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유방암세포주에서 고농도 5-fluorouracil의 세포주기 조절효과
장정순,양중일,장세호,이원섭,이종석,안명주,박병규,Jang, Joung Soon,Yang, Jung Ill,Chang, Seho,Lee, Won Sup,Lee, Jong Seok,Ahn, Myung-Ju,Park, Byung-Kiu 대한면역학회 2002 Immune Network Vol.2 No.1
Background: Chemotherapy with 5-fluorouracil (5-FU) has been one of the mainstay in breast cancer treatment. The effects of high dose 5-FU on cell cycle regulation were studied in breast caner cells. Methods: A breast cancer cell line MCF-7 was used. Protein expressions of G1/S cyclins, $p21^{Waf1/Cip1}$, cdk2, E2F1 and retinoblastoma were tested by western blot analysis. Immunoprecipitation and immune complex kinase assay were done for the assessment of E2F1/RB interacton and the activity of cdk2 respectively. Results: $p21^{Waf1/Cip1}$ expression was barely detectable in control cells. With addition of 5-FU level of $p21^{Waf1/Cip1}$ were induced and cyclin D3 level was decreased as cell growth decreases. In accordance with increased expression of $p21^{Waf1/Cip1}$, cyclin E-associated cdk2 kinase activity was reduced. Retinoblastoma protein (RB) became dephosphorylated and E2F-1 binding activity with RB was increased. Conclusion: In this situation of high concentration of 5-FU breast cancer cells tend to be G1/S cell cycle arrested. Overexpression of $p21^{Waf1/Cip1}$ and dephosphorylation of RB may mediate the effectss of 5-FU by inhibiting E2F-1 activity, which contributes to G1/S cell cycle arrest. These results could be an indicating landmark for further study of high dose chemotherapy with 5-FU.
김현정,백주은,하혜정,양중일,함종렬,장세호,전은실 대한내과학회 2003 대한내과학회지 Vol.64 No.1
저자들은 28세의 그레이브스 병으로 진단 받은 환자에서 그레이브스 병의 악화에 동반되어막성 신병증이 발생함을 경험하여 보고하조가 한다. 자가면역 갑상선 질환과 이에 동반되는 막성 신병증간의 연관관계는 아직 명확하지 않으나, 질환의 발병기전을 고려할 때 두 질환간의 관련성이 제시되고 있으므로 자가면역 갑상선 질환 환자에서 진단 혹은 치료를 하는 과정에서 요검사를 시행하여 혈뇨와 단백뇨의 유무를 관찰하는 것은 필요하다고 생각한다. Membranous nephropathy is one of the most common causes of the nephrotic syndrome in adults. Membranous nephropathy is known as a disease associated with many other disorders and the presumed etiology of the disease is a deposition of circulating immune complexes. But, it has rarely been reported in association with autoimmune thyroiditis. We report a case of membranous nephropathy associated with Graves' disease and review the literature regarding this disease entity. (Korean J Med 64:130-136, 2003)