Effects of Dimaine, Diacid and Dintitro Derivatives on the Inhibition of Adenosine Deaminase; Experimental, Molecular Docking and QSAR Studies

Ajloo, Davood,Najafi, Leila,Saboury, Ali Akbar Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.11

Effects of some diacid, diamine and dinitro aromatic compounds on the structure and activity of adenosine deaminase (ADA) were investigated by UV-Vis spectrophotometry in 50 mM phosphate buffer at pH = 7.5 and 27 ${^{\circ}C}$ and molecular docking studies. The results showed that all tested ligands are showing inhibition; five ligands are uncompetitive and other two ligands are mixed of competitive and noncompetetive inhibitors with majority of competitive behavior. For the later case analysis was done based on competitive inhibition. Diacids have larger size and higher inhibition constant ($K_I$) relative to others. A logical correlation between calculated free energy of binding and experimental values was obtained for un-competitive. Experimental and calculated data showed that competitive inhibitors are distributed near the active site of enzyme and form several cluster of ranks, whereas uncompetitive inhibitors bind to the enzyme-substrate complex and distributed far from the active site. Results of structure-activity relationship showed that, larger, more hydrophobe, less spherical and more aromatic ligands have higher inhibition constants.

A program for cost estimation of forest road construction using engineer’s method

Ismael Ghajar,Akbar Najafi,Amir Mohsen Karimimajd,Kevin Boston,Seyed Ali Torabi 한국산림과학회 2013 Forest Science And Technology Vol.9 No.3

Modeling the cost of road construction is a prerequisite for evaluation and planning of different alternatives for low-volume road networks included in a forest management plan. In this paper, a model for cost estimation of forest roads is presented, based on the standard engineering properties of cross sections and the location-specific parameters of terrain slope and vegetation information. The model assumes six main cost elements of clearing operations, embankment, pavement, grading, culverts and ditch for total construction cost calculation. To validate the performance, the outputs of the model were compared with the experts’ prediction for an existing forest road project in a mountain condition. The final result of the research showed that the model could estimate total cost of road construction in an accuracy range of 6.5%. The results of the validation process showed a 66.51% underestimate for clearing operation, 3.56% underestimate for embankment, 3.85% underestimate for surfacing, 3.32% underestimate for culverts, 20.54% underestimate for ditch excavation, and 22.33% overestimate for grading of the cut slope and travel way. According to the reasonable estimation for total cost, the model could be applied as an evaluation function in finding the optimized layout of a forest road network.

Effects of Dimaine, Diacid and Dintitro Derivatives on the Inhibition of Adenosine Deaminase; Experimental, Molecular Docking and QSAR Studies

Davood Ajloo,Leila Najafi,Ali Akbar Saboury 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.11

Effects of some diacid, diamine and dinitro aromatic compounds on the structure and activity of adenosine deaminase (ADA) were investigated by UV-Vis spectrophotometry in 50 mM phosphate buffer at pH = 7.5 and 27°C and molecular docking studies. The results showed that all tested ligands are showing inhibition; five ligands are uncompetitive and other two ligands are mixed of competitive and noncompetetive inhibitors with majority of competitive behavior. For the later case analysis was done based on competitive inhibition. Diacids have larger size and higher inhibition constant (KI) relative to others. A logical correlation between calculated free energy of binding and experimental values was obtained for un-competitive. Experimental and calculated data showed that competitive inhibitors are distributed near the active site of enzyme and form several cluster of ranks, whereas uncompetitive inhibitors bind to the enzyme-substrate complex and distributed far from the active site. Results of structure-activity relationship showed that, larger, more hydrophobe, less spherical and more aromatic ligands have higher inhibition constants.

Estimation of the rate and number of underreported deliberate self-poisoning attempts in western Iran in 2015

Mehdi Moradinazar,Farid Najafi,Mohammad Reza Baneshi,Ali Akbar Haghdoost 한국역학회 2017 Epidemiology and Health Vol.39 No.-

OBJECTIVES: Rates of attempted deliberate self-poisoning (DSP) are subject to undercounting, underreporting, and denial of the suicide attempt. In this study, we estimated the rate of underreported DSP, which is the most common method of attempted suicide in Iran. METHODS: We estimated the rate and number of unaccounted individuals who attempted DSP in western Iran in 2015 using a truncated count model. In this method, the number of people who attempted DSP but were not referred to any health care centers, n0, was calculated through integrating hospital and forensic data. The crude and age-adjusted rates of attempted DSP were estimated directly using the average population size of the city of Kermanshah and the World Health Organization (WHO) world standard population with and without accounting for underreporting. The Monte Carlo method was used to determine the confidence level. RESULTS: The recorded number of people who attempted DSP was estimated by different methods to be in the range of 46.6 to 53.2% of the actual number of individuals who attempted DSP. The rate of underreported cases was higher among women than men and decreased as age increased. The rate of underreported cases decreased as the potency and intensity of toxic factors increased. The highest underreporting rates of 69.9, 51.2, and 21.5% were observed when oil and detergents (International Classification of Diseases, 10th revision [ICD-10] code: X66), medications (ICD-10 code: X60-X64), and agricultural toxins (ICD-10 codes: X68, X69) were used for poisoning, respectively. Crude rates, with and without accounting for underreporting, were estimated by the mixture method as 167.5 per 100,000 persons and 331.7 per 100,000 persons, respectively, which decreased to 129.8 per 100,000 persons and 253.1 per 100,000 persons after adjusting for age on the basis of the WHO world standard population. CONCLUSIONS: Nearly half of individuals who attempted DSP were not referred to a hospital for treatment or denied the suicide attempt for political or sociocultural reasons. Individuals with no access to counseling services are at a higher risk for repeated suicide attempts and fatal suicides.

Solid phase extraction using nanoporous MCM-41 modified with 3,4-dihydroxybenzaldehyde for simultaneous preconcentration and removal of gold(III), palladium(II), copper(II) and silver(I)

Mohammad Behbahani,Fatemeh Najafi,Mostafa M. Amini,Omid Sadeg,Akbar Bagheri,Parmoon Ghareh Hassanlou 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4

In this paper, functionalized MCM-41 nanoporous silica with 3,4-dihydroxybenzaldehyde was applied for trace determination of copper, silver, gold and palladium in real samples. The content of solutions containing the mentioned metals was determined by flame atomic absorption spectrometry (FAAS), and the limit of detection was 0.09, 0.03, 0.5 and 0.08 ng mL 1 for gold, copper, silver, and palladium, respectively. The recoveries and precisions for mentioned ions were >97.0% and <3%, respectively. The adsorption capacity of the modified MCM-41 was 290 mg g 1 for gold, 130 mg g 1 for copper, 160 mg g 1 for silver and 155 mg g 1 for palladium, respectively.

Utilization of woody pruning residues of apple trees

Najibeh Gilanipoor,Rafaele Spinelli,Ramin Naghdi,Akbar Najafi 한국산림과학회 2020 Forest Science And Technology Vol.16 No.4

Utilize agricultural residues from pruning brings many advantages including employment, social and economic benefit, rural development, natural forest protection, increased energy efficiency, and lower costs of raw material for the production of particleboard industry. In this study, the use of wood utilization of pruning residues from apple trees has been investi�gated by using chipping at the landing chipping methods (LCMs) and farm chipping meth�ods (FCM). These methods were conducted on seven farms, totaling 9.2 ha. A time study was used to estimate operation time and cost. Transportation of chips from the study area to factories was done with semi-trailers, trucks, and pickup trucks. The residue yield was between 1.8 and 2.0 green ton per hectare. The maximum time was related to chipping and the collection of residues and the most delay was mechanical. The residues were collected, chipped, and transported to the particleboard factory at a cost between US$10.18 and US$19.46 per ton, and the profit rate between US$15.5 and US$24.8 per ton depending on chipping methods and secondary transport system. Cost and the total time of LCM were lower than the FCM, and also production rate of LCM was higher than the FCM; therefore, this method was more effective in processing residues from apple trees. Regression techni�ques showed that in LCM, the effect of diameter and age was significant on residue process�ing time and in FCM, the effect of diameter, age, residue density, and functional the area was significant in residue processing time.