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      • Upregulation of MicroRNA 181c Expression in Gastric Cancer Tissues and Plasma

        Cui, Mei-Hua,Hou, Xiao-Lin,Lei, Xiao-Yan,Mu, Fang-Hong,Yang, Gui-Bin,Yue, Lin,Fu, Yi,Yi, Guo-Xing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

        Objective: To test the microRNA-181c (miR-181c) expression in tissues and plasma of gastric cancer (GC) cases, analyze any correlations, and explore the possibility of miR-181c as a potential molecular marker for GC diagnosis. Materials and Methods: Relative miR-181c expression levels in cancers and plasma from 30 GC patients was tested using reverse transcription-real-time fluorescent quantitation PCR and compared to that in samples from 30 gastric ulcer and 30 chronic gastritis patients. Results: The miR-181c expression level in the GC tissues was significantly higher than that in the gastric ulcer and chronic gastritis tissues (P = 0.000), as was the miR-181c expression level in the GC plasma (P = 0.000). We determined that miR-181c expression in GC plasma was positively correlated to its expression in the GC tissues (P = 0.000). Conclusions: The expression of miR-181c is upregulated in GC tissues and plasma, and the miR-181c expression level in GC plasma is positively correlated to that in the corresponding cancer tissues. Plasma miR-181c is possibly a new serological marker for GC diagnosis.

      • Biotoxins for Cancer Therapy

        Liu, Cui-Cui,Yang, Hao,Zhang, Ling-Ling,Zhang, Qian,Chen, Bo,Wang, Yi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12

        In recent times, a number of studies have provided evidence that biotoxins present great potential as antitumor agents, such as snake venom, bee venom, some bacteria toxins and plant toxins, and thus could be used as chemotherapeutic agents against tumors. The biodiversity of venoms and toxins make them a unique source from which novel anticancer agent may be developed. Biotoxins, also known as natural toxins, include toxic substances produced by plants, animals and microorganisms. Here, we systematically list representative biological toxins that have antitumor properties, involving animal toxins, plant toxins, mycotoxins as well as bacterial toxins. In this review, we summarize the current knowledge involving biotoxins and the active compounds that have anti-cancer activity to induce cytotoxic, antitumor, immunomodulatory, and apoptotic effects in different tumor cells in vivo or in vitro. We also show insights into the molecular and functional evolution of biotoxins.

      • KCI등재

        남성 주인공 변복 모티프의 한중 비교 연구 - <구운몽(九雲夢)>과 <양교혼(兩交婚)>을 중심으로

        최예화 ( Cui Yi-hua ) 택민국학연구원 2018 국학연구론총 Vol.0 No.22

        <구운몽>과 <兩交婚>은 한국과 중국 양국에서 거의 동시대에 출현하였다고 할 수 있다. 그런 작품 속에서 남성 변복 모티프가 등장하는 것은 예사로 볼 일이 아니다. 더욱이 <兩交婚> 역시 <구운몽>과 마찬가지로 여성과의 결연을 목적으로 변복하고 있다는 점도 주목할 필요가 있다. 이런 점에서 두 작품을 비교해 보는 것은 흥미로운 일이다. 하지만 본고에서는 영향 관계를 따지거나, 선후를 밝혀 볼 생각은 전혀 없다. 단지 같은 모티프가 각각의 작품 속에서 어떻게 작동하는지를 살피고, 공통점과 차이를 찾아 그 의미를 모색해보았다. <구운몽>과 <兩交婚>은 여성과의 결연을 앞둔 남성이 변복을 한다는 공통점을 갖는다. 결국, 두 작품의 변복 모티프는 결연 서사와 밀접한 관련을 맺는다. <구운몽>과 <兩交婚>은 변복 모티프에 따른 서사 전개가 동일함을 확인할 수 있다. 하지만 <구운몽>과 <兩交婚>의 변복모티프 관련 서사단락의 대비에서 살펴보다시피, 구체적인 부분에서는 차이를 보인다. 이는 아마도 당시 조선과 중국의 향유층 사이에 놓인 의식의 차이에 따른 것이라고도 할 수 있다. < The Cloud Dream of The Nine九雲夢 > and < Two marriages兩交婚 > appeared in Korea and China around the same period. Both works use character disguise as a motif. Furthermore, it is remarkable that the main character in < Two marriages兩交婚 > is disguised as a woman for the relationship with woman, as is the case for < The Cloud Dream of The Nine九雲夢 >. In this sense, it would be interesting to compare the two works. The purpose of this study is not to find out how one work influenced the other,# or which work came out first. Instead, this study examines how the same motif is applied in each work and observes how similar and distinct features determine meaning. < The Cloud Dream of The Nine九雲夢 > and < Two marriages兩交婚 > employ the same literary device where a man disguises himself before beginning a relationship with woman. Thus, the disguising motif in the two works are closely related to relationships. This study identifies that < The Cloud Dream of The Nine九雲夢 > and < Two marriages兩交婚 > had the same story development based on the disguising motif. However, a comparison of the narratives which relate to the use of the disguising motif in < The Cloud Dream of The Nine九雲夢 > and < Two marriages兩交婚 >, show differences in the details. It is assumed that such differences are caused by the different perceptions of the Joseon and Chinese people who were fans of both works.

      • KCI등재

        이기영의 만주 상상과 『대지의 아들』

        최일 ( Cui Yi ) 민족문학사학회·민족문학사연구소 2017 민족문학사연구 Vol.65 No.-

        이기영은 1939년 8월에 20여 일간의 만주 답사를 진행하고 나서 장편소설 『대지의 아들』을 창작했다. 그 만주 답사는 『조선일보』의 ‘대륙문학’ 기획에 의하여 진행된 것으로 이기영은 짧은 시간 동안 만주의 한국 이주 농민들의 집거지에 대하여 밀도 높은 조사를 진행했고 그렇게 얻어진 견문들을 그대로 소설에 이용했다. 『대지의 아들』에 대한 그간의 논의를 보면 대체로 일제의 ‘국책’에 협력한 작품이라는 평가와 나름의 글쓰기 책략을 통해 완성된 비협력 내지는 항거의 작품이라는 평가로 갈리고 있다. 본고는 이러한 평가를 내리기에 앞서 이기영이 만주에서 무엇을 얻으려 했고, 무엇을 얻었고 또 그렇게 얻어진 것을 어떻게 소설화하고 있는가 하는 문제를 해명하려고 했다. 바꿔 말하면 만주가 아니면 불가능 했을 이기영의 문학적 상상력을 밝히는 것이 본고의 취지이다. 이기영의 만주 체험이 어떻게 그의 만주 상상과 만주 서사로 작동되고 있는가를 고찰하는 것은 만주(나아가 중국)이라는 탈경계 체험이 한국 근대문학에 준 영향을 분석하는 하나의 표본으로 될 수 있다. 이는 또한 기존의 연구이 전면에 내세워 깊게 다루지 않은 문제이기도 하다. 따라서 본고는 같은 경로로 창작된 이기영의 만주 기행문에 대한 해독을 곁들여 인문지리학의 시각으로 만주라는 ‘장소’가 소설에 준 상상력과 그 효과, 즉 이기영이 만주에서 무엇을 보았고 그것을 어떻게 텍스트에 담아냈느냐 하는 문제를 해명하고자 했다. 이에 본고는 이기영이 기행문에서 그려 낸 부조리한 만주의 풍경이 소설화의 과정을 거치면서 조화의 판타지로 탈바꿈하는 과정, 그리고 그 과정에서 그려진 ‘무장소’의 장소로서의 만주의 이미지를 분석하였다. Lee Ki-young conducted more than twenty-day investigation during August 1938 in Manchu, china. After that, he wrote the novel Sons of the Earth. Lee Ki-young’s travel in Manchu was supported by the plan of “Mainland Literature” of The Chosun Ilbo. During this short period of time, he did an intensive research to the South Korean immigrant villages in Manchu area, and wrote what he had seen and heard into his novel faithfully. The evaluation to Sons of the earth can be divided into two aspects. First, some thought this novel conformed to the national policy of Japanese imperialists. Second, some thought this novel fought against the national policy of Japanese imperialists by a series of writing strategies. This article aims to clarify the purpose and gains of Lee Ki-young’s travel in Manchu and find the process of the fictionalization of what Lee Ki-young had seen and heard. That is the literary imagination which can only be gained in Manchu. The transformation from Lee Ki-young’s Manchu experience to his Manchu imagination and narrative process can serve as a template, which can also be used to analyze Manchu (even China) beyond boundaries narrative’s influence on modern Korean literature. And this question isn’t discussed deeply in previous studies. By the supporting text of Lee Ki-Young’s Manchu travels and the application of the method of human geography, this paper illustrates the imagination and its artistic effects which Manchu (this place) brought to Sons of the earth. And for this it discusses the process in which unharmonious Manchu “scenery” evolved into harmonious fantasy and also the placelessness of Manchu image during this process.

      • Disorders of Liver : The Study Of The Relationship Between Morphological Characteristics Of Tumor Microvessel And The Clinical Pathology Features Of The Hepatocellular Carcinoma

        ( Zhuan Yi Cui ),( Gui Qi Wang ) 대한소화기학회 2007 SIDDS Vol.9 No.-

        Background/Aims: There is sufficient evidence that tumour microvessels are pathology foundation and requisite condition of infarctate tumor in growthing and transferring. It is more to study primary hepatocellular carcinoma microvessels densities, while it is few to study the relation between microvessels morphous and tumor`s clinical pathology features. This aim of study is to explore the relation between the morphological characteristics of tumor microvessels and the clinical pathology features of hetatocellular carcinoma (HCC). Methods: To collect 55 primary hepatocellular carcinoma tissues preoperatively without artery embolotherapy, and there microvessels appearance was divided into 4 types: punctiform, filate, cireunduction, strip. The microvessels typing, differentiation level, tumors diameter, envelope and satellitic nubble were surveyed. Methods: To collect 55 primary hepatocellular carcinoma tissues preoperatively without artery embolotherapy, which was divided into 4types by microvessels modality: punctiform, filate, circumduction, strip. The microvessels typing, differentiation level, tumors diameter, envelope and satellitic nubble were surveyed. Results: Tumor microvessels typing degrees has the tendency of positive correlation with differentiation level and tumors diameter. Tumor microvessels typing degrees in HCC without envelope is higher than that in HCC with envelope. Tumor microvessels typing is no difference between HCC without satellitic nubble and HCC with satellitic nubble. Conclusions: The morphological Characteristics of HCC`s tumor microvessel were distinctive in different vegetal phases, and had definite rule. Tumor microvessels typing degrees is higher in low-grade differentiation level HCC, bigger HCC and HCC without envelope.

      • KCI등재

        Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials

        Huanqin Cui,Yi Yao,Zhunan Xu,Zhenli Gao,Jitao Wu,Zhongbao Zhou,Yuanshan Cui 대한배뇨장애요실금학회 2020 International Neurourology Journal Vol.24 No.1

        Purpose: Transcutaneous electrical neural stimulation (TENS), as a non-invasive modality, has been clinically used as an alternative treatment for children with overactive bladder (OAB). We conducted a pooled analysis to explore the effect of TENS on OAB. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analysis guideline was followed in this study. The MEDLINE, Embase, and Cochrane Central Register of Controlled Trials databases, as well as the reference lists of the retrieved studies, were used to find trials relevant for assessing the use of TENS to treat OAB. Results: Of the 246 records identified, 8 publications were analyzed in our study. Our analysis found that TENS resulted in a greater decrease of wet days/wk, daily voiding frequency, daily incontinence episodes, and daily number of voids than was observed in the control group. Furthermore, TENS-treated patients showed similar visual analogue scale (VAS) scores to patients in the control group, demonstrating that the application of TENS did not increase patients’ discomfort and pain. TENS had a relative advantage in the number of partial responses, but no clear differences were found in frequency of no response or a full response compared to the control group. In urodynamic testing, TENS led to obvious improvements in average voided volume and maximum voided volume in children with OAB. Conclusions: TENS had a remarkable effect on the improvement of urodynamic indexes and objective OAB symptoms without a significant increase in VAS scores for children with OAB.

      • SCIESCOPUSKCI등재

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