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Yeo, A-Reum,Lee, Jung-Lim,Tae, In-Hwan,Park, Seok-Rae,Cho, Young-Ho,Lee, Bong-Ho,Shin, Hyeon-Cheol,Kim, Seong-Ho,Yoo, Yung-Choon The Korean Society of Food Science and Nutrition 2012 Preventive Nutrition and Food Science Vol.17 No.1
The inhibitory effect of polyphenol extracts (Seapolynol$^{TM}$, SPN) of the marine brown algae Ecklonia cava and dieckol, a major component of SPN, on hyperlipidemia was investigated in ICR mice fed a high-fat diet (HFD) for five weeks. For analysis of the anti-hyperlipidemic effects of SPN and dieckol, these two agents were given orally on a daily basis to HFD-fed mice for four weeks, starting one week after the beginning of HFD feeding. Groups administered with SPN as well as dieckol showed lower body weight gains than the HFD only group. Administration of SPN and dieckol also resulted in a significant reduction of the level of total cholesterol (TCHO), triglyceride (TG), and low-density lipoprotein (LDL) cholesterol in the serum of HFD-fed mice. In Oil Red O staining using 3T3-L1 preadipocytes, it was shown that both SPN and dieckol markedly inhibited lipid accumulation of 3T3-L1 cells. Furthermore, SPN and dieckol (50 ${\mu}g$/mL) significantly inhibited 3-hydroxyl-methyl glutaryl coenzyme A (HMGCoA) reductase activity in vitro. Taken together, these results suggest that polyphenols of Ecklonia cava (SPN) and dieckol reduce body weight gain and fat accumulation in HFD-induced obese mice, and that their hypolipidemic effect is related to the inhibition of adipogenesis of adipocytes and HMGCoA reductase activity.
A-Reum Yeo,Junglim Lee,In Hwan Tae,Seok-Rae Park,Bong Ho Lee,Hyeon Cheol Shin,Seong Ho Kim,Yung Choon Yoo 한국식품영양과학회 2012 Preventive Nutrition and Food Science Vol.17 No.1
The inhibitory effect of polyphenol extracts (SeapolynolTM, SPN) of the marine brown algae Ecklonia cava and dieckol, a major component of SPN, on hyperlipidemia was investigated in ICR mice fed a high-fat diet (HFD) for five weeks. For analysis of the anti-hyperlipidemic effects of SPN and dieckol, these two agents were given orally on a daily basis to HFD-fed mice for four weeks, starting one week after the beginning of HFD feeding. Groups administered with SPN as well as dieckol showed lower body weight gains than the HFD only group. Administration of SPN and dieckol also resulted in a significant reduction of the level of total cholesterol (TCHO), triglyceride (TG), and low-density lipoprotein (LDL) cholesterol in the serum of HFD-fed mice. In Oil Red O staining using 3T3-L1 preadipocytes, it was shown that both SPN and dieckol markedly inhibited lipid accumulation of 3T3-L1 cells. Furthermore, SPN and dieckol (50 ㎍/mL) significantly inhibited 3-hydroxyl-methyl glutaryl coenzyme A (HMGCoA) reductase activity in vitro. Taken together, these results suggest that polyphenols of Ecklonia cava (SPN) and dieckol reduce body weight gain and fat accumulation in HFD-induced obese mice, and that their hypolipidemic effect is related to the inhibition of adipogenesis of adipocytes and HMGCoA reductase activity.
Calcaneal Osteomyelitis due to Non-tuberculous Mycobacteria: A Case Report
Tae Im Yi,Seung-A Ha,Yeo-Reum Choe,Joo Sup Kim,Kye Won Kwon 대한재활의학회 2016 Annals of Rehabilitation Medicine Vol.40 No.1
Osteomyelitis is a bone infection caused by bacteria or other germs. Gram-positive cocci are the most common etiological organisms of calcaneal osteomyelitis; whereas, non-tuberculous mycobacteria (NTM) are rarely documented. We reported a case of NTM calcaneal osteomyelitis in a 51-year-old female patient. She had been previously treated in many local clinics with multiple local steroid injection over 50 times and extracorporeal shock-wave therapy over 20 times with the impression of plantar fasciitis for 3 years prior. Diagnostic workup revealed a calcaneal osteomyelitis and polymerase chain reaction assay on bone aspirate specimens confirmed the diagnosis of non-tuberculous mycobacterial osteomyelitis. The patient had a partial calcanectomy with anti-tubercular therapy. Six months after surgery, a follow-up magnetic resonance imaging showed localized chronic osteomyelitis with abscess formation. We continued anti-tubercular therapy without operation. At 18-month follow-up after surgery and comprehensive rehabilitation therapy, she was ambulating normally and able to carry out her daily activities without any discomfort.
투과전자현미경을 이용하여 관찰한 건성안 유발 마우스 눈물샘 선세포의 변화
서유리,여아름,노혜미,정동룡,김태임,서경률,김응권,이형근,Yu Ri Seo,A Reum Yeo,Hye Mi Noh,Dong Yong Chung,Tae Im Kim,Kyoung Yul Seo,Eung Kweon Kim,Hyung Keun Lee 대한안과학회 2014 대한안과학회지 Vol.55 No.8
Purpose: To determine the change in lacrimal gland (LG) acinar cells induced by in vivo dry eye (DE). Methods: Six to 8-week-old (C57BL/6) mice were placed in a controlled environment chamber at <20% humidity for 2 weeks, and a control group was bred in a normal environment. After these 2 weeks of dry eye (DE) induction, the mice were sacrificed and their LGs were collected. Lacrimal gland acinar cell organelle structures were observed with Transmission Electron Microscopy (TEM). TEM images were analyzed using the Image J program. Results: The size of the LGs of DE-induced mice decreased compared to those of normal mice. Terminal deoxynucleotidyl transferase dUTP Nick End Labeling (TUNEL) staining was negative in DE-induced LGs. Under the TEM, the endoplasmic reticulum (ER) lumen was dilated and the lumen density increased in DE-induced mice. Additionally, cell organelles were surrounded by elongated ER lumens. The mitochondrial structure was destroyed and the number of vacuoles increased in the LGs of DE-induced mice. Conclusions: Structural changes of the LG developed due to DE induction. This suggests that the detailed mechanisms of these changes were ER stress and autophagy. However, there were no definite signs of apoptosis in the acinar cells of the DE-induced LGs. These findings are regarded as an important clue of the pathogenesis of non-Sjogren-type dry eye. J Korean Ophthalmol Soc 2014;55(8):1187-1194
Bae, Se Won,Cho, Min Sun,Jeong, A Reum,Choi, Bo-Ra,Kim, Dong-Eun,Yeo, Woon-Seok,Hong, Jong-In WILEY-VCH Verlag 2010 Small Vol.6 No.14
<B>Graphic Abstract</B> <P>Ru(bpy)<SUB>3</SUB><SUP>2+</SUP>-doped silica nanoparticles surface-functionalized with a phosphatidylserine-selective synthetic ligand are designed for the purpose of detecting and imaging apoptotic cells (see image). The preferential binding of this ligand to phosphatidylserine in preference to other phospholipids is confirmed and the ligands are conjugated onto the highly fluorescent and biocompatible Ru(bpy)<SUB>3</SUB><SUP>2+</SUP>-doped silica nanoparticles in a multivalent fashion. <img src='wiley_img_2010/16136810-2010-6-14-SMLL201000564-content.gif' alt='wiley_img_2010/16136810-2010-6-14-SMLL201000564-content'> </P>