신문고 - 식품포장 안전관리 연구의 현재와 미래

김소희,Kim, So-Hui (사)한국포장협회 2011 包裝界 Vol.222 No.-

우리나라 청소년의 수면시간 및 질과 체질량지수와의 관련성

김소희,김유숙,장영희,박종,류소연,Kim, So-Hui,Kim, Yu-Suk,Jang, Young-Hee,Park, Jong,Ryu, So-Yeon 한국학교보건학회 2012 韓國學校保健學會誌 Vol.25 No.1

Purpose: This study aims to discover the relation between the sleep duration and quality of adolescents and their body mass index. Methods: The study used data obtained through the 2009 online survey on adolescents health behaviors, targeting a total of 75,066 middle and high school students (39,612 of male students and 35,454 of female students). We first performed t-test, ANOVA and Scheffe's test and then the potential variables which was possibly related to the body mass index are determined from the tests. Using the potential variable, we performed the multiple regression analysis to finally identify the relation between the duration and quality of sleep. Results: As a result, the 39.8% of male students and the 46.5% of female students most frequently respond that the sleep duration was less than 6 hours, and 36.4% of male students and the 45.3% of female students respond that the quality of sleep was not good enough. The body mass index of both the male and the female students portionally decreases to their sleep duration, but the better quality of sleep makes their body mass index higher. Conclusion: In conclusion, the body mass index has some notable relationship with the sleep duration and quality for adolescents. It is advised to consider the sleep duration and quality in the business plans for adolescents in order for the prevention of their body mass index.

15년간(1991~2005년) 우리나라 소아에서 분리된 폐구균의 혈청형 분포의 변화

김소희,송은경,이준호,김남희,이진아,최은화,이환종,Kim, So-Hee,Song, Eun-Kyung,Lee, Jun-Ho,Kim, Nam-Hee,Lee, Jin-A,Choi, Eun-Hwa,Lee, Hoan-Jong 대한소아감염학회 2006 Pediatric Infection and Vaccine Vol.13 No.2

목 적 : 폐구균 단백 결합 백신이 개발되었지만 이에 포함되는 혈청형은 7가지로 한정되어 있어, 지역별 주요 폐구균 혈청형의 분포에 따라 백신의 유용성에 차이가 있을 수 있다. 본 연구에서는 우리나라 소아에서 분리된 폐구균의 혈청형의 분포를 분석하고 지난 15년간 시기에 따른 변화 양상을 분석하고자 하였다. 방 법 : 1991년 1월부터 2005년 5월까지 서울대학교 어린이병원 소아 환자의 각종 임상 검체에서 분리된 폐구균 465균주의 혈청형을 quellung reaction으로 결정하였고, penicillin 감수성은 oxacillin 디스크 확산법으로 검사하였다. 연구기간은 1991~1995년(I분기), 1995~2000년(II분기), 2001~2005년(III분기) 등 3개의 분기로 나누어 분석하였다. 결 과 : 465균주의 주된 혈청형은 19F(22%), 23F(18%), 19A(10%), 6B(8%), 14(7%), 6A(7%), 9V(5%) 등이었고, 전체 균주의 79%이었다. 60개월 미만 연령군의 침습성 감염 검체에서 분리된 101균주에서의 주된 혈청형은 혈청형 23F(21%), 14(17%), 19F(15%), 19A(11%), 6B(10%), 6A(7%), 9V(7%) 등으로 총 70%이었다. 전체 균주에서 I, II, III의 각 분기별 혈청형 분포는 백신 혈청형에 포함된 혈청형 19F, 14가 감소하는 추세이었고, 교차 반응 혈청형에 포함된 혈청형 6A, 19A가 증가하는 추세이었다. 침습성 감염 균주에서 폐니실린 내성률은 백신 혈청형에서 92.6%, 교차 반응 혈청형에서 75.0%로 높았으나, 비백신 혈청형에서는 34.4%로 낮았다. 결 론 : 최근 15년간 소아의 임상 검체에서 분리된 폐구균의 혈청형은 주로 19F, 23F, 19A, 6B, 14, 6A, 9V 등이 가장 흔하였고, 최근에 혈청형 19A, 6A가 증가하는 추세이고, 혈청형 19F와 14가 감소하였다. 향후 백신 사용과 관련하여 국내 폐구균 혈청형의 분포에 관한 지속적인 관찰이 필요하다고 생각된다. Purpose : The prevalence of serotypes can be changed with respect to age of the patients, regions and times of the surveillance. The aim of this study is to analyze changes in serotype distribution of pneumococcal isolates from Korean pediatric patients. Methods : Four hundred and sixty five strains of S. pneumoniae were isolated from various clinical specimens at the Seoul National University Children's Hospital during a 15 year-period, from 1991 to 2005, were subjected to serotype and penicillin susceptibility. The study period was divided into three 5 year-periods, 1991~1995(period I), 1996~2000(period II), and 2001~2005(period III). Results : Common serotypes were 19F, 23F, 19A, 6B, 14, 6A and 9V in decreasing orders of frequency, and these 7 serotypes accounted for 79% of total 465 strains. In the serotype distribution of invasive infection isolates from children <60 months of age, similar serotypes accounted for 70% of 101 strains. In total strains, the proportion of serotype 19A and 6A increased, while that of serotype 19F and 14 decreased. The majority(75~92%) of vaccine types and cross-reactive types from invasive infection isolates was penicillin-resistant, whereas 34.4% of non-vaccine types was penicillin-resistant. Conclusion : Distribution of serotypes of S. pneuomoniae isolated from Korean children has changed significantly over the last 15 years. The surveillance for pneumococcal serotypes should be continued to monitor changes in serotype distribution which are essential for the establishment of pneumococcal vaccine policy.

넙치, Paralichthys olivaceus의 미세플라스틱 급성 노출에 따른 혈액성상 및 혈장성분의 변화

김소희,김가현,김지수,김준환,전유현,조재황,김석렬,김대희,Kim, So-Hee,Kim, Ga-Hyun,Kim, Ji-Su,Kim, Jun-Hwan,Jeon, Yu-Hyeon,Cho, Jae-Hwang,Kim, Seok-Ryel,Kim, Dae-Hee 한국환경생물학회 2021 환경생물 : 환경생물학회지 Vol.39 No.3

Juvenile olive flounder, Paralichthys olivaceus (mean weight 66.7±7.1 g; mean length 19.2±0.9 cm) in a bio-floc environment were exposed to microplastic (PE: polyethylene, size 40-48 ㎛) at 0, 4, 20, 100, 500 and 2,500 mg L^-1 for 96 hours. No P. olivaceus deaths were observed following microplastic exposure. In the plasma components, calcium was significantly decreased whereas there was no significant change with magnesium following microplastic exposure. Glucose was significantly decreased with over 100mg L^-1 at 48 hours and 20mg L^-1 at 96 hours. Cholesterol was significantly decreased with over 20mg L^-1 after 48 hours, whereas there was no significant change in the total protein content. In enzymatic plasma components, the AST(Aspartate aminotransferase) was significant decreased by microplastic exposure. The results of this study indicate that acute exposure to microplastic induces blood physiological changes in P. olivaceus. 본 실험에서 미세플라스틱의 노출은 넙치의 혈액학적 성상인 hemoglobin 및 hematocrit 수치의 유의적인 감소를 유발하였다. 또한 미세플라스틱의 노출은 넙치 혈장 무기성분인 calcium, 유기성분인 glucose 및 cholesterol, 효소성분인 AST의 유의적인 변화를 나타냈다. 본 연구에서 바이오플락 환경에서 미세플라스틱의 노출이 어류의 혈액생리에 영향을 주며 독성으로 작용하는 것을 확인할 수 있었다. 향후, 일반 해수와 바이오플락 환경으로 각각 양성한 넙치를 이용하여 사육환경의 변화에 의한 미세플라스틱 노출영향의 차이에 대해서도 추가적인 연구가 이루어져야 할 것이다. 본 연구는 다양한 어종에서 종별 미세플라스틱의 농도 연구에서 미세플라스틱 노출에 따른 종별 독성영향비교평가를 위한 기본 자료로 활용될 수 있을 것이다. 하지만, 바이오플락 환경에서 미세플라스틱의 응집은 미세플라스틱의 독성에 영향을 미치는 중요한 요소이기 때문에(Choi et al. 2020), 향후 연구에서 철저한 모니터링과 함께 다양한 미세플라스틱 독성에 미치는 요소에 대한 추가연구가 필요할 것이다.

생달나무 잎 추출물 유래 항염 및 항산화 활성 성분

김소희,김정은,이남호,Kim, So Hee,Kim, Jung Eun,Lee, Nam Ho 대한화학회 2021 대한화학회지 Vol.65 No.1

본 연구에서는 생달나무 잎 추출물 및 용매 분획물의 항염 및 항산화 효능을 확인하고 유효성분을 분리하여 화학구조를 동정하였다. RAW 264.7 세포를 이용한 분획 시료의 NO 생성 억제 활성 실험 결과, EtOAc 분획물이 세포 독성 없는 농도에서 NO의 생성을 억제시키는 효능을 확인하였다. 또한 EtOAc 분획물이 iNOS 단백질의 발현 및 전염증성 사이토카인(TNF-α, IL-1β) 생성 저해 효과를 나타내었다. 항산화 활성 실험 결과, EtOAc 분획물이 DPPH 및 ABTS+ 라디칼 소거능이 우수함을 확인하였다. EtOAc 분획물의 활성 성분을 규명하기 위해 컬럼 크로마토그라피를 수행하여 5개의 화합물을 분리하였다; (4S,5R)-4-hydroxy-5-isopropyl-2-methylcyclohex-2-enone (1), methoxy-(3,5-dimethoxy-4-hydroxyphenyl)ethanediol (2), afzelin (3), nicotiflorine (4), narcissin (5). 화합물 1-5는 모두 생달나무에서 처음으로 분리되었다. 분리 화합물에 대한 항염 활성 실험 결과, 화합물 1, 3, 4 및 5는 세포 독성 없이 NO 생성 저해 효과를 나타내었다. 또한 화합물 1은 염증 매개인자인 TNF-α, IL-1β, IL-6의 생성 억제 활성을 보여주었다. 이상의 연구결과를 바탕으로 생달나무 잎은 항염 및 항산화 효과를 갖는 의약품 및 화장품 관련 천연 소재로의 개발이 가능할 것이라 사료된다. In this study, the extract of Cinnamomum yabunikkei leaves were investigated for the anti-inflammatory and anti-oxidative activities and their active constituents were identified. In the anti-inflammatory tests using LPS-stimulated RAW 264.7 cells, the ethyl acetate (EtOAc) fraction inhibited the production of nitric oxide (NO) without causing cell toxicity. In addition, the EtOAc fraction reduced expression of iNOS protein and production of pro-inflammatory cytokines (TNF-α, IL-1β). Upon the anti-oxidative studies by DPPH and ABTS+ radicals, potent radical scavenging activities were observed in the EtOAc fraction. Five phytochemicals were isolated from the extract of C. yabunikkei leaves; (4S,5R)-4-hydroxy-5-isopropyl-2-methylcyclohex-2-enone (1), methoxy-(3,5-dimethoxy-4-hydroxyphenyl)ethanediol (2), afzelin (3), nicotiflorine (4) and narcissin (5). As far as we know, compounds 1-5 were isolated for the first time from this plant. In the anti-inflammatory tests for the isolates, compound 1, 3, 4 and 5 were determined to decrease NO production without causing cell toxicity. Furthermore, compound 1 reduced expression of iNOS protein and exhibited potent inhibitory activities of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). Based on these results, it was suggested that the extract and isolated compounds from C. yabunikkei leaves could be potentially applicable as natural source for pharmaceutical and/or cosmetic ingredients.

베트남 결혼이주여성의 문화적응 스트레스와 자녀양육효능감의 관계에서 배우자 지지의 영향

김소희,노윤구,Kim, So Hee,Noh, Yoon Goo 한국여성건강간호학회 2018 여성건강간호학회지 Vol.24 No.2

Purpose: To identify the effects of spousal support on the relationship between acculturative stress and sense of parenting competence among married Vietnamese immigrant women. Methods: The sample for this study consisted of 175 married Vietnamese immigrant women in Gyeongsangnam-do. Data were analyzed using descriptive statistics, t-test, ANOVA, $Scheff{\acute{e}}$ test, Pearson correlations, and hierarchical multiple regression with SPSS/WIN 23.0. Results: (a) sense of parenting competence was negatively correlated with acculturative stress, whereas a positive correlation was observed with spousal support; (b) spousal support mediated the relationship between acculturative stress and sense of parenting competence. Conclusion: Results of the study suggest that spousal support decreases the negative effects of acculturative stress on sense of parenting competence. Therefore, we need to find ways to strengthen spousal support for married Vietnamese immigrant women.

식품첨가물 관리 동향

김소희,박성관,임호수,Kim, So-Hui,Park, Seong-Gwan,Im, Ho-Su 한국식품산업협회 2009 좋은식품 Vol.210 No.-

공공 클라우드 기술과 정책의 개선방안에 대한 연구

김소희,이유림,이일구,Kim, So Hui,Lee, Yu Rim,Lee, Il-Gu 한국디지털정책학회 2021 디지털융복합연구 Vol.19 No.8

코로나19 팬데믹으로 인해 전 세계는 대공황 이후 가장 심각한 위기에 당면하였으며, 언택트 시대라는 새로운 패러다임을 맞이하고 있다. 우리나라도 이에 발맞춰 '한국판 뉴딜'을 비롯한 다양한 정책과 법제도를 발표하였지만, 정보의 활용과 정보의 보호 사이에서 갈등하고 있다. 본 논문에서는 공공 클라우드의 정책과 법령 및 기술을 분석하여 한계점을 도출하고, 이를 바탕으로 모든 국민이 평등한 정보 접근권을 보장받으며 신뢰할 수 있는 안전한 환경에서 디지털 서비스를 이용할 수 있도록 '범국가적 차원의 공공 가상머신 구축'을 차세대 국가 성장 동력 확보를 위한 핵심과제로 도입하는 방안을 제안하였다. 이를 통해 모든 국민이 저가·저사양의 단말만으로 다양한 디지털 신기술 서비스를 이용할 수 있도록 하며, 정보보호 전담센터 구축을 통해 급증하는 보안 위협에 대응하고자 한다. 또한, 국내 클라우드 관련 법제도가 보안의 중요성을 간과한 채 정보의 활용만을 강조하고 있다는 점을 지적하고, 법제도가 나아가야 할 올바른 방향을 제시한다. Due to the Covid-19 Pandemic, the world is facing the most serious crisis since the Great Depression, and is facing a new paradigm of the Untact era. Korea has also announced various policies and legal systems, including the 'Korean version of the New Deal', but it is conflicting between the use of information and the protection of information. In this paper, we derive thresholds by analyzing policies, statutes and technologies in the public cloud. Based on this, we propose to introduce the "Building a Nationwide Public Virtual Machine" as a key task to secure the next-generation national growth engine so that all citizens can use digital services in a secure and reliable environment with equal access to information. Through this, all citizens can use various digital new technology services only with low-priced and low-specification terminals, and by establishing a dedicated center for information protection, we want to respond to rapidly increasing security threats. It also points out that the domestic cloud-related legal system only emphasizes the use of information while overlooking the importance of security, and suggests the right direction for the legal system to move forward.

샴푸 제형의 in vitro 항비듬력 평가법

김소희 ( So Hee Kim ),윤유나 ( Yu Na Yun ),박태훈 ( Tae Hun Park ),이존환 ( John Hwan Lee ),안수선 ( Su Sun An ) 한국동물실험대체법학회 2014 동물실험대체법학회지 Vol.8 No.1

Dandruff is a common scalp disorder that affects almost half of population. Cosmetic companies have developed anti-dandruff shampoo containing antimicrobial materials such as zinc pyrithione (ZPT) and climbazole which inhibit fungal growth especially Malassezia yeast, dandruff-causing organism. It is essential to examine whether anti-dandruff shampoo reduces Malassezia growth, so that improve dandruff. The aim of this investigation was to establish a test method for antifungal activity of shampoo. The basic methods of antimicrobial susceptibility testing are the minimum inhibitory concentration (MIC) and disk diffusion test. We have compared a disk diffusion test that uses nitrocellulose filter paper and artificial skin substrate (Vitro-Skin) as disks to estimate antifungal activity of shampoo or materials after rinse-off. We have identified that ZPT, climbazole and three commercial shampoos containing ZPT were deposited on disks with nitrocellulose filter paper and artificial skin substrate (Vitro-Skin) even after rinse-off, so zone of inhibition were observed.

연구논문 : 샴푸 제형의 in vitro 항비듬력 평가법

김소희 ( So Hee Kim ),윤유나 ( Yu Na Yun ),박태훈 ( Tae Hun Park ),이존환 ( John Hwan Lee ),안수선 ( Su Sun An ) 한국동물실험대체법학회 2014 동물실험대체법학회지 Vol.8 No.1

Dandruff is a common scalp disorder that affects almost half of population. Cosmetic companies have developed anti-dandruff shampoo containing antimicrobial materials such as zinc pyrithione (ZPT) and climbazole which inhibit fungal growth especially Malassezia yeast, dandruff-causing organism. It is essential to examine whether anti-dandruff shampoo reduces Malassezia growth, so that improve dandruff. The aim of this investigation was to establish a test method for antifungal activity of shampoo. The basic methods of antimicrobial susceptibility testing are the minimum inhibitory concentration (MIC) and disk diffusion test. We have compared a disk diffusion test that uses nitrocellulose filter paper and artificial skin substrate (Vitro-Skin) as disks to estimate antifungal activity of shampoo or materials after rinse-off. We have identified that ZPT, climbazole and three commercial shampoos containing ZPT were deposited on disks with nitrocellulose filter paper and artificial skin substrate (Vitro-Skin) even after rinse-off, so zone of inhibition were observed.