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위암에서 Helicobacter pylori cagA, vacA, iceA 유전자와 숙주 Interleukin-1β및 Interleukin-1 수용체 길항제 유전자 다형성
이성훈 ( Seong Hun Lee ),김태오 ( Tae Oh Kim ),이동현 ( Dong Hyun Lee ),박원일 ( Won Il Park ),김광하 ( Gwang Ha Kim ),허정 ( Jeong Heo ),강대환 ( Dae Hwan Kang ),송근암 ( Geun Am Song ),조몽 ( Mong Cho ) 대한내과학회 2006 대한내과학회지 Vol.71 No.1
Background: Both Helicobacter pylori (H. pylori) cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms play a role in determining the clinical consequences of H. pylori infection. This study aimed to investigate whether there might be any combinations of H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms that are particularly associated with the occurrence of gastric carcinoma in Korean patients. Methods: This study population was comprised of 239 patients with H. pylori infection: 122 with gastric carcinoma and 117 with gastritis only. DNA was isolated from gastric biopsy sample and H. pylori cagA, vacA and iceA genotype were determined by PCR. IL-1B-511 polymorphisms were genotyped by PCR-RFLP and IL-1RN polymorphisms were analyzed with variable number of tandom repeat after PCR. Results: H. pylori cagA, vacA, and iceA genotype were not associated with an increased risk for gastric carcinoma. IL-1B-511*T carriers and IL-1RN*2 carriers did not show increased risk for gastric carcinoma. On combination of bacterial/host genotypes, cagA+/IL-1B-511*T carriers and cagA+/IL-1RN*2 carriers, vacA s1/IL-1B-511*T carriers, vacA s1/IL-1RN*2 carriers, vacA m1/IL-1B-511*T carriers, vacA m1/IL-1RN*2 carriers, iceA1/IL-1B-511*T carriers, iceA1/IL-1RN*2 carriers showed no increased risk of gastric carcinoma. Conclusions: Combined H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms shows no increased risk of gastric carcinoma. Therefore, it seems other endogenous or exogenous factors may play more important role in the development of gastric carcinoma in Korean.(Korean J Med 71:24-37, 2006)
토끼의 난소 과자극증후군 유발에 미치는 내인성 Angiotensin 2의 작용 및 Angiotensin-converting Enzyme Inhibitor의 치료효과
박원일 ( Won Il Park ),송찬호 ( Chan Ho Song ),김병길 ( Pyung Kil Kim ),조동제 ( Dong Je Cho ),박기현 ( Ki Hyun Park ),장병철 ( Byung Chul Chang ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12
Ovarian hyperstimulation syndrome is most serious complication during ovulation induction. Although the incidence of this disease is increasing, the pathophysiology remains uncertain. Consensus is that main pathophysiology of the disease is increased vascular permeability, but the etiologic agent causing hyperpermeability is still unknown, Prostaglandin, histamine, angiotensin, some cytokines and growth factors have been suspected as etiologic agent. At present, angiotensin is mostly suspected agent of this disease. The purpose of this study is revealing etiologic role of angiotensin II in ovarian hyperstimulation and assessing the therapeutic or preventive effect of lowering angiotensin II by angiotensin converting enzyme inhibitor. After developing of ovarian hyperstimulation in rabbit, Captopril were administerd in study group. The correlations between angiotensin II and clinical parameters of severity of the disease such as ovarian volume, amount of ascites or changes of hematocrit were assessed. The correlations between angiotensin II and prostaglandin or estradiol were also assessed. The Microfil was perfused through the ovarian arteries and morphology of vascularities were revealed. The differences in ovarian volume, amount of ascites, changes of hematocrit, prostaglandin and estradiol were checked between study and control group. The parameters of severity of ovarian hyperstimulation were closely related with the level of angiotensin II. The levels of prostaglandin and estradiol were also positively correlated with the level of angiotensin II. The degree of neovascularization tended to be increased in control group, but the individual variations were existed. The parameters of severity of ovarian hyperstimulation were markedly improved in captopril group. From this data, we can conclude that angiotensin II is related with development of ovarian hyperstimulation syndrome and angiotensin converting enzyme inhibitor can prevent the development of this disease.
박상일 ( Sang Ill Park ),최형일 ( Hyung Il Choi ),정경훈 ( Kyung Hoon Cheong ),정원삼 ( Won Sam Jeong ),김난희 ( Nan Hee Kim ),이종국 ( Jong Kuk Lee ),오남승 ( Nam Seung Oh ) 조선대학교 공학기술연구원 2008 공학기술논문지 Vol.1 No.2
Quantitative evaluation for the sound source to predict the noise in the field point for the Road Traffic Noise was conducted. The traffic noise level and frequency characteristics as per types of cars for wave process until the noise reaches the field point was measured. 1. Frequency Characteristics while Driving Under freely flowing conditions of traffic, when you drive a bus on a public road, the traffic noise level showed a change of 6.2 dB(Z) from 83.1 dB(Z) to 89.3 dB(Z).The change of traffic noise level was 6.3 dB(Z) from 81.7 dB(Z) to 88 dB(Z) when a van was driven, and 10.8 dB(Z) from 79.5 dB(Z) to 90.3 dB(Z) when a one-ton truck was driven. Also, the change of traffic noise level was 18.6 dB(Z) from 81.3 dB(Z) to 99.9 dB(Z) when a motorcycle was running. All vehicles except for the motorcycle showed similar noise levels of 31.5, 500, 1 k and 2 kHz. The bus showed the highest noise level at 63 Hz and 125 Hz, and a van and an 11 ton truck showed the highest levels at 125 Hz. The one-ton truck was measured at 63 Hz for the highest noise level. The motorcycle was measured at 250 Hz with the highest noise level of 96.7 dB(Z) and at 500 Hz with 95.5 dB(Z), indicating the highest noise level among specific vehicles. 2. Characteristic of Frequency upon Departure The noise level when an urban bus stops to depart was 94.6 dB(Z), which is higher than that of stoppage and driving. When a bus stops, the normal car have an influence on the noise level, and after departure, it brings out the highest noise at 250 Hz and 500 Hz, which is caused by noises from the engine and exhaust. The noise level when a normal car stops to depart was higher than that of stoppage and driving at 85.7 dB(Z). It is high at 63 Hz as it is being reduced from 250 Hz. While a normal car is stopping, higher noise is made at 31.5 Hz, which is considered to be caused by engine noise.
염산 트라마돌을 함유하는 PLGA 미립구의 제조 및 방출거동
박종학 ( Jong Hak Park ),엄신 ( Shin Eom ),안식일 ( Sik Il Ahn ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),이동원 ( Dong Won Lee ),유일수 ( Il Sou Yoo ),이종문 ( John M Rhee ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Tramadol HCl(TH)-loaded poly(L-lactide-co-glycolide)(PLGA) microspheres were prepared by O/O solvent evaporation method for sustained release. We investigated the release behavior according to PLGA molecular weight and concentration. TH-loaded PLGA microspheres were characterized on the surface and cross-section morphology by SEM. TH-loaded PLGA microspheres had smooth surfaces and various pores in internal structure. As the PLGA molecular weight and PLGA concentration increased, the release rate of TH decreased. The behaviors of degradation was decreased according to increased PLGA molecular weight. These results showed that the release behaviors can be controlled by various of molecular weight and concentration of PLGA.