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      • 급성충수염에 대한 임상적 고찰

        양두현 中央醫學社 1988 中央醫學 Vol.53 No.12

        This study is a clinical analysis of 394 cases of acute appendicitis, which operated on the Department of Surgery, Nam Won Medical center, during 2 year 10 months period from Jan. 1986 to Oct. 1988. The results were as follows; 1) The age distribution of appendicitis -was at any age from 1 year to 82 years; and the peak incidence was in the 10 to 19 age group-33.8%. 2) The sex ratio of male to female was 1: 1.1. 3) The ratio of urban to rurality was 1: 2.6. 4) It occurred most frequently in the spring and the summer season, and its peak incidence was in April and September. 5) Histopathologically, there showed 11.7 % of focal, 57.9 % of suppurative, 16.5 of gangrenous, 13.9 % of perforative type. 6) In duration of symptoms, 188 patients (47.7 %) were within 1 day. The mean duration was 2.5 days of focal type, 2.2 days of suppurative type, 1.9 days of gangrenous type, 3.3 days of perforative type. 7) The most common symptoms & signs were RLQ pain which migrated from epigastrium, being present in 47.5 % of patients. 8) Leukocytosis over 10,000/cu, mm was found in 53.3 % and 7.6 % of patients had a elevated temperature over 38°C' 9) The most frequent method of skin incision was Rocky-Davis type (87.3 %), and it had non-specific problems. 10) In operative procedures, appendectomy was performed in 340 patients (86.3 %), and appendectomy with drainage in 54 patients (13.7 %). 11) Postoperative complications were occured in 65 patients (16.5 %). The most common complication was wound infection (7.1 %) and others were paralytic ileus and mechanical ileus. 12) The most common duration of hospitalization was 8 days and its percentage was 67% 13) There were no death after operation.

      • 카보닐화된 글루코즈유도체의 이산화탄소에서의 용해도 연구

        양두현,전병완,김학원 경희대학교 자연과학종합연구원 2003 자연과학논문집 Vol.9 No.2

        이산화탄소에 대한 높은 용해도를 갖는 새로운 물질인 카보닐화된 글루코즈 유도체들의 합성과 그 물질들의 용해도를 측정하였다. 이는 여러 기능을 갖는 친이산화탄소성 작용기를 설계하는데 매우 유용한 자료로 쓰일 것으로 기대된다. We report here the synthesis of new CO_(2)-philic materials such as highly carbonylated(or acylated) glucose derivatives 1 and their solubilities in liquid and supercritical CO_(2). New carbonylated(or acylated) glucose might be a most promising candidate for the design of CO_(2)-philic materials.

      • KCI등재

        외상성 간 손상에 대한 임상적 고찰

        양두현,유희철,이철종 대한외상학회 1997 大韓外傷學會誌 Vol.10 No.1

        Recently, the number of trauma patients and subsequent traumatic liver injury cases have been increased due to increased traffic and industrial accidents and violences. The purpose of this study is to analyze the factors that determine the mortality of patients who sustain liver injuries. Seventy seven patients with traumatic liver injury underwent operation from l971 to 1995 at Department of Surgery, Chonbuk National University Hospital. The results obtained were as follows; 1) The peak age was 4th decade, 24 cases(31.2%) and sex ratio of male to female was 5: l. 2) In the causes of injury, blunt abdominal trauma were 71 cases(92.2%) and penetrating abdominal trauma were 6 cases(7.8%). 3) Abdominal tenderness and rebound tenderness were existed in 64 cases(83.1%) and 40 cases(5 l.9%) respectively. Other clinical symptoms were abdominal distention, dyspnea and so on. 4) The degree of injury were classified by AAST(American Association for the Surgical Trauma). There were 7 cases(9.1 %) in type I. 38 cases(49.4%) in type II, 25 cases(32.5%) in type III, 3 cases(3.9%) in type IV, and 4cases(5.2%) in type V. Surgically managed patient were divided two groups, resection and non-resection group, l2 cases(15.6%) and 65 cases(84.4%) respectively. 5) 73 patients had associated injuries(94.8%), and the injury site were 51 cases in other intraabdominal organs.37 cases in retroperitoneal organ, 31 cases in chest, 22 cases in extremities, 2 cases in spine, and 1 case in pelvis. 6) The total complication rate was 44.2%(34 cases), and the most common complication was respiratory failure in 33(42.9%) out of 77 cases. 7) Postoperative mortality rate was 16.9%(13 cases), and compounded causes of death were adult respiratory distress syndrome in 9 cases(69.2%), renal failure in 8 cases(61.5%), sepsis in 7 cases(53.8%), hepatic failure and hypovolemic shock 4 cases(30.8%) each. 8) The several mortality factors were analyzed by use of the Logistic analysis method. Most influencing factor was post traumatic shock(p=0.0001) and the second was liver injury grade (p=0.0192). Therefore accurate recognition of shock and liver injury grade are very important factors causing mortality in traumatic liver injury patients.

      • KCI등재
      • 젊은 층과 노년층 위암 환자들의 임상병리학적 특성의 비교와 생존율

        김찬영,양두현,Kim, Chan-Young,Yang, Doo-Hyun 대한위암학회 2006 대한위암학회지 Vol.6 No.4

        목적: 젊은 층과 노년층 위암 환자들의 치료와 치료 성적을 포함한 임상병리학적 특성을 비교해 보고, 생존율을 알아보고자 하였다. 대상 및 방법: 본원에서 10년간($1990{\sim}1999$) 위암으로 위절제술을 받은 환자 1,086명 중 40세 미만의 젊은 층(A) 91명과 70세 이상의 노년층(B) 85명을 대상으로 하였다. 결과: A와 B군 각각 여자의 비율이 47.3%와 32.9%로 A군에서 여자가 상대적으로 많고 가족력은 15.4%와 3.5%, 조직학적 미분화형은 84.4%와 40.2%, Lauren 분류의 미만형은 69.1%와 35.1%로 A군에서 많았다(P<0.05). 두 군의 TNM 병기는 차이가 없었다. 동반된 심폐질환은 각각 1.1%와 11.8%로 B군에 많았다(P<0.01). 수술의 림프절 D3 이상 절제율은 각각 27.4%와 4.7%로 B군이 적었다(P<0.001). 수술시간은 평균 258분과 235분, 획득한 림프절의 수는 평균 53.1개와 28.0개였다(P<0.001). 그러나 수술의 근치도는 차이가 없었다. 수술 후 항암요법은 5-FU, adriamycin, mitomycin 또는 5-FU, cisplatin의 투여 비율이 34%와 3.5%로 B군이 적었다(P<0.001). 수술 합병증은 23.1%와 30.6%이고 수술 사망률은 1.1%와 1.2%이며 재발률은 23.4%와 21.2%이고 질병관련 5년 생존율은 67.6%와 67.0%로 차이가 없었다. 결론: 젊은 층과 노년층의 위암 환자들은 서로 다른 임상병리학적 특성을 가진다. 특히 노년층 환자에게는 젊은 층에 비해 축소된 치료방법이 선택되었다. 그러나 이런 차이들에도 불구하고 치료 성적과 질병 관련 생존율의 차이는 없었다. Purpose: We analyzed the clinicopathologic features, including treatment and outcome, and the survival rates between young and elderly patients with gastric cancer. Materials and Methods: Clinical information was reviewed for 1086 patients who had undergone a gastrectomy for gastric cancer during a 10-year period from 1990 to 1999, and the patients were assigned to one of two groups: the A group (<40 years of age, 91 patients) and the B group (${\geq}70\;years\;of\;age,\;85\;patients)$). Results: Compared to the B group, the A group had more females (47.3% vs 32.9%), a greater frequency of family history of cancer (15.4% vs 3.5%), and greater proportions of histologically poorly differentiated tumors (84.5% vs 40.2%) and Lauren diffuse-type tumors (69.1% vs 35.1%)(P<0.05). There was no difference in TNM stage. Cardiopulmonary co-morbidities were more in the B group, respectively, 1.1% (A group) and 11.8% (B group)(P<0.01), but the morbidity and the mortality were similar. Although there was no difference in curability, the B group underwent less aggressive operations in lymph-node dissection above D3 and had a shorter operation time, a smaller number of retrieved lymph nodes, and less adjuvant chemotherapy (P<0.001). However, there were no differences in the disease-specific 5-year survival rates, 67.6% and 67.0% respectively. Conclusion: Young and elderly patients with gastric cancer had different clinicopathological features. Especially, elderly patients underwent relatively less aggressive treatment. In spite of these facts, the outcome of treatment and the disease-specific survival rates were not different.

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