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Adaptogenic effects of Panax ginseng on modulation of immune functions
Zubair Ahmed Ratan,Soo Hyun Youn,Yi-Seong Kwak,Chang-Kyun Han,Mohammad Faisal Haidere,Jin Kyeong Kim,Hyeyoung Min,You-Jung Jung,Hassan Hosseinzadeh,Sun Hee Hyun,Jae Youl Cho 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.1
Traditional medicinal practices have used natural products such as adaptogens to treat inflammatory, autoimmune, neurodegenerative, bacterial, and viral diseases since the early days of civilization. Panax ginseng Myer is a common herb used in East Asian countries for millennia, especially in Korea, China, and Japan. Numerous studies indicate that ginseng can modulate the immune system and thereby prevent diseases. Although the human immune system comprises many different types of cells, multiple studies suggest that each type of immune cell can be controlled or stimulated by ginseng or its derivatives. Provisional lists of ginseng’s potential for use against viruses, bacteria, and other microorganisms suggest it may prove to be a valuable pharmaceutical resource, particularly if higher-quality evidence can be found. Here, we reviewed the role of ginseng as an immune-modulating agent in attempt to provide a valuable starting point for future studies on the herb and the human immune system.
Ginseng, a promising choice for SARS-COV-2: A mini review
Zubair Ahmed Ratan,Fazla Rabbi Mashrur,Nusrat Jahan Runa,Ki Woong Kwon,Hassan Hosseinzadeh,Jae Youl Cho 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2
The current Covid-19 pandemic has changed the entire world and bought so many unprecedented challenges to the scientific community. More than 5 million people died due to the SARS-COV-2 outbreak. For many thousands of years, ginseng, the traditional herb has been used for various infectious diseases by traditional healers. Ginseng showed promising antiviral effects by modulating both natural and acquired immunity. Ginseng might be used as a potential therapeutic agent to prevent SARS-CoV-2 infection along with the vaccine. In this current review, we offer an alternative approach for SARS-COV-2 prevention during this unprecedented pandemic.
Pharmacological potential of ginseng and its major component ginsenosides
Zubair Ahmed Ratan,Mohammad Faisal Haidere,Yo Han Hong,Sang Hee Park,Jeong-Oog Lee,Jongsung Lee,Jae Youl Cho 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.2
Ginseng has been used as a traditional herb in Asian countries for thousands of years. It contains a large number of active ingredients including steroidal saponins, protopanaxadiols, and protopanaxatriols, collectively known as ginsenosides. In the last few decades, the antioxidative and anticancer effects of ginseng, in addition to its effects on improving immunity, energy and sexuality, and combating cardiovascular diseases, diabetes mellitus, and neurological diseases, have been studied in both basic and clinical research. Ginseng could be a valuable resource for future drug development; however, further higher quality evidence is required. Moreover, ginseng may have drug interactions although the available evidence suggests it is a relatively safe product. This article reviews the bioactive compounds, global distribution, and therapeutic potential of plants in the genus Panax.
Rajib Chandra Das,Zubair Ahmed Ratan,Md Mustafizur Rahman,Nusrat Jahan Runa,Susmita Mondal,Konstantin Konstantinov,Hassan Hosseinzadeh,Jae Youl Cho 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.6
Due to the Covid-19 pandemic more than 6 million people have died, and it has bought unprecedentedchallenges to our lives. The recent outbreak of monkeypox virus (MPXV) has brought out new tensionsamong the scientific community. Currently, there is no specific treatment protocol for MPXV. Severalantivirals, vaccinia immune globulin (VIG) and smallpox vaccines have been used to treat MPXV. Ginseng, one of the more famous among traditional medicines, has been used for infectious disease forthousands of years. It has shown promising antiviral effects. Ginseng could be used as a potentialadaptogenic agent to help prevent infection by MPXV along with other drugs and vaccines. In this minireview, we explore the possible use of ginseng in MPXV prevention based on its antiviral activity.
COVID-19 Vaccine: Critical Questions with Complicated Answers
( Mohammad Faisal Haidere ),( Zubair Ahmed Ratan ),( Senjuti Nowroz ),( Sojib Bin Zaman ),( You-jung Jung ),( Hassan Hosseinzadeh ),( Jae Youl Cho ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.1
COVID-19 has caused extensive human casualties with significant economic impacts around the globe, and has imposed new challenges on health systems worldwide. Over the past decade, SARS, Ebola, and Zika also led to significant concerns among the scientific community. Interestingly, the SARS and Zika epidemics ended before vaccine development; however, the scholarly community and the pharmaceutical companies responded very quickly at that time. Similarly, when the genetic sequence of SARSCoV- 2 was revealed, global vaccine companies and scientists have stepped forward to develop a vaccine, triggering a race toward vaccine development that the whole world is relying on. Similarly, an effective and safe vaccine could play a pivotal role in eradicating COVID-19. However, few important questions regarding SARS-CoV-2 vaccine development are explored in this review.
Han, Sang Yun,Kim, Eunji,Hwang, Kyeonghwan,Ratan, Zubair Ahmed,Hwang, Hyunsik,Kim, Eun-Mi,Kim, Doman,Park, Junseong,Cho, Jae Youl MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.5
<P>Epigallocatechin gallate (EGCG) is a well-studied polyphenol with antioxidant effects. Since EGCG has low solubility and stability, many researchers have modified EGCG residues to ameliorate these problems. A novel EGCG derivative, EGCG-5′-<I>O</I>-α-glucopyranoside (EGCG-5′Glu), was synthesized, and its characteristics were investigated. EGCG-5′Glu showed antioxidant effects in cell and cell-free systems. Under SNP-derived radical exposure, EGCG-5′Glu decreased nitric oxide (NO) production, and recovered ROS-mediated cell viability. Moreover, EGCG-5′Glu regulated apoptotic pathways (caspases) and cell survival molecules (phosphoinositide 3-kinase (PI3K) and phosphoinositide-dependent kinase 1 (PDK1)). In another radical-induced condition, ultraviolet B (UVB) irradiation, EGCG-5′Glu protected cells from UVB and regulated the PI3K/PDK1/AKT pathway. Next, the proliferative effect of EGCG-5′Glu was examined. EGCG-5′Glu increased cell proliferation by modulating nuclear factor (NF)-κB activity. EGCG-5′Glu protects and repairs cells from external damage via its antioxidant effects. These results suggest that EGCG-5′Glu could be used as a cosmetics ingredient or dietary supplement.</P>