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제5차 대한간학회 춘계학술대회 초록집 : C형 간염 바이러스로 인한 만성 간질환 환자에서 HCV-RNA의 유전자형에 관한 연구
이철종 ( Lee Cheol Jong ),신우원 ( Sin U Won ),안현숙 ( An Hyeon Sug ),이성욱 ( Lee Seong Ug ),노명환 ( No Myeong Hwan ),한상영 ( Han Sang Yeong ),최석렬 ( Choe Seog Lyeol ),정진숙 ( Jeong Jin Sug ) 대한간학회 1999 Clinical and Molecular Hepatology(대한간학회지) Vol.5 No.1(S)
식도절제술 환자에서 식도내압 및 위배출시간에 대한 고찰
이철종(Cheol Jong Lee),최석렬(Seok Reyol Choi),지삼룡(Sam Ryong Jee),김광진(Kwang Jin Kim),금동주(Dong Joo Keum),홍기봉(Ki Bong Hong),이종훈(Jong Hun Lee),한상영(Sang Young Han),최필조(Pill Jo Choi) 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.2
N/A Backgroud/Aims: Resection of the esophagus for malignant disease or a benign stenosis, has a choice not only of palliative surgery, but also of replacement of the esophagus with a transposed stomach, jejunum, or colon. The first-line method is replacement with a tubulized stomach. The purpose of this study was to investigate the association of esophageal motor dysfunction and gastric emptying time with symptoms after esophagectomy. Methods: We performed the esophageal manometry and gastric emptying time after esophagectomy for esophageal cancer in 12 patients and for benign esophageal disease in 2 patients. Results: In manometric studies, a zone of high pressure in the esophago-gastric anastomosis distal to the upper esophageal sphincter was associated with symptoms after esophagectomy. The gastric emptying rate was slowed in 7 out of 14 patients, but not associated with symptoms after esophagectomy. Conclusions: Our data suggest that a high-pressure zone distal to the upper esophageal sphincter was associated with symptoms after esophagectomy in manometric study. The gastric emptying rate was not associated with postoperative symptoms. (Korean Journal of Gastrointestinal Motility 2001;7:197-203)
Floxuridine 의 간동맥내 국소 투여를 이용한 전이성 간종양 치료의 임상체험
이종훈(Jong Hun Lee),한상영(Sang Young Han),김완수(Wan Soo Kim),박성욱(Seung Wook Park),이철종(Cheol Jong Lee),노명환(Myung Hwan Roh),최석렬(Seok Reyol Choi),신우원(Woo Won Shin),최홍조(Hong Jo Choi),박병호(Byeong Ho Park) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.5
Background/Aims: This study aimed to evaluate the outcome and the side effect of floxuridine (FUDR) hepatic artery infusion (HAI) in patients with metastatic liver cancer. Methods: From October 1997 to December 1999, FUDR HAI was performed for 10 patients with hepatic metastases from colorectal carcinoma (CRC) and gastric cancer and the regimen's effect and toxicity were evaluated. The primary cancer lesions had been resected before FUDR HAI. FUDR was continuously infused at a rate of 0.3 mg/kg/day for 14 days through hepatic artery by percutaneous catheter-guided chemoport. All patients received steroid to prevent hepatic toxicity. Some of the patients were also treated with systemic chemotherapy to treat the extrahepatic metastases. Results: Two patients showed complete response and five patients showed partial response. Stable disease and progressive disease were detected in two patients and one patient, respectively. Most patients revealed decreased lesion of hepatic metastases during the FUDR HAI. The systemic toxicities of the FUDR HAI were nausea, vomiting, diarrhea and mucositis. The hepatic side effect was not detected. Conclusions: In patients with CRC and gastric cancer, the regimen using FUDR HAI and steroid was effective against metastatic liver cancer and revealed no hepatic toxicity. Because of the limitation of this study due to small patient group and short duration of follow-up, further studies are needed for large group of patients. (Korean J Gastroenterol 2001;38:342-349)
포스터 발표 : 위 ; 위암 환자에서 chronotherapy의 부작용에 대한 고찰
박성욱 ( Seong Wook Park ),지삼룡 ( Sam Ryong Jee ),홍기봉 ( Ki Bong Hong ),이철종 ( Cheol Jong Lee ),김완수 ( Wan Su Kim ),이종훈 ( Jong Hun Lee ),한상영 ( Sang Young Han ),최석렬 ( Seok Reyol Choi ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 위암은 국내에서 가장 흔한 악성종양으로 암으로 인한 사망 중 가장 높은 빈도를 차지한다. 5-FU, mitomycin C, doxorubicin, cisplatin 등을 사용한 현재까지의 위암의 화학요법은 완전관해는 매우 드물며, 관해 지속기간도 수개월 이내로 짧기 때문에 소수의 환자에서 고식적인 치료효과만 기대할 수 있다. 본 교실에서는 DNA합성이 낮보다 밤 동안에 감소하며, 5-FU의 대사의 관여하는 dihydropyrimidine deh
5-FU 내성 대장암 세포주에서 생물학적 지표로서 단백 분해효소발현의 유용성
조몽(Mong Cho),최석렬(Seok Reyol Choi),이주일(Joo Il Lee),이철종(Cheol Jong Lee),김영식(Young S Kim) 대한내과학회 1999 대한내과학회지 Vol.57 No.3
N/A There have been many reports that colon cancer responds poorly to chemotherapy. Several classes of matrix metalloproteinases(MMPs) have been implicated in the process of invasion of epithelial and endothelial basement membranes in several steps of tumor invasion and metastasis. This study was performed to determine the biologic behavior and the histopathological characteristics of a 5-FU resistant colon cancer cell line. Methods : We performed several biologic assays including liver colonization assay, cell adhesion assay, invasion assay and zymogram for protease activity using parental HT29 cell and 5-FU resistant HT29 cell (HT29-FU cell). Results : In liver colonization assay, HT29-FU cell revealed a 2.5-fold increase in the liver weight and tumor burden compared with HT29 cell. HT29-FU cell showed moderate increase in adhesion and invasion assays in comparison to HT29 cell. HT29-FU cell revealed increased activity of MMPs and serine protease. Xenograft tumors of HT29-FU cell formed moderately differentiated adenocarcinoma with more glandular formations of mucin. Conclusion : The increased expression of MMPs in 5-FU resistant colon cancer cell can explain poor prognosis. These are potentially poor prognostic indicators in 5-FU resistant colon cancer. Consequently, it can be suggested that modulation of MMPs is needed to prevent invasion and metastasis in colon cancer by using inhibitors of these enzymes. (Korean J Med 57:323-332, 1999)
양두현,유희철,이철종 대한외상학회 1997 大韓外傷學會誌 Vol.10 No.1
Recently, the number of trauma patients and subsequent traumatic liver injury cases have been increased due to increased traffic and industrial accidents and violences. The purpose of this study is to analyze the factors that determine the mortality of patients who sustain liver injuries. Seventy seven patients with traumatic liver injury underwent operation from l971 to 1995 at Department of Surgery, Chonbuk National University Hospital. The results obtained were as follows; 1) The peak age was 4th decade, 24 cases(31.2%) and sex ratio of male to female was 5: l. 2) In the causes of injury, blunt abdominal trauma were 71 cases(92.2%) and penetrating abdominal trauma were 6 cases(7.8%). 3) Abdominal tenderness and rebound tenderness were existed in 64 cases(83.1%) and 40 cases(5 l.9%) respectively. Other clinical symptoms were abdominal distention, dyspnea and so on. 4) The degree of injury were classified by AAST(American Association for the Surgical Trauma). There were 7 cases(9.1 %) in type I. 38 cases(49.4%) in type II, 25 cases(32.5%) in type III, 3 cases(3.9%) in type IV, and 4cases(5.2%) in type V. Surgically managed patient were divided two groups, resection and non-resection group, l2 cases(15.6%) and 65 cases(84.4%) respectively. 5) 73 patients had associated injuries(94.8%), and the injury site were 51 cases in other intraabdominal organs.37 cases in retroperitoneal organ, 31 cases in chest, 22 cases in extremities, 2 cases in spine, and 1 case in pelvis. 6) The total complication rate was 44.2%(34 cases), and the most common complication was respiratory failure in 33(42.9%) out of 77 cases. 7) Postoperative mortality rate was 16.9%(13 cases), and compounded causes of death were adult respiratory distress syndrome in 9 cases(69.2%), renal failure in 8 cases(61.5%), sepsis in 7 cases(53.8%), hepatic failure and hypovolemic shock 4 cases(30.8%) each. 8) The several mortality factors were analyzed by use of the Logistic analysis method. Most influencing factor was post traumatic shock(p=0.0001) and the second was liver injury grade (p=0.0192). Therefore accurate recognition of shock and liver injury grade are very important factors causing mortality in traumatic liver injury patients.
폐출혈과 위장관출혈이 합병된 Henoch-Sch nlein Purpura 1예
김광진,한상영,이철종,최석렬,노명환,신우원,이종훈,양두경,허기영 대한소화기학회 2000 대한소화기학회지 Vol.36 No.4
Henoch-Sch nlein purpura is an immunologically mediated systemic vasculitis of small blood vessels that primarily involves the skin, gastrointestinal tracts, joints, and kidneys. Henoch-Sch nlein purpura is a common vasculitic disease of childhood. It is diagnosed by characteristic clinical manifestations: nonthrombocytopenic purpura, arthritis or arthralgia, abdominal pain which may be complicated by gastrointestinal hemorrhage, and urinary sediment changes. Pulmonary hemorrhage is a rare complication which occurred predominantly in adolescent and adult according to previously reported cases. We experienced 34-year-old man with Henoch-Sch nlein purpura in whom gastrointestinal bleeding and bilateral, massive, pulmonary hemorrhage developed. He died of respiratory failure.
C형 간염 바이러스로 인한 만성 간질환 환자에서 Hepatitis C Virus-RNA의 유전자형에 관한 연구
안현숙,이성욱,정진숙,한상영,이철종,최석렬,신우원,노명환 대한소화기학회 2000 대한소화기학회지 Vol.35 No.1
Background/Aims: Hepatitis C virus (HCV) genotype is classified into 6 groups and such diversity is related with the detection rate of the virus, the severity of liver disease and the response to interferon treatment. Methods: We investigated the genotypes of HCV in anti-HCV-positive and HCV-RNA-positive patients with chronic liver disease in Pusan-Kyungnam area by polymerase chain reaction with type-specific primers from the core region. Results: Among the 107 patients, HCV genotype was determined in 105 cases (98.1%) and HCV genotype 1b was dominant (59.0%), followed by genotype 2a (33.4%) and 2b (5.7%). There were no significant differences in the prevalence of genotypes according to diagnosis, age, sex, serum alanine aminotransferase level. In cases of liver cirrhosis, genotype 1b was more predominant in the B group (83.3%) and the C group (100%) of Child-Pugh grades, and all patients with genotype 2a were graded as A group. There were no significant differences in the prevalence of genotypes according to the pathologic findings on liver biopsies. However, genotype 1b (10/13) was more frequently observed than genotype 2a (2/13) in patients with above-moderate fibrosis. Conclusions: Genotype 1b showed more advanced cirrhosis- grade and more severe fibrosis than other genotypes. Further study is required to prove this tendency.