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전립선암 환자에서 Leuprolide Acetate Depot (루피어<SUP>Ⓡ</SUP> 데포주 3.75mg)의 유효성과 안전성 평가를 위한 다기관 임상시험
김형진(Hyung-Jin Kim),유정현(Chong-Hyon Ryu),이영구(Yong-Goo Lee),김청수(Choung-Soo Kim),류수방(Soo-Bang Ryu),김법완(Bup-Wan Kim),장성구(Sung-Goo Chang),김세중(Se-Joong Kim),이현무(Hyun-Moo Lee),최한용(Han-Yong Choi),홍성준(Sung-Joon 대한비뇨기종양학회 2009 대한비뇨기종양학회지 Vol.7 No.1
서노교,김법완 啓明大學校 醫科大學 1984 계명의대학술지 Vol.3 No.2
Multicystic kidney is considered as common cause of neonatal abdominal mass but only one case reported in Korea. Multicystic kidney can be identified as two forms: 1) the large multicystic kidney, tending to haved a normal contralateral kidney, and 2) the small multicystic kidney, which has a high incidence of contralateral anomalies and other congenital anomalies. We report a case of multicystic kidney in a 2 year-old male patient, which was suspected by clinical investigation and confirmed by exploration and microscopic examination.
정성광,변진석,백봉수,김법완 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2
Reconstruction of the penis is indicated in a traumatic or surgical amputation, congenital penile absence, micropenis, male pseudohermaproditism, or transsexualism. Initially, penile reconstruction has been performed using a local flap, but often failed because of the multiple procedures, fistula or stricture of the urethra, and no sensation of the phallus. Ideally, penile reconstruction should be a one-stage procedure, creating a phallus with both tactile and aerogenous sensibility, water-tight neourethra allowing for voiding while standing, enough bulk with stiffness, and aesthetically acceptable appearance. Since August 1989 we have constructed a penis in 4 patients. We selected the radial forearm flap as a donor site because it offers a reliable artery, veins, nerves, and stiffner. It also offers thin, malleable skin with adequate width and length. We have followed these patients from 5 months to 10 months. All operations were successful except for one fistula formation.
김법완,권태균,노기석,정성광,장세국,정운복,김정완 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1
The objective of this study was to characterise the pattern of p53 mutations in bladder turmor. In this study, 25 bladder transitional cell carcinomas were analyed by immunohistochemistry (IHC) for p53 nuclear overexpression, and the results were compared with those of polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis in exon 5-8 of the p53 gene and DNA sequencing analysis. 15 out of 20 cases (75%) showed p53 nuclear immunoreactivities on IHC. On PCR-SSCP analysis, 10 out of 25 cases(40%) had abnormal shifts on mobility. 62% of the mutations were in exon 8. Direct DNA sequencing analysis were performed in these 10 cases to confirm the presence of mutated p53 genes and to determine the type of mutations. Sixteen point mutations were detected in 10 cases. Tow specimens had double mutations and another two had triple mutations. G:C→A:T transitions were the most frequent patterns (62.5%). One mutation was a premature stop codon and two were silent mutations. There out of 10 had a point mutation at codon 285 (GAG/Glu→AAG/Lys) and two had at codon 280(GAG/Glu→AAG/Lys). One of 16 mutations was transition at hot spot codon 273 with CpG site. These results suggest that altered expressions and point mutations of p53 occured in all grade of bladder cancer, but are more associated with hight grade bladder tumors. To elucidate the carcinogenesis of bladder cancer, further studies should be carried out.