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- 저자 : Mônic (검색결과 3 건)
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Antinociceptive Action and Redox Properties of Citronellal, an Essential Oil Present in Lemongrass
Lucindo Quintans-Júnior,Ricardo Fagundes da Rocha,Fernanda Freitas Caregnato,José Claudio Fonseca Moreira,Francilene Amaral da Silva,Adriano Antunes de Souza Araújo,João Paulo Almeida dos Santos,Mônic 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.6
Citronellal (CT) is a monoterpenoid and the major constituent of the mixture of terpenoids that give the citronella oil its lemon scent. Citronella oil is widely used around the world for various purposes and is mainly obtained from plants of the Cymbopogon genus, which are known as “lemongrass.” Considering these plants have been used worldwide for various medicinal purposes, the interest of researchers to understand the biological activities of monoterpenoids related to the Cymbopogon genus has been increasing. In the present work, we investigated the antinociceptive action and the redox properties of CT. Our results indicate that intraperitoneal injection of CT was effective in reducing nociceptive face-rubbing behavior in both phases of the formalin test, which was also naloxone-sensitive. CT also evoked antinociceptive response in the capsaicin and glutamate tests. The total radical-trapping antioxidant parameter and total antioxidant reactivity assays indicate that CT at doses of 0.1 and 1 mg/mL exerts a significant antioxidant activity, which is probably related to its ability to scavenge superoxide and nitric oxide, but not H_2O_2 or hydroxyl radicals, as evaluated separately by specific in vitro tests. These results show for the first time the antinociceptive potential of CT and indicate that the antioxidant properties of this compound may rely on its mechanism of biological actions because CT-containing natural products are used to treat various diseases related to oxidative stress and reactive species.
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Body-centered cubic phase in 3-arm star mesogens: a torsional tapping AFM and GISAXS study
Weber, Christa H. M.,Liu, Feng,Zeng, Xiang-bing,Ungar, Goran,Mullin, Nic,Hobbs, Jamie K.,Jahr, Michael,Lehmann, Matthias The Royal Society of Chemistry 2010 SOFT MATTER Vol.6 No.21
<P>The mode of liquid crystal (LC) self-assembly of asymmetric three-arm star oligobenzoate mesogens has been investigated by torsional tapping mode AFM imaging, and by bulk and grazing-incidence X-ray diffraction. It was confirmed that the cubic liquid crystal phase has <I>Im</I>3&cmb.macr;<I>m</I> symmetry and established that it consists of spherical aggregates arranged on a body-centered lattice, rather than having a bicontinuous structure. Molecular simulation suggests that, in spite of their perceived rigidity, the oligobenzoate mesogens are folded, often sharply, within the supramolecular spheres, and that they act effectively as conical objects. The recently introduced torsional tapping AFM technique has allowed high resolution and contrast to be obtained from the soft mobile surface of the samples, showing the (110) plane of highly ordered supramolecular spheres. Notably the fine structure of the observed steps reveals that nearly isolated micelles still preserve their integrity. Finally, the equilibrium habits of the cubic LC droplets were shown by optical microscopy to be polyhedral with crystallographic facets, rather than spherical. This suggests that the air–LC interface is below the roughening transition temperature, which is attributed to the whole micelles rather than the isolated molecules acting as the interacting units.</P> <P>Graphic Abstract</P><P>A combination of torsional tapping atomic force microscopy and X-ray diffraction confirmed a cubic liquid crystal phase in 3-arm star mesogens, displaying faceted gem-like droplets and stable isolated self-assembled micelles at surface steps. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0sm00420k'> </P>
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Transcriptome analysis reveals key defense-related genes upon SA induction in Cocos nucifera L.
C. Silverio-Gómez,J. Vega-Arreguín,G. Nic-Matos,M. Narváez-Cab,L. Sáenz-Carbonell,C. Oropeza 한국유전학회 2022 Genes & Genomics Vol.44 No.2
Background: Salicylic acid (SA) is an important regulator of genes involved in plant defense and pathogen-triggered systemic acquired resistance (SAR). Coconut is an important crop affected by several pathogens. Reported evidence suggests SA involvement in defense responses, including SAR in coconut. Objective: To identified differentially expressed genes in leaf and root tissues of coconut plantlets, as a result of SA, that might be involved in coconut defense responses. Methods: Comparative transcriptomic analysis by RNA-Seq of leaf and root tissues from in vitro coconut plantlets unexposed and exposed to SA 2.5 mM for 48 h. And in silico validation of gene expression by qRT-PCR. Results: We identified 4615 and 3940 differentially expressed unigenes (DEUs) in leaf and root tissues respectively. Our GO analysis showed functional categories related to the induction of defense responses, such as "systemic acquired resistance" and highly enriched hormone categories, such as abscisic acid. The most abundant KEGG pathway in our results was "Biosynthesis of antibiotics". Our findings support that exogenous application of SA to plantlets induced the activation of PRs, RGAs, ICS2, NLTP2, PER4, TRXM and some WRKYs mediated by NPR1-dependent pathways. Also, we found DEUs, such as BZR1, HSL1, and WHY2 that support that SA could regulate defense-related genes through NPR1-independent pathways. Conclusion: The present study of massive data analysis carried out on coconut plantlets exposed to SA, generates valuable information that increases our understanding of defense molecular mechanisms in coconut and open new venues for research for the improvement of management of coconut diseases.
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