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Ahn, So Yoon,Yoo, Hye Soo,Lee, Jang Hoon,Sung, Dong Kyung,Jung, Yu Jin,Sung, Se In,Lim, Keun Ho,Chang, Yun Sil,Lee, Jung Hee,Kim, Ki Soo,Park, Won Soon The Korean Academy of Medical Sciences 2013 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.28 No.7
<P>This study was performed to determine the accuracy of proton magnetic spectroscopy (<SUP>1</SUP>H-MRS) lipid peak as a noninvasive tool for quantitative in vivo detection of brain cell death. Seven day-old Sprague Dawley rats were subjected to 8% oxygen following a unilateral carotid artery ligation. For treatment, cycloheximide was given immediately after hypoxic ischemia (HI). Lipid peak was measured using <SUP>1</SUP>H-MRS at 24 hr after HI, and then brains were harvested for fluorocytometric analyses with annexin V/propidium iodide (PI) and fluorescent probe JC-1, and for adenosine-5'-triphosphate (ATP) and lactate. Increased lipid peak at 1.3 ppm measured with <SUP>1</SUP>H-MRS, apoptotic and necrotic cells, and loss of mitochondrial membrane potential (ΔΨ) at 24 hr after HI were significantly improved with cycloheximide treatment. Significantly reduced brain ATP and increased lactate levels observed at 24 hr after HI showed a tendency to improve without statistical significance with cycloheximide treatment. Lipid peak at 1.3 ppm showed significant positive correlation with both apoptotic and necrotic cells and loss of ΔΨ, and negative correlation with normal live cells. Lipid peak at 1.3 ppm measured by <SUP>1</SUP>H-MRS might be a sensitive and reliable diagnostic tool for quantitative in vivo detection of brain cell death after HI.</P>
Mesenchymal Stem Cells Prevent Hydrocephalus After Severe Intraventricular Hemorrhage
Ahn, So Yoon,Chang, Yun Sil,Sung, Dong Kyung,Sung, Se In,Yoo, Hye Soo,Lee, Jung Hee,Oh, Won Il,Park, Won Soon Ovid Technologies Wolters Kluwer -American Heart A 2013 Stroke Vol.44 No.2
<P>Severe intraventricular hemorrhage (IVH) in premature infants and the ensuing posthemorrhagic hydrocephalus cause significant mortality and neurological disabilities, and there are currently no effective therapies. This study determined whether intraventricular transplantation of human umbilical cord blood-derived mesenchymal stem cells prevents posthemorrhagic hydrocephalus development and attenuates brain damage after severe IVH in newborn rats.</P>
Idiopathic severe hypermagnesemia in an extremely low birth weight infant on the first day of life
Hye Sun Hyun,Hyun Sin Choi,Jin Kyu Kim,So Yoon Ahn,유혜수,Eun Sun Kim,Yun Sil Chang,Won Soon Park 대한소아청소년과학회 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.7
A preterm female infant born at 27 weeks of gestation with a birth weight of 990 g developed acute hypotonia, apnea, hypotension and bradycardia mimicking septic shock syndrome at 14h after birth. Laboratory tests indicated a severe hypermagnesemia of 45mg/dL. The renal function, complete blood count and maternal blood concentrations of magnesium were normal, and the blood cultures were negative. The patient recovered with treatment including exchange transfusion. However, the etiology of the severe hypermagnesemia remains unknown.
Ahn, Dalrae,Lee, Eun Byeol,Kim, Ban Ji,Lee, So Yeon,Lee, Tae Gwan,Ahn, Min-Sil,Lim, Hye Won,Cha, Dong Seok,Jeon, Hoon,Kim, Dae Keun The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.6
Quercetin-3-O-${\alpha}$-$\small{L}$-rhamnopyranosyl($1{\rightarrow}2$)-O-${\alpha}$-$\small{L}$-rhamnopyranoside (QDR) was isolated from the remaining underground parts of Curcuma longa after harvesting the medicinal parts, and the antioxidant activities in vitro and lifespan-extending effect of QDR were elucidated using the Caenorhabditis elegans model system. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging effect of QDR showed similar potent activities in comparison with vitamin C. QDR also showed strong superoxide quenching activities as measured by the riboflavin- and xanthine-originated superoxide quenching activities. QDR demonstrated potent lifespan extension of worms under normal culture condition. Subsequently, the protective effect of QDR on the stress conditions such as thermal and oxidative stresses was determined. In the case of heat stress, QDR-treated worms exhibited enhanced survival rate, as compared to control worms. In addition, QDR-fed worms lived longer than control worms under oxidative stress induced by paraquat. To verify the possible mechanism of QDR-mediated increased lifespan and stress resistance of worms, we investigated whether QDR might alter superoxide dismutase (SOD) activity and intracellular reactive oxygen species (ROS) levels. Our results showed that QDR was able to elevate SOD activity of worms and reduce intracellular ROS accumulation in a dose-dependent manner.