Apolipoprotein E 다형성에 따른 사업장 근로자의 혈중 지질농도, 영양소 섭취 및 건강관련 생활습관

박유경,조상운,강지연,백윤미,성숙희,최태인 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.5

The purpose of this study was to investigate the association among nutrient intakes and health-related lifestyles with cardiovascular disease risk assessed by blood lipid profile according to Apolipoprotein E genotypes. Middle-aged industrial male workers who had completed their annual medical examination were recruited and data of 675 subjects who finished the nutrient survey were used in the analysis. Anthropometric parameters, dietary assessment (FFQ), health-related lifestyles and blood profiles were used for statistical analyses. Apo E genotype groups were classified into the following three genotypes: Apo E2 group (including E2/E2, E2/E3, E2/E4), Apo E3 group (including E3/E3), Apo E4 group (including E3/E4, E4/E4). The frequency of Apo E2, E3, and E4 allele were 13.3%, 75.0% and 11.7% respectively. There were no significant differences in the anthropometric parameters depending on different Apo E genotypes. Also, no significant differences in the nutrient intakes were found according to the genotype groups. The nutrient intakes of all subjects were similar to or higher than the level of KDRIs (Dietary Reference Intakes For Koreans) except for intakes of calcium (67.44% of KDRIs), vitamin A (73.83% of KDRIs) and vitamin B2 (78.02% of KDRIs). Also, there were no significant differences of health-related lifestyles according to Apo E genotype groups. As for the lipid profiles, Apo E4 group had significantly higher total and LDL-cholesterol concentrations than the Apo E2 group (p < 0.05). We confirmed that plasma total and LDL-cholesterol concentrations were greatly influenced by Apo E genotypes. However, nutrient intakes and health-related lifestyles were not associated with Apo E genotypes.

내압 및 수직하중 작용시 Radial Tire Sidewall부 변형의 시간에 따른 변화 연구

성경진,박인정,유현승,김두만 한국 항공대학교 항공산업기술연구소 2001 航空宇宙産業技術硏究所 硏究誌 Vol.11 No.-

본 연구에서는 타이어 sidewall부에 대한 내압 및 수직하중 그리고 시간에 따른 변형율 변화를 strain gage를 사용하여 측정하였다. 결과적으로 타이어에 최초 내압 작용 후 24시간이 지나면서 타이어의 strain 값이 안정되는 것을 확인하였으며 수직하중에 대한 실험 수행 시 1시간 이상 지난 후에 측정해야 하중작용 실험의 영향이 나타나지 않는 것을 확인하였다. 이로서 Strain gage를 이용한 실험 및 해석의 기반을 마련하였다. In this paper, variation of the strain on the radial tire sidewall with inflation pressure and vertical loading has been measured with respect to the time by experiment of method. As a result, the strain was stable after 24 hours, and vertical loading test must be done after I hour later from the prior loading test. The experiment was conducted to verify the deformation behavior experiment analyze method using strain gage. So the basis for the experiment and analysis of sidewall strain was established.

창원지역에서의 대기오염물질 배출량 산정

김유근,박상철,문윤섭,오인보,황미경 부산대학교 환경문제연구소 2002 環境硏究報 Vol.20 No.-

Emissions of air pollutants (TSP, SO2, NO2, CO, and HC) was estimated in Changwon city that has the industrial complex and basin terrain. We found that the emissions of TSP, SO2, NO2, CO, and HC were 897 tons, 3,287 tons, 5,706 tons, 10,057 tons, and 1,470 tons for a year, respectively and the main source of air pollutants were vehicle. The ratios of vehicle emissions to total emissions ware TSP 63.8%, SO2 26.1%, NO2 65.5%, CO 91.0%, HC 94.4%. The ratios of industry emissions to total emissions were TSP 30.8%, SO2 60.2%, NO2 25.2%, CO 6.4%, HC 3.7%. The ratio of life emissions to total emissions are TSP 5.4%, SO2 13.7%, NO2 9.3%, CO 2.6%, HC 1.9%. The concentration distributions of air pollutants simulated by ISCST3 model were similar to its emission distributions, and relatively high concentrations of air pollutants occurred in the Palyong-dong (industrial area) and Banlim and Chungang (residual area).

안전한 이동 에이전트를 위한 게이트웨이의 설계

元裕獻,朴宰卿,朴宰必 弘益大學校 科學技術硏究所 2001 科學技術硏究論文集 Vol.12 No.-

In the course of Internet proliferation, many network-related technologies are examined for possible growth and evolution. The use of Internet-based technologies in private networks has further fuelled the demand for network-based applications. The most promising among the new paradigms is use of mobile agents. The mobile agent is capable of migrating autonomously from node to node in the network, to perform some computation on behalf of the user. The mobile agent paradigm is attractive alternative to traditional client-server programming for a significant class of network-centric applications. It also however, suffers from a major drawback, namely, the potential for malicious attacks, abuse of resources pilfering of information, and other security issues. These issues are significantly hampering the acceptance of the mobile-agent paradigm. This paper describe the design & implementation of secure mobile agent gateway that split and merge the agent code with security policy database. This mechanism will promote the security in mobile agent systems and mobile agent itself.

지대치 재료의 환경변화에 따른 물리적 성질에 관한 연구

황유숙,최경규,박상진 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.2

The purpose of this study was to measure the flexural strength and hardness of four core materials in 4 different medias and to evaluate the relationship between the physical properties. For the flexural strength, the specimens were prepared from each of the following materials: Bisfil Core, Core Max, Fuji IX GP, Miracle Mix and randomly divided into four groups and stored at 37 degree C in the following medias: distilled water for 24 hours (DW/1), distilled water for 30 days (DW/30). 2%NaF for 30 days (NF/30), 0.02N lactic acid for 30 days (LA/30). After storage, the specimens were subjected to flexural strength testing and calculated to flexural modulus. For hardness testing, specimens were prepared from four materials and storaged in the uniform way. After storage, the specimens were subjected to Vicker's hardness testing. 1. The flexural strength of Core Max were the highest, and the flexural strength of Miracle Mix were the lowest. 2. The hardness of Bisfil Core were the highest. 3. The hardness of Core Max were the highest. 4. The hardness of Miracle Mix were the lowest. 5. 2%NaF and 0.02N lactic acid negatively affected the flexural strength and hardness of four core materials. 비금속 지대치 재료의 구강 내 환경변화에 따른 물리적 성질을 구명하기 위하여 4종의 지대치 재료를 다양한 환경에 보관한 후 굴곡강도 및 표면경도의 변화를 관찰하여 조건에 따른 영향을 구명하고자 이 연구를 시행하였다. Bisfil Core, Core Max, Fuji IX GP, Miracle Mix를 사용하여 굴곡강도 측정을 위한 시편을 제작한 후 최대하중을 측정하여 굴곡강도와 굴곡탄성계수를 계산하였다. 표면경도 측정을 위하여 아크릴릭 레진블럭에 상기 4종의 재료를 충전하여 중합시킨 후 순차 연마하여 경도측정을 위한 시편을 제작하고 Vickers hardness를 계산하였다. 1. 굴곡강도는 Core Max에서 가장 높고 Miracle Mix에서 가장 낮았다. 2. 37℃ 증류수에 24시간 보관한 군에서 Bisfil Core가 경도가 가장 높았다. 3. 30일 저장군에서는 Core Max가 경도가 가장 높았다. 4. 모든 군에서 Miracle Mix가 가장 낮은 경도를 나타냈다. 5. 2% NaF용액과 0.02N lactic acid용액은 증류수보다 지대치 재료의 굴곡강도와 표면경도를 저하시켰다.

치료용 방사선의 입사각에 따른 광섬유 방사선량계의 체렌코프 빛 측정 및 분석

장경원,조동현,유욱재,신상훈,서정기,이봉수,박병기,문주현 제주대학교 방사선응용과학연구소 2008 방사선응용과학연구소논문집 Vol.22 No.-

In this study, we have measured scintillating light generated in a fiber-optic dosimeter by high energy photon and electron beams using a charge-coupled device. The intensity of Cerenkov lights are also measured and characterized as functions of incident angles and energies of the high energy beams from a clinical linear accelerator. To minimize or remove Cerenkov light, a simple subtraction method using a background optical fiber and wavelength discrimination method using optical filters are investigated. Also, the intensities of Cerenkov light induced by high energy photon and electron beams are compared.

국내 살모넬라 분리주에서 spvR 유전자 분포와 단일 뉴클레오티드 다형 연구

권혁준,박경윤,박주연,박용호,김선중,유한상 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 지금까지 병원성 살모넬라를 확인하기 위해 분자량이 큰 플라스미드의 존재 유무를 확인하여 왔으나 살모넬라 혈청형 및 검출 방법에 따라 양성율에 큰 차이를 보이고 있고, 일부 병원성 살모넬라 분리주에서 병원성 플라스미드가 관찰되지 않아 spv 유전자들의 유무에 대한 아른 확인방법이 필요하다. 본 실험은 국내 동물 유래 주요 살모넬라 혈청형에서 spvR 유전자의 분포를 알아보고, 병원성 살모넬라 분자진단을 위한 분자표지로써의 가치를 평가하기 위해 실행하였다. 재료 및 방법 : 국내 가축 유래 S. lyphimurium (ST, 26주), S. enteritidis (SE, 10주), S. pullorum (SP, 40주), S. gallinarum (SG, 53주)에 대해 GenBank에 등록된 ST, SE, SP의 spvR 유전자를 비교하여 ST와 SE 간에 차이를 보이는 single nucleotide polymorphism (SNP, 625번 뉴클레오티드)을 포함하도록 시발자를 합성하여 집락-PCR을 수행하였다. 증폭 산물(194bp)은 자동 염기서열장치를 이용하여 염기서열을 결정하였고, 제한효소인 MseI을 사용하여 PCR-RFLP를 실시하였다. 결과 : 집락-중합효소연쇄반응 결과 SP, SG, SE의 모든 (100%) 분리주에서 특이 증폭산물이 검출되었으나 ST의 경우 19주(73%)에서만 증폭되었다. 특히 병원성 관련 플라스미드가 관찰되지 않았던 SP 4주에서 특이적인 증폭산물이 검출되었다. 염기서열 분석결과 SE, SG, SP는 625번 뉴클레오티드에 아데닌을, ST는 구아닌을 가지고 있어 PCR-RFLP를 이용하여 쉽게 구분할 수 있었다. 결 론 : spvR에 대한 집락-중합효소연쇄 반응법은 병원성 플라스미드 검출법보다 SE, SP, SG 병원성 주를 신속하게 검출하는데 유용하고, 625번 뉴클레오티드의 SNP는 ST와 SE, SG, SP를 구분하는 분자표지로 사용될 수 있을 것으로 기대되며, ST에 비해 SE는 진화적으로 SG와 SP에 가까운 것으로 생각되었다. Background : The Salmonella virulence plasmid (spv) genes (spvR, A, B, C and D) on the large virulence plasmids of pathogenic Salmonella serotypes can replace the virulence of the whole plasmid. Recently, virulence plasmid-negative pathogenic Salmonella isolates were isolated. However, positive rates of spv genes among Korean Salmonella serotypes have been obscure. spv genes are conserved in compared to other virulence genes but there are single nucleotide polymorphisms (SNPs) conserved in only certain serotype. Such SNPs are useful for differentiation and understanding evolution of certain serotypes. Materials and Methods : Salmonella serotypes isolated from live stocks [Salmonella typhimurium (ST, 26), S. enteritidis (SE, 10), S. gallinarum (SG, 40) and S. pullorum (SP, 53)] were used for colony-PCR. A primer set covering single nucleotide polymorphism (SNP) at 625th nucleotide of spvR was designed. The nucleotide sequences of amplicons were determined by cyclic sequencing method and RFLP was performed by using MseI. Results : All isolates of SE, SG and SP, including four plasmid-negative isolates, showed specific amplicons but not all of ST (19/26, 73%) were positive to spvR. Based on the nucleotide sequence of 625th nucleotide and PCR-RFLP, SE, SG and SP [A(625)] and ST [G(625)] could be differentiated. Conclusion : spvR can be used as a molecular marker to detect virulent SE, SG, SP and the SNP may be useful for differentiation of SE, SG, SP and ST. According to the SNP study SE may be evolutionarily closer to SG and SP than ST.

骨盤炎患者 1例에 대한 症例報告

이보라,이정은,박경미,정진홍,유동열 대전대학교 한방병원 2001 惠和醫學 Vol.10 No.1

After treating a patient suffering from pelvic inflammatory disease, a significant result is gained as follows. This study was done from the patient who were at the oriental Medicine Hospital of Daejeon university during 15 days, from 12. 12 to 12. 26, 2001. A 27-year-old patient had complained an abdominal pain, chest discomfort, nausea, vomiting, urination difficulty and constipation. During the hospital periods, the kinds of therapy are acupuncture, moxibustion, herb-med and physical therapy. Given the treatment, she felt so satisfied about her symptom's improvement. But as a result of Ultrasonogram of pelvis, she had multiple follicles on the right ovary, so it had to be given a surgical operation. For the surgical operation, she was transferred to the Chungnam University Hospital

광섬유 집합체 센서를 이용한 6MV 광자선의 반음영 및 심부선량백분율 측정

신상훈,장경원,조동현,유욱재,서정기,이봉수,문주현,박병기 제주대학교 방사선응용과학연구소 2008 방사선응용과학연구소논문집 Vol.22 No.-

In this study, a fiber-optic bundle sensor has been developed using water-equivalent organic scintillating fibers for photon beam measurement. Beam penumbra and percent depth doses(PDD) are measured according to the depth of the photon beam. This sensor has many advantages such as high resolution, real-time measurement and ease of calibration over conventional radiation measurement devices.

광섬유 방사선 센서와 EBT 필름을 이용한 심부선량 백분율 측정 및 비교

조동현,장경원,유욱재,신상훈,이봉수,문주현,박병기 제주대학교 방사선응용과학연구소 2008 방사선응용과학연구소논문집 Vol.22 No.-

In this study, fiber-optic sensor is fabricated to measure PDD of CLINAC. As a scintillating light generated by a high energy X-ray from the medical LINAC is measured using photo diode amp system, It is expected that a high-resolution, real-time fiber-optic dosimeter for medical LINAC can be developed.