The effect of engineered PLGA nanoparticles on nitrifying bacteria in the soil environment

Susmita Das Nishu,Seungbin Park,Yuhyun Ji,Il Han,Jaehong Key,Tae Kwon Lee 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.84 No.-

As a result of their biodegradability and biocompatibility, various nanoparticles using poly(lactic-coglycolicacid) (PLGA) as a copolymer have shown promising results in biomedical engineeringfields,including molecular imaging and drug delivery. However, the potential nanotoxicity of PLGA-basednanoparticles in the environment was poorly understood. Measurement of bacterial nitrificationactivities and changes in the soil microbial community are both critical parameters that should be used toevaluate potential distrurbances in the functioning of the environmental ecosystem. This study aimed toinvestigate the impact of PLGA nanoparticles with different zeta-potentials on nitrifying bacterialcommunities in the soil environment. In pure culture studies, the ammonia oxidation was inhibited byhigher than 50% when PLGA cocentration is more than 0.05 mg/L or more regardless of zeta potential andexposure time, but the negligible effects were observed on the nitrite oxidation by most conditions. In thesoil microcosm experiment, at the 0.05 concentration of the oparticles, the ammonia and nitriteoxidation were inhibited by more than 50% on thefirst day regardless of the nanoparticle composition,but all the activity was recovered after 14 days. These results provide a fundamental information on thetoxcity of PLGA nanparticles on ecologcial function.

A genomic approach to identify core gene clusters in drought-tolerant diazotroph to alleviate drought stress in plant

Nishu Susmita Das,Hye Rim Hyun,Tae Kwon Lee 대한환경공학회 2019 대한환경공학회 학술발표논문집 Vol.2019 No.12

Enhancement of drought stress tolerance in crops by plant growth promoting rhizobacria

Nishu Susmita Das,Hye Rim Hyun,No Jee Hyun,Wee Gui Nam,Tae Kwon Lee 대한환경공학회 2018 대한환경공학회 학술발표논문집 Vol.2018 No.11

Antiviral activities of ginseng and its potential and putative benefi ts against monkeypox virus: A mini review

Rajib Chandra Das,Zubair Ahmed Ratan,Md Mustafizur Rahman,Nusrat Jahan Runa,Susmita Mondal,Konstantin Konstantinov,Hassan Hosseinzadeh,Jae Youl Cho 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.6

Due to the Covid-19 pandemic more than 6 million people have died, and it has bought unprecedentedchallenges to our lives. The recent outbreak of monkeypox virus (MPXV) has brought out new tensionsamong the scientific community. Currently, there is no specific treatment protocol for MPXV. Severalantivirals, vaccinia immune globulin (VIG) and smallpox vaccines have been used to treat MPXV. Ginseng, one of the more famous among traditional medicines, has been used for infectious disease forthousands of years. It has shown promising antiviral effects. Ginseng could be used as a potentialadaptogenic agent to help prevent infection by MPXV along with other drugs and vaccines. In this minireview, we explore the possible use of ginseng in MPXV prevention based on its antiviral activity.

Removal of toxic hydroquinone

Ankit Tyagi,Susmita Das,Vimal Chandra Srivastava 대한환경공학회 2019 Environmental Engineering Research Vol.24 No.3

In this study, iron (Fe) impregnated granular activated carbon (Fe-GAC) has been synthesized and characterized for various properties. Comparative studies have been performed for use of Fe-GAC as an adsorbent as well as a catalyst during catalytic oxidation of hydroquinone (HQ). In the batch adsorption study, effect of process parameter like initial HQ concentration (C₀ = 25-1,000 ㎎/L), pH (2-10), contact time (t: 0-24 h), temperature (T: 15-45℃) and adsorbent dose (w: 5-50 g/L) have been studied. Maximum HQ adsorption efficiency of 75% was obtained at optimum parametric condition of: pH = 4, w = 40 g/L and t = 14 h. Pseudo-second order model best-fitted the HQ adsorption kinetics whereas Langmuir model best-represented the isothermal equilibrium behavior. During oxidation studies, effect of various process parameters like initial HQ concentration (C₀: 20-100 ㎎/L), pH (4-8), oxidant dose (CH2O2: 0.4-1.6 mL/L) and catalyst dose (m: 0.5-1.5 g/L) have been optimized using Taguchi experimental design matrix. Maximum HQ removal efficiency of 83.56% was obtained at optimum condition of C₀ = 100 ㎎/L, pH = 6, CH2O2 = 0.4 mL/L, and m = 1 g/L. Overall use of Fe-GAC during catalytic oxidation seems to be a better as compared to its use an adsorbent for treatment of HQ bearing wastewater.

The association between body mass index and abdominal obesity with hypertension among South Asian population: findings from nationally representative surveys

Gupta Rajat Das,Parray Ateeb Ahmad,Kothadia Rohan Jay,Pulock Orindom Shing,Pinky Susmita Dey,Haider Shams Shabab,Akonde Maxwell,Haider Mohammad Rifat 대한고혈압학회 2024 Clinical Hypertension Vol.30 No.-

Objective This study aimed to determine the association between body mass index (BMI) and abdominal obesity with hypertension among the South Asian adults (18–69 years). Methods This study utilized the nationally representative WHO STEPwise approach to surveillance data (n=24,413) from Afghanistan, Bangladesh, Bhutan, Nepal, and Sri Lanka. Hypertension was defned as having a systolic blood pressure of 140 mmHg or higher, a diastolic blood pressure of 90 mmHg or higher, and/or taking antihypertensive medications. A waist circumference≥90 cm in men and≥80 cm in women was considered as abdominal obesity. BMI was categorized according to Asia-specifc cutof and overweight was defned as BMI of 23.0–27.5 kg/m2 and obesity was defned as BMI≥27.5 kg/m2 . Multivariable logistic regression analyses were conducted to identify the association between BMI and abdominal obesity with hypertension. The odds ratio (OR) with a 95% confdence interval (CI) was reported. Results Abdominal obesity increased the odds of hypertension 31%-105% compared to those who did not have abdominal obesity (OR: Afghanistan: 2.05; 95% CI: 1.27–3.31; Bangladesh: 1.55; 95% CI: 1.18–2.04; Bhutan: 1.31; 95% CI: 1.03–1.66; Nepal: 1.69; 95% CI: 1.31–2.18; Sri Lanka:1.55; 95% CI: 1.23–1.95). The odds increased among participants with both overweight/obesity and abdominal obesity. In all fve countries under study, participants with both overweight and abdominal obesity (OR: Afghanistan: 2.75; 95% CI: 1.75–4.34; Bangladesh: 2.53; 95% CI: 1.90–3.37; Bhutan: 2.22; 95% CI: 1.64–3.00; Nepal: 2.08; 95% CI: 1.54–2.81; Sri Lanka: 2.29; 95% CI: 1.77–2.98), as well as those with obesity and abdominal obesity (OR: Afghanistan: 6.94; 95% CI: 4.68–10.30; Bangladesh: 2.95; 95% CI: 2.19–3.97; Bhutan: 3.02; 95% CI: 2.23–4.09; Nepal: 4.40; 95% CI: 3.05–6.34; Sri Lanka: 3.96; 95% CI: 2.94–5.32), exhibited higher odds of having hypertension as compared to participants with a normal BMI and no abdominal obesity. Conclusion Having both abdominal obesity and overweight/obesity increased the odds of hypertension among South Asian adults. Preventing overweight/obesity and abdominal obesity is necessary for preventing the burden of hypertension in South Asia.

Foliar Application of Magnesium Sulphate and Basal Application of Calcium Carbonate: A New Dimension in Production of Tasar Crops

Sinha, Uma S.P.,Das, Susmita,Sinha, Manoj K. Korean Society of Sericultural Science 2012 International Journal of Industrial Entomology Vol.25 No.1

An experiment was carried out to boost the production of tasar crops through application of secondary nutrients. Different combinations of secondary nutrients were prepared and its effect was studied on the yield and quality of leaves of tasar food plant Terminalia tomentosa W & A with 2.4 m ${\times}$ 2.4 m spacing and cocoon characters of tasar silkworm Antheraea mylitta Drury reared on them. Among different combinations of secondary nutrients, foliar application of magnesium sulphate (2%, w/v) and basal application of 3 quintal/ha of calcium carbonate (secondary nutrient combination SM5) was found to be the best in crop improvement. It improves the quantity and quality of leaves as well as the commercial characters of cocoons. As a result, silk production improves. Under this combination, leaf yield increased by 26.55% in comparison to control. Average increase in moisture, total mineral, crude protein and total carbohydrate was 3.26%, 20.84%, 15.39% and 17.85% respectively as compared with control. Further, bio assay studies revealed that average larval weight, E.R.R., cocoon weight, shell weight and silk ratio percent increased by 11.25%, 25.71%, 20.05%, 35.14% and 12.17% respectively over control which indicates that secondary nutrient combination $SM_5$ has significant role in improving the production of tasar crops.

Foliar Application of Magnesium Sulphate and Basal Application of Calcium Carbonate A New Dimension in Production of Tasar Crops

( Uma S P Sinha ),( Susmita Das ),( Manoj K Sinha ) 한국잠사학회 2012 International Journal of Industrial Entomology Vol.25 No.1

An experiment was carried out to boost the production of tasar crops through application of secondary nutrients. Different combinations of secondary nutrients were prepared and its effect was studied on the yield and quality of leaves of tasar food plant Terminalia tomentosa W & A with 2.4 m × 2.4 m spacing and cocoon characters of tasar silkworm Antheraea mylitta Drury reared on them. Among different combinations of secondary nutrients, foliar application of magnesium sulphate (2%, w/v) and basal application of 3 quintal / ha of calcium carbonate (secondary nutrient combination SM5) was found to be the best in crop improvement. It improves the quantity and quality of leaves as well as the commercial characters of cocoons. As a result, silk production improves. Under this combination, leaf yield increased by 26.55% in comparison to control. Average increase in moisture, total mineral, crude protein and total carbohydrate was 3.26%, 20.84%, 15.39% and 17.85% respectively as compared with control. Further, bio assay studies revealed thataverage larval weight, E.R.R., cocoon weight, shell weight and silk ratio percent increased by 11.25%, 25.71%, 20.05%, 35.14% and 12.17% respectively over control which indicates that secondary nutrient combination SM5 has significant role in improving the production of tasar crops.

내건성 식물생장 촉진 균주인 Glutamicibacter halophytocola DR408의 유전체 분석

수스미타 다스 니슈,현혜림,이태권,Nishu, Susmita Das,Hyun, Hye Rim,Lee, Tae Kwon The Microbiological Society of Korea 2019 미생물학회지 Vol.55 No.3

제천에서의 콩 근권 시료로부터 분리한 Glutamicibacter halophytocola DR408 균주는 내건성 식물생장촉진력을 보이고 있다. 본 연구에서 DR408 균주의 완전한 유전체 서열을 해독한 결과, 유전체의 크기는 3.77 Mbp였으며, G + C 함량이 60.2%였다. 또한 총 3,352개의 유전자 서열과 65개의 tRNA, 19개의 rRNA, 3개의 ncRNA가 존재하였다. 유전체 분석을 통해 식물의 내건성을 향상시킬 수 있는 삼투질 합성과 식물생장촉진 효소를 코딩하는 유전자를 다수 포함하는 것을 확인하였다. Glutamicibacter halophytocola DR408 isolated from the rhizospheric soil of soybean plant at Jecheon showed drought tolerance and plant growth promotion capacity. The complete genome of strain DR408 comprises 3,770,186 bp, 60.2% GC-content, which include 3,352 protein-coding genes, 64 tRNAs, 19 rRNA, and 3 ncRNA. The genome analysis revealed gene clusters encoding osmolyte synthesis and plant growth promotion enzymes, which are known to contribute to improve drought tolerance of the plant.

Electro-Optical Characterization of Cyanine-Based GUMBOS and nanoGUMBOS

Anirban Sarkar,Kalyan Kanakamedala,Naveen N. Jagadish,Atiya Jordan,Susmita Das,Noureen Siraj,Isiah M. Warner,Theda Daniels-Race 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.5

Over the last decade in materials science, molecular electronics has emerged as one of the most rapidly developing interdisciplinary research areas with the prospects of ultimate miniaturization and integration of functional organic species with traditional silicon based semiconductor technology. To this end, fundamental studies to investigate the electrical and optical properties of organic nanomaterials deserve special attention. In this work, conductive probe atomic force microscopy (CP-AFM) and Raman spectroscopy have been performed on a new class of ionic materials, referred to as group of uniform materials based on organic salts (GUMBOS) and nanoparticles derived from these GUMBOS, termed as nanoGUMBOS. The GUMBOS investigated in this study are 1,1'-Diethyl-2,2'-cyanine bis (trifluoromethanesulfonyl) imide ([PIC][NTf2]) and 1,1'-Diethyl-2,2'-cyanine bis (pentafluoromethanesulfonyl) imide ([PIC][BETI]), which have been synthesized by use of a facile, template free anion exchange reaction between their respective parent compounds, followed by an ultrasonication assisted, additive free re-precipitation reaction to obtain the nanoscale particles (nanoGUMBOS). The ([PIC][NTf2] nanoGUMBOS were found to self-assemble into distinct diamond-like, trapezoid structures whereas [PIC][BETI] exhibited rod-like structures. [PIC][NTf2] nanoGUMBOS induced ~25 and ~38 times enhancement in the Raman signal intensity as compared to the parent compound [PIC][I] and [PIC][BETI] nano- GUMBOS respectively. In conjunction with the results of Raman spectra, the current-voltage (I-V) data obtained by CP-AFM are also presented as first-time evidence of electrical performance exhibited by these unique class of materials. The results reported in this study are indicative of their potential incorporation into next generation organic thin film applications in optoelectronics, dye-sensitized solar cells, and chemical sensors.