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자궁 경부의 선암과 혼합된 신경내분비 소세포 암종 - 1 증례 보고 -
박혜림,이용우,박영의,Park, Hye-Rim,Lee, Yong-Woo,Park, Young-Euy 대한세포병리학회 1990 대한세포병리학회지 Vol.1 No.1
Small cell neuroendocrine carcinoma of the uterine cervix is a distinct subtype of cervical cancer that appears analogous to oat cell carcinoma and carcinoid tumors of the lung. It has been assumed to be derived from the neural crest via argyrophilic cells in the normal endocervix. We have recently encountered a case of small cell neuroendocrine carcinoma of the uterine cervix coexisting with adenocarcinoma which was argyrophil negative. A 66-year-old multiparous woman was admitted because of vaginal bleeding for 2 months. Cervicovaginal smear revealed several scattered clusters and sheets of monotonous small cells with some peripheral palisading in the background of hemorrhage and necrosis. Radical hysterectomy specimen revealed an ulcerofungating tumor on endocervical canal which was composed of two components. Major component of the tumor was made up of monomorphic population of small oval-shaped tumor cells arranged in sheets and partly in acinar structures or trabecular fashion. Other component was adenocarcinoma, endocervical well-differentiated type. Argyrophilia was present on the Grimelius stain and immunohistochemical studies revealed diffuse positivity to neuron-specific enolase and carcinoembryonic antigen. Electron microscopic examination showed clusters of small round to oval cells, which had a few well-formed desmosomes and several membrane-bound, dense-core neurosectetory granules.
박혜림,남주현,박영의,Park, Hye-Rim,Nam, Joo-Hyun,Park, Young-Euy 대한세포병리학회 1992 대한세포병리학회지 Vol.3 No.2
Although there have been a few reports of cases in which cancer cells of extrauterine origin were observed in vaginal smears, such findings are relatively uncommon. We recently experienced a case of ovarian serous cystadenocarcinoma diagnosed by cervicovaginal smear in a 56-year-old woman in routine work-up of carcinoma peritonei. The cellular features were several scattered cellular clusters of adenocarcinoma cells in clear background without tumor diathesis. Psammoma body was not present. Exploratory laparotomy confirmed the diagnosis of bilateral ovarian serous cystadenocarcinoma with multiple metastases.
태반부 영양막세포 종양의 세포학적 소견 - 자궁경부질 도말 1예 보고 -
박혜림,이용우,박영의,Park, Hye-Rim,Lee, Yong-Woo,Park, Young-Euy 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2
We report a case of placental site trophoblastic tumor with cytologic features of cervico-vaginal smear. The smear revealed several loose clusters of atypicai cells in slightly hemorrhagic and inflammatory background. Tumor cells were large in size and polyhedral to round with abundant cytoplasm Nuclei revealed consider-able variation in size, shape, and degree of chromatin clumping. Cytologically, it was difficult to differentiate from squamous cell carcinoma of uterine cervix. Curettage and hysterectomy specimen revealed typical histologic features of placental site trophoblastic tumor composed of intermediate type trophoblasts.
갑상선의 여포상 종양의 감별에 있어서 TCM-9의 발현양상
김윤정,심정원,안혜경,박영의,Kim, Yun-Jung,Shim, Jung-Weon,Ahn, Hye-Kyung,Park, Young-Euy 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.2
Monoclonal antibody(TCM-9) against human thyroid cancers have been studied by screening with human thyroid cancers, normal and benign thyroid tissue, and normal human serum protein. A monoclonal antibody(TCM-9) that is known to have strong specificity for human thyroid cancer but not for Graves' disease, adenoma or normal thyroid does not bind to native or mature human thyroglobulin(Tg). We used to TCM-9 antibody by immunohistochemical staining on 5 follicular cancer, 2 follicular adenoma, 1 follicular neoplasm with suspicious invasion, 2 papillary cancer to ascertain being of help in differentiation between follicular carcinoma and adenoma. Reactivity of TCM-9 was observed in follicular carcinoma and papillary carcinoma but not observed in follicular adenoma. Thus TCM-9 is a novel monoclonal antibody against the thyroid cancer.
타액선 종양에서 제4형 교원질과 Fibronectin 발현
박혜림(Hye Rim Park),남은숙(Eun Sook Nam),손진희(Jin Hee Sohn),신형식(Hyung Shik Shin),박영의(Young Euy Park),노영수(Young Soo Rho),민헌기(Heun Ki Min),임현준(Hyun Joon Lim) 대한두경부종양학회 1997 대한두경부 종양학회지 Vol.13 No.2
Objectives: Salivary gland tumors pose considerable difficulty in diagnostic and prognostic assessment based on the histopathologic features alone. We studied the expression of type IV collagen and fibronectin in salivary gland tumors with special emphasis on the differential diagnostic significance. Materials and Methods: We did immunohistochemical stain on paraffin embedded tissues of 33 benign and 24 malignant salivary gland tumors using monoclonal antibody for type IV collagen and polyclonal antibody for fibronectin. Results: 1) Well preserved linear basement membrane-like staining of type IV collagen was detected in duct-cell-derived benign salivary gland tumors. But pleomorphic adenoma exhibited a heterogeneous pattern as focal augmentation and interruption. 2) In malignant tumors, type IV collagen was distributed in an irregular, interrupted manner or completely absent. Adenoid cystic carcinomas displayed a marked staining of the basal membrane associated substances in the pseudocysts. 3) The staining pattern of fibronectin was similar to that of type IV collagen execpt more dense in the stroma. 4) Salivary gland tumors which have a prominent myoepithelial cell component revealed a particular deposition of basement membrane materials adjacent to the myoepithelial cells. Conclusion: The study of the basal membrane substances may be helpful for differential diagnosis of benign and malignant salivary gland tumors and identifying special features of salivary gland tumors such as pseudocystic pattern of adenoid cystic carcinoma. Also we think that the myoepithelial cells contribute to the formation of basement membrane materials.
박혜림,채승완,손진희,박영의,Park, Hye-Rim,Chae, Seung-Wan,Sohn, Jin-Hee,Park, Young-Euy 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2
Morphometry of nuclei of the benign and malignant prostatic lesions was performed to study the relationship between nuclear size and shape and the prognosis of prostatic adenocarcinoma fifty one cases of prostatic adenocarcinoma and 13 cases of benign prostatic hyperplasia were included to evaluate area, perimeter, Dmax, Dmin, and 5 form factors of the nuclei by image analyzer(Zeiss Ibas 2000) using hematoxylin-eosin stained slides. All analytic factors of nuclear size and shape were significantly different between benign lesions and adenocarcinomas. Increased nuclear size was associated with nuclear irregularity, presence of metastasis, advanced clinical stage, and high Gleason's grade and score of prostatic adenocarcinoma. On Kaplan-Meier method, survival was decreased with older age, no hormonal treatment, stage D, high Gleason's grade and stage as well as with larger size and irregular shape of the nuclei in conclusion, morphometry of nuclei of the prostate can be a helpful tool to differentiate between be nign and malignant lesions. Nuclear morphology is thought to be associated with prognosis of prostatic adenocarcinoma.
노원식(Won Shick Loh),이해선(Hae Sun Lee),박영의(Young Euy Park),백승진(Seung Jin Paik),강진경(Jin Kyung Kang),최흥재(Heung Jai Choi) 대한소화기학회 1972 대한소화기학회지 Vol.4 No.1
N/A Cancer is now the leading cause of death in most countries, and there appears to be an actual increase in the prevalence of cancer in recent vears. Recent statistics of the United States of America and 3Vestern Europe indicated that the cancer is the second most frcquent cause of death being only preceded by cardiovascular diseases. During the last four dcades our kiiosvledge of the causation oi turriouvs has advanced rapidly. The following studies of tavo sorts have contribu.ed to this advance; a) statistieaJ studies of occupationa1, social and racial f-ctors in the causation of human neop!asms, and b; studics in the experimental production of turr.ours in animals by rneans of chemical and other agents. This statistical studies was done on 4, 905 cases of malignancies, diagnosed pathologically and clini- cally among 76,763 patients admitted to Severance Hospital during the last 10 years from 1960 tn 1969, and the following results vere obtained. L. Annual incidence of malignancies showed gradual increase in total nurnber, however there is no significant variation in ratio to the number of total in-patients during the years of observation, mean being 6. 4%. 2. Ma!e to fem!e ratio of all malignancies avas about 1: 1. 3, Over the hzlf (56,7%) of a!I malignancies ivas in 5th and 6th decades, the peak age being in 6th decade in male (33, 5%) and 5th decade in female (28. 9%). 4. The relative frequency of all malignancies by system was in order of cancer of digestive system (43. 1%), genitourinary system and breast(32. 2%), respiratory system (9. 0%), hematopoietic system (8. 1%), musculoskeletal system and skin (3. 4%), endocrine system (1.3%) znd others (2. 9%). 5. The over all frequency of maIignancies by organ ivas in order of cancer of stomach (24. 1%), uterus (19, 9%), liver (10. 8%), lung(7. 4%), leukemia(4. 8%). In male the order of frequency was cancer of stomach (34. 2%), liver (17. 9%) 3, Iung (11. 5%), leukemia (5. 3%), lymphoma (4. 4%), while ir; female it was cancer of uterus (40.2%), stomach (13. 8%), breast (8. 2%), ovary (5. 2%), leukemia (4. 4%). 6. The peak age of relatively frequent ma]ignancies was as follows: the peak age of the cancer of the stomach, liver, lymphoma and lung was in the 6th decade; that of uterus, breast, and coIo-rectal