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Hypoxia-induced Angiogenesis during Carcinogenesis
최규실,배문경,정주원,문효은,김규원,Choe, Gyu-Sil,Bae, Mun-Gyeong,Jeong, Ju-Won,Mun, Hyo-Eun,Kim, Gyu-Won Korean Society for Biochemistry and Molecular Biol 2003 Journal of biochemistry and molecular biology Vol.36 No.1
The formation of new blood vessels, angiogenesis, is an essential process during development and disease. Angiogenesis is well known as a crucial step in tumor growth and progression. Angiogenesis is induced by hypoxic conditions and regulated by the hypoxia-inducible factor 1 (HIF-1). The expression of HIF-1 correlates with hypoxia-induced angiogenesis as a result of the induction of the major HIF-1 target gene, vascular endothelial cell growth factor (VEGF). In this review, a brief overview of the mechanism of angiogenesis is discussed, focusing on the regulatory processes of the HIF-1 transcription factor. HIF-1 consists of a constitutively expressed HIF-1 beta(HIF-1β) subunit and an oxygen-regulated HIF-1 alpha(HIF-1α) subunit. The stability and activity of HIF-1α are regulated by the interaction with various proteins, such as pVHL, p53, and p300/CBP as well as by post-translational modifications, hydroxylation, acetylation, and phosphorylation. It was recently reported that HIF-1α binds a co-activator of the AP-1 transciption factor, Jab-1, which inhibits the p53-dependent degradation of HIF-1 and enhances the transcriptional activity of HIF-1 and the subsequent VEGF expression under hypoxic conditions. ARD1 acetylates HIF-1α and stimulates pVHL-mediated ubiquitination of HIF-1α. With a growing knowledge of the molecular mechanisms in this field, novel strategies to prevent tumor angiogenesis can be developed, and form these, new anticancer therapies may arise.
대구지역 저소득층 성인여성의 비만, 나트륨 섭취 및 식행동 특성
윤진숙(Yoon, Jin Sook),정주원(Jeong, Ju Won) 계명대학교 생활과학연구소 2014 科學論集 Vol.40 No.-
The purpose of this study was to investigate the relationship among obesity, sodium intake and dietary behavior of low-income women adult in Deagu. Subject were 85 adult women from low-income classes. Dietary information was collected by 24 hrs-recall method for nonconsecutive two days including weekday and weekend and by food frequency method. The results were compared among groups classified by BMI and sodium intake level. Mean Na intake of women exceeded the recommended upper level. When we compare each food group by BMI, there was no significant differences in food intakes. By cotrast, significantly higher intake of grains and vegetables were observed in the higher sodium intake group. However, there was no significant differences of soup saltness between groups classified by sodium intake level. Soup saltness was significantly higher in obese group. This study suggested the need for continuous efforts on reducing Na intake among low income women regardless of obesity status.