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( Alistair Schofield ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
A 3D geological model was constructed during development of the design for the Kidston Pumped Storage Hydro Project, located in Northern Queensland, Australia. The project utilises two abandoned open-pits and comprises various dams, tunnels, caverns and shafts. The initial model was constructed using project specific geotechnical data including deep boreholes to provide an indication of subsurface geotechnical conditions. Additional data was required to allow further validation of the geological model. Data sources included information saved from disposal by a previous geologist to the mines and also provided data. Loss of records from the mine was significant and borehole files recovered were formatted for use in obsolete software. Data from such files was extracted and “decoded” to allow its use. A significant number of boreholes were primarily for lithological and ore grade purposes. Extraction of useful pieces of information such as fault locations from a combination of digital data and scanned logs was required. Lineament analysis, field mapping of the pits and drone collected photogrammetry data was also utilised to supplement the model. Lessons in data management were learned such as borehole positional information and understandings of “digital data”. Data usage and intellectual property issues were also navigated successfully. The model has assisted in the location of potential faults through the Paleoproterozoic basement rock and assisted in the optimisation of the design. It has utilised traditional and innovative methods of engineering geological data capture. It is also anticipated that the model will be updated during construction to assist with construction planning.
( Alistair B A Boxall ) 한국환경농학회 2016 한국환경농학회 학술대회집 Vol.2016 No.-
Over the past 15 years, there has been increasing concern over the impacts of the so called emerging environmental contaminants (ECs) on ecosystem and human health. ECs are substances that are not routinely monitored in environmental matrices and include pharmaceuticals, veterinary medicines, personal care products and engineered nanoparticles. Many ECs can be released to agricultural systems either directly or indirectly when manures, sewage sludge and wastewater is applied to soils. Once in an agricultural systems, ECs have the potential to be transported to surface waters and ground waters and can then enter drinking water supplies. ECs can also enter the food chain through uptake into plants, fish and shellfish. In this presentation, I will provide an overview of the evidence for the occurrence of ECs in agricultural systems and of the potential movement of these substances into food items and drinking water. Using pharmaceuticals and veterinary medicines as examples, I will explore the potential risks of ECs to human health through direct toxicity and through indirect effects such as selection of antmicrobial resistant micro-organisms. I will evaluate how environmental exposure compares to other exposure pathways and provide an overview of the major knowledge gaps and priorities for future research.
Jack Alistair Sargeant,Joseph Henson,James Adam King,Thomas Yates,Kamlesh Khunti,Melanie Jane Davies 대한내분비학회 2019 Endocrinology and metabolism Vol.34 No.3
Weight loss is an important goal in the management of several chronic conditions, including type 2 diabetes mellitus, and pharmacological therapies that aid weight loss are appealing. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) are novel glucose-lowering therapies that have been shown to induce clinically significant reductions in body weight. However, this weight loss may not be attributed solely to fat mass (FM). Given the importance of skeletal muscle and lean body mass (LBM) on cardio-metabolic health and physical function, we reviewed the available literature reporting theeffects of GLP-1RAs and SGLT2is on body composition. Results demonstrate that, in most circumstances, the weight loss associatedwith both therapies predominantly comprises a reduction in FM, although significant heterogeneity exists between studies. In overhalf of the studies identified, the proportion of LBM reduction ranged between 20% and 50% of total weight lost, which is consistentwith diet-induced weight loss and bariatric surgery. No clear differences existed between GLP-1RAs and SGLT2is. Consequently,the loss of LBM and skeletal muscle associated with weight loss induced by GLP-1RAs and SGLT2is warrants attention. Strategiesto preserve skeletal muscle and improve physical function, for example through structured exercise, are of great importance.