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체외 수정 시술에서 면역 억제가 임신율 및 그 결과에 미치는 영향
최안나,김선행,구병삼,Choi, An-Na,Kim, Sun-Haeng,Ku, Pyong-Sahm 대한생식의학회 1995 Clinical and Experimental Reproductive Medicine Vol.22 No.2
A prospective study was undertaken to test whether immunosuppression improves implantation, pregnancy rates and their outcomes in an in-vitro fertilization-embryo transfer( IVF-ET) cycles in patients with tubal factor infertility. The implantation and pregnancy rates was not significantly higher in patients recieving prednisolone than in control patients in routine IVF-ET cycles and unstimulated IVF-ET cycles. It can be concluded that prednisolone dose not support implantation and pregnancy outcomes of in routine IVF-ET cycles at least.
사람 난소조직의 초자화 냉동보존과 면역결핍 동물에의 이식
이경아,윤세진,이숙현,신창숙,최안나,조용선,윤태기,차광렬,Lee, Kyung-Ah,Yoon, Se-Jin,Lee, Sook-Hyun,Shin, Chang-Sook,Choi, An-Na,Cho, Yong-Seon,Yoon, Tae-Ki,Cha, Kwang-Yul 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.2
Objective: The present study was conducted to evaluate the viability of germ cells from the adult and fetal ovarian tissues after vitrification followed by xenografting. Method: The human adult ovarian tissues were obtained from 33 years old patient, and the fetal ovarian tissues were obtained from 22 weeks and 25 weeks in gestation. Ovarian tissues were cryopreserved by vitrification with 5.5 M ethylene glycol (EG 5.5) and 1.0 M sucrose as cryoprotectants. Adult and fetal ovarian tissues were pre-equilibrated with EG 5.5 at room temperature for 10 and 5 minutes, respectively and plunged into liquid nitrogen immediately. Frozen-thawed tissues were xenografted into NOD-SCID mice to evaluate the viability and capacity for further growth of the primordial follicles. Grafts were recovered from the recipients 4 weeks after transplantation and histological analysis was accomplished. Result and Conclusion: Grafts recovered 4 weeks after transplantation contained less number of oocytes and primordial follicles compared to that of the fresh tissues. Survived follicles were mainly primordial and intermediary with larger diameter and more granulosa cells. It is confirmed that 1) the ovarian tissues were healthy and the germ cells were survived after vitrification, and 2) the survived fetal primordial follicles after vitrification resumed the growth in the xenografts.
과잉치와 유합된 상악 우측 제 1 대구치의 직접 치수 복조 및 2급 복합레진 수복
배인혜(In-Hye Bae),최안나(An-Na Choi),손성애(Sung-Ae Son),박정길(Jeong-Kil Park) 대한치과의사협회 2018 대한치과의사협회지 Vol.56 No.6
Among developmental anomalies of tooth shape, fusion and gemination are comparatively common. Developed with different etiologies, both fusion and gemination show similar clinical features. Therefore, many clinicians have difficulty diagnosing those morpho-anatomic anomalies. The purpose of this study is to report malformed right maxillary first molar in a 20-year-old female. With the aid of computed tomography (CT), the tooth was diagnosed as fusion with supernumerary tooth and dental caries lesion was detected. After performing direct pulp capping, the tooth was permanently restored with microhybrid composite resin using direct method to alter union groove into smooth surface for improving oral hygiene management. Until 6 months of follow-up visits, patient’s chief complaint was resolved and tooth is still vital. In conclusion, identifying exact anatomy, conservative treatment and improving oral hygiene are essential in managing unusual morphologic anomalies of tooth.
자궁 경부암종에서 Epstein-Barr Virus의 검출 - 중합효소연쇄반응법과 In Situ PCR을 이용한 연구 -
김인선(In Sun Kim),강재성(Jae Seong Kang),최안나(An Na Choi),김영식(Young Sik Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.2
목적: 자궁 경부암은 우리나라 여성에서 가장 흔한 암종으로 정확한 원인은 규명되어 있지 않지만 대부분의 경우 인유두종 바이러스가 발암과정에 관여하는 것으로 알려져 있으며 그 외에도 포진바이러스, 싸이토메갈로바이러스, 흡연 등이 관여할 것으로 추정하고 있다. EBV가 자궁경부암종에 관련이 있으리라는 사실은 자궁경부의 상피세포에서 EBV가 증식하고 배설될 수 있다는 점 때문이다. 국내에서 자궁 경부 암종에서 EBV에 관한 연구는 전무한 상태로 경부암종의 발암과정에 EBV가 관여하는지 규명하기 위해서 본 연구를 시행하였다. 연구방법: 자궁 경부의 상피내암과 침윤성 편평상피암종에서 EBNA-1에 대한 소식자를 이용한 중합효소연쇄반응을 시행하였고 바이러스가 존재하는 부위를 확인하고자 in situ PCR을 시행하였다. 연구 재료로 상피내암 32예, 미세침윤성 편평상피암종 9예, 침윤성 편평상피암종 37예, 경부 선암종 7예, 경부 선-편평상피암종 7예와 대조군으로 종양이 없는 자궁경부조직 12예를 대상으로 하였다. 또한 EBNA-3C를 이용한 유형 분류를 시행하였다. 결과: EBV는 종양이 없는 자궁 경부에서 16.7%가 검출된 반면 자궁경부암종에서는 51.4% 이상의 빈도로 검출되었으나 침윤정도나 조직학적 유형에 따른 차이는 없었다. EBV는 종양 세포 뿐 아니라 정상 자궁경부의 상피세포와 림프구에서도 관찰되었다. 검출된 EBV는 모두 1형에 속하였다. 결론: 이상의 결과로 자궁 경부암종의 발생에 Epstein-Barr virus가 관여 할 것으로 사료되나 발암과정에 관여하는 정확한 기전은 앞으로 연구가 필요하다. Objective: Uterine cervical cancer is the most common malignant tumor in Korean women. Human papillomaviruses are associated in 85-90% of the cases. However, other cofactors are considered to be important in carcinogenesis. There is an evidence that the uterine cervix is the site of shedding of the Epstein-Barr viruses(EBV). Furthermore the virus has been detected in cervical intraepithelial neoplasia and invasive carcinoma of the uterine cervix. We studied to evaluate the role of EBV in cervical carcinogenesis. Methods: Non-neoplastic cervices(12), carcinoma in situ(32), microinvasive squamous cell carcinomas(9), invasive squamous cell carcinomas(37) and adenocarcinomas and adenosquamous carcinomas(14) were studied for EBV infection. PCR and in situ PCR for EBNA-1 were done and subtyping was done using PCR for EBNA 3C. Results: In non-neoplastic cervix, EBV was detected in 16.7% by PCR and found in normal epithelial cells and lymphocytes in in situ PCR. By PCR technique, EBV was detected in 65.6% of CIS, 66.3% and 51.4% of microinvasive and invasive squamous cell carcinomas, 57.1% of adenocarcinomas and adenosquamous carcinomas. EBV subtyping was done in EBV positive cases by PCR and all showed type 1. Conclusion: EBV was detected in higher frequency in cervical cancer than in non-neoplastic cervix. However the frequency was not correlated to the invasion depth and histologic types of cervical carcinomas. EBV was detected in tumor cells as well as normal epithelial cells and lymphocytes also. It was suggested that EBV may play a role in cervical cancers but the mechanism in carcinogenesis remains to be solved.
정상적인 부모에서 산전초음파로 진단된 Holt-Oram 증후군 1 예
이용희,이정건,이정노,이숙환,최안나,지은경,권태희,조주연,정창조,계정웅 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.11
Holt-Oram Syndrome is an autosomal dominant disorder characterized by the association of upper-limb abnormalities and congenital heart disease. A woman with no family history of genetic disease underwent antenatal sonography at 27 weeks' menstrual age to screen for fetal anomalies. Ultrasonography revealed abnormalities in the upper limbs. The limb abnormalities included abscence of bilateral thumbs and radius: the left humus was short. Pregnancy termination was performed. The postnatal chromosomal analysis revealed a normal 46XX karyotype and the autopsy finding confirmed the Holt-Oram syndrome. We report a case of Holt-Oram Syndrome in fetus with unaffected parents with brief of the literatures.