임상 지표들을 이용한 생체 나이 추정

배철영(Chul-Young Bae),강영곤(Young-Gon Kang),김세현(Se-Hyun Kim) 대한임상노인의학회 2006 대한임상노인의학회지 Vol.7 No.2

연구 배경: 임상에서 쉽게 측정할 수 있는 임상 지표들과 연대적 연령과의 연관성을 알아보고자 하였다. 또한 임상 지표들을 신체, 생화학 및 호르몬 지표로 구분하여 생체 나이 추정에 있어 미치는 영향과 이에 따른 최적의 생체 나이 모델을 개발하고자 하였다. 방법: 경기도 소재 모 대학병원 건강 증진 센터에서 1999년 1월부터 2003년 12월까지 일반 종합 건진을 시행한, 40세 이상 남녀 3,574명(남자는 1,301명, 여성은 2,273명, 연령범위: 40~88세)을 대상으로 신체, 생화학, 호르몬 임상 지표들을 검사하였다. 각 임상 지표들과 연령과의 상관 관계를 조사하였고 다중 회귀 분석을 통하여 전체 및 각각의 생체 나이 모델을 추정하였다. 결과: 남성의 전체, 신체, 생화학, 및 호르몬 임상 지표들에 따른 최적의 생체 나이 모델에는 각각 15, 7, 5, 4개의 변수가 포함되었고(R²'s= 0.62, 0.38, 0.33, 0.36). 여성에서는 각각 14, 6, 8, 3개의 변수가 포함되었다(R²'s= 0.66, 0.40, 0.42, 0.37). 결론: 본 연구에서 제시된 생체 나이 모델은 임상에서 쉽게 시행할 수 있는 검사 혹은 일반 종합 건진의 검사 결과를 이용하여 객관적인 생체 나이 추정이 가능하기에 개인의 노화 정도와 건강상태를 추정하는 임상 보조 수단으로 사용될 수 있을 것으로 생각된다. Background: Biological age is the objective assessment of a person's health status and may be used to investigate individual variation of organs and functions during aging. To determine biological age in clinical practice settings, we developed models for predicting biological age of individuals by employing all parameters of physical, biochemical, and hormonal characteristics. Methods: This was a community based cross-sectional study. Subjects were recruited from the health promotion center at one community hospital in Korea from 1999 to 2003. Among these, data obtained from the 3,575 participants (1,302 men and 2,273 women) was used for clinical evaluation and statistical analysis. For our test battery we selected twenty-five parameters among the routine tests that are conducted in annual health check-ups. Results: For males, the best models were developed using 15-, 7-, 5-, 4- of the 25 chosen parameters for total, physical, biochemical and hormonal characteristics, respectively (R²'s= 0.62, 0.38, 0.33, 0.36). Similar to males, for the females, 14-, 6-, 8-, 3-paramaters were developed as the models for total, physical, biochemical, and hormonal characteristics, respectively (R²'s= 0.66, 0.40, 0.42, 0.37). Conclusion: Our biological age prediction models may be useful as supplementary tools in the evaluation of aging and health status. A profile of physical, biochemical, and hormonal parameters selected in the prediction model are feasible to be used in annual health check-up or in the clinical practice.

임상 생체지표를 이용한 오장생체나이 추정 모델

김태희 ( Tae-hee Kim ),김석 ( Seok Kim ),배철영 ( Chul-young Bae ),강영곤 ( Young-gon Kang ),조경희 ( Kyung-hee Cho ),권수경 ( Su-kyung Kwon ),박미화 ( Mei-hua Park ) 대한한의진단학회 2011 大韓韓醫診斷學會誌 Vol.15 No.2

Objectives Even though there has been no consensus on the concept of viscera organ between the oriental and western medicine, we tried to investigate the correlation between clinical biomarkers of five Jang and chronological age and develop the models for predicting five Jang biological ages by statistical analysis. Methods We obtained data from about 120,000 subjects who visited health promotion centers for health promotion and disease prevention from January 2004 to June 2009. Participants were included if they were over 20 years old, and excluded if reported to have cardiovascular disease or other serious medical illness such as cancer, malignant hypertension, uncontrolled diabetes, cardiopulmonary insufficiency, liver disease, pancreatic disease or renal disease. Among the clinical biomarkers obtained, we selected the biomarkers which were associated with the function of 5 Jang in previous studies, or showed statistically significant correlation with age. Multiple regression models were used for building prediction models of biological age after adjusting for potential confounders for men and women, respectively. Pearson correlation coefficient was calculated to examine the linear relationship between age and various biomarkers, and multiple regression analysis was used for building the prediction models of five Jang biological ages for men and women, respectively. All statistical data analysis was performed by using SPSS Version 12.0 software and statistical significance was obtained if p<0.05. Results For males, the best models were developed using 12, 2, 8, 3, and 4 biomarkers for predicting biological ages of heart, lung, liver, pancreas, and kidney, respectively (R2 = 0.57, 0.43, 0.11, 0.24, and 0.93, respectively). Similar to males, for the females, 10, 2, 8, 3, and 4 biomarkers were selected as the models respectively (R2 = 0.76, 0.44, 0.14, 0.38, and 0.89, respectively). Conclusions As we have developed for the first time the models for predicting five Jang biological ages with common clinical biomarkers, it is expected that these models may be used as clinical supplementary tools in the evaluation of aging status and functional decline of five Jang according to age in health promotion centers and private clinics. At the same time, it is considered that the use as objective tools to evaluate aging status and functional decline of each Jang.

척추 압박 골절의 임상 양상 및 노인 기능에 미치는 영향

박경채(Park Kyung Chae),김소림(Kim So Lim),강영곤(Kang Young Gon),신경균(Shin Kyung Kyun),김문종(Kim Moon Jong),이영진(Lee Young Jin),배철영(Bae Chul Young) 대한임상노인의학회 2002 대한임상노인의학회지 Vol.3 No.3

연구배경 : 척추 압박 골절은 노인에 있어 신체적, 정서적 활동 및 일상 생활에 제한을 가져올 수 있다. 국내에서는 아직까지 척추 압박 골절이 신체적, 정서적 활동 및 일상 생활에 어떠한 영향을 미치는지에 대한 연구는 아직까지 미흡한 실정이다. 이에 본 연구에서는 척추 압박 골절의 임상 양상과 노인 기능에 미치는 영향을 알아보고자 하였다. 연구방법 : 1995년 9월부터 1999년 6월까지 분당의 모 대학병원 가정의학과에 입원한 60세 이상의 환자들 중에서 과거 척추 압박 골절로 진단된 68명을 대상으로 척추 압박 골절의 부위와 골절수, 요통유무, 골대사율(골흡수율, 골생성율) 및 골밀도를 조사하였다. 신체 기능 평가를 위하여 일상 생활 동작 수행 능력(ADL)과 도구적 생활 동작 수행 능력(IADL) 및 노인 우울 척도(GDS)를 평가하였고, 척추 압박 골절과의 관계를 분석하였다. 결과 : 연구 대상군의 평균 연령은 74.16(±6.88)세였고, 68명중 여자가 62명(91.2%)이었다. 낙상의 병력이 있는 경우가 77.8%, 요통이 있는 경우는 71.2% 이었으며, 휠체어와 지팡이를 사용하는 경우가 각각 6.1%, 12.2%였다. 평균 척추 압박 골절수는 2.63(±0.29)개였으며 척추 압박 골절이 가장 많은 부위는 제1요추였으며 다음으로 많은 부위는 제 12 흉추였다. 척추 압박 골절수의 증가에 따라서 골밀도가 감소하였으나 통계학적 의의는 없었고(age adjusted, r= -0.179, p=0.239) 동통에 따른 척추 압박 골절 수의 유의한 차이를 보였으나(P<.01) 다발성 척추 압박 골절군(2개 이상)과 1개의 척추 압박 골절 군에 따른 일상 생활 동작 수행 능력, 도구적 생활 동작 수행 능력 및 우울 정도와의 차이는 없었다(P>.05). 결론 : 척추 압박 골절수에 따른 기능의 유의한 차이는 없었으나 동통에 따른 척추 압박 골절수의 유의한 차이를 보였다. 따라서 고위험군이나 이미 척추 압박 골절이 있는 대상자들에서 이에 대한 진단 및 예방을 위한 적극적인 노력이 필요함을 제시한다. Background : Vertebral compression fractures cause the limitation of physical, emotional, and daily living activity in elderly persons. There is no work that evaluates the effects of vertebral compression fractures on the physical, emotional, and daily living activity among Korean elderly patients. Thus, we undertook this study to learn about the clinical consequences and the functional impairment among elderly persons with vertebral compression fractures. Methods : The 68 patients over 60 years of age who had vertebral comperssion fractures documented in their medical records and admitted to the department of family medicine, Pundang CHA general hospital from September 1995 to June 1999 were enrolled in this study. We reviewed their medical records and investigated the site and the number of vertebral compression fractures, the presence of the associated pain, bone turnover markers and bone mineral density(BMD). The Katz Activities of Daily Living Scale(ADL) and Instrumental Activities of Daily Living Scale(IADL) were used to asses the patient's physical function, and Geriatric depression scale(GDS) was used to asses the patient's depression. Results: 62 women and 6 men comprised the study population. Their mean(±SD) age was 74.16(±6.88) years. 77.8%, 71.2%, 6.1%, and 12.2% of the patients had documented the past medical history of fall, back pain, use of wheel chair and cane, respectively. The mean number of vertebral compression fractures was 2.63(±0.29). Vertebral compression fractures were most commonly located in the L1 and Tl2 spines in sequence. The number of vertebral compression fracture was negatively correlated with BMD, but there was no significance(age adjusted, r=-0.179, p=0.239). There showed no difference of ADL, IADL, and GDS between single fracture and multiple fractures groups(p>.05). Conclusions : These data showed that the most common sites of vertebral compression fracture were LI and Tl2 spine. And there was no significant difference of functional status between single fracture and multiple fractures groups. But, significant difference of the number of vertebral compression fracture between the two groups who had or dindn't have back pain was noted in this study population.

노인에게 흔한 숨겨진 질환이 빈도

강영곤,원정문,배철영,이호택,이석기,이영진 대한가정의학회 1998 Korean Journal of Family Medicine Vol.19 No.10

폐경 후 여성의 악력과 골밀도와의 연관성

김곤,이정호,이석기,강영곤,이호택,이영진,배철영 대한가정의학회 2000 Korean Journal of Family Medicine Vol.21 No.4

중년 남성에서 요골 골밀도와 악력과의 관련성

최영아,박인숙,김문종,김경진,강영곤,이호택,이영진,배철영 대한가정의학회 2001 Korean Journal of Family Medicine Vol.22 No.10

노인들의 우울성향과 관련요인

원정문,강영곤,배철영,이호택,이석기,이영진 대한가정의학회 1998 Korean Journal of Family Medicine Vol.19 No.1

중년 남성에서 총테스토스테론과 혈중 지질의 관계

박인숙,최영아,김문종,이상현,강영곤,이호택,이영진,배철영 대한가정의학회 2001 Korean Journal of Family Medicine Vol.22 No.7

Alzheimer's Disease Assessment Scale과 MMSE-K 및 기타 노인기능 평가도구들 간의 상관관계

이석기,이호택,김영동,박경채,강영곤,이영진,배철영 대한가정의학회 2000 Korean Journal of Family Medicine Vol.21 No.7