白鼠에 있어서 肝吸蟲感染에 대한 獲得抵抗에 관한 硏究

趙星煥,朱炅煥,林漢鍾 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3

The development of acquired resistance in clonorchiasis was studied in rats experimentally infected with Chonorchis sinesis. The induction of acquired resistance was attempted by first exposing adult rats to 15 or 50 metacercariae of C. sinesis from naturally infected Pseudorasbara parva and then treated with praziquantel prior being challenged. The reinfection was performed at 1, 2, 4, and 8 weeks after elimination of flukes. Worm recovery rates and growth of the worms obtained from rats necropsied at 4 weeks after reinfection were compared to those of control group. End point titers of rat's serun were studied by ELISA at the time of reinfection and morphological findings of bile ducts were also studied by the light microscope. In other experiments, rats were infected repeatedly with 5 or 10 metscercariae at 1 week interval for 5 times. Animals were kills 4 weeks after the last exposure and the results were compared to a single infection of 25 or 50 metacercariae. Worm collection was failed in rats challenged with 50 metacercariae at 1 or 2 weeks after treatment. Worm recovery rates were 3.5 and 20.0% in rats reinfected at 4 and 8 weeks respectively after treatment, while 41.5% in control rats. In other experiment, 15.6%, 18.3% and 33.3% in worm recovery rates were obtained in rats, challenged with reinfections at 2, 4, and 8 weeks respectively after treatment of these rats initially infected with 15 metacercariae. Recovery rates were 50.0% in control group. Worm racovered in this experiment were found retarded in growth compared to control group. High end point antibody titers of the rat serum at the time of reinfections were presented by ELISA and it seemed too suppress maturation of the worms. Histopathological recovery of the bile ducts were not remarkable until 4 weeks after treatment and it may be contributed to reinfection as an another protecting factor. Multiple low dose repeated infection showed lower recovery rates compared to high dose single infection. Worm recovery rates of animals infected 5 times with 5 metacercariae were 11.0% and single infection on 25 were 53.0%. That of animals infected 5 times with 10 metacercariae was 13.0% compared to 41.5% of single infection of 50 metacercariae. In conclusion, the data presented in this study indicate that during the course of infection by C. sinesis acquired resistance is induced by preceding infection although complete protection may not be elicited.

韓國經濟의 成長過程과 政策評價(1955∼1986)

趙誠煥 서울大學校 經濟硏究所 1988 經濟論集 Vol.27 No.4

무증상 당뇨환자의 T 반사 변화

안규환,조용진,김상화,사은희,임용빈,김대성,정대수,박규현 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

악성종양에서 혈청 Intercellular Adhesion Molecule-1의 혈청

조덕연,김현수,박상준,김종숙,최지영,윤환중,김삼용 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1

Intercellular adhesion molecule-1 (ICAM-1) is a glycoprotein serving as ligands for leukocyte intergrin receptors, i.e. LFA-1, MAC-l. It has been suggested that the expression of ICAM-1 and the levels of circulating ICAM-1 were increased in several malignancies. We measured serum ICAM-1 by ELISA in patients with stomach cancer (n=25), acute lymphoblastic leukemia (n=7), non-Hodgkin's lymphoma (n=14), and metastasis of unknown origin (n=5). Serum levels of circulating ICAM-1 in all malignancies were significantly higer than in normal controls. And serum level of ICAM-1 in stomach cancer ptients having metastatic disease was higher than in patients with localized disease (p=0.027). These results suggest that elevated serum ICAM-1 is a rather common feature for malignancies, not unique for certain types of cancer such as malignant melanoma. It remains to be clalified whether marked increase of serum ICAM-1 in metastatic stomach cancers simply reflect tumor burden or this molecule plays a role in progression in stomach cancer.

전두부 골절 환자의 임상적 연구

조용민,이동근,오승환,장관식,한대희,민승기 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.1

Fracture of frontal bone is infrequent, but may have serious complications because of their proximity to the brain, eyes and noses. Fractures of the frontal area range from 5% to 15% of all facial bone fracture and include supraorbital rim and frontal sinus. As frontal bone fractures most frequently occur in the multiply injured patient, a thorough clinical and radiological examination of the patient is required before diagnosis and treatment plans are established. Sometimes coorperative treatment with other department is requried. It is specially considered that incision for access to frontal region and surgical methods for open reduction, cranialization, cannulization, sinus obliteration. After surgical or conservative treatment, it may have complication. Complication of frontal bone injury vary in severity and may occur at several years after the incidents. The major types of complications are those that occur directly at the time of injury, infection and chronic problems. This is clinical study on 31 patients with frontal bone fracture, at department of oral and maxillofacial surgery in dental hospital of Wonkwang university during past ten years. The results were as follows : 1. The sex ratio of all patients is 29 (94%) male to 2 (6%) female, the average age is 33 and the prominent groups are 2nd, 3rd decade age. 2. The causative factors are mostly traffic accident 22 cases (70%) and fall dawn, industrial accidents, so on. 3. The 17 cases has shown alert mental status, but neurologic problems is in 14 (45%) cases in initial accessment. 4. Associated facial bone fractures are prominent in the maxilla (42%) and panfacial fracture (39%). 5. Involved general problems are in department of neurologic surgery problems (65%), orthopaedic problems (23%) and ophthalmologic problems (19%) in order. 6. Open reduction has done in 15 cases and 16 cases with conservative management. 7. Postoperative complications are chronic headache (42%), esthetic problems (39%) and ophthalmologic problems (35%)in order.

九山禪門 寺刹의 立地 硏究 : 風水的 측면을 중심으로

趙成鎬,成東桓 대구효성카돌릭대학교사회과학연구소 1998 사회과학연구 Vol.5 No.-

The purpose of this study is to examine the chracteristics of the location of Zen Buddhist temples which are the Nine-Mountain Zen School from feng-shui perspective. As the Truth-plot(place for teaching, learing or practicing) of Buddhist asceticism, Buddhist temple is the holy place where the Buddhists truth has been instructed, and where Buddhist monks have cultivated their religious discipline. In ancient and medieval times, those Buddhist temples were not only places for monks to study instructions of Buddha, but also centers for adjusting social ideology. At that time Buddhist temples were taken to be as important as the palace where the royal family lived. Therefore the problems of where temples are built and how they are constructed were very important. A large number of temples have been built for about 1600 years ever since Buddhism had influenced on Korea. They have been built nationwide in different times by differnet sects of Buddhism. The pattern of location of Buddhist temples is different according to its phase of times(political, economic, cultural aspect) and difference of tenent(difference in sects of Buddhism) when the temples were built. But the general location of Korean Buddhist temples is in accordance with feng-shui theory. Feng-shui is a traditional geographic thought in China and Korea. It is necessary to understand the whole scale of feng-shui in order to understand Korean landscape and cultural geography. It had had a tremendous impact on Korean landscape through selective buildings of cities, settlements, houses, mounments, temples, pagodas, and so on. Before feng-shui was prevailing in Korea, Buddhist temples were mostly built on sacred place which was connected with folk beliefs. In the case of the Silla Dynasty when Zen Buddhism was prevailing, feng-shui became popular and many temples were built in accordance with feng-shui. The typical examples are found in the location of Nine-Mountain Zen School. The interpretation of geomantic location of Nine-Mountain Zen School temples will show us how feng-shui was applied to and reflected in the Korean peninsula. In Zen Buddhism, feng-shui was applied to the selection of the temple site. Also feng-shui theory was usually used to select the site of stupa(Budo) where the remains of the founder of sect. Among Nine-Mountain Zen School temples, 5 temples were ruined. In this study, we will interpret the geomantic charateristies of Nine-Mountai n Zen School temples. The geomantic interpretations of the temples are as follow. 1. The temples are located at the foot of a hill with surrounding mountains and a watercourse in front. Feng-shui texts often describe it as an ideal site. This geomantic situation is well equipped with natural drainage; protection from cold wind from the north or evil spirits; a good view with open space to the front; protection from unnecessary weather damage; and security and protection from strangers and invaders. 2. The sitting and facing direction of the temples correspond to the oncoming dragon's direction. 3. Many feng-shui texts discuss the types of Sa(surrounding mountains) in detail and morphologically describe them with certain animate and inanimate auspicious objects. In case of Taean temple, the geomantic landscape of it can be compared to a phoenix returing to its nest. This is morphological marker for the description of configulation features of Taean temple. 4. Most auspicious places are not perfect, but the shortcomings can be overcome by many means. We can observe modification of landscape for the purpose of fulfilling the geomantic harmony of the temple.

성인의 천미추부 종괴

조길환,이백권,장도명,김영진,안상태 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

We developed an animal model to recreate the condition of an open fracture in communication with the maxillary sinus. We then studied wound healing of the sinus wall structures following fracture in the presence of autogenous bone and alloplastic implant. This model is designed to simulate the repair of an orbital floor fracture in humans. The New Zealand White rabbit was used as the animal model. Standardized 8mm defects were made bilaterally in the maxillary sinuses to include bone and mucosa in 36 rabbits. Two different implants and autogenous calvarial bone graft were placed in the soft-tissue pockets to obturate the defects, exposing one surface of the implant to the open sinus. Medpor porous polyethylene, silicone and calvarial bone implant were compared. Animals were killed at 1, 2 and 8 weeks after implantation. Gross examination of the specimens for the amount of mucosal closure and implant tissue fixation was performed. Histological sections were evaluated for bone and soft-tissue morphology juxtaposed to the implant. Complete closure of the mucosal defect was demonstrated with each type of implant. Medpor implants showed both vascular and soft-tissue ingrowth into pores by week 1. Bone ingrowth was seen by week 2. Closure of the Medpor obturated defects occurred more rapidly than in the silicone group. The Medpor implants and calvarial bone demonstrated bone and soft-tissue fixation, callus formation and maturation, while mature overlying mucosa was reconstituted over the defects. Silicone implants demonstrated a fibrous tissue reaction within 1 week of implantation and they never became fixed to bone or soft tissue. Maxillary sinus wall regeneration occurred in all defects. This study supports clinical observations of maxillary sinus wall regeneration in humans. Although sacrococcygeal mass is rare and usually found in infants or children, adolescent or adult patients with protruding mass in sacrococcygeal region occasionally come to us simply for a cosmetic problem. In this situation, even though there is no definite neurological deficit, it should be evaluated whether or not the underlying bony pathology or dural defect exists. Few cases about the sacrococcygeal mass have been reported in adults. We reviewed our cases including preoperative evaluation methods and postoperative diagnosis. From March, 1993 to February, 1997, we experienced 6 adult patients with sacrococcygeal mass and no neurological abnormality. Preoperative evaluation were made by plain X-ray, myelogram, computed tomography(CT), and magnetic resonance imaging (MRI), as needed. Postoperative diagnoses were 2 meningoceles, 2 lipomyelomeningoceles, 1 desmoid tumor, and 1 teratoma. From our experiences, CT or MRI is essential to evaluate the sacrococcygeal mass preoperatively. These methods can visualize the precise anatomic location and extent of the mass, its relation to the spinal cord, and associated bony abnormalities. MRI is superior to CT, especially in defining the nature of the mass and involvement of the spinal cord. Conclusively, even a simple mass in the sacrococcygeal region in adults needs MRI or CT evaluation, and MRI is the most valuable method of evaluating the mass preoperatively and provides important information to establish a treatment plan.

상악골 전벽골 겸손에 대한 재건술에 있어서 동결건조 콜라겐 매식과 소강판고정술의 임상적 유용성

오승환,장관식,조병호,민승기,이동근,김수남 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6

Maxilla is located in midfacial area and has intimate relationship with adjacent anatomical structure such as nasal cavity, orbit, oral cavity, and zygoma. Skeletal defects of maxillary antral wall may be developed by various postoperative causes for comminuted maxillary fractures, tumors of head and neck area or cystic lesions of maxillary sinuses. If these bony defects are left untreated state, this results in several postoperative complications such as soft tissue impingement into bony defects or dysfunction of sinus mucosa. Hence, these defects should be pertinently treated as possible. The main purpose of such surgery is to preservation of normal physiologic function of maxillary sinus. In the past, a variety of materials have been used to reconstruct defects of the maxillary antral wall. Alloplastic materials are popular today because of availability without an additional operation and their ease of use. With favorable results and review of related literatures, we report the availability of lyophilized collagen implantation and microplate fixation as the reconstructive surgical methods on the defects of maxillary anterior wall resulted from various reasons.

란크릭 캅셀(플루옥세틴 20mg)에 대한 프로작 캅셀의 생물학적 동등성 시험

심상범,조요나,오한석,류재환,이경태,김남재,서성훈 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Bioequivalence of two flouxetine capsule, ProzacR (Lilly kora Ltd.) and LanclicR (Samsung Pharm. IND. Co.), was evalated according to the guideline of KFDA. Twenty four healthy male volunteers (21-26 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After 60mg of fluoxetine was orally administered, blood was taken at 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, 24, 32, 48 and 72 hours after administration and just before administration. Plasma was analyzed for fluoxetine and internal standard (clomipramine) by a sensitive and validated HPLC assay. The pharmaco kinetic parameters (AUCt, Cmax and Tmax) wre calculated and ANOVA test was used for the statistical analysis of parameters. Differences in (AUCt, Cmax and Tmax between two capsules were -0.90, 3.46 and -14.08% respectively. All powers (1-β) for AUGt, Cmax and Tmax were more than 0.9. Detectable differences (Δ) and confidence interval were all less than ±20%. All the parameters above met the criteria of KFDA for bioequivalence and indicated that LanclicR capsules are bioequivalent to ProzacR capsules.

온도 변화에 따른 DW-100 용접재의 기계적특성에 관한 연구

박원조,정재욱,변상열,허선철,유재환 경상대학교 해양산업연구소 2002 해양산업연구소보 Vol.15 No.-

In recent years, the studies of mechanical property of weld materials were one of the most important basic test of our welding indursty. The used specimen in this study is weld metal of DW-100 flux cored wire which is using for flux cored are welding and one type of flux cored wires were used in this test. This paper is based on the quality of the mechanical property of welding material under the different temperture, test temperature of each weld metal is from RT to 900℃ and temperature gap is 100℃ for each weld metal. It is particularly important to assess tensile properties and each specimen was examined using by the following methods; Reduction of area rate, Tensile strength test, and observation of SEM. All tensile tests were performed in accordance with the ASTM standard test method, tension testing of metallic materials (ASTM I-8). This study proves that the mechanical properties of until 400℃ were good as the increasing temperature compare with mechanical properties of RT. As the results of this study, the tensile strength of 300℃ was higher than other weld metals. Also the reduction of area rate was the lowest at 300℃ according to the previous test results. Consequently, this weld metal is a good substitute for the existing welding materials until 400℃ which is used in the development of welding industries today.