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고혈압증(高血壓症)의 원인(原因)과 침구치료(針灸治療)에 대(對)한 문헌적(文獻的) 고찰(考察)
장경전,Jang, Kyung-Jeon 대한한방내과학회 1991 大韓韓方內科學會誌 Vol.12 No.1
Hypertension is not the name of disease but that of syndrome, about which the record of causes and treatments did not exist in the classics. So I surveyed the oriental medical category of hypertension in the classics and studied on the causes and principal acupuncture points of treatment in the modern literature. And a result, I came to the following conclusion. 1. According to the category of hypertension in oriental medicine way, WIND(風), FIRE(火), PHLEGM(痰) were the evoked causes of hypertension. And the greater oart of hypertension's line in the classics was related to DIZZINESS(眩暈), APOPLEXY(中風), WIND OF THE LIVER(肝風). 2. There were exceedingly various causes such as inheritance, mind, emotion, change of nerve, other disease, etc. 3. In the treatment of acupuncture and moxibustion, there were Zusanli(足三里), Quchi(曲池), Fengchi(風池), Baihui(自會), Hegu(合谷), Sanyinjiao(三陰交), Taichong(太衝) which, 7 acupuncture points, showed high ratio. 4. According to the evoked causes, the major acupuncture points became to be different as follow; FIRE(火) : Neiguan(內關 ; P6) WIND(風) : Fengchi (風池 ; G20), Yanglingquan (陽陵泉 ; G34), Taichong(太衝 ; Liv3) PHLEGM(痰) : Zusanli(足三里 ; S36); Sanyinjiao(三陰交 ; Sp6). Basing on the Literature research, I have studied hypertension. I found that there were objective studies on the causes. But I couldn't find any objective study on the category of hypertension in oriental medicine way and the treatment of acupuncture and moxibustion. So I think that more profound study on the category and the interrelation between the acupuncture points of treatment and its dis tribution of the 14 meridians deserves to be continued from now on.
호도약침액(胡桃藥鍼液)이 가토(家兎) 뇌조직(腦組織)의 Na<sup>+</sup>-pump 활성(活性) 장애(障碍)에 미치는 영향(影響)
김동훈,장경전,송춘호,안창범,Kim, Dong-Hoon,Jang, Kyung-Jeon,Song, Choon-Ho,Ahn, Chang-Beohm 대한약침학회 1999 Journal of pharmacopuncture Vol.2 No.1
This study was undertaken to determine whether Juglandis Semen (JAS) extraction exerts protective effect against oxidant-induced inhibition of $Na^+$-pump activity in cerebral cortex. $Na^+$-pump activity was estimated by measuring ouabain-sensitive oxygen consumption. The oxygen consumption significantly inhibited by 1 mM t-butylhydroperoxide (tBHP), which was prevented by addition of 2% JAS extraction. The oxygen consumption was increased by an increase in $Na^+$ concentration from 5 to 100mM, $K^+$ concentration from 0.5 to 10 mM, and $Mg^{++}$ concentration from 0.2 to 5 mM. These changes in ion concentrations did not affect the inhibitory effct of tBHP and protective action of JAS on oxygen consumption. tBHP(1mM) produced a significant increase in lipid peroxidation in cerebral cortex, which was prevented by 2% JAS extraction. These result suggest that JAS exerts protective effect against tBHP-induced inhibition of $Na^+$-pump activity in the cerebral cortex, this effect may be due to by an antioxidant action.
족삼리자침(足三里刺鍼)이 가토소장(家兎小腸)의 운동성(運動性)에 미치는 영향(影響)
이방성,윤현민,장경전,송춘호,안창범,Lee, Bang-Sung,Youn, Hyoun-Min,Jang, Kyung-Jeon,Song, Choon-Ho,Ahn, Chang-Beohm 대한침구의학회 2000 대한침구의학회지 Vol.17 No.2
This study was undertaken to determine effect of Zusan1i(ST36) acupuncture (AP) on the small intestinal motility in the rabbit. Changes in the motility in vivo of ileum was measured before and 20 min. after AP. In order to examine whether AP effect was affected by autonomic nerves, norepinephrine or acetylcholine was applicated. AP significantly increased the mean wave amplitude and motor index, but not the mean wave duration and motor activity. Infusion of norepinephrine ($2{\mu}m$) into an ear vein resulted in a decrease in the mean wave amplitude and motor index, which was not affected by AP. Acetylcholine ($10{\mu}m$) produced inhibition followed by stimulation of motility. The stimulation of motility was induced by an increase in the mean wave amplitude and motor index, but not the mean wave duration and motor activity. The effect of acetylcholine was not significantly different between before and after AP. These results suggest that Zusan1i(ST36) acupuncture stimulates the small intestinal motility, which is not mediated by autonomic nerves. Therefore, Zusan1i(ST36) acupuncture seems to be applicable to impaired small intestinal movement.
호도약침액(胡桃藥鍼液)이 가토(家兎) 뇌(腦)의 Synaptosome에서 Oxidant에 의한 물질이동계(物質移動系)의 장애(障碍)에 미치는 영향(影響)
김태국,윤현민,장경전,송춘호,안창범,Kim Tae-Kook,Youn Hyoun-Min,Jang Kyung-Jeon,Song Choon-Ho,Ahn Chang-Beohm 경락경혈학회 2000 대한침구의학회지 Vol.21 No.5
This study was undertaken to determine whether Juglandis semen extract solution (JLS solution) exerts protective effect against oxidant-induced inhibition of glutamate uptake by synaptosomes. Synaptosome was prepared from rabbit brain cortex. Glutamate uptake increased by incubation time during 10 minutes, which was significantly inhibited by 1mM t-buthylhydroperoxide(t-BHP). JLS solution prevented t-BHP-induced inhibition of glutamate uptake in a dose-dependent manner. t-BHP reduced glutamate uptake in dose-dependent fashion, which was significantly prevented by 2% JLS solution. t-BHP(1mM) and $ascorbate/Fe^{2+}(50/1{\mu}M)$ increased lipid peroxidation in synaptosomes by 5-fold, and it was significantly prevented by 2% JLS solution. $HgCl_2(0.1mM)$ inhibited glutamate uptake and increased lipid peroxidation. These changes were prevented by 2% JLS solution. Synaptosomal Na-K-ATPase activity was inhibited by t-BHP(1mM) and $H_2O_2(50mM)$, which was prevented by 2% JLS solution. The results indicate that JLS solution prevents oxidant-induced inhibition of glutamate by synaptosomes, and this may result from inhibition of lipid peroxidation induced by oxidants.
단삼약침액(丹蔘藥鍼液)이 신장(腎臟) 근위세뇨관세포(近位細尿管細胞)에서 산화제(酸化劑)에 의한 인산(燐酸)의 이동억제(移動抑制)에 미치는 영향(影響)
이호동,윤현민,장경전,송춘호,안창범,Lee, Ho-Dong,Youn, Hyoun-Min,Jang, Kyung-Jeon,Song, Choon-Ho,Ahn, Chang-Beohm 대한침구의학회 2000 대한침구의학회지 Vol.17 No.3
This study was undertaken to determine if Salviae Radix (SR) exerts protective effect against oxidant-induced inhibition of phosphate uptake in renal proximal tubular cells. Membrane transport function and cell death were evaluated by measuring phosphate uptake and trypan blue exclusion, respectively, in opossum kidney (OK) cells, an established proximal tubular cell line. $H_2O_2$ was used as a model oxidant. $H_2O_2$ inhibited the phosphate uptake in a dose-dependent manner over the concentration range of 0.1-0.5 mM. Similar fashion was observed in cell death. However, the phosphate uptake was more vulnerable to $H_2O_2$ than cell death, suggesting that $H_2O_2$-induced inhibition of phosphate uptake is not totally attributed to cell death. Decreasedphosphate uptake was associated with ATP depletion and inhibition of $Na^+$-pump activity as determined by direct inhibition of $N^+-K^+$-ATPase activity. When cells were treated with $H_2O_2$ in the presence of 0.05% SR, the inhibition of phosphate uptake and cell death induced by $H_2O_2$ was significantly attenuated. SR restored ATP depletion and decreased $Na^+-K^+$-ATPase activity, and this is likely responsible for the protective effect of SR on decreased phosphate uptake. The protective effect of SR was similar to the $H_2O_2$ scavenger catalase. SR reacts directly with $H_2O_2$ to reduce the effective concentration of the oxidant. The iron chelator deferoxamine prevented the inhibition of phosphate uptake and cell death induced by $H_2O_2$, suggesting that $H_2O_2$-induced cell injury is resulted from an iron-dependent mechanism. These results indicate that SR exerts the protective effect against $H_2O_2$-induced inhibition of phosphate uptake by reacting directly with $H_2O_2$ like the $H_2O_2$scavenger enzyme catalase, in OK cells. However, the underlying mechanism remains to be explored.
폐유(肺兪)·격유(膈兪)의 호도약침(胡桃藥鍼) 자극이 알레르기 반응에 미치는 영향
백승일,이용태,장경전,Baek, Seung-il,Lee, Yong-tae,Jang, Kyung-jeon 대한침구의학회 2003 대한침구의학회지 Vol.19 No.3
Objective & Methods : Experimental studies were done to research the clinical effects of Juglandis Semen aqua-acupuncture and acupuncture($BL_{13}{\cdot}BL_{17}$) on the anti-allergic response. anaphylaxis provoked by the compound48/80, delayed type hypersensitivity response to picryl chloride and SRBC and inflammation response to egg albumin. Results : The following results have been obtained; 1. Juglandis Semen aqua-acupuncture and acupuncture($BL_{13}{\cdot}BL_{17}$) group were increased the survival rate in compound 48/80 induced systemic anaphylactic reaction. 2. Picryl chloride induced contact dermatitis and delayed type hypersensitivity in SRBC challenged mouse were significantly decreased in Juglandis Semen aqua-acupuncture and acupuncture($BL_{13}{\cdot}BL_{17}$) group. 3. Inflammation response-WBC, CRP and Nitric Oxide in egg albumin induced allergic rat were significantly decreased in Juglandis Semen aqua-acupuncture and acupuncture($BL_{13}{\cdot}BL_{17}$) group. Conclusions : According to the above results, Semen aqua-acupuncture and acupuncture($BL_{13}{\cdot}BL_{17}$) both depress the allergy reaction.
현훈(眩暈)의 침구치료(鍼灸治療)에 대한 문헌적(文獻的) 고찰(考察)
송춘호,안창범,장경전,윤현민,Song Choon-Ho,Ahn Chang-Beohm,Jang Kyung-Jeon,Youn Hyoun-Min 경락경혈학회 2003 Korean Journal of Acupuncture Vol.20 No.4
Objectives & Methods : This study was to study acupuncture and moxibustion treatments for dizziness, I've got compared and analyzed 41 kinds of books since Nei Jing(內經). It seems that the meridians of Bladder, Gall bladder and Governing vessel were mostly used for them in connection with functions of each meridians. Results and Conclusion : 1. The symptoms of dizziness are illusion, nausea, vertigo, tinnitus and mild headache 2. The meridians of acupuncture points which was used much for dizziness were Bladder meridian, Gall bladder meridian and Governing Vessel 3. The frequency of using acupuncture points in this treatment were P'ung Ji(GB20)-27th, Chok-Samni(S36)-17th, Paek'oe(GV20)-15th, Pungnyung(S40)-9th, Shinmack (B62)-9th.
활락탕(活絡湯)의 NO 억제, DPPH 소거 및 Microarray상 유전자 발현에 미치는 영향
김철홍,윤현민,장경전,송춘호,안창범,Kim, Cheol-hong,Youn, Hyoun-min,Jang, Kyung-jeon,Song, Choon-ho,Ahn, Chang-bum 대한침구의학회 2004 대한침구의학회지 Vol.21 No.5
Objective : This study was undertaken to determine the inhibitory effect of Whallak-tang against Nitric Oxide, the scavenging effect of Whallak-tang on DPPH radical. Methods : Both nitric concentration 1, 3, 6 and 24 hours after treatment with Vit. C and Whallak-tang at 0.1, 1, 10 mg/ml and scavenging effect 10, 20, 30 and 60 minute after treatment with Vit. C and Whallak-tang at 0.1, 1, 10 mg/ml were estimated. Results : The inhibitory effect of Whallak-tang against Nitric Oxide was dose-dependent. The scavenging effect of Whallak-tang on DPPH radical was dose-dependent. Conclusion : These results would provide important basic data on the possibility of the clinical treatment of Whallak-tang in musculoskeletal disease.
Carrageenan 유발염증에 대한 15Hz 전침의 효과에 대한 연구
한유진,이용태,장경전,Han, You-jin,Lee, Yong-tae,Jang, Kyung-jeon 대한침구의학회 2003 대한침구의학회지 Vol.20 No.3
Objective : The aim of this study is to investigate the anti-inflammatory effects of 15Hz electroacupuncture(EA) on carrageenan-injected rats. Inflammation was induced by an intraplantar injection of 1% carrageenan into the right hind paw. Methods : Bilateral EA stimulation with 15 Hz were delivered at those acupoints corresponding to Zusanli and Sanyinjiao in man via the needles for a total of 30 min duration in carrageenan-injected rats. Results: The developing edema was measured 30 minutes interval afer carrageenan injection and 15 Hz EA stimulation presented significant edema inhibition. Three hours after carrageenan injection, prostaglandin $E_2(PGE_2)$ and nitric oxide(NO) levels were measured. The 15Hz EA stimulation significantly inhibited $PGE_2$ and NO production in the right paw. The pro-inflammatory mRNA expression such as cyclooxygenases(COX)-2 and interleukin(IL)-$1{\beta}$ were slightly down-regulated by EA stimulation. The number of COX-2, IL-$1{\beta}$, tumor necrosis factor-${\alpha}$ immunoreactive cells were abundantly observed in paw edema. But these cells were decreased in nmber according to anti-edema effect of 15Hz EA. Conclusions: These results indicate that 15Hz EA stimulation have an alleviation action against carrageenan-induced edema and local inflammation.