http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Dipeptidyl Peptidase-4 (DPP-4) 억제제
이대호 ( Dae Ho Lee ) 대한내과학회 2014 대한내과학회지 Vol.87 No.1
Recent advances in incretin biology have led to the development of a new class of oral anti-diabetic drugs. To date, there are two known incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), of which the former is a more important therapeutic target for type 2 diabetes. GLP-1 is secreted by intestinal L-cells in response to oral nutrient intake, and it stimulates insulin secretion and suppresses glucagon secretion in a glucose-dependent manner. However, both GLP-1 and GIP are rapidly degraded by dipeptidyl peptidase-4 (DPP-4), a multifunctional type II transmembrane glycoprotein. Thus, several DPP-4 inhibitors with different pharmacologic features are now available and can be used either as monotherapy or in combination with other anti-diabetic agents for the treatment of type 2 diabetes. In both therapeutic regimens, DPP-4 inhibitors have been shown to reduce hemoglobin A1c levels by approximately 0.5-0.8%. In clinical trials, DPP-4 inhibitors were generally well-tolerated, posed a low risk of hypoglycemia, and did not increase body weight. Despite some reports of a possible increased risk of pancreatitis with GLP-1 receptor agonists and DPP-4 inhibitors, no causal associations have been found. Recent randomized controlled clinical trials have shown that DPP-4 inhibitors did not increase or decrease the rates of major adverse cardiovascular events in patients with type 2 diabetes at high risk of cardiovascular disease, even though this class of anti-diabetic agents had various salutary effects in many studies involving animals or healthy and diabetic humans. Additional studies will be required to resolve these disparate conclusions. (Korean J Med 2014;87:1-8)
평판형 고체산화물 연료전지의 유로 설계변수에 따른 성능비교를 위한 유동 해석 연구
이대호(Dae Ho Lee),손정락(Jeong Lak Sohn),노승탁(Sung Tack Ro) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.11
Solid oxide fuel cell (SOFC) is expected to be a promising candidate for the power source in the next generation due to its high efficiency, utilization of high-temperature waste heat and low emission of pollutant to the environment. SOFC is, however, very sensitive to thermal stress because of its high operating temperature. In this study, three-dimensional CFD analyses are conducted to investigate the influence of flow pattern in the performance of a planar SOFC. Numerical results show that the temperature increases along the flow direction in the co-flow case and the temperature profile has a peak near the fuel inlet in the counter-flow case. Simulations of staggered flow channel model prove that overall performance is almost the same as that of unstaggered one although local distribution of current density is different.
종설 : 종양면역치료: 중세 암흑시대에서 르네상스시대로
이대호 ( Dae Ho Lee ) 대한내과학회 2014 대한내과학회지 Vol.87 No.3
Cancer immunotherapy has come a long way since William Coley observed that a mixture of killed bacteria, or Coley`s toxin, induced tumor regression. However, enthusiasm for cancer immunotherapy has changed to skepticism over recent decades due to its lack of efficacy, inconsistency, and significant toxicity. Of course, much of that skepticism was the result of a lack of understanding of the immune system. The recent expansion of our understanding of immunity and immune system and the success of new cancer immunotherapies has raised hope that we can treat cancer effectively via immunotherapy or combination approach using immunotherapy and other cancer therapies. Indeed, there is no doubt that cancer immunotherapy is experiencing a renaissance. Here, I will briefly review the current status of various immunotherapies, including cytokine therapy, antibody therapy, cancer vaccines, and adoptive cell therapy, and then I will summarize the results of recent clinical trials using anti-immune checkpoint monoclonal antibodies. (Korean J Med 2014;87:284-295)
정신분열병 환자에서 Heat Shock Protein 70(HSP70) 유전자 다형성
이대호(Dae-Ho Lee),이선우(Sun-Woo Lee),왕성근(Seong-Keun Wang),신윤오(Yun-O Shin),지익성(Ik-Seoung Chee),김정란(Jeong-Ran Kim),이영호(Young-Ho Lee),김지욱(Ji-Wook Kim) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.2
목적 : 본 연구는 정신 분열병과 관계 있다고 알려진 HSP70 유전자 중, HSP70-2(HSPA1B) 유전자 다형성에 초점을 맞추어 정신분열병과 관계가 있는지를 알아보기 위해 시행되었다. 방법 : DSM-Ⅳ 진단기준에 의해 진단된 정신분열병 환자군 104명과 정상 대조군 107명을 대상으로 하였다. HSPA1B 유전자형 판별을 위해 restriction fragment length enzyme(RFLP)을 이용한 polymerase chain reaction(PCR)이 사용되었다. 결과 : 정신분열병 환자군에서 HSPA1B 유전자형의 분포는 AA 32(30.8%), AG 57(54.8%), GG 15(14.4%)였으며, 대립 유전자의 빈도는 A 121(58.2%), G 87(41.8%)였다. 정상 대조군에서 HSPA1B 유전자형의 분포는 AA 35(32.7%), AG 63(58.9%), GG 9(8.4%)였으며 대립 유전자의 빈도는 A 133(62.1%), G 81(37.9%)였다. 정신분열병 환자군과 대조군 간 HSPA1B 유전자형의 분포와 대립 유전자의 빈도에 있어서의 차이는 유의하지 않았다. 또한, 환자군을 성별, 정신과적 질병의 가족력, PANSS scale에 따른 증상 심각도 등의 변수에 따라 분류하였을 때도 유전자형의 분포와 대립 유전자의 빈도 차이는 유의하지 않았다. 결론 : 이 연구의 결과는 한국인 정신분열병 환자들에서 HSPA1B 유전자 다형성이 정신분열병의 병인과 관계가 없음을 나타낸다. 가족-기초 비교 위험 연구와 정신분열병의 다른 임상적 변수들을 포함한 향후의 연구가 필요할 것이다. Objectives:The heat shock protein 70(HSP70) is believed to be involved in the pathogenesis of schizophrenia with regards to neurodevelopment. An aberration in the HSP70 has been proposed in schizophrenia patients, suggesting that it is a candidate gene for schizophrenia. This study aimed to investigate the association between polymorphsims of HSP70-2(HSPA1B) and schizophrenia. Methods:One hundred and four patients with schizophrenia and One hundred and seven normal controls were enrolled in the study. A polymerase chain reaction(PCR) with restriction fragment length enzyme(RFLP) was used to genotype the HSPA1B polymorphisms. Results:1) In schizophrenic patients, genotype distributions of the HSPA1B polymorphism were AA 32(30.8%), AG 57(54.8%) and GG 15(14.4%), and allele frequencies were A 121(58.2%), and G 87(41.8%). In normal control, genotype distributions of the HSPA1B polymorphism were AA 35(32.7%), AG 63(58.9%) and GG 9(8.4%), and allele frequencies were A 133(62.1%), and G 81(37.9%). There were no significant differences in the allelic or genotype frequencies of the HSPA1B polymorphisms between the schizophrenia patients and the controls. 2) There were no difference in genotype distribution and allele frequencies of the HSPA1B polymorphism, when patients were categorized by sex, family history of psychiatric disease, severity of symptom with PANSS scale. Conclusion:These results suggest a HSPA1B polymorphism is not causally related to the pathogenesis of schizophrenia in the Korean population. Further study of HSPA1B polymorphism should be needed, including family based association study and other clinical variations of schizophrenia.
프레임간 차를 이용한 교차로 영상에서 차량검지 및 추적 기법
이대호(Dae-Ho Lee),박영태(Young-Tae Park) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.1B
지능형 교통 시스템(ITS)은 1) 도로의 상황 분석과 2) 위반 차량의 검지를 자동으로 수행하여 원활한 교통 제어를 제공하는 목적을 가지고 있다. 본 논문에서는 교차로에서 위반 차량을 검지하기 위하여 도로위의 차량을 검지하고 차량의 진행 경로를 추적하는 기법으로 주간에는 배경 영상을 사용하지 않고 프레임간의 차를 이용하여 차량의 움직임 정보를 추출하고 야간에는 전조등을 검출하여 차량을 추적하는 기법으로 주간의 경우 차량의 움직임만을 검지하므로 칼만 필터(Kalman Filter) 등에 의한 예측이 불가능하므로 현재 위치와 진행 방향으로 움직임 정보를 추적하는 기법을 제안한다. 제안하는 기법은 주간 그림자의 영향과 야간의 난반사의 영향을 제거할 수 있고 입력 영상을 320×240으로 축소하여 초당 10프레임 이상을 처리하므로 정확한 차량의 움직임을 추적할 수 있다.