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Anqi Luo,Min Meng,Guanying Wang,Rui Han,Yujiao Zhang,Xin Jing,Lin Zhao,Shanzhi Gu,Xinhan Zhao 한국유방암학회 2020 Journal of breast cancer Vol.23 No.2
Purpose: Numerous studies have shown that the frequency of myeloid-derived suppressor cells (MDSCs) is associated with tumor progression, metastasis, and recurrence. Chemokine (C-C motif ) ligand 3 (CCL3) may be secreted by tumor cells and attract MDSCs into the tumor microenvironment. In the present study, we aimed to explore the molecular mechanisms whereby CCL3 is involved in the interaction of breast cancer cells and MDSCs. Methods: The expression of CCL3 and its receptors was investigated using real-time polymerase chain reaction, western blotting, and enzyme-linked immunosorbent assay. The cell counting Kit-8, wound healing, and transwell assays were performed to study cell growth, migration, and invasion. Cell cycling, apoptosis, and the frequency of MDSCs were investigated through flow cytometry. Transwell assays were used for co-culture and chemotaxis detection. Markers of the epithelial-mesenchymal transition (EMT) were determined with western blotting. The role of CCL3 in vivo was studied via tumor xenograft experiments. Results: CCL3 promoted cell proliferation, migration, invasion, and cycling, and inhibited apoptosis of breast cancer cells in vitro. Blocking CCL3 in vivo inhibited tumor growth and metastases. The frequency of MDSCs in patients with breast cancer was higher than that in healthy donors. Additionally, MDSCs might be recruited by CCL3. Co-culture with MDSCs activated the phosphoinositide 3-kinase-protein kinase B-mammalian target of rapamycin (PI3K-Akt-mTOR) pathway and promoted the EMT in breast cancer cells, and their proliferation, migration, and invasion significantly increased. These changes were not observed when breast cancer cells with CCL3 knockdown were co-cultured with MDSCs. Conclusion: CCL3 promoted the growth of breast cancer cells, and MDSCs recruited by CCL3 interacted with these cells and then activated the PI3K-Akt-mTOR pathway, which led to EMT and promoted the migration and invasion of the cells.
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Anqi Fan,Bao-Long Hou,Zhishu Tang,Ting Wang,Dongbo Zhang,Yanni Liang,Zheng Wang 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.12
Ulcerative colitis (UC), often known as UC, is an inflammatory disease of the intestines that has frequent andlong-lasting flare-ups. It is unknown precisely how the traditional Chinese drug Indigo Naturalis (IN) heals inflammatorybowel disease, despite its long-standing use in China and Japan. Finding new metabolite biomarkers linked to UC couldimprove our understanding of the disease, speed up the diagnostic process, and provide insight into how certain drugs work totreat the condition. Our work is designed to use a metabolomic method to analyze potential alterations in endogenoussubstances and their impact on metabolic pathways in a mouse model of UC. To determine which biomarkers and metabolismsare more frequently connected with IN’s effects on UC, liquid chromatography-tandem mass spectrometry analysis ofthe serum metabolomics of UC mice and normal mice was performed. The outcomes demonstrated that IN boosted the healthof UC mice and reduced the severity of their metabolic dysfunction. In the UC model, it was also found that IN changed theway 17 biomarkers and 3 metabolisms functioned.
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Anqi Zhou,Younghwan Pan 한국서비스디자인학회 2023 한국서비스디자인학회 학술대회자료집 Vol.2023 No.1
This paper discuss the application of scene thinking and product Construction design (SAPAD) theoretical framework based on semiotics in unmanned self-service coffee machine products, and reconstructs the service content and service system of the new unmanned self-service coffee machine products. Taking the unmanned self-service coffee machine in an office building in China of Hangzhou as an example, Firstly the product application scenario of unmanned self-service coffee machine is determined. Then the SAPAD theoretical framework is applied to conduct multidimensional analysis of behavior--meaning--object, and a new functional module of self-service coffee machine was constructed in the objective scene. Finally, the service system of unmanned self-service coffee machine is designed in the target scene, to help improve the product function and enhance user experience of unmanned self-service coffee machine.
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ENHANCING CUSTOMER EXPERIENCES IN THE AUGMENTED REALITY ERA
Anqi Hu,Ruizhi Yuan,Martin J. Liu,Ruolan Chen 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
In recent years E-commerce platforms recommend some products for consumers based on their shopping history and user persona. However, sometimes, unfamiliar products or styles would be recommended to consumers unintentionally or intentionally. Curiosity drives consumers to try but this idea would be declined with the consideration of product fit uncertainty. Augmented Reality (AR) is the integration of digital information with the user‘s environment in real-time (Hilken et al. 2018), it can deal with issues related to physical apprehension that hinder consumers’ online shopping (i.e, clothes, cosmetics), especially for the unfamiliar style. This study aims to investigate whether AR technology could improve consumers' purchase likelihood. Augmented Reality (AR) can enhance customer experiences in a multichannel environment (Hilken et al. 2017). AR Integrates online experiences into the offline experience (Hilken et al. 2018), such as virtual try-on or magic mirrors. Customers often find it difficult to imagine how firms’ products and services fit them personally or fit with their environment (Hilken et al. 2018). Drawn on AR, consumers can easily evaluate the fitness between themselves and the selected products. Prior studies have explored the different underlying processes of why AR technology could improve consumer purchase intention and customer experience. For instance, according to the situated cognition theory, AR creates a feeling of spatial presence (Hilken et al. 2017). The usage of AR benefits mental imagery, improving decision comfort (Heller et al. 2019). AR can compensate for consumers’ need for touch and offer hedonic and/or utilitarian benefits (Gatter et al. 2022). Based on media richness theory, AR offers more information for customers (Hoffmann et al. 2022), which represents a fitting concept for customers to evaluate the product (Javornik 2016).
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Exploring the Influencing Factors of TFBOYS Xi'an Music Concert on Tourists' Tourism Intention
Li Anqi,김현태 중국지역학회 2023 중국지역연구 Vol.10 No.4
This study situates itself at the nexus of celebrity music concerts and tourism intention, delving into the impact of the TFBOYS Xi'an music concert on tourists' tourism intention. Although celebrity music concerts are increasingly recognized as pivotal cultural and entertainment events influencing the tourism sector, the intricate relationship between these concerts and tourism intention remains incompletely explored in existing literature. Hence, the current research endeavors to fill this void. By engaging in meticulous analysis and empirical study, it elucidates how factors such as music concert tourist involvement, tourist satisfaction, and tourist destination image synergistically shape the tourists' tourism intention. A structured questionnaire was disseminated to 388 tourists, and the structural equation modelling was employed for empirical validation of the proposed model. The results divulge a positive correlation between tourist involvement in the music concert and tourist satisfaction, both of which markedly influence the tourist destination image. However, counterintuitively, tourist satisfaction was found not to have a significant impact on tourism intention, a revelation that contests the conventional tourist satisfaction-loyalty model. The findings highlight the roles of tourist involvement and destination image in influencing tourism intention, offering valuable insights and practical strategies for concert organizers and city managers, aiding in maximizing the cultural and economic benefits of celebrity concerts.
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