKs are upregulated in response to H. armigera and two are downregulated. Additionally, they show differential expression on comparing Helicoverpa-infestation and wounding. Jasmonates and Ethylene mainly regulate CaMAPK genes that may play a role in defense against Helicoverpa-infestation. This study provides insights into the participation of MAPKs in defense against insects.

Treatment of monazite processed effluent to recover rare earth metals (REMs)

Archana Kumari,Sunidhi Singh,Kavita Parmar,Devendra Deo Pathak,Manis Kumar Jha 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.83 No.-

Improper disposal of effluent generated in rare earth mining areas and ore processing industries resultsin loss of REMs and miserably affects the ecosystem. Thus, their appropriate treatment is required, whichcan be achieved via environmentally feasible processes. In this connection, systematic scientificadsorption studies were carried out to separate REMs using cationic resin, Amberlite IR120 Na from theeffluent generated during monazite processing for REMs recovery. To optimize feasible conditions forREMs recovery, bench scale studies were carried out varying different process parameters viz. pH, contacttime, resin dose, etc. It was observed that adsorption of 92.63% La, 92.79% Ce, 91.45% Nd, 90.95% Pr and95.09% Sm was achieved at aqueous/ resin (A/R) ratio 25 mL/g, pH 1.3 and contact time 10 min. Loadingcapacity of resin was found to hold 48.57 mg REMs/g resin. The adsorption data followed the second orderreaction ((t/q) = (1/h) + (1/qe)(t)) and Langmuir adsorption isotherm (1/q = [(1/k1 qm)(1/Ce)] + (1/qm)). The loaded REMs was effectively eluted using 15% H2SO4 in 10 min. The REMs enriched solution wastreated to get pure REM oxides as precipitate. This technical application will be useful for REMs recoveryas well as to mitigate environmental pollution.

Temporary Endoscopic Stimulation in Gastroparesis-like Syndrome

( Sanjeev Singh ),( Jeff Mccrary ),( Archana Kedar ),( Stephen Weeks ),( Brian Beauerle ),( Andrew Weeks ),( Omer Endashaw ),( Chris Lahr ),( Warren Starkebaum ),( Thomas Abell ) 대한소화기기능성질환·운동학회 2015 Journal of Neurogastroenterology and Motility (JNM Vol.21 No.4

Background/Aims Gastroparesis-like syndrome (GLS) is defined as gastroparesis-like symptoms with normal gastric scintigraphy. While the efficacy of gastric electrical stimulation (GES) in gastroparesis is well known, the utility of GES in GLS is largely unknown. Our aim was to clarify the role of GES in GLS. We implanted consecutive patients with symptoms of gastroparesis with temporary gastric electrical stimulation and observed changes in gastric scintigraphy and total symptom score. Methods Five hundred and fifty-one patients suffering from symptoms of gastroparesis (nausea, vomiting, bloating/distension, anorexia/ early satiety, and abdominal pain) with negative endoscopy underwent gastric scintigraphy with analysis of 1) solid radionuclide gastric emptying at 1, 2, and 4 hours (% remaining); 2) area under the gastric emptying curve (AUC) at 1, 2, and 4hours; and 3) total gastric emptying test (GET) (the sum of 1, 2, and 4 hour values). Patients were stratified into: delayed gastric emptying, normal gastric emptying, and rapid gastric emptying (Appendix). Of the 551 patients in the larger cohort, 379 had implantation of temporary gastric electrical stimulation (tGES). Gastrointestinal symptoms and gastric emptying were com - pared pre and post tGES implantation. Results After tGES, 2 hour gastric retention decreased (P < 0.01) for the delayed patients, and increased (P < 0.001) for normal and rapid patients. These changes were accompanied by improvements (P < 0.001) in vomiting, nausea, and total symptom scores in all 3 subgroups. Conclusions Gastric electrical stimulation may be an effective therapy for treating the symptoms of gastroparesis with normal gastric emptying.Further exploration of endoscopic electrical stimulation as a treatment for gastroparesis-like symptoms with non-delayed gastric emptying is needed. (J Neurogastroenterol Motil 2015;21:520-527)

Imprinted Graphene-Starch Nanocomposite Matrix-Anchored EQCM Platform for Highly Selective Sensing of Epinephrine

Juhi Srivastava,Archana Kushwaha,Meenakshi Singh 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.11

In this paper, an electrochemical sensor for epinephrine (EP), a neurotransmitter was developed by anchoring molecularly imprinted polymeric matrix (MIP) on the surface of gold-coated quartz crystal electrode of electrochemical quartz crystal microbalance (EQCM) using starch nanoparticles (Starch NP) — reduced graphene oxide (RGO) nanocomposite as polymeric format for the first time. Use of EP in therapeutic treatment requires proper dose and route of administration. Proper follow-up of neurological disorders and timely diagnosis of them has been found to depend on EP level. The MIP sensor was developed by electrodeposition of starch NP-RGO composite on EQCM electrode in presence of template EP. As the imprinted sites are located on the surface, high specific surface area enables good accessibility and high binding affinity to template molecule. Differential pulse voltammetry (DPV) and piezo-electrogravimmetry were used for monitoring binding/release, rebinding of template to imprinted cavities. MIP-coated EQCM electrode were characterized by contact angle measurements, AFM images, piezoelectric responses including viscoelasticity of imprinted films, and other voltammetric measurements including direct (DPV) and indirect (using a redox probe) measurements. Selectivity was assessed by imprinting factor (IF) as high as 3.26 (DPV) and 3.88 (EQCM). Sensor was rigorously checked for selectivity in presence of other structurally close analogues, real matrix (blood plasma), reproducibility, repeatability, etc. Under optimized conditions, the EQCM-MIP sensor showed linear dynamic ranges (1–10 μM). The limit of detection 40 ppb (DPV) and 290 ppb (EQCM) was achieved without any cross reactivity and matrix effect indicating high sensitivity and selectivity for EP. Hence, an eco-friendly MIP-sensor with high sensitivity and good selectivity was fabricated which could be applied in ""real"" matrices in a facile manner.

Tobacco Cessation in India: How Can Oral Health Professionals Contribute?

Oberoi, Sukhvinder Singh,Sharma, Gaurav,Nagpal, Archana,Oberoi, Avneet Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

Tobacco use is described as the single most preventable cause of morbidity and mortality globally, with the World Bank predicting over 450 million tobacco-related deaths in the next fifty years. In India, the proportion of all deaths that can be attributed to tobacco use is expected to rise from 1.4% in 1990 to 13.3% in 2020 of which smoking alone will cause about 930,000 adult deaths by 2010. Many studies have shown that counseling from a health professional is an effective method of helping patients quit the tobacco habit. Tobacco cessation needs to be urgently expanded by training health professionals in providing routine clinical interventions, increasing availability and subsidies of pharmacotherapy, developing wide-reaching strategies such as quitlines, and costeffective strategies, including group interventions. The WHO Framework Convention on Tobacco Control (FCTC) emphasizes the vital contribution of participation of health professional bodies, as well as training and healthcare institutions in tobacco control efforts. Dentists can play an important role in helping patients quit using tobacco. One of the key strategies to reduce tobacco-related morbidity and mortality is to encourage the involvement of health professionals in tobacco-use prevention and cessation counselling. The dental office is an ideal setting for tobacco cessation services since preventive treatment services, oral screening, and patient education have always been a large part of the dental practice.

Magnetic molecularly imprinted polymer photocatalysts: synthesis, applications and future perspective

Komal Poonia,Pankaj Raizada,Archana Singh,Narinder Verma,Tansir Ahamad,Saad M. Alshehri,Aftab Aslam Parwaz Khan,Pardeep Singh,Chaudhery Mustansar Hussain 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.113 No.-

Effective degradation of low-concentration pollutants is a critical challenge during the water purificationprocess. The use of different chemicals can leave residue in samples that can impose potential ecotoxicologicaland adverse impacts on human health. Presently, Magnetic molecularly imprinted polymers(MMIPs) have attracted much attention as the research material comprises a non-magnetic polymerand magnetic material for selective binding for target molecule and recoverability of catalyst via magnetism,respectively. This review explains the synergistic effect of adsorption with photocatalysis tounderstand their recognition mechanism and the possible interaction between the target molecule andMIPs. Then their common imprinting polymerization processes i.e., free radical polymerization andnon-free radical polymerization are briefly discussed with their respective advantages and disadvantages. In addition, this review highlights the photocatalytic degradation mechanism of photocatalyst cumadsorbent is critically discussed by comparing it with non-imprinted polymers. Finally, the applicationsof MMIPs in the removal or degradation of refractory pollutants, sensing, and recognition have alsobeen delineated. This paper summarises progressive future challenges of the technology that need tobe exploited for the preparation of the targeted catalyst.

Red cell alloimmunization in pregnancy: a study from a premier tertiary care centre of Western India

Meenakshi Gothwal,Pratibha Singh,Archana Bajpayee,Neha Agrawal,Garima Yadav,Charu Sharma 대한산부인과학회 2023 Obstetrics & Gynecology Science Vol.66 No.2

ObjectiveThe study was conducted to determine the frequency of alloimmunization to various blood group antibodies in pregnant women, and the risk of hemolytic disease in the fetus and newborn. MethodsAll antenatal women, irrespective of the period of gestation or obstetric history, were included, whereas those taking anti-D immune-prophylaxis or with a history of blood transfusion were excluded. Antibody screening and identification were performed using a Bio-Rad ID microtyping system. ResultsOf 2,084 antenatal females, 1,765 were D?antigen positive and 319 D?antigen negative. Sixty-five (3.119%) women alloimmunized. Out of 54 (2.591%) who had sensitized to D-antigen, 11 (0.527%) also sensitized to other antibodies. These 11 alloantibodies identified included: anti-M (n=6; 9.23%), anti-C (n=1; 3.076%), anti-E (n=1; 1.538%), anti-e (n=1; 1.538%), anti-Lewis (a) (n=1; 1.538%), and unspecified antibodies (n=1; 1.538%). Multiple antibodies were seen in four patients that combined: anti-D and anti-C (n=2; 3.076%), anti-e and anti-c (n=1; 1.538%), and anti-D and anti-G (n=1; 1.538%). ConclusionThe rate of alloimmunization in D-antigen-negative women was high. Apart from this, the alloimmunization rate in women with bad obstetric history was very high, at 8.1%. In developing countries such as India, universal antenatal antibody screening, though desirable, may not be justified at present, as the cost and infrastructure required would be immense because of the lower alloimmunization rates in RhD antigen-positive women. However, it is necessary to impose properly formulated protocols to screen pregnant women with bad obstetric history.

Epithelial ovarian tumors in a premenarchal girl: a rare case report

( Pushpanjali Ojha ),( Jitendra Singh Nigam ),( Archana Hemant Deshpande ),( Chitrawati Bal Gargade ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.5

Ovarian tumors are relatively uncommon in paediatric age group and mostly occur in the period after menarche and are extremely rare prior to menarche. However, in children and adolescent, the epithelial ovarian tumors account approximately 10% to 28% of all ovarian tumors. In the present case, the patient was presented with abdominal pain for 1 day and no mass was felt on physical examination. Contrast-enhance computed tomography abdomen and pelvis showed a left ovarian cystic mass measuring 7.3×5.1 cm in size and unilateral oophorectomy was done. Tumor shows multiloculated cysts of varying sizes filled with mucinous fluid. Cysts were lined by tall columnar epithelial cells and show predominantly periodic acid-Schiff positive neutral mucin favouring benign nature of lesion. We present this case due to its uncommon age of presentation and the patient was premenarchal girl.

Quantitative histology-based classification system for assessment of the intestinal mucosal histological changes in patients with celiac disease

Prasenjit Das,Gaurav PS Gahlot,Alka Singh,Vandana Baloda,Ramakant Rawat,Anil K Verma,Gaurav Khanna,Maitrayee Roy,Archana George,Ashok Singh,Aasma Nalwa,Prashant Ramteke,Rajni Yadav,Vineet Ahuja,Vishnu 대한장연구학회 2019 Intestinal Research Vol.17 No.3

Background/Aims: The existing histological classifications for the interpretation of small intestinal biopsies are based on qualitative parameters with high intraobserver and interobserver variations. We have developed and propose a quantitative histological classification system for the assessment of intestinal mucosal biopsies. Methods: We performed a computer-assisted quantitative histological assessment of digital images of duodenal biopsies from 137 controls and 124 patients with celiac disease (CeD) (derivation cohort). From the receiver-operating curve analysis, followed by multivariate and logistic regression analyses, we identified parameters for differentiating control biopsies from those of the patients with CeD. We repeated the quantitative histological analysis in a validation cohort (105 controls and 120 patients with CeD). On the basis of the results, we propose a quantitative histological classification system. The new classification was compared with the existing histological classifications for interobserver and intraobserver agreements by a group of qualified pathologists. Results: Among the histological parameters, intraepithelial lymphocyte count of ≥25/100 epithelial cells, adjusted villous height fold change of ≤0.7, and crypt depth-to-villous height ratio of ≥0.5 showed good discriminative power between the mucosal biopsies from the patients with CeD and those from the controls, with 90.3% sensitivity, 93.5% specificity, and 96.2% area under the curve. Among the existing histological classifications, our quantitative histological classification showed the highest intraobserver (69.7%–85.03%) and interobserver (24.6%–71.5%) agreements. Conclusions: Quantitative assessment increases the reliability of the histological assessment of mucosal biopsies in patients with CeD. Such a classification system may be used for clinical trials in patients with CeD.