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Hirata, Yuho,Watanabe, Kenichi,Uritani, Akira,Yamazaki, Atsushi,Koba, Yusuke,Matsufuji, Naruhiro The Korean Association for Radiation Protection 2016 방사선방어학회지 Vol.41 No.3
Background: We are developing a small size dosimeter for dose estimation in particle therapies. The developed dosimeter is an optical fiber based dosimeter mounting an radiation induced luminescence material, such as an OSL or a scintillator, at a tip. These materials generally suffer from the quenching effect under high LET particle irradiation. Materials and Methods: We fabricated two types of the small size dosimeters. They used an OSL material Eu:BaFBr and a BGO scintillator. Carbon ions were irradiated into the fabricated dosimeters at Heavy Ion Medical Accelerator in Chiba (HIMAC). The small size dosimeters were set behind the water equivalent acrylic phantom. Bragg peak was observed by changing the phantom thickness. An ion chamber was also placed near the small size dosimeters as a reference. Results and Discussion: Eu:BaFBr and BGO dosimeters showed a Bragg peak at the same thickness as the ion chamber. Under high LET particle irradiation, the response of the luminescence-based small size dosimeters deteriorated compared with that of the ion chamber due to the quenching effect. We confirmed the luminescence efficiency of Eu:BaFBr and BGO decrease with the LET. The reduction coefficient of luminescence efficiency was different between the BGO and the Eu:BaFBr. The LET can be determined from the luminescence ratio between Eu:BaFBr and BGO, and the dosimeter response can be corrected. Conclusion: We evaluated the LET dependence of the luminescence efficiency of the BGO and Eu:BaFBr as the quenching effect. We propose and discuss the correction of the quenching effect using the signal intensity ratio of the both materials. Although the correction precision is not sufficient, feasibility of the proposed correction method is proved through basic experiments.
Measurements of Minute Unsteady Pressure on Three-Dimensional Fan with Arbitrary Axis Direction
Hirata, Katsuya,Fuchi, Takuya,Onishi, Yusuke,Takushima, Akira,Sato, Seiji,Funaki, Jiro Korean Society for Fluid machinery 2010 International journal of fluid machinery and syste Vol.3 No.1
The present study is a fundamental approach to develop the measuring technology for minute fluctuating pressures on the three-dimensional blade surfaces of the fan which rotates with an arbitrary rotation-axis direction. In this situation, we are required to correct the centrifugal-force effect, the gravitational-force effect and the other leading-error effects for accurate measurements of the minute pressures. The working fluid is air. A pressure transducer rotating with an arbitrary attitude is closely sealed by a twofold shroud system. The rotational motion with an arbitrary attitude is produced by fixing the pressure transducer to the cantilever which is connected to a motor-driven disc of 500mm in diameter and 5mm in thickness. As a result, we have quantitatively determined main governing effects upon the non-effective component of the pressure-transducer signal.
Distribution of cytomegalovirus genotypes among ulcerative colitis patients in Okinawa, Japan
Saifun Nahar,Akira Hokama,Atsushi Iraha,Tetsuya Ohira,Tetsu Kinjo,Tetsuo Hirata,Takeshi Kinjo,Gretchen L. Parrott,Jiro Fujita 대한장연구학회 2018 Intestinal Research Vol.16 No.1
Background/Aims: To determine the prevalence of glycoprotein B (gB), glycoprotein N (gN), and glycoprotein H (gH) genotypes of human cytomegalovirus (HCMV) superimposed on ulcerative colitis (UC) patients in Japan. Methods: Four archivedstool samples and 7-archived extracted DNA from stool samples of 11 UC patients with positive multiplex polymerase chainreaction (PCR) results for HCMV were used UL55 gene encoding gB, UL73 gene encoding gN, and UL75 gene encoding gH were identified by PCR. Genotypes of gB and glycoprotein N were determined by sequencing. Results: Among 11 samples, 8samples were amplified through PCR. gB, gN, and gH genotypes were successfully detected in 3 of 8 (37.5%), 4 of 8 (50%), and8 of 8 (100%), respectively. The distribution of gB and gN genotypes analyzed through phylogenetic analysis were as follows:gB1 (2/3, 66.7%), gB3 (1/3, 33.3%), gN3a (2/4, 50%), and gN3b (2/4, 50%). Other gB genotypes (gB2 and gB4) and gN genotypes(gN1, gN2, and gN4) were not detected in this study. Out of successfully amplified 8 samples of gH genotype, gH1 and gH2 weredistributed in 12.5% and 75% samples, respectively. Only 1 sample revealed mixed infection of gH genotype. The distribution ofgH1 and gH2 differed significantly (1:6, P <0.05) in UC patients. The distribution of single gH genotype also revealed significantdifference in UC patients who were treated with immunosuppressive drug (P <0.05). Conclusions: In this study, gB1, gN3, andgH2 gene were determined as the most frequently observed genotypes in UC patients, which suggest that there might be an association between these genotypes of HCMV and UC.
Putra, Heriansyah,Yasuhara, Hideaki,Kinoshita, Naoki,Hirata, Akira Techno-Press 2017 Geomechanics & engineering Vol.12 No.5
This study discussed the possible optimization of enzyme-mediated calcite precipitation (EMCP) as a soil-improvement technique. Magnesium chloride was added to the injection solution to delay the reaction rate and to improve the homogenous distribution of precipitated minerals within soil sample. Soil specimens were prepared in 1-m PVC cylinders and treated with the obtained solutions composed of urease, urea, calcium, and magnesium chloride, and the mineral distribution within the sand specimens was examined. The effects of the precipitated minerals on the mechanical and hydraulic properties were evaluated by unconfined compressive strength (UCS) and permeability tests, respectively. The addition of magnesium was found to be effective in delaying the reaction rate by more than one hour. The uniform distribution of the precipitated minerals within a 1-m sand column was obtained when 0.1 mol/L and 0.4 mol/L of magnesium and calcium, respectively, were injected. The strength increased gradually as the mineral content was further increased. The permeability test results showed that the hydraulic conductivity was approximately constant in the presence of a 6% mineral mass. Thus, it was revealed that it is possible to control the strength of treated sand by adjusting the amount of precipitated minerals.
Masahiro Takeuchi,Takefumi Katsuki,Kumiko Yoshida,Kumiko Yoshida,Michinori Iwamura,Toshihiro Inokuchi,Akira Furutani,Tomoe Katoh,Kazuaki Kawano,Keiji Hirata 한국유방암학회 2021 Journal of breast cancer Vol.24 No.5
Locally advanced breast cancer (tumor > 5 cm, widespread infiltration of the skin and muscle, or metastases to lymph nodes) is difficult to resect by surgery, and even when it is resectable, there is a high probability of local recurrence and distant metastasis. Therefore, systemic therapy should be administered first. However, as cutaneous infiltration progresses, the patient's quality of life is impaired by pain, bleeding, presence of exudates, and a foulsmelling odor. Treatment with Mohs paste with systemic therapy can control symptoms associated with skin infiltration and can also be expected to decrease tumor volume. Herein, we report a case in which a tumor was resected following Mohs paste and systemic chemotherapy administration, and the skin defect was reconstructed with a latissimus dorsi myocutaneous flap. We also review the literature for previously reported cases of breast cancer involving Mohs paste.