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골격근 세포에서 ATP-의존성 $K^+$통로의 활성화가 근피로에 미치는 영향
구현모,남기원,김석범,이선민,김진상,Koo Hyun-Mo,Nam Ki-Won,Kim Suck-Bum,Lee Sun-Min,Kim Jin-Sang 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.2
Excitation-contraction coupling in skeletal muscle is process by which depolarization of the muscle fiber membrane, elicited by a nerve action potential, triggers the release of $Ca^{2+}$ from the sarcoplasmic reticulum(SR). The resulting rise in intracellular $Ca^{2+}$ concentration$([Ca^{2+}]_i)$ activates the troponin complex, thereby initiating the contraction of the muscle. The question remains as to what factors are involved in the inhibition of SR $Ca^{2+}$ release in fatigued muscle. The purpose of this study was determine whether ATP-sensitive $K^+(K_{ATP})$ channels are activated and contribute to decrease in $[Ca^{2+}]_i$ during fatigue development in the mouse skeletal muscle. To elucidate a role of $K_{ATP})$ in relation to ECC, I measured the modulation effects of $K_{ATP})$ channel blocker(glibenclamide) and opener(pinacidil) on $[Ca^{2+}]_i$ after fatiguing electrical field stimulation(FEFS). Intracellular $Ca^{2+}$ signals were recorded by conforcal laser microscopy(LSM 410) and monitored using the fluorescent $Ca^{2+}$-Sensitive indicator Fluo-3 AM. The results of this study were as followed: 1. The relative [Ca2'li after FEFS in the pre-glibenclamide-treated group was higher than the control. And relative $[Ca^{2+}]_i$ after FEFS in the pre-glibenclamide-treated group was lower than the control. 2. The relative $[Ca^{2+}]_i$ after FEFS for 3 min in the control, pre-glibenclamide-treated group and pre-pinacidil-treated group showed a similar pattern; the gradually significant decrease in $[Ca^{2+}]_i$. But, these decreasing pattern was most significant in the control. These findings suggest a tight relationship between $K_{ATP})$ and $Ca^{2+}$ in ECC during fatigue. Therefore, 1 thought that activation of $K_{ATP})$ channels may be one of mechanisms of the fatigue in skeletal muscle.
골격근 수축에 있어서 근장그물로부터의 Ca$^{2+}$ 유리 기전에 대한 고찰
구현모,김진상,Koo, Hyun-Mo,Kim, Jin-Sang 대한물리치료학회 2001 대한물리치료학회지 Vol.13 No.1
Skeletal muscle cells are activated by ${\alpha}$-motorneurons which release acetylcholine at the neuromuscular junction. This results in a local depolarization of surface membrane which triggers an action potential. The action potential propagates along the surface membrane and also into the T-tubule system. In the triads T-tubules are in close connection with the terminal cisternae of the sarcoplasmic reticulum(SR). The action potential activaies T-tubule voltage sensors(DHP receptors). which activates SR Ca$^{2+}$ release channels(ryanodinc receptors). Ca$^{2+}$ have a key role in skeletal muscle in that an increase of free myoplasmic Ca$^{2+}$ concentration. The process of coupling chemical and electrical signals at the cell surface to the intracellular release of Ca$^{2+}$and ultimate contraction of muscle fibers is termed excitation-contraction coupling(ECC). Coupling of cel1 surface signals to intracellular Ca$^{2+}$ release proceeds by several mechanisms in skeletal muscle cells. This review focus on sarcopiasmic reticulum(SR) Ca$^{2+}$ releasing mechanisms from sarcoplasmic reticulum in the skeletal muscle. The mechanisms include DCCR, CICR, and HCR.
흰쥐의 피부화상 후 저강도 레이저 조사가 Substance P의 발현에 미치는 영향
구현모,이선민,남기원,김석범,천송희,강종호,김진상,Koo Hyun-Mo,Lee Sun-Min,Nam Ki-Won,Kim Souk-Boum,Cheon Song-Hee,Kang Jong-Ho,Kim Jin-Sang 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.3
This study was performed to investigate the effect of low power laser irradiation on Substance P(SP) expression in the burned skin of the rats. Burns of about 3cm in diameter were created with $75^{\cric}C$ water on the back of the rats, and the lesion of experimental group were irradiated on days 1, 2, 3 and 4 postwounding. Control leasions were not irradiated. After burns, low power laser irradiation was applied by using 1000Hz, 830nm GaAlAs(Gallium-aluminum-arsenide) semiconductor diode laser. The expression of evaluated Substance P(SP) immunohistochemistry on rabbit anti-SP The results of this study wereas follows 1. The Substance P was expressed in the lamina I and II of dorsal horn of spinal cord. In expression of SP, the lesion of control group made SP to more induce significantly than experimental leasions. 2. SP immunoreactivity in burned leasion of spinal cord were decreased markedly 4 days after burns, and decreased gradually from 1 day to 2 days in burns which is laser irradiation These data suggest that low power laser have a pain release effect in the burned skin of the rats.
구현모,남기원,김진상,Koo Hyun-Mo,Nam Ki-Won,Kim Jin-sang 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.4
A role for ATP in nociception and pain induction was proposed. ATP-gated P2X ion channel receptors are localized throughout the nervous system and have been identified on neurons which participate in conduction of nociceptive information from the periphery to central nervous system. We consider the role of ATP as a peripheral activator of nociceptive sensory neuron via ATP-gated ion channels.
일부 재활관련 전문가의 업무 스트레스와 주관적 삶의 질의 관계 연구 - 물리치료사와 작업치료사 중심으로-
구현모 ( Hyun-mo Koo ),이인희 ( In-hee Lee ) 대한물리치료학회 2010 대한물리치료학회지 Vol.22 No.2
Purpose: The purpose of this study was to investigate the relationship between subjective quality of life and job stress with regard to general characteristics and health characteristics of physical therapists (PTs) and occupational therapists (OTs). Methods: The study involved administering questionnaires to 93 PTs and OTs who worked in urban medical institutions between November 2009 and October 2009. A questionnaire (KvSBQOL) developed by Dunbar and colleagues and translated into Korean version by Yoon et al was used for measuring subjective quality of life. A questionnaire developed by Kim was used for measuring job stress. Results: Among PTs and OTs, the mean quality of life score was 3.10 points and the mean level of job stress was 3.42. Female PTs and OTs had significantly greater levels of job stress. Those PTs and OTs in the `Lowest pay` group and in the `Associated Degree` group reported the lowest quality of life. Those in the `Very healthy` group of PTs and OTs had significantly lower job stress than the other groups. The group with the highest job stress had the lowest quality of life. A limitation of this study was that all data was self-reported and subject to associated bias. Conclusion: To prevent loss of business services by PTs and OTs, it is important to know how job stress affects quality of life. Our findings suggest that a reduction in job stress can improve quality of life among PTs and OTs.
흰쥐의 관절연골에서 맥동전자장과 맥동초음파가 HSP70의 과발현을 통한 연골형성에 미치는 영향
구현모 ( Hyun Mo Koo ) 대한물리의학회 2013 대한물리의학회지 Vol.8 No.1
연구목적: 본 연구는 흰쥐를 대상으로 정강뼈의 관절 연골에 적용한 맥동전자장과 맥동초음파가 HSP70(Heat shock protein 70)의 발현을 통한 연골 형성에 미치는 영향을 알아보고자 실시하였다. 연구방법: 36마리의 200∼250g의 Sprague-Dawley 흰쥐를 대조군, 맥동전자장 적용군, 맥동초음파 적용군으로 각 집단별로 12마리씩 무작위 배정하여 실험을 진행 하였다. 맥동전자장은 27.12 MHz의 주파수, 5가우스의 강도, 450 W의 출력으로 10분간 적용하였고, 맥동초음파는 20%의 맥동비, 1MHz의 주파수, 1.5 W/cm2의 강도로 10분간 적용하였다. 연구결과: 맥동전자장 적용군과 맥동초음파 적용군의 관절연골 조직에서 유의한 수준의 HSP70 발현량을 나타냈다. 또한 맥동전자장 적용군과 맥동초음파 적용군에서는 Akt, Erk1, CREB의 높은 활성도를 나타내었고, 맥동초음파 적용군에 비해서 맥동전자장 적용군의 더 높은 수준의 활성도를 보였다. 결론: 맥동전자장과 맥동초음파는 HSP70의 과발현을 유발하고, 이를 통해 연골형성을 증가시키는 것으로 나타나, 향후 관절연골의 손상에 대한 임상적 적용을 위한 추가적인 연구가 진행되어야 할 것으로 생각된다.
구현모 ( Hyun Mo Koo ) 대한물리의학회 2012 대한물리의학회지 Vol.7 No.1
Purpose:The purpose of this study was to examine the gait parameter and plantar foot pressure of adults with Down syndrome(DS) during walking in order to provide data for developing evidence-based deficit or common rehabilitation strategies. Method:15 participants with DS(12 men, 3 women; age 26.06±4.47) and 15 healthy subjects(12 men, 3 women; age 25.33±3.43) were matched age. They walked at self selected speeds on a GAITRite system and RS-scan system, and had the following measurements done: cadence, stride length, step width, foot angle, percent stance, percent double support, and plantar foot pressure in 10 areas of the foot. Results:In comparison of gait parameter(cadence, stride length, step width, foot angle, percent stance, and percent double support) between adults with DS and healthy subjects, there was significant differences(p<.05). Regarding plantar foot pressure during gait with or without DS, there were statisically significant differences in the area of Toes 1-5, Metatasal 1-4, Midfoot, and Heel(Medial and lateral)(p<.05). Conclusion:Our data show that DS walk with a less physiolosical gait pattern and plantar foot pressure than healthy subjects. Based on our results, DS patients need targeted rehabilitation and exercise strategies.