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- 저자 : Araújo João Ricardo (검색결과 2 건)
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Ismael Shámila,Rodrigues Catarina,Santos Gilberto Maia,Castela Inês,Barreiros-Mota Inês,Almeida Maria João,Calhau Conceição,Faria Ana,Araújo João Ricardo 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.4
BACKGROUND/OBJECTIVES: Indole-3-propionic acid (IPA) is a tr yptophan-derived microbial metabolite that has been associated with protective effects against inflammator y and metabolic diseases. However, there is a lack of knowledge regarding the effects of IPA under physiological conditions and at the intestinal level. MATERIALS/METHODS: Human intestinal epithelial Caco-2 cells were treated for 2, 24, and/ or 72 h with IPA or its precursors – indole, tr yptophan, and propionate – at 1, 10, 100, 250, or 500 μM to assess cell viability, integrity, differentiation, and proliferation. RESULTS: IPA induced cell proliferation and this effect was associated with a higher expression of extracellular signal-regulated kinase 2 (ERK2) and a lower expression of c-Jun. Although indole and propionate also induced cell proliferation, this involved ERK2 and c-Jun independent mechanisms. On the other hand, both tr yptophan and propionate increased cell integrity and reduced the expression of claudin-1, whereas propionate decreased cell differentiation. CONCLUSIONS: In conclusion, these findings suggested that IPA and its precursors distinctly contribute to the proliferation, differentiation, and barrier function properties of human intestinal epithelial cells. Moreover, the pro-proliferative effect of IPA in intestinal epithelial cells was not explained by its precursors and is rather related to its whole chemical structure. Maintaining IPA at physiological levels, e.g., through IPA-producing commensal bacteria, may be important to preser ve the integrity of the intestinal barrier and play an integral role in maintaining metabolic homeostasis.
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Antinociceptive Action and Redox Properties of Citronellal, an Essential Oil Present in Lemongrass
Lucindo Quintans-Júnior,Ricardo Fagundes da Rocha,Fernanda Freitas Caregnato,José Claudio Fonseca Moreira,Francilene Amaral da Silva,Adriano Antunes de Souza Araújo,João Paulo Almeida dos Santos,Mônic 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.6
Citronellal (CT) is a monoterpenoid and the major constituent of the mixture of terpenoids that give the citronella oil its lemon scent. Citronella oil is widely used around the world for various purposes and is mainly obtained from plants of the Cymbopogon genus, which are known as “lemongrass.” Considering these plants have been used worldwide for various medicinal purposes, the interest of researchers to understand the biological activities of monoterpenoids related to the Cymbopogon genus has been increasing. In the present work, we investigated the antinociceptive action and the redox properties of CT. Our results indicate that intraperitoneal injection of CT was effective in reducing nociceptive face-rubbing behavior in both phases of the formalin test, which was also naloxone-sensitive. CT also evoked antinociceptive response in the capsaicin and glutamate tests. The total radical-trapping antioxidant parameter and total antioxidant reactivity assays indicate that CT at doses of 0.1 and 1 mg/mL exerts a significant antioxidant activity, which is probably related to its ability to scavenge superoxide and nitric oxide, but not H_2O_2 or hydroxyl radicals, as evaluated separately by specific in vitro tests. These results show for the first time the antinociceptive potential of CT and indicate that the antioxidant properties of this compound may rely on its mechanism of biological actions because CT-containing natural products are used to treat various diseases related to oxidative stress and reactive species.
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