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한국인 집단에서 새로운 Quadruplex STR 시스템의 개발과 분석
이승환,안태인,박수정,오혜현,우광만 한국유전학회 2000 Genes & Genomics Vol.22 No.2
A quadruplex PCR system for polymorphic 4 STR loci that shows high discrimination power (D2S1371, D8S1477, D12S391, and D20S470) has been developed. Nucleotide sequence of alleles from each locus has been determined to verify the exact repeat motif and allele size. The developed quadruplex system has amplification product size range of 96-321 bp, which can be easily separated by conventional denaturing PAGE. The allele and genotype distributions satisfied Hardy-Weinberg equilibrium. This should be useful for the construction of National DNA Intelligence Database as well as forensic analyses.
동일한 시료에 대한 국내 기관간의 STR 분석결과 비교 : STR 유전자좌 분석법의 표준화 설정을 위하여
박종태,신경진,양윤석,우광만,이숭덕,이승환,이정빈,정연보,조승희,한길로,한면수,홍승범 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1
This paper described a collaborative exercise intended to see what kinds of short tandem repeat (STR) loci are used in different DNA typing laboratories in Korea and to compare their results for the demonstration whether uniformity of DNA profiling results from different laboratory could be achieved in Korea Laboratories were asked to test five tissue DNAs using methods routinely used in each laboratory and to report the results to the coordinating laboratory. The exercise demonstrated that each laboratory was using different STR loci for the typing with different STR numbers,2 VNTRS,36 STRs and amelogenin in total, and the direct comparison of the results from all the laboratory for the 18 loci could not be done as only one laboratory submitted typing results. Among 21 loci for which several laboratories submitted typing results, results for 14 loci were the same and results for the other 7 loci were different depending on the participating laboratory. D1S80, F13A01, D16S539, D21S11, D18S51, D3S1744 were the loci with different typing results. Even in the cases where commercial kits were used, the results were not the same depending on the machines used, that is the capillary electrophoresis or the gel based electrophoresis. The reason for the different results, points about the standardization of the methods arid the profiling data were described.
한국인 집단에서의 STR 마커에 대한 유전적 특성 연구
이정숙,이승환,김종열,조병남,이하규,우광만 한국유전학회 2000 Genes & Genomics Vol.22 No.4
A population study of 600 unrelated individuals from Korea was carried out to investigate the allelic distribution of the four STR loci HumvWA. HumTH01, HumTPOX, and HumCSF1PO. PCR products were separated by polyacrylamide gels followed by silver staining. The allelic distribution was considerably different when compared with caucaian, hispanic and black population. The PD values for the 4 STR markers studied here ranged from 0.824 to 0.934. These population data can be useful for the forensic analyses of korean violent crimes.