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운동강도의 차이가 60주령된 흰쥐의 Soleus와 EDL에서 Bcl-2, Bax, caspase-3와 DNA 절편화에 미치는 영향
Ji Yung Lee(이지영),Yong An Kim(김용안) 한국생명과학회 2010 생명과학회지 Vol.20 No.4
본 연구에서 60 주령된 쥐를 대상으로 8 주간 트레드밀 운동강도와 근섬유 유형에 따른 apoptosis 관련 인자를 연구하였다. 결론적으로 노후된 쥐의 apoptosis 관련 인자는 운동강도와 근육유형에 따라 차이가 났다. EDL이 Soleus보다 apoptosis인자의 변화가 운동강도에 의해 더 민감하게 나타났다. 또한 casepase-3의 발현은 고강도 운동에서 나타났으나 DNA 절편화는 나타나지 않았기에 실질적인 apoptosis는 발생되지 않았다. 이는 노후된 개체의 운동 수행방법으로 고강도 운동은 적합하지 않으며, 고강도 운동상태를 지속할 경우 근섬유의 apoptosis를 유도할 가능성이 있다는 것을 시사한다. 그러므로 추후 실험에서는 운동시간과 빈도에 의한 apoptosis의 timecourse impact 관찰과 외재적 경로(caspase independent apoptosis)에서의 apoptosis 관련 단백질 변화에 대한 연구를 통하여 노화에 의한 근손실의 원인 규명이 요구된다. The purpose of this study was to find out the Bcl-2 (B-cell leukemia/lymphoma-2), Bax, and caspase-3 (cysteine-aspartic proteases-3) protein expression in soleus and EDL muscle according to treadmill exercise intensity in 60 week-old SD rats. The SD rats were randomly divided into four groups (n=10 in each group): control (CON), low intensity exercise (LE), moderate intensity exercise (ME), and high intensity exercise (HE). The exercise was given to the rats for 8 wk, 5 day/wk. The animals underwent treadmill exercise at intensities of 30 min at 8 m/min for the LE group, 15 min at 16 m/min for the ME group, and 9 min at 24 m/min for the HE group. The results were as follows: the expression of Bcl-2 protein was lowest in the HE group and the expression of Bax protein was highest in the HE group. The expression of caspase-3 (cleaved form) protein was observed in the HE group. For the different types of muscle fiber, Bcl-2 protein expression in the soleus muscle was decreased in all groups. Bax protein expression in the soleus muscle was increased in the HE group only. Bcl-2 protein expression in the EDL muscle was decreased in the HE group, and Bax protein expression in the EDL muscle was increased in the ME and HE groups. Consequently, the protein expression related to the aged rats shows a difference according to the intensity of exercise. In addition, caspase-3 protein expression appeared in the HE group; however, in all amounts of intensity, DNA fragmentation was not observed. Therefore, apoptosis on skeletal muscles of aged mice can be intervened with optimal exercise. On the other hand, high intensity exercise can potentially accelerate the apoptosis of muscle fiber in aged rats.
남녀 유아의 거친 신체 놀이와 또래유능성 및 또래인기도와의 관계
이지영(Lee Ji-Young),이경옥(Lee Yung-Ok) 한국열린유아교육학회 2008 열린유아교육연구 Vol.13 No.3
바깥놀이에서 발생하는 남녀 유아의 거친 신체 놀이의 양상을 분석하여 거친 신체놀이와 또래 관계와의 관계를 살펴보기 위하여 경기도에 소재하고 있는 유치원의 만 5세 2학급 55명의 유아를 대상으로 바깥놀이를 관찰하였다. 연구결과 만 5세 유아들의 바깥놀이에서 대상물 놀이(29.1%)와 더불어 거친 신체 놀이(23.8%)가 가장 빈번하게 관찰되었다. 이러한 유아의 거친 신체 놀이는 또래유능성과 또래인기도와 정적인 상관을 보였으며 특히, 남아의 거친 신체 놀이는 또래유능성 중 사교성 및 주도성뿐만 아니라 또래인기도와 높은 상관을 나타내었다. 유아의 바깥놀이에서 나타난 거친 신체 놀이의 양상을 구체적으로 살펴보면 추적 놀이가 유사 싸움보다 빈번하게 일어났으나 성별에 따라 매우 다른 특성을 보였다. 나아는 여아들보다 팔이나 발을 휘두르거나 태권도ㆍ권투 흉내내기 소리치기 장난으로 싸우기 쫓고 쫓기기 장난으로 끌어당기기 등과 같은 도구적 놀이가 많이 관찰된 반면 여아들은 장난으로 놀리거나 찝쩍거리기 장난으로 밀기 장난으로 때리거나 찌르기 등과 같은 관계적 놀이가 주로 관찰되어 친구에게 친근한 표시로 거친 신체 놀이가 발생됨을 알 수 있다. This study investigated young children's rough and tumble play in kindergarten outdoor plays and examined the relationship of rough and tumble play with children's peer competence and peer popularity. The results shown in this study are as follows: It is concluded that rough and tumble play is a play that frequently occurs during children's outdoor play. Boys are more involved in rough and tumble plays than Rough and tumble play is closely related with the peer competence and peer popularity, especially for boys. Children's rough and tumble play is recognizedas a natural it not a negative play. Rough and tumble play is a play type in which children try to improve their harmonious peer relationships. In order to advance young children's rough and tumble play as a better play, appropriate understanding and guidance from the teachers or adults are needed.
조준영,이지영,이진무,장준복,이경섭,Cho, Jun-Young,Lee, Ji-Yung,Lee, Jin-Moo,Jang, Jun-Bock,Lee, Kyung-Sub 대한한방체열의학회 2010 대한한방체열의학회지 Vol.8 No.1
Purpose : The purpose of this study is to know the temperature difference between hysterectomy patients and non-hysterectomy patients. Methods : We studied 45 who had and 45 non-hysterectomy visiting ${\bigcirc}{\bigcirc}$ medical center from January 1st 2010 to December 31st 2010. We measured 3 points temperature of specific acupoints-Chonjung(CV17), Chungwan(CV12), Kwanwon(CV4) by DITI in each group. And then we checked the difference of temperature between CV17 and CV4, CV12 and CV4. For statistics, we used Independent T-test and SPSS version 17.0 for windows. Results : There is no statistically differences between hysterectomy group and non-hysterectomy group on CV17, CV12, CV4 and CV12-CV4 temperature. There is statistically significant difference between group and group on CV17-CV4 temperature. Conclusion : The result showed that the difference between Chonjung(CV17) and Kwanwon(CV4) is higher in group than non-hysterectomy group. Further study will be needed.
중소기업/중견기업/소상공인/지역기업/사례 : 재무설계상담이 재무복지수준 향상에 미치는 영향 : 중소기업 종업원을 대상으로
오종윤 ( Jong Yoon Oh ),이지영 ( Ji Young Lee ),최현자 ( Hyun Cha Choe ),박주영 ( Joo Yung Park ) 한국중소기업학회 2014 中小企業硏究 Vol.36 No.1
본 연구는 기업체에서 비용을 지불하여 중립적 재무전문가가 개입하는 재무설계상담이 재무복지수준 향상에 영향을 미치는 가를 규명하기 위해 진행되었다. 110명이 재직 중인 서울소재 중소기업 종사자들 중 35명을 대상으로 재무설계상담을 진행한 후 일대일 대면면접을 통해 상담 전후 1회씩 총 2회에 걸쳐서 자료가 수집되었다. 이렇게 수집된 자료를 토대로 재무관리태도, 재무관리능력, 재무만족도로 구성된 주관적 재무복지수준과 단순재무지표와 재무비율지표로 측정한 객관적 재무복지수준의 변화를 분석하였다. 그 결과 재무설계상담을 받은 이후 중소기업 종사자들의 주관적 재무복지를 구성한 재무관리태도, 재무관리능력, 재무만족도의 대부분 항목들이 긍정적으로 변화였다. 또한 유량적 측면의 단순재무지표와 재무비율지표들도 재무설계상담 이후 유의미한 변화가 나타나 재무설계상담이 가계의 객관적 재무복지수준을 향상시켰다고 볼 수 있다. The objective of the study was to test the effectiveness of financial planning counseling for small and medium sized enterprises (SMEs) with an emphasis on the role of financial specialists. The employers of the participants paid for the counseling service, and the participants were selected on a voluntary basis. Among the volunteers, 35 employees were selected, who subsequently underwent a one-to-one interview, and two sets of data were collected before and after the interview. Indicators were identified to measure the effect in terms of changes in the employees` financial wellness. The indicators of subjective financial wellness included financial management attitude, financial management ability, and the level of financial satisfaction. Indicators for objective financial wellness included simple indicators and proportion indicators. The analysis of the collected data showed that the subjective financial wellness of the participants improved at a statistically significant level for all aspects of financial management attitude, financial management ability, and the level of financial satisfaction. The results were the same for objective financial wellness. In addition, flow indicators improved after the counseling service, supporting the finding that objective financial wellness had improved at a statistically significant level.
백선피지부자복합방(白鮮皮地膚子複合方)의 항아토피피부염 효능에 관한 실험적 연구
심부용 ( Boo Yong Sim ),지중구 ( Joong Gu Ji ),이원융 ( Won Yung Lee ),김수정 ( Su Jung Kim ),김효영 ( Hyo Young Kim ),이지영 ( Ji Young Lee ),김동희 ( Dong Hee Kim ) 대전대학교 한의학연구소 2014 혜화의학회지 Vol.22 No.2
In order to investigate the efficacy of BJBB on atopic dermatitis, various immune related factors were studied. The results and conclusions are as follows. Atopic dermatitis symptoms were improved in BJBB treated group and significant decrease in dermatitis index were observed in 13 weeks. ALT, AST and BUN, Cr levels were all with in the normal ranges in BJBB treated group, indicating no induced toxicity. BJBB treated group showed significant decrease in CD4+, CD11b+/Gr-1+ immune cell ratio in dorsal skin by 33% and 62% respectively. BJBB treated group showed significant decrease in the expression of IL-4, IL-5, IL-13 and histamine by 83%, 62%, 53% and 61% respectively. Also the group showed decrease in the transcription of IL-4, IL-5 and IL-13 mRNA in spleen by 41%, 52% and 50% respectively. BJBB treated group showed decrease in the expression of IgE by 57% respectively. The results above indicated that treatment of BJBB improved atopic dermatitis symptoms by immune modulation activity a clinical evidence. thus, BJBB has a potential use as a composition of medicinal plants for treatment against inflammation related disease.