Preoperative short course radiotherapy with concurrent and consolidation chemotherapies followed by delayed surgery in locally advanced rectal cancer: preliminary results

Aghili, Mahdi,Sotoudeh, Sarvazad,Ghalehtaki, Reza,Babaei, Mohammad,Farazmand, Borna,Fazeli, Mohammad-Sadegh,Keshvari, Amir,Haddad, Peiman,Farhan, Farshid The Korean Society for Radiation Oncology 2018 Radiation Oncology Journal Vol.36 No.1

Purpose: This study aimed to assess complications and outcomes of a new approach, that is, combining short course radiotherapy (SRT), concurrent and consolidative chemotherapies, and delayed surgery. Materials and Methods: In this single arm phase II prospective clinical trial, patients with T3-4 or N+ M0 rectal adenocarcinoma were enrolled. Patients who received induction chemotherapy or previous pelvic radiotherapy were excluded. Study protocol consisted of three-dimensional conformal SRT (25 Gy in 5 fractions in 1 week) with concurrent and consolidation chemotherapies including capecitabine and oxaliplatin. Total mesorectal excision was done at least 8 weeks after the last fraction of radiotherapy. Primary outcome was complete pathologic response and secondary outcomes were treatment related complications. Results: Thirty-three patients completed the planned preoperative chemoradiation and 26 of them underwent surgery (24 low anterior resection and 2 abdominoperineal resection). Acute proctitis grades 2 and 3 were seen in 11 (33.3%) and 7 (21.2%) patients, respectively. There were no grades 3 and 4 subacute hematologic and non-hematologic (genitourinary and peripheral neuropathy) toxicities and perioperative morbidities such as anastomose leakage. Grade 2 or higher late toxicities were observed among 29.6% of the patients. Complete pathologic response was achieved in 8 (30.8%) patients who underwent surgery. The 3-year overall survival and local control rates were 65% and 94%, respectively. Conclusion: This study showed that SRT combined with concurrent and consolidation chemotherapies followed by delayed surgery is not only feasible and tolerable without significant toxicity but also, associated with promising complete pathologic response rates.

CERTAIN RESULTS INVOLVING FRACTIONAL OPERATORS AND SPECIAL FUNCTIONS

Aghili, Arman The Kangwon-Kyungki Mathematical Society 2019 한국수학논문집 Vol.27 No.2

In this study, the author provided a discussion on one dimensional Laplace and Fourier transforms with their applications. It is shown that the combined use of exponential operators and integral transforms provides a powerful tool to solve space fractional partial differential equation with non - constant coefficients. The object of the present article is to extend the application of the joint Fourier - Laplace transform to derive an analytical solution for a variety of time fractional non - homogeneous KdV. Numerous exercises and examples presented throughout the paper.

Numerical Inversion Technique for the One and Two-Dimensional L₂-Transform Using the Fourier Series and Its Application to Fractional Partial Differential Equations

Aghili, Arman,Ansari, Alireza Department of Mathematics 2012 Kyungpook mathematical journal Vol.52 No.4

In this paper, we use a computational algorithm for the inversion of the one and two-dimensional $\mathcal{L}_2$-transform based on the Bromwich's integral and the Fourier series. The new inversion formula can evaluate the inverse of the $\mathcal{L}_2$-transform with considerable accuracy over a wide range of values of the independent variable and can be devised for the functions which are not Laplace transformable and have damping motion in small interval near origin.

Short-course versus long-course neoadjuvant chemoradiotherapy in patients with rectal cancer: preliminary results of a randomized controlled trial

Mahdi Aghili,Nastaran Khalili,Neda Khalili,Mohammad Babaei,Farshid Farhan,Peiman Haddad,Samaneh Salarvand,Amir Keshvari,Mohammad Sadegh Fazeli,Negin Mohammadi,Reza Ghalehtaki 대한방사선종양학회 2020 Radiation Oncology Journal Vol.38 No.2

Purpose: Colorectal cancer is becoming an increasing concern in the middle-aged population of Iran. This study aimed to compare the preliminary results of short-course and long-course neoadjuvant chemoradiotherapy treatment for rectal cancer patients. Materials and Methods: In this clinical trial we recruited patients with rectal adenocarcinoma located from 5 cm to 15 cm above the anal verge. Patients in group I (short-course) received three-dimensional conformational radiotherapy with a dose of 25 Gy/5 fractions in 1 week plus concurrent XELOX regimen (capecitabine 625 mg/㎡ from day 1-5 twice daily and oxaliplatin 50 mg/㎡ on day 1 once daily). Patients in group II (long-course) received a total dose of 50-50.4 Gy/25-28 fractions for 5 to 5.5 weeks plus capecitabine 825 mg/m2 twice daily. Both groups underwent consolidation chemotherapy followed by delayed surgery at least 8 weeks after radiotherapy completion. The pathological response was assessed with tumor regression grade. Results: In this preliminary report on complications and pathological response, 66 patients were randomized into two study groups. Mean duration of radiotherapy in the group II (long-course) was 5 ± 1 days (range, 5 to 8 days) and 38 ± 6 days (range, 30 to 58 days). The median follow-up was 18 months. Pathological complete response was achieved in 32.3% and 23.1% of patients in the short-course and long-course groups, respectively (p = 0.558). Overall, acute grade 3 or higher treatment-related toxicities occurred in 24.2% and 22.2% of patients in group I and II, respectively (p = 0.551). No acute grade 4 or 5 adverse events were observed in either group except one grade 4 hematologic toxicity that was seen in group II. Within one month of surgery, no significant difference was seen regarding grade ≥3 postoperative complications (p = 0.333). Conclusion: For patients with rectal cancer located at least 5 cm above the anal verge, short-course radiotherapy with concurrent and consolidation chemotherapy and delayed surgery is not different in terms of acute toxicity, postoperative morbidity, complete resection, and pathological response compared to long-course chemoradiotherapy.

Preoperative short course radiotherapy with concurrent and consolidation chemotherapies followed by delayed surgery in locally advanced rectal cancer: preliminary results

Mahdi Aghili,Sarvazad Sotoudeh,Reza Ghalehtaki,Mohammad Babaei,Borna Farazmand,Mohammad-Sadegh Fazeli,Amir Keshvari,Peiman Haddad,Farshid Farhan 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.1

Purpose: This study aimed to assess complications and outcomes of a new approach, that is, combining short course radiotherapy (SRT), concurrent and consolidative chemotherapies, and delayed surgery. Materials and Methods: In this single arm phase II prospective clinical trial, patients with T3-4 or N+ M0 rectal adenocarcinoma were enrolled. Patients who received induction chemotherapy or previous pelvic radiotherapy were excluded. Study protocol consisted of three-dimensional conformal SRT (25 Gy in 5 fractions in 1 week) with concurrent and consolidation chemotherapies including capecitabine and oxaliplatin. Total mesorectal excision was done at least 8 weeks after the last fraction of radiotherapy. Primary outcome was complete pathologic response and secondary outcomes were treatment related complications. Results: Thirty-three patients completed the planned preoperative chemoradiation and 26 of them underwent surgery (24 low anterior resection and 2 abdominoperineal resection). Acute proctitis grades 2 and 3 were seen in 11 (33.3%) and 7 (21.2%) patients, respectively. There were no grades 3 and 4 subacute hematologic and non-hematologic (genitourinary and peripheral neuropathy) toxicities and perioperative morbidities such as anastomose leakage. Grade 2 or higher late toxicities were observed among 29.6% of the patients. Complete pathologic response was achieved in 8 (30.8%) patients who underwent surgery. The 3-year overall survival and local control rates were 65% and 94%, respectively. Conclusion: This study showed that SRT combined with concurrent and consolidation chemotherapies followed by delayed surgery is not only feasible and tolerable without significant toxicity but also, associated with promising complete pathologic response rates.

Influence of Fluorine Doping on Hardness and Compressive Stress of the Diamond-Like Carbon Thin Film

Sayed Mohammad Adel Aghili,Raheleh Memarzadeh,Reza Bazargan Lari,Akbar Eshaghi 한국재료학회 2023 한국재료학회지 Vol.33 No.4

This study assessed the influences of fluorine introduced into DLC films on the structural and mechanical properties of the sample. In addition, the effects of the fluorine incorporation on the compressive stress in DLC films were investigated. For this purpose, fluorinated diamond-like carbon (F-DLC) films were deposited on cobalt-chromium-molybdenum substrates using radio-frequency plasma-enhanced chemical vapor. The coatings were examined by Raman scattering (RS), Attenuated total reflectance Fourier transform infrared spectroscopic analysis (ATR-FTIR), and a combination of elastic recoil detection analysis and Rutherford backscattering (ERDA-RBS). Nano-indentation tests were performed to measure hardness. Also, the residual stress of the films was calculated by the Stony equation. The ATR-FTIR analysis revealed that F was present in the amorphous matrix mainly as C-F and C-F2 groups. Based on Raman spectroscopy results, it was determined that F made the DLC films more graphitic. Additionally, it was shown that adding F into the DLC coating resulted in weaker mechanical properties and the F-DLC coating exhibited lower stress than DLC films. These effects were attributed to the replacement of strong C = C by feebler C-F bonds in the F-DLC films. F-doping decreased the hardness of the DLC from 11.5 to 8.8 GPa. In addition, with F addition, the compressive stress of the DLC sample decreased from 1 to 0.7 GPa.

Atorvastatin on Treatment of Nonalcoholic Fatty Liver Disease Patients

Zahra Eslami,Samaneh Sadat Aghili,Amir Ghaleh Ghafi 전남대학교 의과학연구소 2024 전남의대학술지 Vol.60 No.1

Non-alcoholic fatty liver disease (NAFLD) is a condition in which excess fat builds up in the liver, often related to obesity and insulin resistance, which can lead to inflammation and scarring of the liver tissue. While efforts have been made to develop effective treatments for NAFLD, the need for pharmaceutical interventions remains unmet. Large clinical trials investigating the association between statin use and NAFLD are scarce, leading to contradictory results. Statins play a crucial role in cholesterol synthesis in the liver. Several studies have demonstrated that statins possess anti-inflammatory, anti-thrombotic, and anti-fibrotic properties. These properties make statins potentially useful in preventing the progression of NAFLD from simple steatosis to more severe forms like non-alcoholic steatohepatitis (NASH) and fibrosis. The results indicate that statin use is associated with a lower prevalence of NASH and fibrosis and may have a preventive effect on NAFLD.

Analysis, optimization and control of an adaptive tuned vibration absorber featuring magnetoactive materials

Fan Lin,Masoud Hemmatian,Ramin Sedaghati,Farhad Aghili 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.28 No.4

Excessive vibration may cause premature fatigue failure on structural components if it is not properly controlled. One effective way to attenuate vibration is to attach a tuned vibration absorber to the main structural component. Passive tuned vibration absorbers are mainly effective to attenuate vibration at a specific range of frequencies and thus they become infective under varied environmental conditions which can significantly alter the tuning frequencies. The present study aims at development of a wide-bandwidth and light-weight adaptive tuned vibration absorber (ATVA) featuring a magnetorheological elastomer (MRE) which is tuned to absorb the vibrations of a flexible beam. The accelerance transfer function is derived for both beam with and without ATVA. The effectiveness of the ATVA to control vibration of the flexible beam caused by external excitation under wide range of frequencies is demonstrated. The proposed ATVA consists of C-Shape frame with winding coils, two isometric MRE specimens with 40% volume fraction, and active mass. An empirical model for the MRE has been developed through an experimental identification method in order to predict the MRE's elastic modulus under various levels of excitation frequencies and applied magnetic fields. Using MRE models and magneto-circuit analysis, the frequency bandwidth of the ATVA is analytically obtained. The analytical model is then used to develop a multidisciplinary design optimization formulation to minimize the mass and maximize the frequency bandwidth of an ATVA featuring MRE given several geometrical and physical constraints. Finally, a tuning algorithm has been presented to determine the required applied magnetic flux density to the MRE layers based on the identified phase difference between the absolute acceleration of the host and relative acceleration of the host and ATVA's resonator.

Current approaches in intensification of long-course chemoradiotherapy in locally advanced rectal cancer: a review

Peiman Haddad,Reza Ghalehtaki,Arefeh Saeedian,Farshid Farhan,Mohammad Babaei,Mahdi Aghili 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.2

Rectal cancer is one of the most prevalent cancers in the world. In many countries, the current standard of care is long-course chemoradiation (CRT), followed by total mesorectal excision. Some efforts have been made by intensifying radiation or chemotherapy components of the neoadjuvant therapy to further decrease the local recurrence and augment surgery’s feasibility and improve the oncological outcomes. This paper reviews recent intensified neoadjuvant interventions in locally advanced rectal cancer (LARC) in terms of efficacy and treatment-related toxicity. Many maneuvers have been made so far to improve the oncological outcomes of rectal cancer with intensified neoadjuvant long-course CRT. Some of these approaches seem compelling and deserve further study, while some have just increased the treatment-related toxicities without evident benefits. Those endeavors with greater pathological complete response than the standard of care may make us await the long-term results on survival rates and chronic treatment-related toxicity. After introduction of neoadjuvant CRT for LARC there have been many efforts to improve its outcomes. Here, this study gathered most of these efforts that intensified the neoadjuvant therapy with some being promising and some being futile.