Poster Session : PS 0330 ; Hematology : Experience of Chemotherapy of Malignant Lymphoma in More Than 90 Years

( Kazuhiko Natori ),( Susumu Ishihara ),( Daisuke Nagase ),( Yukitoshi Toyoda ),( Akiko Sakai ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Chemotherapy of the elderly person was common practice. Clinical outcome is force to equal an adult. However, a patient 90 years or older has a high risk of chemotherapy. We report our experience with two patients of malignant lymphoma 90 years or older. Methods: In periods from 2003 to 2013, patients whom malignant lymphoma was diagnosed in our hospital, we extracted a case 90 years or older. We reviewed gender, clinical stage, chemotherapy, dosage, clinical outcome, and prognosis. Results: Case 1: 91-year-old male, fi rst manifestation was systemic lymphadenopathy, Sufferings from dyspnea, he became the hospitalization. Pleural effusion was revealed, after lymph node biopsy, he was diagnosed non-Hodgkin`s lymphoma diffuse large B cell (NHL DLBCL). We performed chemotherapy by his strong wish. After 3 course of R-CHOP (dosage 50%), he achieved partial remission and was able to return to the house. He died after a diagnosis in 13 months. Case 2: 90-year-old female, fi rst manifestation was dysfunction of artifi cial denture, she had a checkup in dentistry. At the time dentist discovered a mass lesion and performed biopsy. Diagnosis was NHL DLBCL, and she was referred and had performed chemotherapy our hospital. After 6 course of R-CHOP (dosage 65%), she achieved complete remission and he still alive. Conclusions: It is got enough cinical outcome from even a case 90 years or older bychemotherapy. However, drug reduction criteria are not established that are indispensable for safe chemot

Poster Session:PS 0224 ; Gastroenterology : HBV Infection Screening for Malignant Lymphoma

( Kazuhiko Natori ),( Susumu Ishihara ),( Daisuke Nagase ),( Akiko Sakai ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Malignant lymphoma(ML) is the ninth place cause of death in Japan and chemotherapy(CTx) is fi rst choice. Side effect of CTx, rituximab, reactivation of the Hepatitis B type virous(HBV) is serious problem. We reviewed the situation of the HBV infection check of patients that was performed CTx. Methods: We intended for patient which ML was diagnosed in our hospital from January 2003 to December, 2012. The pretreatment HBV check factor is hepatitis B surface antigen(HBsAg), hepatitis B surface antibody(anti-HBs), antihepatitis B core antibody(anti-HBc). When either anti-HBs or anti-HBc is positive, we measure viral amount by HBV-DNA Taqman. In the case of HBV check is imcomplete, additional HBV check followed as much as possible. We reviewed positive rate of HBsAg, anti-HBs, anti-HBc. Also we investigated HBV reactivation rate of R+CTx. Results: All cases were 446 cases, about type of malignant lymphoma, Hodgkin`s lymphoma(HL) 39 cases, non-Hodgkin`s lymphoma(NHL) 401 cases, Adult T cell Lymphoma( ATL) 6 cases. Among 446 patients, 411 cases received CTx or CTx+radiation therapy(RTx). HBsAg was examined in all cases, anti-HBs, anti-HBc was 351 cases, 261 cases respectively. The case searched three factors before CTx was 150 cases. 30 cases were searched HBV-DNA Taqman that indicated anti-HBs and/or anti-HBc were positive. In theses cases, treatment needed situation were 5 cases. These 5 cases treated by entecavir and after 2 weeks, CTx performed. The case that already given an antiviral drug with HBsAg positive for treatment was 4 cases. 107 cases were searched anti-HBs, anti-HBc or either after CTx. 2 cases was revealed to have needed the administration of antiviral drug. HBV reactivation rate was 0%. Conclusions: Only 2 cases needed therapy for HBV infection that were revealed after CTx. We do check in all cases and try for safe chemotherapy especially rituximab including regimen.

Poster Session : PS 0338 ; Hematology : The Multiple Neoplasms Consist of Colon Cancer and Hematological Malignancy

( Kazuhiko Natori ),( Susumu Ishihara ),( Daisuke Nagase ),( Yukitoshi Toyoda ),( Akiko Shibuya ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Colon cancer accounts for number of cases, a superior of the cause of death like gastric cancer, lung cancer. Wereport aggregates the multiple neoplasms including hematological malignancy and colon cancer. Methods: In the case that hematologic malignancy was diagnosed in our hospital by 1988 from 2013, The multiple cancer including colon cancer and the hematologic malignancy was 45 cases. So we reviewed and reported. Results: All cases are 45 cases, including female 14 cases, male 31cases, synchronous type 15 cases, metechronous type 30 cases. Multiple neoplasms consist of double cancer 33 cases, triple cancer 11 cases, quadrop cancer 1case. The median interval period in double cancer is 58 months. Hematological malignancy consist of non-Hodgkin`s lymphoma 24 cases, Hodgkin`s lymphoma 1 case, myelodysplastic syndrome 6 cases, chronic myelogeneou leukemia 3 cases, multiple myeloma 5 cases, macroglobrinemia 2 cases, acute lymphoblastic leukemia 3 cases, acute myelogeneous leukemia 2 case. Chronic lymphocytic leukemia 1 case. The sites of colon cancer studied 41 cases and results were that ascending colon 7cases, transverous colon 3cases, descending colon 2cases, sigmoid colon 9cases, rectum 8 cases. In a double cancer, 12 cases were preceding colon cancer and 9 cases were preceding hematological malignancy, an interval of the colon cancer precedence cases, the median time was 83M, hematological malignancy precedence cases was 42M. Median survival time is 15M, about cause of death, 21 cases still alive and 24 cases are dead. In 24 cases, hematological malignancy 17 cases, colon cancer 7 cases. Conclusions: In the case of hematological malignancy precedence case, 4 of 9 colon cancer occurred within three years. We should take attention about incidence of other malignancies, particularly those that occur from gastrointestinal tract and serious observation about distant metastasis site, such as liver and lung.

Poster Session : PS 0327 ; Hematology : Multiple Neoplasms Including Myelodysplastic Syndrome

( Kazuhiko Natori ),( Susumu Ishihara ),( Daisuke Nagase ),( Akiko Sakai ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The myelodysplastic syndrome is blood stem cell disease and in many cases, have cytogenetic abnormality. And myelodysplastic syndrome has characteristic that there is defi ection in elderly. But progress of therapy and supporting therapy improved a prognosis. The possibility that a survivor had the second malignancy rise. we reviewed multiple neoplasms including the myelodysplastic syndrome and we report. Methods: In the case that hematologic malignancy was diagnosed in our hospital from 1988 to 2012, we intended for double cancer 271 cases including hematological malignancy. We reviewed 43 multiple neoplasms including the myelodysplastic syndrome. The examination factors are type of the hematological malignancy, treatment, gender, interval with the second cancer. Results: All cases are 43 cases, including male 29 cases, female 14 cases, type of multiple neoplasms, double 40 cases, triple 3 cases, kind of multiple neoplasms, metachronous 31 cases, synchronous 12 cases. The malignancies to constitute multiple neoplasms with myelodysplastic syndrome are gastric cancer 11 cases, esophangeal carcinoma 5 cases, breasr cancer 3 case, multiple myeloma 6 cases, non-Hodgkin`s lymphoma 3 cases, colon cancer 5 cases, lung cancer 4 cases, renal carcinoma 2 cases, urinary bladder carcinoma 2 cases, prostate carcinoma 1 case, thyroid cancer 1 case, pharyngeal cancer 1 case, laryngeal cancer 1 case, angiosarcoma 1 case. On the other hand, acute myelogeneous leukemia, therapy-related leukemia are11 cases, de novo myelodysplastic syndrome 32 cases. Conclusions: The survivors by the fi rst cancer therapy are paid attention to therapy- related myelodysplastic syndrome.

Poster Session : PS 0339 ; Hematology : Study of Multiple Neoplasms Including Hematological Malignancies and Lung Cancer

( Daisuke Nagase ),( Susumu Ishihara ),( Akiko Sakai ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ),( Kazuhiko Natori ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: It is a well-known fact that the prevalence of malignancy increases year by year. In addition, other malignancies may be found in the systemic screening before treatment or after several therapy during observation. Malignant lymphoma is often the most number of patients. We reviewed the complication with lung cancer that was a poor prognosis. We look for possibility of the prognosis improvement by determining a characteristic. Methods: In 290 cases multiple cancer including hematological malignancy in our department, we examined 20 cases that including lung cancer & malignant lymphoma. Reviewed the following is gender, age, outbreak style, strategy of therapy, clinical income, and overall survival. Diagnostic criteria of multiple cancer is according to Warren&Gates. It was distinguish synchronous and metachronous that synchronous double cancer diagnosed interval of 6 months. Results: The subjects were 20 patients, median age was 70 years. Synchronous cancer was found in 5 patients and metachronous in 15 patients. Malignant lymphoma was non-Hodgkin`s lymphoma in 11 patients, Hodgkin`s lymphomain 2 patients and lymphoma- stage mycosis fungoides in 1patient. Acute myelogeneous leukemia 3 cases, myelodysplastic syndrome 3 cases. All of the patients with ML underwent chemotherapy (CTx) and 8 and 4 of them achieved completeand partial remission, respectively, while 2cases had progressive disease. In 20 cases with LC, operation (Ope) alone was conducted in 6 cases, Ope+ adjuvant therapy in 3 cases, radiation therapy (RTx) in 1case, RTx + CTx in 1case, and CTx alone in 7 cases, non therapy 2 cases. The median survival was 11 months. Conclusions: For metachronous type, there is chance to fi nd second cancer, if they observed long time. I think that we must understand he has or will have another cancer. Prognosis improvement of the advanced lung cancer is expected.

PROPERTIES OF DUST IN VARIOUS ENVIRONMENTS OF NEARBY GALAXIES

HIDEHIRO KANEDA,Takuma Kokusho,Rika Yamada,DAISUKE ISHIHARA,SHINKI OYABU,TORU KONDO,MITSUYOSHI YAMAGISHI,Akiko Yasuda,TAKASHI ONAKA,Toyoaki Suzuki 한국천문학회 2017 天文學論叢 Vol.32 No.1

We have performed systematic studies of the properties of dust in various environments of nearby galaxies with AKARI. The unique capabilities of AKARI, such as near-infrared (near-IR) spectroscopy combined with all-sky coverage in the mid- and far-IR, enable us to study processing of dust, particularly carbonaceous grains includings polycyclic aromatic hydrocarbons (PAHs), for unbiased samples of nearby galaxies. In this paper, we first review our recent results on individual galaxies, highlighting the uniqueness of AKARI data for studies of nearby galaxies. Then we present results of our systematic studies on nearby starburst and early-type galaxies. From the former study based on the near-IR spectroscopy and mid-IR all-sky survey data, we find that the properties of PAHs change systematically from IR galaxies to ultra-luminous IR galaxies, depending on the IR luminosity of a galaxy or galaxy population. From the latter study based on the mid- and far-IR all-sky survey data, we find that there is a global correlation between the amounts of dust and old stars in early-type galaxies, giving an observational constraint on the origin of the dust.

Amounts served and consumed of school lunch differed by gender in Japanese elementary schools

Nozue, Miho,Yoshita, Katsushi,Jun, Kyungyul,Ishihara, Yoko,Taketa, Yasuko,Naruse, Akiko,Nagai, Narumi,Ishida, Hiromi The Korean Nutrition Society 2010 Nutrition Research and Practice Vol. No.

School lunches serve to improve nutritional status and to promote the health of children. The purpose of this study was to investigate the portion sizes of school lunches served and consumed in Japanese elementary schools. In addition, gender difference in servings and consumption were also studied. A cross-sectional study was undertaken between October 2007 and February 2008 in schools located in Tokyo and Okayama, Japan. A total of 192 fifth-grade children attending four elementary schools participated in this study. Weighed plate waste methods and observation were used to collect dietary data for two non-consecutive days. The proportion of children who chose staple foods along with main dishes and/or side dishes for at least one day was higher in boys than in girls (respectively, for staple food: 42.1% vs. 9.3%, for main dish and/or side dish: 68.4% vs. 44.3%, P < 0.001). The ratio of initial amount served to amount offered was $0.88{\pm}0.11$ for boys and $0.84{\pm}0.10$ for girls (P < 0.05). The ratio of amount consumed to amount offered was $1.04{\pm}0.19$ for boys and $0.88{\pm}0.12$ for girls (P < 0.001). Weight was related to amount consumed both in boys (r = 0.222, P < 0.05) and in girls (r = 0.201, P < 0.05). These findings suggest that the nutritional standards of school lunch programs should take into account gender differences. Clearly, boys were more likely to consume more than the initial amounts served due to their higher propensity to take second helpings. Boys feel few reservations about taking second helpings to adjust their total intake. However, school lunch plans should take into consideration girls' reluctance to do so, by serving appropriate initial portion sizes.

A comparative study for the development of a health promotion policy through an analysis of the mortality rates in Korea and Japan, 1983~2003

남은우,YEA-LI-A SONG,Masaki Moriyama,Akiko Ishihara 한국보건교육건강증진학회 2007 보건교육건강증진학회지 Vol.24 No.5

본 연구는 1983년부터 2003년까지 21년간의 한국과 일본의 사망통계자료를 이용하여 두 나라간의 사망원인을 비교 분석하였다. 사망률은 일본의 2003년 인구를 표준인구로 한 직접법을 통해 표준화되었다. 분석 결과, 2001/2003년에 한국과 일본의 주요사인의 순위가 크게 바뀌어 가고 있음을 알 수 있었다. 즉, 한국에서는 악성신생물, 당뇨, 신부전, 추락, 자살로 인한 사망률이 증가하였 고, 일본에서는 당뇨보다는 폐렴으로 인한 사망률이 증가하고 있었다. 또한, 2001/2003년에는 만성질환으로 인한 사망률의 비율이 급성질환으로 인해 사망하는 경우가 많았다. 이상의 분석 결과, 한국의 건강증진사업은 악성신생물, 당뇨, 신부전, 추락사고, 그리고 자살의 예방과 관리에 대한 다양한 사업이 필요함을 알 수 있었다. 또한, 노인 인구가 많은 일본의 경우, 폐렴으로 인한 사망자가 증가하는 경향을 볼 때에, 한국의 경우도 노인의 경우 폐렴 관련 건강관리가 필요함을 시사하고 있다. This study atempts to provide fundamental information for a health policy and health services by looking at the trends and types of the mortality rates in Korea and Japan. In this study, data of the death statistics of Korea and Japan over the 21-year period from 1983 to 2003 are analyzed. Mortality data are standardized 100,000 to the 2003 Japan population, according to the direct method. In 2001/203, the ranking of major causes of death in Korea and Japan has ben greatly changed. In Korea, mortality rates from malignant neoplasms, diabetes melitus, renal failure, fals and suicide have increased. In Japan, the mortality rates from pneumonia increase more than those from diabetes melitus. In 2001/2003, the proportions of the mortality rates from chronic diseases are higher than those from acute diseases. In the Korean health promotion policy "Health Promotion 2020", a more intensive goal management is needed.

Dietary patterns and colorectal cancer risk in middle-aged adults: A large population-based prospective cohort study

Shin, Sangah,Saito, Eiko,Sawada, Norie,Ishihara, Junko,Takachi, Ribeka,Nanri, Akiko,Shimazu, Taichi,Yamaji, Taiki,Iwasaki, Motoki,Sasazuki, Shizuka,Inoue, Manami,Tsugane, Shoichiro,Tsugane, S.,Sawada, Elsevier 2018 Clinical nutrition Vol.37 No.3

<P><B>Summary</B></P> <P><B>Background & aims</B></P> <P>A finding between dietary pattern and cancer may provide visions beyond the assessment of individual foods or nutrients. We examined the influence of dietary pattern with colorectal cancer (CRC) among a Japanese population.</P> <P><B>Methods</B></P> <P>A total of 93,062 subjects (43,591 men, 49,471 women) who participated in the Japan Public Health Center-based Prospective Study were followed from 1995–1998 to the end of 2012, during which 2482 cases of CRC (1514 men, 968 women) were newly identified. Dietary data was obtained from a validated food-frequency questionnaire between 1995 and 1998.</P> <P><B>Results</B></P> <P>Three dietary pattern was derived from principal components factor: prudent, westernized, and traditional pattern. After controlled for potential confounders, the prudent pattern showed a decreased association of CRC risk in men (HR for highest quintile vs lowest: 0.85; 95% CI: 0.72–1.00; <I>P</I> trend <0.05), slightly more strongly with distal colon cancer (<I>P</I> trend <0.05); but an increased risk of rectal cancer in women (<I>P</I> trend <0.05). The westernized pattern showed a significant positive linear trend for colon (<I>P</I> trend <0.05) and distal cancer (<I>P</I> trend <0.05) in women. There was no apparent association of traditional Japanese dietary pattern on the overall or any specific sites risk of CRC.</P> <P><B>Conclusions</B></P> <P>A prudent dietary pattern showed an inverse association with CRC risk in men, and a westernized pattern was related with a higher risk of colon and distal cancer in women.</P>

Poster Session : PS 0336 ; Hematology : Hodgkin`s Lymphoma in Our Hospital

( Kazuhiko Natori ),( Daisuke Nagase ),( Susumu Ishihara ),( Akiko Sakai ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: In Japan, ML is hematological malignancies with much number of cases. non-Hodgkin`s lymphoma(NHL) is more than 90%. There is extremely little number of patients Hodgkin`s lymphoma(HL). In Europe, the rarion between NHL and HL, is almost half and half. So we paid attention to HL and examined. Methods: We intended for patient which ML was diagnosed in our hospital from January 2003 to December, 2012. We studied and reported 38 cases about age, gender, pathological fi ndings, therapy, median survival time, 5 years survival rate. Survival was measured from the diagnosis of multiple cancer to time of death or last contact. Results: All cases were 38 cases, gender ration was male 23 cases, female 16 cases. Median age was 45 years, pathological fi ndings, L-D 1 case, L-P 1 case, L-R 6 cases, MC 15 cases, PHL 1 case, NS 14 cases. About clinical stage, I was 5 cases, II was 15 cases, III was 10 cases, IV was 7 cases. Adult patients were 25 cases, elderly patients were 13 cases. About therapy, more than 65 years old that assumed Bleomycine skipped. ABVD therapy performed 26 cases, ABVD therapy + RTx 1 case, AVD therapy 8 cases, C-MOPP therapy 3 cases. Median survival time was 84 months, and 5 years survival rate was 79. 6%. About age, less than 60 years group did not reach median survival time, median survival time of more than 60 years group was 76 months. There is no signifi cant difference between 2 group. 29 cases were survivor and death cases were 9 cases. Cause of death, 8 cases due to original disease, 1 case another reason( because of lung cancer). Conclusions: HL is good prognosis disease in hematological malignancies, but in more than 60 years patients, there is many problem.