Deformation Mechanism of 5052 Aluminum Alloy Using Electrically Assisted Electromagnetic Forming

Ang Xiao,Changqing Huang,HongSheng Liu,Xiaohui Cui,Shipeng Wang 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.10

A technology named as electrically assisted electromagnetic forming (EAEMF) was used to improve the plastic deformationability of 5052 aluminum alloy at room temperature. The ANSYS software is used to study the force and deformation ofworkpiece based on sequential coupling method. The simulation results show that the pulse current can increase the currentdensity, improve the uniformity of current distribution, and increase the forming height of the sample. The primary strainand secondary strain are increased by 53.8% and 27.4% respectively. Under the same deformation condition, the elongationof EAEMF sample increases by 160%, while the strength decreases slightly. From the perspective of microstructure evolution,the dislocation density of EAEMF sample is lower than that of EMF sample, and the pinning effect of the second phaseparticles on the dislocation is weakened. Under the action of the pulse current, the dislocations continue to move around thesecond phase particles with higher energy, and the dislocations appear directional arrangement.

Numerical Simulation on Energy Concentration and Release Process of Strain Rockburst

Ang Lu,Peng Yan,Wenbo Lu,Ming Chen,Gaohui Wang,Sheng Luo,Xiao Liu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.10

Rockburst mechanism has been a hot topic in the stability analysis of underground carven excavation, and the accurate description of energy evolution process is very critical to rockburst prediction. To study the evolution process of rockburst, such as V-shaped rockburst pit, theoretical formula derivation and numerical simulation are adopted to research the dynamic response characteristics during the formation process of rockburst pits quantitatively. The results show that rockburst intensity distribution varies with failure depth. It can be divided into three zone: slow-increase, rapid-increase and slow-decrease. For a circular tunnel with radius R, the strain energy release rate and vibration response of surrounding rock increases gradually within (0 − 0.06) R; reaches the peak value around (0.06 − 0.1) R and drops to a balance beyond 0.1R. Due to the same law of them, the rockburst risk can be conveniently predicted by monitoring vibration of surrounding rock with a certain depth. This work is beneficial to provide a good reference for rockburst prediction.

The Application of Kalman Filter to the Natural Gamma Spectrum Well Logging

Naig Ang Cui,Xiao Hui Lin,Yong De Jin 대한전자공학회 1995 ICEIC:International Conference on Electronics, Inf Vol.1 No.1

The Application of Decellularized Adipose Tissue Promotes Wound Healing

Xia Zenan,Guo Xiao,Yu Nanze,Zeng Ang,Si Loubin,Long Fei,Zhang Wenchao,Wang Xiaojun,Zhu Lin,Liu Zhifei 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.6

Background: Due to adipose-derived stem cells (ASCs) being easy to obtain, their rapid proliferation rate, and their multidirectional differentiation capabilities, they have been widely used in the field of regenerative medicine. With the progress of decellularized adipose tissue (DAT) and adipose tissue engineering research, the role of DAT in promoting angiogenesis has gradually been emphasized. Methods: We examined the biological characteristics and biosafety of DAT and evaluated the stem cell maintenance ability and promotion of growth factor secretion through conducting in vitro and in vivo studies. Results The tested ASCs showed high rat:es of proliferation and adhered well to DAT. The expression levels of essential genes for cell stem maintenance, including OCT4, SOX2, and Nanog were low at 2–24 h and much higher at 48 and 96 h. The Adipogenic expression level of markers for ASCs proliferation including PPARγ, C/EPBα, and LPL increased from 2 to 96 h. Co-culture of ASCs and DAT increased the secretion of local growth factors, such as VEGF, PDGF-bb, bFGF, HGF, EGF, and FDGF-bb, and secretion gradually increased from 0 to 48 h. A model of full-thickness skin defects on the back of nude mice was established, and the co-culture of ASCs and DAT showed the best in vivo treatment effect. Conclusion: The application of DAT promotes wound healing, and DAT combined with ASCs may be a promising material in adipose tissue engineering and regenerative medicine.

Temperature Dependency of Hydrogen Embrittlement in Thermally H-precharged STS 304 Austenitic Stainless Steel

Shipeng Wang,Xiaohui Cui,Ang Xiao,Peng Zhao,Lei Zhang 대한금속ᆞ재료학회 2023 METALS AND MATERIALS International Vol.29 No.2

In this study, the effect of induced electro-pulsing treatment (IEPT) on the microstructure evolution and correspondingchanges in the mechanical properties of pre-stretched 5052-O aluminum alloy was investigated. Microstructural changesin the alloy were observed using electron backscatter diffraction, transmission electron microscopy, and scanning electronmicroscopy. The application of induced current significantly reduced the yield strength of pre-stretched specimens whilethe elongation increased. In terms of microstructure, more uniformly distributed dimples were observed after induced currentapplication, which indicate the increased plasticity of the alloy. The average grain size and number of low angle grainboundaries increased with application of induced current. The texture types did not change, however, the cube-type texturebecame less pronounced, whereas brass-type and copper-type textures were enhanced. Furthermore, the dislocation densitydecreased and dislocation rearrangement occurred. Thus, IEPT provides a new way to alter the microstructure and mechanicalproperties of the deformed components.

MicroRNA-214-mediated UBC9 expression in glioma

( Zhi Qiang Zhao ),( Xiao Chao Tan ),( Ani Zhao ),( Li Yuan Zhu ),( Bin Yin ),( Jiang Ang Yuan ),( Bo Qin Qiang ),( Xiao Zhong Peng ) 생화학분자생물학회(구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.11

It has been reported that ubiquitin-conjugating enzyme 9 (Ubc9), the unique enzyme2 in the sumoylation pathway, is up-regulated in many cancers. However, the expression and regulation of UBC9 in glioma remains unknown. In this study, we found that Ubc9 was up-regulated in glioma tissues and cell lines compared to a normal control. UBC9 knockdown by small interfering RNA (siRNA) affected cell proliferation and apoptosis in T98G cells. Further experiments revealed that microRNA (miR)-214 directly targeted the 3` untranslated region (UTR) of UBC9 and that there was an inverse relationship between the expression levels of miR-214 and UBC9 protein in glioma tissues and cells. MiR-214 overexpression suppressed the endogenous UBC9 protein and affected T98G cell proliferation. These findings suggest that miR-214 reduction facilitates UBC9 expression and is involved in the regulation of glioma cell proliferation.

Mechanical Properties and Microstructure Evolution of Pre-stretched Aluminum Alloy After Induced Electro-Pulsing Treatment

Shipeng Wang,Xiaohui Cui,Ang Xiao,Lei Zhang,Peng Zhao 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.3

In this study, the effect of induced electro-pulsing treatment (IEPT) on the microstructure evolution and correspondingchanges in the mechanical properties of pre-stretched 5052-O aluminum alloy was investigated. Microstructural changesin the alloy were observed using electron backscatter diffraction, transmission electron microscopy, and scanning electronmicroscopy. The application of induced current significantly reduced the yield strength of pre-stretched specimens whilethe elongation increased. In terms of microstructure, more uniformly distributed dimples were observed after induced currentapplication, which indicate the increased plasticity of the alloy. The average grain size and number of low angle grainboundaries increased with application of induced current. The texture types did not change, however, the cube-type texturebecame less pronounced, whereas brass-type and copper-type textures were enhanced. Furthermore, the dislocation densitydecreased and dislocation rearrangement occurred. Thus, IEPT provides a new way to alter the microstructure and mechanicalproperties of the deformed components.

Cervical Cancer Screening and Analysis of Potential Risk Factors in 43,567 Women in Zhongshan, China

Wang, Ying,Yu, Yan-Hong,Shen, Keng,Xiao, Lin,Luan, Feng,Mi, Xian-Jun,Zhang, Xiao-Min,Fu, Li-Hua,Chen, Ang,Huang, Xiang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Objective: The objective of this study was to establish a program model for use in wide-spread cervical cancer screening. :Methods: Cervical cancer screening was conducted in Zhongshan city in Guangdong province, China through a coordinated network of multiple institutes and hospitals. A total of 43,567 women, 35 to 59 years of age, were screened during regular gynecological examinations using the liquid-based ThinPrep cytology test (TCT). Patients who tested positive were recalled for further treatment. Results: The TCT-positive rate was 3.17%, and 63.4% of these patients returned for follow-up. Pathology results were positive for 30.5% of the recalled women. Women who were younger than 50 years of age, urban dwelling, low-income, had a history of cervical disease, began having sex before 20 years of age, or had sex during menstruation, were at elevated risk for a positive TCT test. The recall rate was lower in women older than 50 years of age, urban dwelling, poorly educated, and who began having sex early. Ahigher recall rate was found in women 35 years of age and younger, urban dwelling, women who first had sex after 24 years of age, and women who had sex during menstruation. The positive pathology rate was higher in urban women 50 years of age and younger and women who tested positive for human papillomavirus. Conclusion: An effective model for large-scale cervical cancer screening was successfully established. These results suggest that improvements are needed in basic education regarding cervical cancer screening for young and poorly educated women. Improved outreach for follow-up is also necessary to effectively control cervical cancer.

Forming Limit and Mechanical Properties of 2024-O Aluminum Alloy Under Electromagnetic Forming

Yuhong Lin,Xiaohui Cui,Kanghua Chen,Ang Xiao,Ziqin Yan 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.10

The effect of electromagnetic forming (EMF) on the forming limit and properties of 2024-O aluminum alloy is studied in thispaper. This was done to address the important problems related to the poor forming limit of aluminum alloy when conventionalstamping is used. The evolution of the microstructure of the alloy during quasi-static stamping (QS) and the dynamicdeformation is analyzed. This was done using mechanical testing, texture analysis, scanning electron microscopy (SEM),fracture analysis, and transmission electron microscopy (TEM). Compared with QS, the forming limit for EMF increases by36.9%. For the same deformation height with 17.6mm, the maximum degree of thickness thinning of the sample for EMF is4.7%, and 6.4% for QS. The thickness distribution of the EMF sample is more uniform than for the QS sample. Numericalsimulation shows the maximum principal stresses at different points were almost same with each other after EMF, whichleads to uniformity plastic deformation of samples. In addition, the grain size of the material decreases, the proportion ofsmall-angle grains increases, and the copper texture increases after EMF. When EMF is used, the dislocation density of thesample is significantly higher than for QS and the dislocation distribution is more uniform. The temperature rise is small,which is not a significant reason for dislocation dispersed in EMF.

SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways

Zhang, Yan-Li,Li, Qing,Yang, Xiao-Mei,Fang, Fang,Li, Jun,Wang, Ya-Hui,Yang, Qin,Zhu, Lei,Nie, Hui-Zhen,Zhang, Xue-Li,Feng, Ming-Xuan,Jiang, Shu-Heng,Tian, Guang-Ang,Hu, Li-Peng,Lee, Ho-Young,Lee, Su-J American Association for Cancer Research 2018 Cancer research Vol.78 No.9

<P>Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.</P><P>Tumor-associated macrophages (TAM) represent key regulators of the complex interplay between cancer and the immune microenvironment. Matricellular protein SPON2 is essential for recruiting lymphocytes and initiating immune responses. Recent studies have shown that SPON2 has complicated roles in cell migration and tumor progression. Here we report that, in the tumor microenvironment of hepatocellular carcinoma (HCC), SPON2 not only promotes infiltration of M1-like macrophages but also inhibits tumor metastasis. SPON2-α4β1 integrin signaling activated RhoA and Rac1, increased F-actin reorganization, and promoted M1-like macrophage recruitment. F-Actin accumulation also activated the Hippo pathway by suppressing LATS1 phosphorylation, promoting YAP nuclear translocation, and initiating downstream gene expression. However, SPON2-α5β1 integrin signaling inactivated RhoA and prevented F-actin assembly, thereby inhibiting HCC cell migration; the Hippo pathway was not noticeably involved in SPON2-mediated HCC cell migration. In HCC patients, SPON2 levels correlated positively with prognosis. Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.</P><P><B>Significance:</B> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.</P><P><B>Graphical Abstract:</B> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg. <I>Cancer Res; 78(9); 2305–17. ©2018 AACR</I>.</P><P><B>Graphical Abstract</B></P><P> [Figure]</P>