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        Temporary Endoscopic Stimulation in Gastroparesis-like Syndrome

        ( Sanjeev Singh ),( Jeff Mccrary ),( Archana Kedar ),( Stephen Weeks ),( Brian Beauerle ),( Andrew Weeks ),( Omer Endashaw ),( Chris Lahr ),( Warren Starkebaum ),( Thomas Abell ) 대한소화기기능성질환·운동학회 2015 Journal of Neurogastroenterology and Motility (JNM Vol.21 No.4

        Background/Aims Gastroparesis-like syndrome (GLS) is defined as gastroparesis-like symptoms with normal gastric scintigraphy. While the efficacy of gastric electrical stimulation (GES) in gastroparesis is well known, the utility of GES in GLS is largely unknown. Our aim was to clarify the role of GES in GLS. We implanted consecutive patients with symptoms of gastroparesis with temporary gastric electrical stimulation and observed changes in gastric scintigraphy and total symptom score. Methods Five hundred and fifty-one patients suffering from symptoms of gastroparesis (nausea, vomiting, bloating/distension, anorexia/ early satiety, and abdominal pain) with negative endoscopy underwent gastric scintigraphy with analysis of 1) solid radionuclide gastric emptying at 1, 2, and 4 hours (% remaining); 2) area under the gastric emptying curve (AUC) at 1, 2, and 4hours; and 3) total gastric emptying test (GET) (the sum of 1, 2, and 4 hour values). Patients were stratified into: delayed gastric emptying, normal gastric emptying, and rapid gastric emptying (Appendix). Of the 551 patients in the larger cohort, 379 had implantation of temporary gastric electrical stimulation (tGES). Gastrointestinal symptoms and gastric emptying were com - pared pre and post tGES implantation. Results After tGES, 2 hour gastric retention decreased (P < 0.01) for the delayed patients, and increased (P < 0.001) for normal and rapid patients. These changes were accompanied by improvements (P < 0.001) in vomiting, nausea, and total symptom scores in all 3 subgroups. Conclusions Gastric electrical stimulation may be an effective therapy for treating the symptoms of gastroparesis with normal gastric emptying.Further exploration of endoscopic electrical stimulation as a treatment for gastroparesis-like symptoms with non-delayed gastric emptying is needed. (J Neurogastroenterol Motil 2015;21:520-527)

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        Multidentate polyzwitterion attachment to polydopamine modified ultrafiltration membranes for dairy processing: Characterization, performance and durability

        Thomas G. Barclay,Hanaa M. Hegab,Andrew Michelmore,Michael Weeks,Milena Ginic-Markovic 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.61 No.-

        Filtration membrane technologies are used extensively in dairy processing and due to the high quantities of both organic and inorganic foulant, membrane fouling is a significant problem in the industry. To address this issue, a polyzwitterionic antifouling coating was applied to polyethersulfone ultrafiltration membranes for reduction of biofouling in skim milk filtration. The novel polyzwitterion was synthesised from a branched polyethyleneimine-based macroinitiator to allow multidentate binding to polydopamine coated membranes. Attachment of polyzwitterion to the polydopamine was confirmed using FTIR-ATR and XPS and the coating proved effective in increasing the wettability and smoothness of the membrane surface as well as reducing its charge. The reduced strength of binding between proteins and the membrane of the coated membrane compared to the control was demonstrated with its positive influence on fouling coefficient and recovery of the membranes while retaining skim milk flux and the rejection characteristics of the control membrane. The improved filtration characteristics of the coated membranes were generally retained through multiple cleaning cycles, though there was evidence of oxidative degradation after sanitation.

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