회춘양격산(回春凉膈散)이 db/db 마우스의 고혈당 및 지질대사에 미치는 효과

장수영,정유선,신현철,Jang, Soo-Young,Jung, Yu-Sun,Shin, Hyeon-Cheol 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.1

Objectives : Hoechunyanggyeok-san (HYS) is a traditional herbal medicine, which has been clinically used for treating febrile and inflammatory diseases. HYS has been reported to be a useful treatment for diabetes, atherosclerosis and hyperlipidemia in the type 1 diabetic model. However, the mechanism of the effects of HYS against hyperglycemia and hyperlipidemia is poorly understood. In the present study, we investigated the underlying mechanism of ameliorative effect of HYS on hyperglycemia and hyperlipidemia in vivo. Methods : HYS (10, 50 mg/kg/day, p.o.) was administered every day for 2 weeks to db/db mice and its effect was compared with vehicle-treated db/db mice. To confirm serum glucose and triglyceride (TG) changes, serological testing was performed. The levels of sterol regulatory element-binding protein-1 (SREBP-1) activity and Sirtuin1 (SIRT1), AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase ${\alpha}$ ($ACC{\alpha}$) expression were analyzed by western blot analysis. Results : The administration of HYS significantly decreased the elevated serum glucose and TG in db/db mice. HYS administration increased the levels of SIRT1 and AMPK expression compared with the vehicle-treated group. Moreover, HYS treatment significantly inhibited SREBP-1 activity and $ACC{\alpha}$ expression in the liver, while the vehicle-treated group exhibited their increase. Conclusions : In conclusion, HYS is suggested to have an improvement effect on hyperglycemia and hyperlipidemia by activating the SIRT1/AMPK signaling pathway and inhibiting SREBP-1.

메니에르 병 환자의 허실별(虛實別) 치험례

장수영,신현철,Jang, Soo-Young,Shin, Hyeon-Cheol 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.1

Meniere's disease is an idiopathic syndrome of endolymphatic hydrops characterized by episodic vertigo, tinnitus, fluctuating hearing loss and ear fullness. The etiology and pathophysiology of the disease is still disputed. As yet, no treatment has conclusively modified the clinical course of the condition and thereby prevented the associated progressive hearing loss. We observed two cases of Meniere's disease treated with oriental herbal medication by the diagnosis of Deficiency-Excess. One patient had taken BangHyunOnDam-tang, and the other had taken ChungGanESa-tang. After treatment, vertigo attacks were controlled in both. Tinnitus and hearing loss were improved in one patient and unchanged in the other. Therefore, we believe that oriental herbal treatment may be a therapeutic modality that is effective in controlling Meniere's disease.

고농도 포도당에 노출된 마우스 신장상피세포에서 상지(桑枝)의 산화 스트레스 억제 효과

장수영,신현철,Jang, Soo-Young,Shin, Hyeon-Cheol 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.1

Objectives : Recent etiological studies show that oxidative stress might play a major role in the diabetes and its complications. Mori Ramulus (MR) has been known to have antioxidative, anti-inflammatory and antidiabetic effects. The methanol extract of MR was tested for its effectiveness in LLC-PK1 cells exposed to high glucose. Methods : The cytoprotective effect of MR was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The antioxidative effect was measured in terms of generation amount of ${\cdot}O_2^-$ by 2',7'-dichlorodihydrofluorescein diacetate (DCFDA), NO by 4,5-diaminofluorescein (DAF-2), $ONOO^-$ by dihydrorhodamine 123 (DHR 123) in the high glucose -treated LLC-$PK_1$ cells. Western blotting was performed using anti-AGE, anti-RAGE, anti-MAPKs(ERK1/2, JNK, p38), anti-PI3K, anti-Akt, and anti-NF-${\kappa}$B (p50, p65) respectively. Results : MR extract reduced cell death and inhibited the generation of ${\cdot}O_2^-$, NO, $ONOO^-$ in the high glucose-treated LLC-$PK_1$ cells. MR inhibited the expression of AGE, RAGE, MAPKs, PI3K, and Akt by means of decreasing NF-${\kappa}$B activation. MR also inhibited NF-${\kappa}$B activation itself. Conclusions : These results indicate MR has cytoprotective, antioxidative, and anti-inflammatory effects. Therefore it is suggested that MR might prevent and cure diabetes and its complications.

한(韓).양방(洋方) 겸치(兼治)로 치유된 폐결핵 환자 1례

장수영,유효정,윤경민,임은영,신현철,Jang, Soo-Young,Yoo, Hyo-Jeong,Yoon, Keong-Min,Im, Eun-Young,Shin, Hyeon-Cheol 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.1

Objective : This study was designed to evaluate the treatment effects and the prevention of side effects from antituberculosis drugs by using oriental medicine on a pulmonary tuberculosis patient. Methods : The clinical data was analyzed on a patient with pulmonary tuberculosis whose main symptoms were general weakness, anorexia, weight loss, tachycardia, night sweats, fever, coughing and chest pain. The patient was treated from June 17, 2008 to April 1, 2009, using herbal medicine (Cheongpyebyeolgab-tang) with antituberculosis drugs. Results : After treatment, the symptoms disappeared faster than with western medicine treatment only. Laboratory examinations and radiograph impressions also improved. No side effects of the antituberculosis drugs were noted. Conclusions : This suggests that oriental medicine therapy is effective for pulmonary tuberculosis and prevents the side effects of the antituberculosis drugs.

한국 여자 대학생의 Iron, Copper 및 Cobalt 평형에 관한 연구

장수영(Soo-Young Jang),최인선(In-Sun Choi),오승호(Seoung-Ho Oh) 한국식품영양과학회 1991 한국식품영양과학회지 Vol.20 No.1

본 연구는 21~23세의 여자 대학생 8명을 대상으로 4주간 평상시와 같은 생활 양식과 적정 체중을 유지 시키면서 각 대상자들이 섭취한 모든 음식과 배설한 대변 및 소변을 수거하여 iron, copper 및 cobalt의 함량을 측정하여 1인 1일당 섭취량과 배설량을 측정하였다. Iron 섭취량은 원자흡광광도계로 측정한 실측치와 식품 분석표에 의거하여 얻은 환산치와의 관계를 비교하였다. 그 성적을 요약하면 다음과 같다. 1일 1인당 각 대상자별 평균 섭취량은 iron 13.85±1.10㎎/day, copper 1.44±0.14㎎/day 그리고 cobalt는 3.25±0.18㎎/day이었다. 1일 1인당 각 대상자별 소변으로의 평균 배설량은 iron 1.38±0.27㎎/day, copper 0.06±0.11㎎/day 그리고 cobalt 0.59±0.07㎎/day이었다. 1일 1인당 각 대상자별 대변으로의 평균 배설량은 iron 7.66±0.79㎎/day, copper 0.59±0.11㎎/day 그리고 cobalt 0.94±0.16㎎/day이었다. Iron의 실측치는 13.85±1.10㎎/day이었고 환산치는 15.26±1.17㎎/day로 실측치가 환산치에 비하여 9% 낮았다. In this study measured were daily intake and excretion of iron, copper and cobalt of eight 21~23years old college women during four weeks by means of analyzing their food intake, urine and feces, while keeping their normal living pattern and maintenance of body weight. This is study also compared the actural measurement value of iron intake by atomic absorption spectrophotometry with the conversion value of it by food table. The results were as follows. Daily mean intakes for iron, copper and cobalt were 13.85±1.10㎎/day, 1.44±0.14㎎/day, and 3.25±0.18㎎/day. Daily mean urinary excretions for iron, copper and cobalt were 1.38±0.27㎎/day, 0.06±0.01㎎/day and 0.59±0.07㎎/day. Daily mean fecal excretions for iron, copper and cobalt were 7.66±0.79㎎/day, 0.59±0.11㎎/day and 0.94±0.16㎎/day. The actual measurement value for iron intake was 13.85±1.10㎎/day and its conversion value 15.26±1.17㎎/day : the former was 9% lower than the latter.

증례(證例) : Bilateral Striopallidodentate Calcinosis 환자 치험 1례

장수영 ( Soo Young Jang ),신현철 ( Hyeon Cheol Shin ) 대구한의대학교 제한동의학술원 2010 東西醫學 Vol.35 No.4

Bilateral striopallidodentate calcinosis(BSPDC) is a rare disaese, and it involves calcification of the both basal ganglia and dentate nuclei of the cerebellum. Associated symptoms include the extrapyramidal signs, ataxia, progressive dementia and so on. If BSPDC is caused by underlying disease, it can be cure by treatment of underlying disease. But if it is Familial BSPDC, there is neither a cure nor a standard course of treatment. A 74-year-old woman was admitted because of headache, dizziness and mild cognitive impairment. She had bilateral calcification of the basal ganglia, dentate nuclei and frontal lobe on a brain CT. We diagnosed as "Zhong Feng(中風)", and had taken the Sunghyangjunggi-san to her at first. The treatment was effective at headache and dizziness, and other symptoms were unchanged. So, our experience suggests that oriental treatment can be a therapeutic modality that is effective in BSPDC.

임베디드 소프트웨어 시뮬레이션을 위한 SWF 기반의 가상 프로토타입 개발 환경

장수영(Soo Young Jang),이우진(Woo Jin Lee) 한국정보과학회 2013 정보과학회 컴퓨팅의 실제 논문지 Vol.19 No.12

현재 임베디드 소프트웨어는 다양한 분야에서 하드웨어를 제어하기 위해 널리 사용되며 그 범위가 확대되고 있다. 그러나 개발자의 관점에서는 소프트웨어가 개발되었다 하더라도 실제 소스 코드가 동작되는 하드웨어가 없이는 소프트웨어를 동작시키거나 검증하기가 힘들다는 단점이 있다. 가상 프로토타이핑 접근 방식은 이런 임베디드 소프트웨어를 실제 하드웨어 및 운영 환경에서 동작되는 것과 같은 시뮬레이션을 수행하는데 적용된다. 하지만 가상 프로토타입의 개발은 많은 비용과 노력을 필요로 하며, 이를 지원하는 도구의 사용 역시 높은 수준의 시각적 효과를 표현하거나 수정하기에 제한되는 점들이 많다. 본 논문에서는 기존의 문제점들을 해결하고 보다 효율적인 임베디드 소프트웨어의 시뮬레이션을 위하여 SWF 포맷을 기반으로 하는 가상 프로토타입 프레임워크를 제안한다. 그리고 제안된 프레임워크가 실제 적용이 가능함을 보이기 위해 개발된 도구를 사용하여 적용 예제를 구현한다. Currently, embedded software are widely used in various fields such as home appliance, avionics, vehicle and so on, whose mission is to control peripheral hardware and to change its operational environment. In developer"s viewpoint, it is difficult to set up its hardware and its operational environment during software development. Virtual prototyping approach is applied for simulating hardware and operational environment of embedded software. However, cost and effort of developing virtual prototyping are very high. Furthermore, related tools required to support the system also have some limitations such as detailed representation, dynamical performance, modifiability, and so on. In this paper, we propose a SWF based virtual prototyping framework for implementing virtual prototype in embedded systems and we have also implemented an VP example using developed tool to show that it is applicable. This approach supports advanced simulation and multi-dimensional analysis during software development process for embedded systems.

증례(證例) : 양측성 안면신경마비 환자 치험 1례

장수영 ( Soo Young Jang ),정유선 ( Yu Sun Jung ),이진원 ( Jin Won Lee ),박수완 ( Su Wan Park ),권형근 ( Hyeong Geun Kwon ),신현철 ( Hyeon Gheol Shin ) 대구한의대학교 제한동의학술원 2013 東西醫學 Vol.38 No.1

Bilateral simultaneous facial nerve palsy is facial paralysis that occurs on both sides of the face. It is a rare problem and only occurs for about 0.3% of the entire facial paralysis cases. Therefore, there have not been many clinical studies carried out particularly in the oriental medicine sector. This study has demonstrated that oriental medical treatment has a marked effect on bilateral facial palsy. The patients with bilateral simultaneous facial nerve palsy were treated through acupuncture, herbal medicine and physiotherapy and we continucd to check the degree of paralysis and progress through the treatment based on House-Brackmann scale(H-B scale). It took 24days to improve from grade VI to grade I on the H-B scale for the left face and 28 days for the right face.

Android 기반 고객관리 프로그램의 설계 및 구현

장수영(Soo-Young Jang),김현기(Hyen-Ki Kim) 한국멀티미디어학회 2010 한국멀티미디어학회 학술발표논문집 Vol.2010 No.2

스마트폰의 대중화로 현재 안드로이드 마켓에는 그 기능의 끝을 알 수 없을 정도로 다양한 분야의 어플리케이션이 나오고 있다. 오프라인에서의 고객 관리는 직접 사람과 대면하는 만큼 그 중요성이 매우 높다고 할 수 있다. 본 논문에서는 고객 정보를 저장하고, 고객의 위치를 파악 할 수 있으며 전화와 SMS, E-mail 서비스 등을 수행하는 어플리케이션을 설계 및 구현하였다. 이것으로 인해 오프라인 마케팅 업자들에게는 효율적인 업무를 돕고 서비스를 받는 고객은 만족도가 높아 질 것으로 기대된다.

임베디드 소프트웨어를 위한 SWF 기반의 가상 프로토타입 프레임워크 개발

장수영(Soo Young Jang),류호동(Hodong Ryu),김지훈(Jihun Kim),이우진(Woo Jin Lee) 한국정보과학회 2013 한국정보과학회 학술발표논문집 Vol.2013 No.6