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      • KCI등재

        Interactions between Alcohol Consumption and Adjuvant Hormone Therapy in Relation to Breast Cancer-Free Survival

        Allison Kowalski,Catherine Woodstock Striley,Deepthi Satheesa Varma,Kathleen Marie Egan,Lusine Yaghjyan 한국유방암학회 2018 Journal of breast cancer Vol.21 No.2

        Purpose: Alcohol consumption is associated with an increase in breast cancer risk, but findings on the association of alcohol with survival after breast cancer diagnosis have been inconsistent. Further, whether these associations could differ by adjuvant hormone therapy status is unknown. We examined interactions between alcohol consumption and adjuvant hormone therapy in relation to breast cancer-free survival among women with a primary breast cancer diagnosis. Methods: Participants in this study included 1,399 women diagnosed with primary breast cancer between 2007 and 2012 at the Moffitt Cancer Center. Alcohol consumption during the year preceding diagnosis was assessed in a patient survey. Information on tumor characteristics, breast cancer treatment and outcomes was available from the Moffitt Cancer Registry. Associations were examined using Cox proportional hazards models in stratified analyses by adjuvant hormone therapy status, after adjustment for potential confounders. Results: Overall, alcohol consumption was associated with significantly improved breast cancer-free survival (any vs. none: hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.65–0.92). Among women without adjuvant hormone therapy, alcohol consumption was associated with better survival in heavy drinkers (HR, 0.63; 95% CI, 0.43–0.93). Among women with adjuvant hormone therapy, survival was better in women consuming alcohol as compared to nondrinkers (moderate: HR, 0.69, 95% CI, 0.51–0.93; heavy: HR, 0.74, 95% CI, 0.57–0.96; any: HR, 0.71, 95% CI, 0.57–0.87). There was no significant interaction between alcohol and adjuvant hormone therapy (p-interaction=0.54 for alcohol modeled as none or any and p=0.34 for alcohol modeled as none, moderate, and heavy). Conclusion: Associations of alcohol consumption with breast cancer-free survival are similar in women with and without adjuvant hormone therapy. Future studies are warranted to elucidate potential mechanisms underlying the observed inverse associations.

      • KCI등재

        The Effects of Bolus Consistencies on the Swallowing Safety in Poststroke Patients

        Allison Trent,박태옥,Elizbeth Oommen,김영선 한국언어청각임상학회 2014 Communication Sciences and Disorders Vol.19 No.2

        Objectives: Thickened liquids or pureed foods are one of the most frequently used compensatory strategies in hospitals and long-term care facilities for patients with dysphagia. The purpose of this study was to determine whether different bolus consistencies (thin liquid, nectar thick liquid, and puree) would improve the safety of swallowing and whether there would be a difference within these consistencies on swallowing safety in poststroke patients. Methods: Videofluoroscopic swallowing examinations (VFSEs) were obtained from 24 poststroke patients. Among them, 12 poststroke patients showed aspiration in thin liquid. VFSEs of these patients were advanced to swallowing nectar thick liquid and puree. To determine the safety of swallow in changes of bolus consistency, penetration-aspiration scale (P-A scale) was used to rate the swallow on a scale of 1 to 8. Statistical comparisons were made by one-way analysis of variance (ANOVA), and the significance level was set at p<.05. Results: For poststroke patients with aspiration, change in bolus consistency had a significant effect on the P-A acale rating (p<.01). The poststroke patients with aspiration exhibited significant decreases in P-A scale between thin liquid and nectar thick liquid and between thin liquid and puree (p<.01), but not between nectar thick liquid and puree (p=.55). Conclusion: The findings have two clinical implications. First, thickened liquid or puree provided an alternative way to obtain liquid or food safely to poststroke patients who aspirated thin liquids. Second, there is no difference on swallowing safety between nectar thick liquids and puree in poststroke patients with aspiration.

      • KCI등재

        The Effects of Bolus Consistencies on the Swallowing Safety in Poststroke Patients

        Allison Trent, 박태옥(Taeok Park),Elizabeth Oommen, 김영선(Youngsun Kim) 한국언어청각임상학회 2014 Communication Sciences and Disorders Vol.19 No.2

        배경 및 목적: 진한 액체나 퓨레 음식은 병원이나 요양원의 삼킴장애 환자에게 가장 많이 쓰이는 보상치료방법이다. 본 연구의 목적은 흡인을 보이는 뇌졸중 환자가 다양한 음식점도(묽은 액체, 진한 액체, 퓨레)를 삼켰을때 삼킴안전에 변화를 보이는지와 다양한 음식 사이에는 삼킴안전에 차이를 보이는지 알아보는 것이다. 방법: 뇌졸중 환자 24명 중 묽은 액체에서 흡인을 보인 환자 12명의 비디오투시조영검사 자료에서 각 환자의 5 mL의 묽은 액체, 진한 액체, 퓨레의 삼킴을 분석하였다. 본 연구에서 삼킴의 안전을 측정하기 위해 사용한 침습-흡인 척도는 1에서 8점 척도이다. 자료분석을 위해 일원분산분석(one way ANOVA)을 실시하였고, 유의수준은 .05로 설정하였다. 결과: 흡인을 보이는 뇌졸중 환자의 경우 음식점도에 따라 침습-흡인 척도에서 유의미한 차이를 보였다(p<.01). 흡인을 보이는 뇌졸중 환자의 묽은 액체와 진한 액체, 묽은 액체와 퓨레에서 침습-흡인 척도의 감소가 나타났고(p<.01), 진한 액체와 퓨레 사이는 유의한 차이를 보이지 않았다(p=.55). 논의 및 결론: 본 연구를 통해서 다음의 두 가지 임상적 의의를 생각해 볼 수 있다. 첫째, 묽은 액체에 흡인을 보이는 환자라 할지라도 진한 액체나 퓨레로 대체하여 액체나 음식을 안전하게 삼킬 수 있다. 둘째, 환자에게 묽은 액체를 대체할 것을 선택 시 진한 액체와 퓨레는 삼킴안전에 차이가 없다는 것이다. Objectives: Thickened liquids or pureed foods are one of the most frequently used compensatory strategies in hospitals and long-term care facilities for patients with dysphagia. The purpose of this study was to determine whether different bolus consistencies (thin liquid, nectar thick liquid, and puree) would improve the safety of swallowing and whether there would be a difference within these consistencies on swallowing safety in poststroke patients. Methods: Videofluoroscopic swallowing examinations (VFSEs) were obtained from 24 poststroke patients. Among them, 12 poststroke patients showed aspiration in thin liquid. VFSEs of these patients were advanced to swallowing nectar thick liquid and puree. To determine the safety of swallow in changes of bolus consistency, penetration-aspiration scale (P-A scale) was used to rate the swallow on a scale of 1 to 8. Statistical comparisons were made by one-way analysis of variance (ANOVA), and the significance level was set at p<.05. Results: For poststroke patients with aspiration, change in bolus consistency had a significant effect on the P-A acale rating (p<.01). The poststroke patients with aspiration exhibited significant decreases in P-A scale between thin liquid and nectar thick liquid and between thin liquid and puree (p<.01), but not between nectar thick liquid and puree (p=.55). Conclusion: The findings have two clinical implications. First, thickened liquid or puree provided an alternative way to obtain liquid or food safely to poststroke patients who aspirated thin liquids. Second, there is no difference on swallowing safety between nectar thick liquids and puree in poststroke patients with aspiration.

      • KCI등재

        An eponymous history of the anterolateral ligament complex of the knee

        ( Allison M. Morgan ),( Andrew S. Bi ),( Daniel J. Kaplan ),( Michael J. Alaia ),( Eric J. Strauss ),( Laith M. Jazrawi ) 대한슬관절학회 2022 대한슬관절학회지 Vol.34 No.-

        Background: Recent interest has surged in the anterolateral ligament (ALL) and complex (ALC) of the knee. Its existence and role in rotary stability of the knee, particularly in the setting of anterior cruciate ligament (ACL) reconstruction, remains a contentious and controversial topic. Understanding the ALC: We must review our history and recognize the pioneers who pushed our understanding of the ALL forward before it was popularly recognized as a discrete structure. Additionally, given that many eponyms remain in common use related to the ALC, we must standardize our nomenclature to prevent misuse or misunderstanding of terms in the literature. In this review, modern understanding of the anterolateral ligament complex (ALC) is traced to 1829 by exploring eponymous terms first in anatomy and then in surgical technique. Understanding our history and terminology will allow us to better understand the ALC itself. Conclusion: This review aims to provide historical context, define terminology, and provide insight into the clinical relevance of the ALC.

      • KCI등재

        Myricetin induces apoptosis mediated by oxidative stress in 4T1 and E0771 mammary cancer cells

        Allison Knickle,Andrea Rasmussen,David W. Hoskin 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

        Background: Myricetin is a polyphenolic compound that is cytostatic and/or cytotoxic for several cancer cell types; however, little is known about its efect on mammary carcinoma cells. Objective: The objective of this study is to determine whether myricetin afects the growth of mammarycarcinoma cells. Results: Myricetin inhibited the growth of 4T1 and E0771 mouse mammary carcinoma cells to a greater extent than either resveratrol or epigallocatechin-3-gallate, which are also present in red wine and green tea, respectively, and also have anticancer activities. Reduced growth of myricetin-treated 4T1 and E0771 cells was the result of apoptosis that was associated with disruption of the outer membrane of mitochondria. Myricetin-induced apoptosis of 4T1 and E0771 cells was prevented by the antioxidant N-acetyl cysteine, indicating that cytotoxicity was the result of oxidative stress caused by the accumulation of reactive oxygen species. Conclusion: We conclude that the pro-oxidant action of myricetin and ensuing apoptosis of mammary carcinoma cells indicate that myricetin may be useful in breast cancer treatment.

      • KCI등재

        Reporting Results of Research Involving Human Subjects: An Ethical Obligation

        Allison Baer Alley,서정욱,홍성태 대한의학회 2015 Journal of Korean medical science Vol.30 No.6

        Researchers have an ethical responsibility to report the results of research involving human subjects. Dissemination of results ensures that patient care is based on good science and that the field of medicine advances based on complete and accurate knowledge. However, current evidence suggests that publication is often neglected or substantially delayed, especially in the case of negative and inconclusive results. Researchers, editors and reviewers should value all high-quality research regardless of the conclusiveness of the results and ensure that all research involving human subjects is registered in a publicly accessible database.

      • KCI등재
      • KCI등재

        ‘All Hands on Deck’: the ‘Sailing’ Landships as unique Cultural Icons of Barbados

        Allison O. Ramsay 국립민속박물관 2016 International Journal of Intangible Heritage Vol.11 No.-

        This article explores Barbados’ intangible cultural heritage through the lens of the Landships of Barbados. Landships are cultural organisations which are complex. Embedded within their histories and origins are British traditions, with an emphasis on the Royal Navy, and Afro-Barbadian cultural practices. A black working class movement, the article highlights two renowned Landships, the BLS Iron Duke1 and the BLS Director that operated in twentieth century Barbados. Emphasis is placed on traditional knowledge in performance by explaining a specific selection of the drills/manoeuvres that contribute to the defining and acknowledgement of Landships in public spaces and in the funerary practices of the 1970s to 1990s. These Landships are unique cultural icons, exemplifying the cultures and peoples that have shaped Barbadian society and represent Barbadian cultural identity and heritage.

      • KCI등재

        Water Sorption/Desorption Characteristics of Eutectic LiCl-KCl Salt-Occluded Zeolites

        Allison Harward,Levi Gardner,Claire M. Decker Oldham,Krista Carlson,유 태식,Guy Fredrickson,Michael Patterson,Michael F. Simpson 한국방사성폐기물학회 2022 방사성폐기물학회지 Vol.20 No.3

        Molten salt consisting primarily of eutectic LiCl-KCl is currently being used in electrorefiners in the Fuel Conditioning Facility at Idaho National Laboratory. Options are currently being evaluated for storing this salt outside of the argon atmosphere hot cell. The hygroscopic nature of eutectic LiCl-KCl makes is susceptible to deliquescence in air followed by extreme corrosion of metallic cannisters. In this study, the effect of occluding the salt into a zeolite on water sorption/desorption was tested. Two zeolites were investigated: Na-Y and zeolite 4A. Na-Y was ineffective at occluding a high percentage of the salt at either 10 or 20wt% loading. Zeolite-4A was effective at occluding the salt with high efficiency at both loading levels. Weight gain in salt occluded zeolite-4A (SOZ) from water sorption at 20% relative humidity and 40℃ was 17wt% for 10% SOZ and 10wt% for 20% SOZ. In both cases, neither deliquescence nor corrosion occurred over a period of 31 days. After hydration, most of the water could be driven off by heating the hydrated salt occluded zeolite to 530℃. However, some HCl forms during dehydration due to salt hydrolysis. Over a wide range of temperatures (320–700℃) and ramp rates (5, 10, and 20℃ min−1), HCl formation was no more than 0.6% of the Cl− in the original salt.

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