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김윤화,이성용,Kim, Yoon Hwa,Lee, Sung Yong 한국시스템엔지니어링학회 2016 시스템엔지니어링학술지 Vol.12 No.2
As the inventory costs of repairable items in military logistics continue to increase, many studies for optimal inventory level of these items are being carried out in advanced countries, including the US, to reduce these costs. Research on inventory level optimization for repairable items aimed to achieve the availability goal of a system with a MIME(Multi Indenture Multi Echelon) repair policy structure first began with Sherbrooke's METRIC and developed into various types. This research is to analyze and compare recent V-METRIC related studies to search for another variation in this field. This paper mainly looks at how to determine optimum inventory level for each repairable item to achieve a specific availability target within a limited budget, and also how to minimize inventory cost while achieving its availability target by determining optimal inventory level of each repairable item.
PBL 계약을 위한 수리부속 재고비용 예측과 V-METRIC의 활용에 관한 연구
김윤화,이성용,Kim, Yoon Hwa,Lee, Sung Yong 한국시스템엔지니어링학회 2017 시스템엔지니어링학술지 Vol.13 No.1
For the PBL contract, it is necessary for the contracting parties to share information regarding the reasonable inventory-level and the cost of its repair parts for the estimated demand. There are various models which can be used for this purpose. Among them, V-METRIC model is considered to be the most efficient and is most frequently applied. However, this model is usually used for optimizing the inventory level of the repair parts of the system under operation. The model uses a time series forecast model to determine the demand rate, which is a mandatory input factor for the model, based on past field data. However, since the system at the deployment stage has no operational performance record, it is necessary to find another alternative to be used as the demand rate of the model application. This research applies the V-METRIC model to find the optimal inventory level and cost estimation for repairable items to meet the target operational availability, which is a key performance indicator, at the time of the PBL contract for the deployment system. This study uses the calculated value based on the allocated MTBF to the system as the demand rate, which is used as input data for the model. Also, we would like to examine changes in inventory level and cost according to the changes in target operational availability and MTBF allocation.
대간간학회지 제6차 춘계학술대회 초록집 : 포스터 전시 ; 부분 비장색전술로 확진 및 부분 관해된 특발성 문맥압항진증 1예
김수영 ( Kim Su Yeong ),김병호 ( Kim Byeong Ho ),이승훈 ( Lee Seung Hun ),오주형 ( O Ju Hyeong ),이상목 ( Lee Sang Mog ),김교영 ( Kim Gyo Yeong ),김윤화 ( Kim Yun Hwa ),이주희 ( Lee Ju Hui ),동석호 ( Dong Seog Ho ),김효종 ( Kim Hy 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)
김효종(Hyo Jong Kim),김윤화(Youn Hwa Kim),정혜전(Heo Jeon Cheong),동석호(Seok Ho Dong),김배영(Bae Young Kim),김병호(Byung Ho Kim),이정일(Joung Il Lee),장영운(Young Woon Chang),장린(Rin Chang),양문호(Moon Ho Yang) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
N/A Background/Aims: Multiple genetic alterations in tumor suppressor genes(APC, MCC, DCC, p53) and oncogenes(K-ras) have been implicated in the development of colorectal carcinomas(CRCs). Recently, mutator genes(hMSH2, hMLH1, hPMS1, hPMS2), which are characterized by the development of particular form of genetic instability, termed RER(replication error) was reported in CRCs. It is postulated that RER may be required for multiple genetic alterations in the development of CRCs. But the mode of genetic alterations caused by RER is not certain. To evaluate the mode of genetic alterations caused by RER in multistage carcinogeneis, we compared the frequency of p53 expression, known to be involved in the pathogenesis of CRC, in two groups of tumors. RER(+); those demonstrating RER, and RER( ); those lacking such genetic alterations. Methods: RER test at microsatellite loci; DNA was extracted from normal and tumor tissues using cryostat sectioning method. Purified DNA was subjected to a PCR-based technique in which(CA)n repeat sequence were amplified and RERs were detected when a change in allele length was detected. Immunohistochemical analysis of p53 expression; Deparaffinized section of formalin-fixed tumor tissue samples were immunostained for p53 protein, using a monoclonal p53-specific DO7 antibody. Results: The frequency of RER in sporadic CRC was 40.1%(9/22). P53 expression was observed in 6 of 18 carcinoma(33.3%). The frequency of p53 immunostaining was lower in tumors demonstrating RER(25% vs. 40%). All tumor demonstrating RER at multiple loci did not exhibited p53 immunostaining. Conclusions: These results suggest that RER is likely to play an important role in the pathogenesis of CRCs probably by the different mode of genentic alterations from those lacking RER. (Korean J Gastroenterol 1996;28: 36-46)