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생물전환 기법을 이용한 토란 뿌리 추출물의 RAW 264.7 세포에 대한 항염증 효과
박태진(Taejin Park),심지한(Ji Han Sim),홍혜현(Hyehyun Hong),한동환(Dong-Hwan Han),김승영(Seung-Young Kim) 한국생물공학회 2020 KSBB Journal Vol.35 No.2
Biorenovation is a method of modifying the structure of a broad range of substrates such as chemical compounds and plant extract by microbial enzymes with the potential benefits of reduced cytotoxicities and enhanced biological activities relative to its parent substrates. We generated Colocasia esculenta L. Schott root extract using Biorenovation technology and tested the anti-inflammatory properties of its Biorenovation product (CEB) in lipopolysaccharide (LPS)-treated RAW264.7 murine macrophages. CEB inhibited the LPS-induced production of pro-inflammatory markers such as nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) in a concentration dependent manner without no noticeable toxicities in RAW 264.7 cells. Then together, our results indicate that CEB could be a new source for the ingredients of cosmetics and pharmaceuticals.
Han Shin Lee,Eun Jung Jung,Ju Yeon Kim,Seung Jin Kwag,Taejin Park,Sang Ho Jeong,Chi Young Jeong,Young Tae Ju,Young Joon Lee,Soon Chan Hong,Sang Kyung Choi,Woo Song Ha 대한갑상선-내분비외과학회 2016 The Koreran journal of Endocrine Surgery Vol.16 No.1
Purpose: Lateral lymph node metastasis of papillary thyroid cancer (PTC) is indicative oftumor aggressiveness and can determine treatment strategies. However, the role ofprophylactic lateral lymph node dissection in the management of PTC is unclear. This studyevaluated factors predictive of lateral lymph node metastasis in patients with suspiciouslymph node enlargement in preoperative imaging.Methods: This retrospective study included 728 patients with newly diagnosed PTC whounderwent therapeutic surgery. Clinicopathologic results were reviewed, and factorspredictive of lateral lymph node metastasis were analyzed.Results: Of the 242 patients with lymph node metastasis, 50 had lateral lymph nodemetastasis. Lateral lymph node metastasis was associated with sex, tumor size, preoperativethyroid stimulating hormone (TSH) concentration and presence of central lymph nodemetastasis. Among patients with suspicious lateral lymph node metastasis by ultrasonography,high TSH level (odds ratio 3.833, P=0.031) and number of metastatic central lymphnodes (odds ratio 3.68, P=0.025) were significantly predictive of lateral lymph nodemetastasis.Conclusion: High serum TSH level and central lymph node metastasis were predictive oflateral lymph node metastasis in PTC patients with suspicious preoperative imagingfindings. These predictive factors might help reduce unnecessary therapeutic lateral lymphnode dissection.
Han Shin Lee,정은정,Ji Sook Park,Taejin Park 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.6
Gastric volvulus (GV) is an uncommon pathology, with 10-20% of cases occurring in children, typically before one year of age. It often occurs in people with congenital diaphragmatic hernias, intestinal malrotation, eventration of the diaphragm, paraesophageal hernias, wandering spleens, asplenism, or intra-abdominal adhesions. We report a rare case of chronic GV after left hemihepatectomy for hepatoblastoma in a child. The patient was a 9-year-old boy who complained of upper abdominal pain and postprandial upper abdominal distension for one year. At the age of 4 months, he was diagnosed with hepatoblastoma and had undergone left hemihepatectomy. The upper gastrointestinal contrast study revealed chronic organoaxial gastric volvulus. After a surgical procedure involving adhesiolysis and an anterior wall gastropexy, the patient improved and the symptoms resolved. Although GV is a rare disease, it should be suspected in a patient with a previous abdominal surgical history who is complaining of abdominal distension and pain.
Han, Ye-Lim,Kim, So-Yeon,Kim, Taejin,Kim, Ki-Hyun,Park, Jae-Woo Elsevier 2020 JOURNAL OF CLEANER PRODUCTION Vol.250 No.-
<P><B>Abstract</B></P> <P>A typical water treatment process consists of a physical, biological, or chemical route or a combination of these options. However, the use of conventional techniques has been challenged due to the diversification of waterborne pollutants. In response, various nanomaterials with advanced functions have been developed to provide effective remediation options. Among such materials, dendrimers have received attention due to their enhanced treatment capacities and multifunctional structures formed by the modification of terminal groups. This review offers comprehensive insight into dendrimers with respect to their practical applications. In particular, we focus on the interactions between dendrimer terminal groups and contaminants in relation to their structures to meaningfully describe the associated mechanisms. To meet this goal, the performances of dendrimers and their composites were evaluated in terms of partition coefficient (PC) values. Accordingly, the best results were observed for chitosan grafted PPI dendrimers (e.g., 6214 mg/g·μM against reactive black 5). Finally, we also addressed the present limitations of dendrimer technology and their prospects in water treatment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Dendrimers are hyperbranched polymers containing core, branch, and terminal groups. </LI> <LI> Dendrimers are potential nanomaterials for water treatment. </LI> <LI> Dendrimer properties can be controlled by various terminal groups. </LI> <LI> Water-contaminant removal mechanisms according to terminal groups are presented. </LI> <LI> Contaminant removal efficiency is enhanced by use and combination of dendrimers. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kwon Taejin,Song Han Wook,Woo Sam Yong,Kim Jong‐Ho,Sung Bong June 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.5
The description of many-body interactions is one of challenging problems in molecular dynamics simulations. Recently, neural network potentials have been spotlighted as an approach to describe many-body interactions. In this study, we obtain the neural network potentials for three-body interactions of helium using a deep learning method. We perform quantum calculations to obtain single point energies for helium trimers and obtain the neural network potentials for three-body interactions by performing a deep learning method. In order to test the validity of the neural network three-body interactions, we perform Mayersampling Monte Carlo simulations and calculate third virial coefficients for helium. We show that the third virial coefficients obtained from three-body neural network potentials are more accurate than those obtained from two-body neural network potentials. The deep learning method in our study would be extended to obtain the high-order virial coefficients for complex molecules.
Kim, Han-Gil,Park, Ji-Ho,Jeong, Sang-Ho,Lee, Young-Joon,Ha, Woo-Song,Choi, Sang-Kyung,Hong, Soon-Chan,Jung, Eun-Jung,Ju, Young-Tae,Jeong, Chi-Young,Park, Taejin The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.1
Purpose: The aims are to: (i) display the multidimensional learning curve of totally laparoscopic distal gastrectomy, and (ii) verify the feasibility of totally laparoscopic distal gastrectomy after learning curve completion by comparing it with laparoscopy-assisted distal gastrectomy. Materials and Methods: From January 2005 to June 2012, 247 patients who underwent laparoscopy-assisted distal gastrectomy (n=136) and totally laparoscopic distal gastrectomy (n=111) for early gastric cancer were enrolled. Their clinicopathological characteristics and early surgical outcomes were analyzed. Analysis of the totally laparoscopic distal gastrectomy learning curve was conducted using the moving average method and the cumulative sum method on 180 patients who underwent totally laparoscopic distal gastrectomy. Results: Our study indicated that experience with 40 and 20 totally laparoscopic distal gastrectomy cases, is required in order to achieve optimum proficiency by two surgeons. There were no remarkable differences in the clinicopathological characteristics between laparoscopy-assisted distal gastrectomy and totally laparoscopic distal gastrectomy groups. The two groups were comparable in terms of open conversion, combined resection, morbidities, reoperation rate, hospital stay and time to first flatus (P>0.05). However, totally laparoscopic distal gastrectomy had a significantly shorter mean operation time than laparoscopy-assisted distal gastrectomy (P<0.01). We also found that intra-abdominal abscess and overall complication rates were significantly higher before the learning curve than after the learning curve (P<0.05). Conclusions: Experience with 20~40 cases of totally laparoscopic distal gastrectomy is required to complete the learning curve. The use of totally laparoscopic distal gastrectomy after learning curve completion is a feasible and timesaving method compared to laparoscopy-assisted distal gastrectomy.
대용량 스토리지 시스템을 위한 pNFS 프로토콜의 성능 평가
김태진(Taejin Kim),김한규(Han Gyoo Kim),노삼혁(Sam H. Noh) 한국정보과학회 2012 한국정보과학회 학술발표논문집 Vol.39 No.1A
많은 대학과 스토리지 업체에서 고성능 병렬 파일시스템 관련 연구를 활발히 진행하고 있다. 그러나 대학이나 업체에서 연구된 병렬 파일시스템 기술은 상호 호환성에 제약이 있다. 네트워크 파일시스템 관련 해서 유일한 표준 기술인 NFS은 최근 pNFS 기능을 포함한 NFSv4.1로 확장되었다. pNFS은 NFS 서버를 거치지 않고 데이터를 병렬적으로 접근함으로써 고성능 입출력을 보장해 주고 있으며 기존 스토리지 기술과의 호환성을 제공하고 있다. 본 연구에서는 pNFS의 성능 평가를 위해서 pNFS을 사용하는 대용량 스토리지 시스템을 구현하고 NFSv4와 NFSv4.1간 성능을 비교한다. 성능 비교는 파일 사이즈와 동시 수행 프로세스 수 별로 수행되며 읽기 및 쓰기 연산에 대한 pNFS의 성능 향상을 확인한다.
Wide dynamic range high-speed three-dimensional quantitative OCT angiography with a hybrid-beam scan
Park, Taejin,Jang, Sun-Joo,Han, Myounghee,Ryu, Sukyoung,Oh, Wang-Yuhl The Optical Society 2018 Optics letters Vol.43 No.10
<P>We demonstrate a novel hybrid-beam scanning-based quantitative optical coherence tomography angiography (OCTA) that provides high-speed wide dynamic range blood flow speed imaging. The hybrid-beam scanning scheme enables multiple OCTA image acquisitions with a wide range of multiple time intervals simultaneously providing wide dynamic range blood flow speed imaging independent of the blood vessel orientation, which was quantified over a speed range of 0.6 similar to 104 mm/s through the blood flow phantom experiments. A fully automated high-speed hybrid-beam scanning-based quantitative OCTA system demonstrates visualization of blood flow speeds in various vessels from the main arteries to capillaries in a 4 mm x 4 mm area (1024 A-lines x 512 B-scans) in vivo in 20 s, showing its potential as a useful imaging tool for various biomedical applications. (C) 2018 Optical Society of America</P>