Triple Negative Breast Cancer in People of North East India: Critical Insights Gained at a Regional Cancer Centre

Sharma, Mousumi,Sharma, Jagannath Dev,Sarma, Anupam,Ahmed, Shiraj,Kataki, Amal Chandra,Saxena, Rahul,Sharma, Dilutpal Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

Background: Breast cancer is a heterogeneous disease comprising of distinct biological subtypes with many targeted prognostic biomarkers having therapeutic implications. However, no specific targeted therapy for triple negative breast cancer has been discovered to date and hence further research is needed. Aim: The aim and objectives of the present study were to examine the prevalence of triple negative breast cancer (TNBC) in North-East India and to compare the clinicopathological parameters in two study groups defined by immunohistochemistry (IHC) - "TNBC" and "Others". Materials and Methods: We carried out a retrospective study in a cohort of 972 patients diagnosed with invasive breast carcinoma in the Department of Pathology, Dr. B. Borooah Cancer Institute, a Regional Cancer Centre for treatment and research, Guwahati, for a period of 3 years and 10 months from January 2010 to October 2013. Based on IHC findings, patients were divided into two groups - "TNBC" and "Others". All relevant clinicopathological parameters were compared in both. TNBC were defined as those that were estrogen receptor (ER), progesterone receptor (PR), and HER2/neu negative while those positive for any of these markers were defined as "Others". Results: In this study, out of total 972 cases 31.9% (310 cases) were defined as TNBC and 662 cases (68.1%) as "Others" based on IHC markers. Compared to the "Others" category, TNBC presented at an early age (mean 40 years), were associated with high grade large tumours and high rate of node positivity, IDC NOS being the most common histological subtype in TNBC. Conclusions: TNBC accounts for a significant portion of breast cancers in this part of India and commonly present at younger age and tend to be large high grade tumours.

Beneficial Effects of Chrysin and Benzoflavone on Virility in 2-Year-Old Male Rats

Anupam Sharma,Kamaldeep Dhawan,Suresh Kumar 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.1

This work describes the potential usefulness of bioflavonoids for countering the deleteriouseffects of aging on male sexuality in 2-year-old rats. A flavone chrysin from Passiflora caeruleaLinn. and a benzoflavone moiety (BZF) recently isolated from Passiflora incarnata Linn. wereadministered to 2-year-old male rats for a period of 30 days. After cessation of these treat-ments, there was a significant improvement in overall sexual functions in the rats givenbioflavonoids, compared with control rats. The rats receiving chrysin (1 mg/kg) and BZF (10mg/kg) exhibited increased libido when they were allowed to interact with nonestrous femalerats. Additionally, both treated groups had increased sperm count, greater fertilization po-tential, and greater litter size when they were allowed to interact with proven proestrous fe-male rats of a similar strain. BZF was more potent than chrysin as an antiaromatase agent andexhibited better effects on the sexual system of the 2-year-old male rats. Plant flavonoids havegreat potential for clinical and therapeutic aplications against the physiological and bio-chemical effects of aging.43

SOME EXISTENCE AND UNIQUENESS THEOREMS ON ORDERED METRIC SPACES VIA GENERALIZED DISTANCES UNDER NEW CONTROL FUNCTIONS

( Anupam Sharma ),( Arslan Hojat Ansari ) 호남수학회 2016 호남수학학술지 Vol.38 No.3

The purpose of this paper is to prove some fixed point theorems in a complete metric space equipped with a partial ordering using ω-distances together with the aid of an altering functions and new functions of admissible type.

Pharmacognostic Standardization of Turnera aphrodisiaca Ward

Anupam Sharma,Suresh Kumar,Ruchi Taneja 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.2

Turnera aphrodisiacaWard (Turneraceae) has been used traditionally as an aphrodisiac, stimulant, nerve tonic,and laxative and in kidney, menstrual, and pregnancy disorders. Despite a long tradition of use in the treatment of various ail-ments, no systematic phytochemical and pharmacological work has ever been carried out on T. aphrodisiaca. The authorssuggest that the major stumbling block in systematic exploration of the plant is non-availability of authentic plant material.In the present investigation, various pharmacognostic standards for the plant have been generated so that authentic T. aphro-disiacacould be explored for its traditional claims. Microscopically, T. aphrodisiacaleaf showed the presence of abundantunicellular, warty, non-glandular trichomes, anomocytic stomata, and a large number of calcium oxalate crystals along theveins. Powdered stem of the plant showed lignified spiral and pitted tracheidal vessels, and pericyclic fibers were observedin powder microscopy of stem. Total ash of the aerial parts of T. aphrodisiacawas approximately eight and four times morethan acid-insoluble and water-soluble ash, respectively. The water-soluble extractive value of the plant was slightly higherthan its ethanol-soluble extractive value. Volatile oil content of T. aphrodisiacawas found to be 0.44% (wt/vol), the thin-layer chromatography of which exhibited seven spots using toluene:ethyl acetate (93:7 vol/vol) as mobile phase. Thin-layerchromatography of the petroleum ether extract showed nine spots using hexane:dichloromethane (1:1 vol/vol), while the chlo-roform extract showed 11 spots using toluene:ethyl acetate:glacial acetic acid (35:4:1 by volume). Phytochemically, the plantwas found to contain alkaloids, cyanogenic glycosides, steroids, saponins, flavonoids, tannins, carbohydrates, and proteins.

SOME EXISTENCE AND UNIQUENESS THEOREMS ON ORDERED METRIC SPACES VIA GENERALIZED DISTANCES UNDER NEW CONTROL FUNCTIONS

Sharma, Anupam,Ansari, Arslan Hojat The Honam Mathematical Society 2016 호남수학학술지 Vol.38 No.3

The purpose of this paper is to prove some fixed point theorems in a complete metric space equipped with a partial ordering using w-distances together with the aid of an altering functions and new functions of admissible type.

Oral Presentations : Parenteral Nutrition, Enteral Nutrition, Home TPN and TEN ; Nutritional and Economical Efficacy of Home Blenderised Feeds in India

( Avantina Sharma ),( Neeta Sharma ),( Anupam Prakash ) 한국정맥경장영양학회 2005 The 11th PENSA Congress Vol.2005 No.-

Clinical presentation of COVID-19 in patients with inflammatory bowel disease: a systematic review and meta-analysis

( Anupam K. Singh ),( Anuraag Jena ),( Praveen Kumar-m ),( Daya Krishna Jha ),( Vishal Sharma ) 대한장연구학회 2022 Intestinal Research Vol.20 No.1

Background/Aims: Coronavirus disease 2019 (COVID-19) is recognized to have variable clinical manifestations. The clinical presentation of patients with inflammatory bowel disease (IBD) having COVID-19 is unclear. Methods: We identified articles reporting about the clinical presentation of COVID-19 in those with underlying IBD from PubMed and Embase. The studies, irrespective of design or language, were included. The overall pooled frequency of various symptoms was estimated. Joanna Briggs Institute Critical appraisal checklist was used to assess the quality of studies. Results: Eleven studies, including 1,325 patients, were included in the pooled analysis. The pooled estimates for clinical presentation were; fever: 67.53% (95% confidence interval [CI], 45.38-83.88), cough: 59.58% (95% CI, 45.01-72.63), diarrhea: 27.26% (95% CI, 19.51-36.69), running nose: 27% (95% CI, 15.26-43.19) and dyspnea: 25.29% (95% CI, 18.52-33.52). The pooled prevalence rates for abdominal pain, nausea and vomiting were 13.08% (95% CI, 9.24-18.19), 10.08% (95% CI, 5.84-16.85) and 8.80% (95% CI, 4.43-16.70) per 100 population, respectively. Conclusions: The clinical presentation of COVID-19 in IBD patients is similar to the general population. (Intest Res 2022;20:134-143)

Economic Power Dispatch with Valve Point Effects Using Bee Optimization Algorithm

Kumar, Rajesh,Sharma, Devendra,Kumar, Anupam The Korean Institute of Electrical Engineers 2009 Journal of Electrical Engineering & Technology Vol.4 No.1

This paper presents a newly developed optimization algorithm, the Bee Optimization Algorithm (BeeOA), to solve the economic power dispatch (EPD) problem. The authors have developed a derivative free and global optimization technique based on the working of the honey bee. The economic power dispatch problem is a nonlinear constrained optimization problem. Classical optimization techniques fail to provide a global solution and evolutionary algorithms provide only a good enough solution. The proposed approach has been examined and tested on two test systems with different objectives. A simple power dispatch problem is tested first on 6 generators and then the algorithm is demonstrated on 13 thermal unit systems whose incremental fuel cost function takes into account the value point loading effect. The results are promising and show the effectiveness and robustness of the proposed approach over recently reported methods.

Concentration Dependent Optical Properties of Rhodamine B Doped Poly(vinyl alcohol) Solutions

Jitendra Tripathi,Anupam Sharma,Shilpa Tripathi,Kallol Kumar Das 한국고분자학회 2016 Macromolecular Research Vol.24 No.7

The optical properties, namely refractive index (RI) studies, are reported on a series of pure and doped poly(vinyl alcohol) (PVA) in solution form. The PVA solutions were synthesized with 1, 2, 3, 4, and 5 wt% of PVA in distilled water followed by doping with Rhodamine B in concentrations ranging from 0.05 wt% to 2 wt%. The absorption spectra show an observable shift in the band edge position towards higher wavelength with increase in PVA wt%. When the dopant molecules are added, the curves are drastically modified with the occurrence of new peaks arising at higher doping concentrations along with change in the bandgap. These effects are prominent for all the concentration of PVA solution. The RI does not change much for low doping wt%. but when dopant is added in higher concentrations, it increases slightly reaching a maximum of ~1.35 at 2 wt%. It is observed that host polymer properties dominate at low doping while a combination of host polymer and dopant dye properties dominate at higher doping concentrations.

Economic Power Dispatch with Valve Point Effects Using Bee Optimization Algorithm

Rajesh Kumar,Devendra Sharma,Anupam Kumar 대한전기학회 2009 Journal of Electrical Engineering & Technology Vol.4 No.1

This paper presents a newly developed optimization algorithm, the Bee Optimization Algorithm (BeeOA), to solve the economic power dispatch (EPD) problem. The authors have developed a derivative free and global optimization technique based on the working of the honey bee. The economic power dispatch problem is a nonlinear constrained optimization problem. Classical optimization techniques fail to provide a global solution and evolutionary algorithms provide only a good enough solution. The proposed approach has been examined and tested on two test systems with different objectives. A simple power dispatch problem is tested first on 6 generators and then the algorithm is demonstrated on 13 thermal unit systems whose incremental fuel cost function takes into account the value point loading effect. The results are promising and show the effectiveness and robustness of the proposed approach over recently reported methods.