1996년도 제35차 대한소화기학회 추계학술대회 / 포스터 발표 : 위장관 ; 소화성궤양에서 H . Pylori 의 박멸을 위한 치료 방법의 비교

김나영,박용주,안경주,이규현,임병철,임선희,이계희 ( Na Young Kim,Yong Ju Park,Kyung Ju Ahn,Gyu Hyun Lee,Byung Chul Lim,Seon Hee Lim,Kye Heui Lee ) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1

기후.환경 변화 분석을 위한 GIS기반의 통합DB 관리시스템 개발

김나영,김계현,박용길,Kim, Na-Young,Kim, Kye-Hyun,Park, Yong-Gil 한국공간정보학회 2011 한국공간정보학회지 Vol.19 No.6

기후변화는 지구환경 시스템을 구성하는 모든 권역에 영향을 미치며 각 권역은 서로 비선형적인 상호작용을 통해 다시 기후변화에 영향을 미친다. 따라서 기후와 지구환경 시스템 사이의 피드백 과정을 종합적으로 분석하고, 변화특성을 진단하여 예측할 수 있는 통합적인 연구가 필요하다. 그러나 현재까지는 기후변화에 따른 지구환경 시스템의 특정 권역의 변화에 대해서만 연구를 진행하고 있어 기후 환경 상호간의 연계 연구 지원이 미흡한 실정이다. 따라서 본 연구에서는 기후 환경 변화를 종합적으로 분석하고 예측하기 위해 자료 저장, 관리 및 배포를 지원하는 GIS기반의 통합DB 관리시스템을 개발하였다. 통합DB 관리시스템은 VB.NET 2005와 지도 기반의 공간 표현을 위한 ArcObjects 컴포넌트를 이용하여 개발하였다. 먼저 기후 환경 전문가의 요구사항을 고려한 연구 대상 및 자료를 선정하였고, 자료 관리 및 활용 방법을 정의하였다. 또한 연구 자료의 효율적인 검색을 위하여 데이터를 표준화하였으며, 이를 적용한 데이터 모델링을 통하여 기후 환경 DB와 자료의 이해도를 높이고, 공간적 상관관계 분석을 위한 GIS DB를 구축하였다. 구축된 DB를 기반으로 사용자에게 DB의 다양한 검색 및 접근을 통해 자료에 대한 세부적인 정보를 제공하고 자료의 배포가 가능한 프로토 타입의 통합DB 관리시스템을 개발하였다. 이러한 GIS기반의 기후 환경 통합DB 관리시스템은 효율적인 자료 관리는 물론 자료를 배포하는 환경을 제공 할 수 있으며, 미래의 기후변화를 종합적으로 진단 및 예측 하는데 기여가 클 것으로 판단된다. Climate change affects all components of the global environment system and, in turn, all components mutually interact and affect climate change through non-linear feedback processes. It is thus necessary to study the interaction between the climate and the environment, in order to comprehensively understand and predict climate and environment change. However, current relevant systems are limited to particular areas and do not sufficiently support the mutual linking of research studies. Therefore, this study develops prototype a GIS based integrated DB management system for supporting the climate and environment data storage, management and distribution. The integrated DB management system was developed using VB.NET languages and ArcObjects component. First, considering the demands of climate environment experts, the study areas are selected and the methods of data management and utilization were defined. In addition, a location-based GIS DB was created in order to aid in understanding climate change through visual representation. Finally, the integrated DB management system provides an efficient data management and distribution data and it creates synergistic effect on climate and environment study. It also contributes significantly to the comprehensive diagnosis and prediction of climate change and environment systems.

여성 난임을 위한 디지털 헬스케어 서비스의 지속적인 사용을 위한 사용자 경험 요구사항 분석

김나영(Na Young Kim),김도연(Do Yeon Kim),소지영(Ji Yong Soh),김수련(Su Ryeon Kim) 한국HCI학회 2023 한국HCI학회 학술대회 Vol.2023 No.2

난임자 및 난임 시술 횟수가 증가하고 있는 추세임에도 불구하고 난임에 특화된 디지털 헬스케어 서비스는 부재한 상황이다. 난임자들은 인지적, 신체적, 정신적 스트레스가 높은 상황에 노출되기 때문에 부하를 최소화할 수 있는 사용자 중심의 서비스와 그에 대한 사용자 경험 향상이 필요하다. 해당 연구에서는 기존 난임자들이 사용하고 있는 어플리케이션의 리뷰 데이터를 크롤링하여 난임서비스 기능과 사용성 관련 요인의 불만/만족사항을 분석하였으며, 심층 인터뷰를 통해서 난임자들의 요구사항을 확인하였다. 데이터 분석 결과, 정보적 측면과 관리적 측면의 기능에 대하여 주요 요구사항이 있었다. 그 이외에는 단축성과 탐색용이성을 바탕으로 직관적인 GUI 와 간편한 입력방식, 체계적이고 자세한 정보에 대한 의견이 있었다. 본 연구의 결과는 난임자들의 상황과 상태를 이해하는데 기초자료로 사용될 수 있으며, 난임디지털 헬스 서비스를 기획/개발함에 있어 도움이 될 수 있다.

Fuel 함량과 annealing time에 따른 용액공정 Indium-Gallium-Zinc-Oxide 반도체 박막트렌지스터의 전기적 특성 변화

김나영(Na-Young Kim),한정인(Jeong-In Han),김영훈(Yong-Hoon Kim) 대한전기학회 2012 대한전기학회 학술대회 논문집 Vol.2012 No.11

IPA 분석 기법을 활용한 농촌체험 방문객의 중요도-만족도 인식에 관한 연구

김나영(Na-Young Kim),김영택(Young-Taek Kim),조중현(Joong-Hyun Cho),김용근(Yong-Geun Kim) 한국농어촌관광학회 2010 농어촌관광연구 Vol.17 No.3

This study was to make an importance-satisfaction analysis of visitors of two selected rural villages in an attempt to find out their awareness of unique rural factors and their satisfaction level with the factors. One of the two selected villages was a folk village named Eoiamri, which was well equipped in terms of hardware. The other was a rural tourism village named Sinronri, which was just one of ordinary rural villages but tried to develop hands-on rural programs. First, there were marked differences in importance-satisfaction level according to the characteristics of the rural villages. Second, those who visited the rural tourism village viewed rural scenery as the most important factor of rural villages regardless of the characteristics of the villages. Third, improvement plans should be devised in light of the characteristics of rural tourism villages. The findings of the study suggested that there were gaps between the important factors stressed by the visitors and the factors that gave them satisfaction. Successful alternative plans should be prepared based on the findings of the study to address the needs of visitors to boost their satisfaction level with rural tourism villages.

심낭 삼출액 환자에서 Adenosine Deaminase를 근거로 한 항결핵 치료 결정의 적합성

김나영 ( Na Young Kim ),민지현 ( Ji Hyun Min ),안종화 ( Jong Hwa Ahn ),조상영 ( Sang Young Cho ),이은주 ( Eun Ju Lee ),황석재 ( Seok Jae Hwang ),박용휘 ( Yong Whi Park ),곽충환 ( Choong Hwan Kwak ),황진용 ( Jin Yong Hwang ),박정랑 대한내과학회 2012 대한내과학회지 Vol.82 No.4

Background/Aims: The prognostic impact of empirical anti-tuberculous management according to adenosine deaminase (ADA) levels in patients exhibiting pericardial effusion (PE) has not been established. We evaluated the appropriateness of ADA-guided anti-tuberculous medication for patients with PE. Methods: From 2001 to 2010, 47 patients with PE and who were diagnosed with either tuberculous pericarditis (TbP) or idiopathic pericarditis (IP) were enrolled. The diagnosis of definite TbP was made by the presence of Tb bacilli or caseous granuloma in pericardial tissue or effusion. The diagnosis of probable TbP was made by the presence of one or more of the following: (1) elevated ADA (≥ 40 IU/L) in pericardial fluid, (2) positive Tb interferon test, or (3) extracardiac presence of Tb. All clinical information was collected by medical record review and telephone contact. Results: Among the 47 patients with PE, 12 were diagnosed with definite TbP; 17, with probable TbP; and 18, with IP. The mean ADA level was significantly higher in patients with definite TbP than in patients with IP (74.97 ± 36.79 vs. 20.14 ± 7.39 IU/L; p < 0.001). The optimal ADA cutoff value for diagnosis of definite TbP was 64 IU/L. The median follow-up time was 12.1 months (range, 0.17-100 months). In patients with low levels of ADA (< 40 IU/L), the incidence of death or recurrence did not different between patients who were prescribed anti-tuberculous medication and those who were not. Conclusions: The ADA level in pericardial fluid was useful for making a rapid diagnosis of tuberculous pericarditis. Even in tuberculosis-endemic areas, patients with ADA < 40 IU/L may have a good prognosis without empirical anti-tuberculous treatment. (Korean J Med 2012;82:441-448)

한국인 만성음주자들에서 HCV 항체 양성률과 간손상 정도와의 상관관계에 관한 연구

김나영 ( Gim Na Yeong ),김안나 ( Kim An Na ),임선희 ( Im Seon Hui ),김성용 ( Kim Seong Yong ),임용성 ( Im Yong Seong ),이계회 ( Lee Gye Hoe ),박성훈 ( Park Seong Hun ),구명숙 ( Gu Myeong Sug ),최신은 ( Choe Sin Eun ) 대한내과학회 1993 대한내과학회지 Vol.44 No.5

연구배경 : 알콜성간질환에서의 간손상 정도는 일반적으로 알콜섭취 정도와 관계한다고 생각되고 있으나, 이들 만성음주자의 10∼20%에서만 심한 간손상 소견을 보여 알콜섭취 정도 외에 유전인자와 영양상태, 환경요인 및 B형 감염바이러스나 NANB형 간염바이러스와 같은 감염 요인이 관여하리라 추측되어 왔다. 최근 HCV 항체 측정이 가능케 됨에 따라 알콜성간질환에서의 HCV의 역할에 대한 연구가 점차 활발해지고 있으나, 우리나라에서는 아직 이에 대한 보고가 드문 실정이다. 방법 : 이에 저자들은 HBsAg음성이면서, 하루 80g 이상의 알콜을 5년 이상 마셔온 62명의 만성음주자들을 대상으로, HCV 항체 양성률을 알아보고, HCV 항체양성 여부와 이들에서의 간손상 정도와의 상관관계를 비교하였다. 결과 : 1) 우리나라 만성음주자에서의 HCV항체 양성률은 1405%였다. 2) 62명의 대상 환자를 임상소견 및 간조직검사소견에 근거한 간손상 정도에 따라 세군으로 분류하였을 때 간질환의 증거가 없거나 지방섬유화 소견처럼 경미한 간손상을 보인 군은 13명(21%)이었으며, 알콜성감염이나 알콜성간경변처럼 심한 간손상 소견을 보인 군은 36명(58%)이었다. 3) 경미한 간손상을 보인 군에서는 HCV 항체 양성이 1예도 없었고, 만성간염처럼 중간 정도의 간손상을 보인 13명 중에서는 1명이 양성으로 HCV 항체 양성률은 7.7%였으며, 알콜성감염이나 알콜성간경변처럼 심한 간손상을 보인 군에서는 36명 중 8명이 양성으로 22.2%의 HCV항체 양성률을 나타냈다. 4) 만성간염군에서 HCV 항체 양성환자의 bilirubin은 10.3㎎/dl로 HCV 항체 음성환자들의 1.6㎎/dl 보다 높았고, prothrombin time도 40%로 HCV 항체 음성환자들의 93.6%보다 매우 길어져 있었다. 알콜성감염이나 알콜성 간경변처럼 심한 간손상소견을 보인 군에서는 HCV 항체 양성환자들의 62.5%에서 황달 증상이 나타나 HCV 항체 음성환자들의 17.9%에 비해 높았고, HCV 항체 양성 환자군의 globulin은 3.9g/dl로 HCV 항체 음성환자의 3.1g/dl 보다 유의하게 높았다. 결론 : 만성음주자들에서 간손상 정도가 심할수록 HCV 항체 양성률이 높고, 동일한 간손상을 보인 군에서도 HCV 항체 양성환자들의 간기능 HCV 항체 음성환자들에 비해 나쁜 소견을 보였다는 이상의 결과는, HCV 간염이 만성음주자에서의 간손상에 하나의 요인으로 관여할 수 있음을 시사한다 하겠다. Backgrounds: It is generally accepted that development of liver disease in alcoholics is related to alcohol consumption. However, only 10~20% of alcoholics have severe liver disease, and therefore it has been suggests that other factors such as genetic, environmental, nutritional and infections factors including HBV and NANB virus, influence the presence of liver damage. As an assay for HCV antibody becomes available, it has been attracting a substantially increasing interst to study the influence of HCV upon alcoholic liver disease. But in Korea there are few reported studies in this area. Methods: To evaluate the prevalence of hepatitis C virus antibodies in chronic alcoholics and its relationship to the severity of liver disease in chronic alcoholics in Korea, anti-HCV was tested in sera from 62 HBsAg negative chronic alcoholics who had consumed more than 80 gm of ethanol daily for at least 5yr and anti-HCV positive rate was compared withe the severity of liver injury. Results: 1) The prevalence of anti-HCV in chronic alcoholics in Korea was 14.5%. 2) According to the severity of liver injury judged from clinical findings and histological features, alcoholics were divided into three group: normal or fibrosteatosis (13 patients), chronic hepatits (13 patients), alcoholic hepatitis or alcoholic cirrhosis (36 patients). The prevalence of anti-HCV is 0%in normal or fibrosteatosis, 7.7% in chronic hepatitis, and 22.2% in alcoholic hepatitis or alcoholic cirrhosis. 3) This patients positive for anti-HCV with chronic hepatitis showed higher serum bilirubin and longer prothrombin time than did patients negativefor anti-HCV. Moreover the patients with anti-HCV with alcoholic hepatitis or alcoholic corrhosis showed higher prevalence of jaundice and higher serum globulin level than patients negative for anti-HCV. Conclusions: The increased prevalence of anti-HCV in alcoholics with severe liver injury and the impaired liver function in patients with anti-HCV suggests that HCV may be involved in liver damages of somes chronic alcoholics.

Scenedesmus sp.로 부터의 지방 추출, 정제 및 특성

김나영(Na-Young Kim),오성호(Sung-Ho Oh),최운용(Woon Yong Choi),이현용(Hyeon-Yong Lee),이신영(Shin-Young Lee) 한국생물공학회 2010 KSBB Journal Vol.25 No.4

Lipid from Scenedesmus sp. was extracted, fractionated and purified by silicic acid column chromatography. Total lipid content of extract was 21.38 ± 1.03 wt%, and triacylglycerol, an index lipid for biodiesel production was detected. Ten species of C16∼C22 with saturated and unsaturated fatty acid were identified showing the very adequate fatty acid profiles for biodiesel production with a good flow property at low temperature. The fractions of glycolipid, neutral and phospholipid were 52.64, 28.10 and 19.26% of total lipid, respectively. The triacylglycerol of 12.63% and chlorophyll a of 49.47% was fractioned using stepwise elution of n-hexane-diethyl ether (95:5, v/v) solvent. The high content of chlorophyll was considered as a potential source of value-added co-product.

흰쥐에서 TNBS 로 유발된 염중성대장염의 병태생리에 관한 연구

김나영(Na Young Kim),김재준(Jae Jun Kim),송인성(In Sung Song),김정룡(Chung Yong Kim),김우호(Woo Ho Kim) 대한내과학회 1994 대한내과학회지 Vol.47 No.1

N/A Objectives: The etiology and pathogenesis of ulcerative colitis and Crohn's disease(inflammatory bowel disease (IBD)) are still unknown although intensive research has been carried out in this area. A major limitation to this area has been the relative paucity of relevant animal models. The aims of this study are, first to establish the appropriate animal model for studying for IBD, and second to find out the chemical mediators involving the pathophysiology of IBD. Method: In the first study for establishing an animal model of IBD, 1 ml of 4% acetic acid was instilled into the lumen of the colon of 8 rats, and 1.2 ml of trinitrobenzene sulfonic acid (TNBS, 25 mg/ml) m 50%(v/v) ethanol was instilled into the lumen of the colon of the 16 rats; on the other hand, 1.2 ml of phosphate buffered saline (PBS) was instilled into the lumen of the colon of the 4 control rats. The gross and microscopic finding of the colon was observed 4Shrs, 1wk, 2wks, 4wks later after the instillation of each material. In the second study, PG₂, LTB₄ and specific activities of superoxide dismutase (SOD), catalase, xanthine oxidase were measured in the colon mucosa of 29 rats 48hrs, 2wks, 4wks after the instillation of 1.2 ml of TNBS (25 mg/ml) in 50% ethanol (v/v), and in the mucosa of 10 control rats 4wks after the instillation of 1.2 ml of FBS. Results: 1) In the first study the gross finding of the control group was all normal, and the acetic acid group showed mild focal hyperemia in 48hrs, 1wk, 2wks after instillation. On the other hand, the TNBS group of 48hrs showed black necrosis up to 7 cm from the anal verge in all 4 rats, in the TNBS group of 1wk, 1-1.5 cm sized active ulcerations, in the group of 2wks, 0.2-1 cm sized shallow ulcerations were scattered, and in the group of 4wks, healing to scar stage ulcerations were found. 2) The microscapic finding of the control group was all normal, and the 4% acetic acid group of 48hrs and 1wk showed infiltration of acute inflammatory cells; all rats of 48hrs and 1wk groups showed infiltration of acute inflammatory cells; all rats of 2wk and 4wk groups showed normal finding except mucosal ulceration in the one rat of two after 2wks. On the other hand, all of the 4 rats of 48hr TNBS group showed very severe acute inflammation, which resolved with appearance of chronic inflammation around the deep ulcer in 1wk later. Two weeks later, chronic inflammation became prominent, and 4wks later, chronic inflammation further progressed with fibrosis. 3) In the second study for studying pathophysiology of IBD caused by TNBS, the mean PGE₂ level of the control group was 289.9 pg/mg mucosa, and that of 4Shr TNBS group was 382.2 pg/mg mucosa without statistical significance. The mean PGE₂ level of 2wk and 4wk TNBS groups were 650.4 pg/mg mucosa and 710.4 pg/ mg mucosa, respectively, which were significantly higher than that of the control group. 4) The mean LTB₄ level of the control group was 4.4 pg/mg mucosa, and those of 48hr, 2wk, 4wk TNBS groups were 44.6 pg/mg mucosa, 106.6 pg/mg mucosa, and 52.8 pg/mg mucosa, respectively, which were all significantly higher than that of the control group. 5) The Cu, Zn SOD activity of the 48hr TNBS group was 0.47 unit/mg protein and this was significantly lower than that of control group, 9.37 unit/mg protein. Those of 2wk and 4wk TNBS groups were 1.84 unit/mg protein and 5.85 unit/mg protein, respectively. The Mn SOD activity of contro1 group was 0.79 unit/mg protein, and that of 48hr TNBS group was 0.57 unit/mg protein without statistical significance. However, those of 2wk and 4wk TNBS groups were 5.58 unit/mg protein and 3.69 unit/mg protein, respectively, which were significantly higher than that of the control group. 6) The catalase activity of the 4Shr TNBS group was 1.32 unit/mg protein and this was significantly lower than that of control group, 2.95 unit/mg protein. Those of 2wk and 4wk TNBS groups were 2.08 unit/mg protein and 2.52 unit/mg protein, and they had no

『日本書紀』神代卷에 보이는 助數詞고찰-神을 헤아리는 助數詞를 중심으로-

金娜瑩(Kim Na-Yong) 대한일어일문학회 2021 일어일문학 Vol.92 No.-

본 연구는 현존하는 일본 최초의 정사(正史)인 『日本書紀』(720년)의 신대권(神代卷)에 보이는 조수사를 조사하고 사용법에 대해 분석하는 것을 목적으로 하고 있다. 『日本書紀』의 신대권에서는 신화(神話)에 대해 중점적으로 다루고 있어 인대권(人代巻)의 기록 방식과는 차이가 있으며, 조수사의 사용에 있어서도 相異한 부분이 보인다. 『日本書紀』신대권에 보이는 조수사에 대해서 살펴본 결과, 신을 헤아리는 조수사에 있어서는 「神」「人」「箇」「頭」「座」로 다양하게 공용되고 있으나, 용법에 있어서는 차이가 있음을 알 수 있었다. 즉, 「神」은 천신(天神), 황조(皇祖) 등 특정되지 않았거나 일본 역사의 신화 속에서 최상위 계급에 속하는 신들과 그러한 신들을 직접적으로 수호하는 신들을 헤아리는 용법으로 사용되었으며, 「人」은 天孫(천손)의 지배를 받는 신분이 낮은 신과 國神(국신)을 헤아리는 용법으로 사용되었다. 「箇」는 아직은 어리거나 버림받은 아이로서의 신을 헤아리는 용법으로 사용되었으며, 「頭」는 天孫(천손)이 다스리는 나라의 일반 백성을 헤아리는 용법으로 사용되었다. 「座」는 국토를 다스리는 아이로서의 신을 헤아리는 용법으로 사용되어 신들의 신분과 존재하는 위치에 따라서 구별 사용되었음을 추정할 수 있다. The purpose of this study is to investigate the numeral classifiers found in the 「神代卷(Jindainomak i)」of 『日本書紀(Nihonshoki)』(720), the first official history of Japan, and to analyze their usage. The 「神代卷(Jindainomaki)」of 『日本書紀(Nihonshoki)』mainly deals with myths, and its writing style differs from the main text. Therefore, it is necessary to examine them differently from the main text, which is also the case with numeral classifiers. Upon studying the auxiliary numerals found in the 「神代卷(Jindainomaki)」of 『日本書紀(Nihonshok i)』, diverse numeral classifiers are used to count gods, such as 「神」, 「人」, 「箇」, 「頭」, and 「座」but with different usages. To be more specific, 「神」is used to count unspecified gods such as 「天神(Tenjin)」or 「皇祖(Emperor)」, or gods of the highest rank in Japanese mythology, or gods guarding them, while 「人」is used to count 「國神(national gods)」and gods of the lower ranks governed by 「天孫(Tengrandchildren)」. 「箇」is used to count gods who are still young or abandoned, and 「頭」is used to count ordinary subjects of a country ruled by 「天孫(Tengrandchildren)」. Lastly, 「座」is used to count gods as children governing the land. The findings suggest that different numerals were used to classify and distinguish gods by status and hierarchy.