http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Cariprazine — an Alternative Treatment for Clozapine-resistant Schizophrenia?
Adam Montgomery(Adam Montgomery ),Marianna Rogowska(Marianna Rogowska ),Luiz Dratcu(Luiz Dratcu ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Treatment-resistant schizophrenia (TRS) poses a significant therapeutic challenge in psychiatric practice. Clozapine is recognized as a treatment of choice in TRS but is not always effective in alleviating patients’ symptoms. Additionally, clozapine therapy is associated with multiple side effects and monitoring requirements that often limit its use and negatively affect patients’ compliance with the treatment. Although clozapine augmentation options are available, there is currently no alternative monotherapy proven to be effective in TRS. We present a case of a young man with TRS who failed to respond to appropriate trials of risperidone, aripiprazole and also clozapine, and who experienced impairing adverse effects of clozapine that made further clozapine treatment not only futile but also detrimental to his health. He was successfully treated with cariprazine monotherapy, which culminated in the remission of his both positive and negative symptoms of psychosis as well as in the marked improvement in social functioning. Cariprazine, a newer atypical antipsychotic endowed with a D3-preferring mode of action, may offer a better tolerated and more acceptable treatment option for patients with difficult-to-treat psychotic symptoms.
Adam Burr(Adam Burr ),Paul Harari(Paul Harari ),Aaron Wieland(Aaron Wieland ),Randall Kimple(Randall Kimple ),Gregory Hartig(Gregory Hartig ),Matthew Witek(Matthew Witek ) 대한방사선종양학회 2022 Radiation Oncology Journal Vol.40 No.4
Purpose: Optimal radiotherapy treatment volumes for patients with locally advanced hypopharynx squamous cell carcinoma should ensure maximal tumor coverage with minimal inclusion of normal surrounding structures. Here we evaluated the effectiveness of a direct 3-mm high-dose gross tumor volume to planning target volume expansion on clinical outcomes for hypopharynx cancers. Materials and Methods: We performed a retrospective analysis of patients with hypopharynx carcinoma treated between 2004 and 2018 with primary radiotherapy using a direct high-dose gross tumor volume to planning target volume expansion and with or without concurrent systemic therapy. Diagnostic imaging of recurrences was co-registered with the planning CT. Spatial and volumetric analyses of contoured recurrences were compared with planned isodose lines. Failures were initially defined as in field, marginal, elective nodal, and out of field. Each failure was further classified as central high-dose, peripheral high-dose, central intermediate/low-dose, peripheral intermediate/low-dose, and extraneous. Clinical outcomes were analyzed by Kaplan-Meier estimation. Results: Thirty-six patients were identified. At a median follow-up at 52.4 months, estimated 5-year overall survival was 59.3% (95% confidence interval [CI], 36.3%–74.1%), 5-year local and nodal control was 71.7% (95% CI, 47.1%–86.3%) and 69.9% (95% CI, 57.0%–82.6%), respectively. The most common failure was in the high-dose primary target volume. The gastrostomy tube retention rate at 1 year among patients without recurrence was 13.0% (95% CI, 3.2%–29.7%). Conclusion: Minimal high-dose target volume expansions for hypopharynx cancers were associated with favorable locoregional control. This approach may enable therapy intensification to improve clinical outcomes.
Confocal Microscopy in the Esophagus and Stomach
Adam Templeton,황주하 대한소화기내시경학회 2013 Clinical Endoscopy Vol.46 No.5
Probe-based confocal microscopy (pCLE) is actively being investigated for applications in the esophagus and stomach. The use of pCLE allows real-time in vivo microscopy to evaluate the microarchitecture of the mucosal epithelium. pCLE appears to be particularly useful in identifying mucosal dysplasia and early malignancies that cannot be clearly distinguished using high-definition white light endoscopy, chromoendoscopy, or magnification endoscopy. In addition, the ability to detect dysplastic tissue in real-time may shift the current screening practice from random biopsy to targeted biopsy of esophageal and gastric cancers and their precursor lesions. We will review the use of pCLE for detection and surveillance of upper gastrointestinal early luminal malignancy.
Inclusive quarkonium production at forward rapidity in pp collisions at [FORMULA OMISSION] TeV
Adam, J.,Adamová,, D.,Aggarwal, M. M.,Aglieri Rinella, G.,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahn, S. U.,Aiola, S.,Akindinov, A.,Alam, S. N.,Aleksandrov, D.,Alessandro, B.,Alexandre, D.,Alfaro M Springer Berlin Heidelberg 2016 The European physical journal. C, Particles and fi Vol.76 No.4
<P>We report on the inclusive production cross sections of [FORMULA OMISSION], [FORMULA OMISSION], [FORMULA OMISSION](1S), [FORMULA OMISSION](2S) and [FORMULA OMISSION](3S), measured at forward rapidity with the ALICE detector in [FORMULA OMISSION] collisions at a center-of-mass energy [FORMULA OMISSION] TeV. The analysis is based on data collected at the LHC and corresponds to an integrated luminosity of 1.23 pb[FORMULA OMISSION]. Quarkonia are reconstructed in the dimuon-decay channel. The differential production cross sections are measured as a function of the transverse momentum [FORMULA OMISSION] and rapidity <I>y</I>, over the [FORMULA OMISSION] ranges [FORMULA OMISSION] GeV/<I>c</I> for [FORMULA OMISSION], [FORMULA OMISSION] GeV/<I>c</I> for all other resonances, and for [FORMULA OMISSION]. The cross sections, integrated over [FORMULA OMISSION] and <I>y</I>, and assuming unpolarized quarkonia, are [FORMULA OMISSION] [FORMULA OMISSION]b, [FORMULA OMISSION] [FORMULA OMISSION]b, [FORMULA OMISSION] nb, [FORMULA OMISSION] nb and [FORMULA OMISSION] nb, where the first uncertainty is statistical and the second one is systematic. These values agree, within at most [FORMULA OMISSION], with measurements performed by the LHCb collaboration in the same rapidity range.</P>
Anomalous Evolution of the Near-Side Jet Peak Shape in Pb-Pb Collisions at sNN=2.76 TeV
Adam, J.,Adamová,, D.,Aggarwal, M. M.,Aglieri Rinella, G.,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahmad, S.,Ahn, S. U.,Aiola, S.,Akindinov, A.,Alam, S. N.,Albuquerque, D. S. D.,Aleksandrov, D.,Aless American Physical Society 2017 Physical review letters Vol.119 No.10
<P>The measurement of two-particle angular correlations is a powerful tool to study jet quenching in a p(T) region inaccessible by direct jet identification. In these measurements pseudorapidity (Delta(eta)) and azimuthal (Delta phi) differences are used to extract the shape of the near-side peak formed by particles associated with a higher p(T) trigger particle (1 < p(T,trig) < 8 GeV/c). A combined fit of the near-side peak and long-range correlations is applied to the data allowing the extraction of the centrality evolution of the peak shape in Pb-Pb collisions at root s(NN) = 2.76 TeV. A significant broadening of the peak in the Delta(eta) direction at low p(T) is found from peripheral to central collisions, which vanishes above 4 GeV/c, while in the Delta(phi) direction the peak is almost independent of centrality. For the 10% most central collisions and 1 < p(T,assoc) < 2 GeV/c, 1 < p(T,trig) < 3 GeV/c a novel feature is observed: a depletion develops around the center of the peak. The results are compared to pp collisions at the same center of mass energy and AMPT model simulations. The comparison to the investigated models suggests that the broadening and the development of the depletion is connected to the strength of radial and longitudinal flow.</P>
Adam Bastovansky,Claudia Stöllberger,Josef Finsterer 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.3
Fatal air embolism to the cerebrum during an endoscopic retrograde cholangiopancreatography (ERCP) has not been reported in a patientwith a biliodigestive anastomosis and multiresistant extended-spectrum β-lactamase Escherichia coli (ESBL) bacteremia. A 59-yearoldwoman with a history of laparoscopic cholecystectomy and iatrogenic injury of the right choledochal duct, choledochojejunostomy(biliodigestive anastomosis), recurrent cholangitis, revision of the biliodigestive anastomosis, recurrent liver abscesses, and recurrentstenting of stenotic bile ducts, was admitted because of fever and tenderness of the right upper quadrant. On ERCP, a previously deployedcovered Wallstent was replaced. Blood cultures grew ESBL. After stent removal 8 days later, the patient did not wake up and developedarterial hypotension and respiratory insufficiency, requiring mechanical ventilation. Computed tomography scans showed extensiveair embolism to the liver, heart, and cerebrum. She died 1 day later. Although the exact pathogenesis of the fatal cerebral air embolism remainsspeculative, the nonphysiological anatomy and chronic infection with ESBL may have been contributory factors.
Measurement of an Excess in the Yield ofJ/ψat Very LowpTin Pb-Pb Collisions atsNN=2.76 TeV
Adam, J.,Adamová,, D.,Aggarwal, M. M.,Aglieri Rinella, G.,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahn, S. U.,Aiola, S.,Akindinov, A.,Alam, S. N.,Aleksandrov, D.,Alessandro, B.,Alexandre, D.,Alfaro M American Physical Society 2016 Physical review letters Vol.116 No.22
<P>We report on the first measurement of an excess in the yield of J/psi at very low transverse momentum (pT < 0.3 GeV/c) in peripheral hadronic Pb-Pb collisions at root s(NN) = 2.76 TeV, performed by ALICE at the CERN LHC. Remarkably, the measured nuclear modification factor of J/psi in the rapidity range 2.5 < y < 4 reaches about 7 (2) in the p(T) range 0-0.3 GeV/c in the 70%-90% (50%-70%) centrality class. The J/psi production cross section associated with the observed excess is obtained under the hypothesis that coherent photoproduction of J/psi is the underlying physics mechanism. If confirmed, the observation of J/psi coherent photoproduction in Pb-Pb collisions at impact parameters smaller than twice the nuclear radius opens new theoretical and experimental challenges and opportunities. In particular, coherent photoproduction accompanying hadronic collisions may provide insight into the dynamics of photoproduction and nuclear reactions, as well as become a novel probe of the quark-gluon plasma.</P>