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3차원 탄소성 유한요소법을 통한 금속복합재료와 지르코니아 접합체의 잔류응력해석
주재황,선동주,최영택,박세만,박명균 明知大學校 産業技術硏究所 1996 産業技術硏究所論文集 Vol.15 No.-
Employing a three dimensional finite element method a thermal elasto-plastic stress analysis was conducted to investigate residual stress distributions on the joining area between a ceramic(ZrO₂) and a SiC whisker-reinforced aluminum (Al composite). For purposes of comparisons, residual stresses at the interfaces on the joining area were first analyzed for varying volume fractions of SiC whiskers utilizing two dimensional elasto-plastic models. The results from the 2-D models were compared with those from 3-D models to understand the Practical nature of residual stresses produced during industrial joining processes for ceramics and metal matrix composites. Additionally, the same procedures were applied to compute stress variations along a line passing through the joining area to obtain a physical insight and to offer a plausible explanations for fracture patterns occuring at the interfaces during bending.
Yin, Jinlong,Jung, Ji-Eun,Choi, Sun Il,Kim, Sung Soo,Oh, Young Taek,Kim, Tae-Hoon,Choi, Eunji,Lee, Sun Joo,Kim, Hana,Kim, Eun Ok,Lee, Yu Sun,Chang, Hee Jin,Park, Joo Yong,Kim, Yeejeong,Yun, Tak,Heo, K Elsevier 2018 Cancer letters Vol.414 No.-
<P><B>Abstract</B></P> <P>Despite expressing high levels of the epidermal growth factor receptor (EGFR), a majority of oral squamous cell carcinoma (OSCC) patients show limited response to cetuximab and ultimately develop drug resistance. However, mechanism underlying cetuximab resistance in OSCC is not clearly understood. Here, using a mouse orthotopic xenograft model of OSCC, we show that bone morphogenic protein-7-phosphorylated Smad-1, -5, -8 (BMP7-p-Smad1/5/8) signaling contributes to cetuximab resistance. Tumor cells isolated from the recurrent cetuximab-resistant xenograft models exhibited low EGFR expression but extremely high levels of p-Smad1/5/8. Treatment with the bone morphogenic protein receptor type 1 (BMPRI) inhibitor, DMH1 significantly reduced cetuximab-resistant OSCC tumor growth, and combined treatment of DMH1 and cetuximab remarkably reduced relapsed tumor growth <I>in vivo</I>. Importantly, p-Smad1/5/8 level was elevated in cetuximab-resistant patients and this correlated with poor prognosis. Collectively, our results indicate that the BMP7-p-Smad1/5/8 signaling is a key pathway to acquired cetuximab resistance, and demonstrate that combination therapy of cetuximab and a BMP signaling inhibitor as potentially a new therapeutic strategy for overcoming acquired resistance to cetuximab in OSCC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> BMP7-p-Smad1/5/8 signaling contributes to cetuximab resistance in OSCC. </LI> <LI> DMHI, a BMP signaling inhibitor, reduced cetuximab-resistant OSCC tumor growth. </LI> <LI> Combined treatment of DMH1 and cetuximab significantly reduced relapsed tumor growth <I>in vivo.</I> </LI> <LI> p-Smad1/5/8 overexpression in OSCC patients was associated with poor disease free survival. </LI> </UL> </P>
Comparison of Fast Neutron Rates for the NEOS Experiment
Y. J. Ko,C. H. Jang,Kim Siyeon,J. Y. Kim,H. S. Kim,K. M. Seo,B. Y. Han,G. M. Sun,E. J. Jeon,Jaison Lee,M. H. Lee,Y. M. Oh,K. S. Park,K. K. Joo,B. R. Kim,H. J. Kim,이주영,Y. D. Kim,H. K. Park,H. S. Park 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.11
The fast neutron rates are compared at the site of the NEOS (Neutrino Experiment Oscillation Short baseline) experiment, a short-baseline neutrino experiment located in a tendon gallery of a commercial nuclear power plant using a 0.78-liter liquid scintillator detector. A pulse shape discrimination technique is used to identify neutron signals. The measurements are performed during the nuclear reactor-on and -off periods, and the fast neutron rates are found to be consistent with each other. The fast neutron rate is also measured at an overground site with a negligible overburden and is found to be ∼ 100 times higher than that at the site of the NEOS experiment.
MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation.
Sun, Bo K,Kim, Joo-Hang,Nguyen, Hoan N,Oh, Seeun,Kim, So Y,Choi, Sujin,Choi, Hye J,Lee, Yong J,Song, Jae J National Hellenic Research Foundation 2011 ONCOLOGY REPORTS Vol.25 No.2
<P>The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to activate mitogen-activated protein kinases (MAPKs) depending on caspase and mammalian sterile 20-like kinase 1 activations. However, the upstream molecule of MAPKs has not yet been identified. The mitogen-activated protein kinase kinase 1 (MEKK1) and the apoptosis signal-regulating kinase 1 (ASK1) are considered to be possible candidates for the action of MAPKKKs induced by TRAIL and the possibility of reactive oxygen species involvement has also been investigated. We found that MEKK1/MEKK4 as opposed to ASK1, are responsible for TRAIL-induced c-Jun NH2-terminal kinase (JNK) or p38 activation, and that their catalytic activity is repressed by the caspase-8 inhibitor, suggesting that the caspase-8 activation induced by TRAIL is indispensible for MEKK activation. The 14-3-3 관 was also shown to interact with and to dissociate from MEKK1 by TRAIL treatment, thus implicating the 14-3-3 protein as a negative regulator of MEKK1 activation. Taken together, we show herein that the upstream molecule of the TRAIL-induced MAPK activation is MEKK, as opposed to ASK1, via the mediation of its signal through JNK/p38 in a caspase-8-dependent manner.</P>
Joo, Y.H.,Jung, C.K.,Kim, M.S.,Sun, D.I. The Academy 2009 Otolaryngology-head and neck surgery Vol.140 No.4
Objective: To determine the role of angiogenesis in lymph node metastasis and the depth of invasion in early tongue cancer. Study Design: Retrospective analysis. Subjects and Methods: The study included 51 subjects with tongue cancer. Immunohistochemical staining for vascular endothelial growth factor, Notch1, and Notch3 was performed. Microvessel density was evaluated by counting the number of CD34-stained microvessels in each pathologic specimen. Results: Significant correlations were found between vascular endothelial growth factor and Notch1 expression and cervical lymph node metastasis (P = 0.020 and P < 0.009, respectively), tumor depth of invasion (P = 0.001 and P < 0.001, respectively), and microvessel density indicated by CD34 staining (P = 0.001 and P < 0.001, respectively). Nodal metastasis (P = 0.022), T stage (P = 0.002), and positive VEGF expression (P = 0.044) were statistically significant prognostic factors for disease-specific survival. Conclusion: Vascular endothelial growth factor and Notch1 expression are significantly related to cervical lymph node metastasis and depth of invasion in tongue cancer patients.
Joo-Hyung Kim,Min-Suk Kim,Sun-Hyung Lim,Young-Mi Kim,Jong-Yeol Lee 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
LMW-GSs represent approximately 1/3 of the total wheat gluten fraction, which have not been widely studied, even though they are important in the context of wheat end-use quality. In this study, we report on the qualitative and quantitative analysis of LMW-GS in korean wheat cultivars by 2DE in 32 cultivars of Korean wheat for the use of the basis of wheat breeding. We firstly identified spots corresponding each of Glu-3 alleles. The 2DE results for each cultivar will be used as reference map or protein marker discriminating wheat cultivars, wheat and rice, imported and Korean flour. Unexpectedly, five LMW-GS spots were found to be expressed at a common position in hexaploid wheat cultivars, and these spots might play something in glutenin biosynthesis. Total spot numbers were expressed variously between 20 and 10, and average spot number was shown 17.12. The average number of spots in Glu-A3, Glu-B3 and Glu-D3 were 3.0, 4.56 and 2.96 respectively. When the Korean wheat cultivars were compared with the Chinese spring (1.0) in the average relative expression level, Korean one’s were lower as 0.67. Especially, Gobun was the highest as 1.32 and Baekjoong was the lowest as 0.24. Also we investigated phylogenetic relationship based on frequency of HMW-GS spots and quantification value of each spot to all LMW-GS spots. As a result, the varieties of Korean wheat could be classified into five groups.
S-186 Clinical Impact of Myocardial Infarction due to Coronary Spasm and 2 Year Follow up
( Young Sun Kim ),( Ju Yeol Baek ),( Yong Mo Yang ),( Won Ik Lee ),( Seung-woon Rha ),( Byoung Geol Choi ),( Dong Joo Oh ),( Woong Chol Kang ),( Kiyuk Chang ),( Shung-chull Chae ),( Seung Ho Hur ),( K 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Backgrounds:?Coronary artery spasm has been identified as an alternative cause for myocardial infarction (AMI) in patients (pts). It has been shown about 50% of ACS pts without obstructive lesion had coronary spasm. However there is few data on the prognosis in these pts. Therefore we aimed to compare prognosis between pts with AMI due to coronary spasm without culprit lesion and AMI due to culprit lesion during 2 year of follow up.?Methods:?A total of 36,797 pts with AMI in the KAMIR (Korea Acute Myocardial Infarction Registry) were grouped according to AMI due to coronary spasm without culprit lesion (CAS MI; N=484) and AMI due to culprit lesion (Stenotic MI; N=36,313). We compared MACE defined as composite of cardiac death (CD), any myocardial infarction (MI), repeat revascularization (RR) at 2 year between the two groups. Results:?The incidence of MACE in pts with CAS MI at 2 follow up was significantly lower than in pts with Stenotic MI (10.8% vs 7.1%; log rank p=0.006). The pts with CAS MI had significantly lower incidence of RR (4.2% vs 0.4%; log rank p<0.001). However the incidence of MI (1.5% vs 0.9%; log rank p=0.594) and CD (5.4% vs 4.6%; log rank p=0.456) were similar between the two groups.?Conclusions:?In overall population with AMI, clinical outcomes of CAS MI was significantly lower than those of Stenotic MI upto 2 years, which is attributable to relatively low rate of RR. However the incidence of CD and MI in the pts with CAS MI could not be so small as compared with those of Stenotic MI.
GDSL lipase-like 1 regulates systemic resistance associated with ethylene signaling in Arabidopsis
Kwon, Sun Jae,Jin, Hak Chul,Lee, Soohyun,Nam, Myung Hee,Chung, Joo Hee,Kwon, Soon Il,Ryu, Choong-Min,Park, Ohkmae K. Blackwell Publishing Ltd 2009 The Plant journal Vol.58 No.2
<P>Summary</P><P>Systemic resistance is induced by necrotizing pathogenic microbes and non-pathogenic rhizobacteria and confers protection against a broad range of pathogens. Here we show that Arabidopsis GDSL LIPASE-LIKE 1 (GLIP1) plays an important role in plant immunity, eliciting both local and systemic resistance in plants. GLIP1 functions independently of salicylic acid but requires ethylene signaling. Enhancement of <I>GLIP1</I> expression in plants increases resistance to pathogens including <I>Alternaria brassicicola</I>, <I>Erwinia carotovora</I> and <I>Pseudomonas syringae</I>, and limits their growth at the infection site. Furthermore, local treatment with GLIP1 proteins is sufficient for the activation of systemic resistance, inducing both resistance gene expression and pathogen resistance in systemic leaves. The <I>PDF1.2</I>-inducing activity accumulates in petiole exudates in a GLIP1-dependent manner and is fractionated in the size range of less than 10 kDa as determined by size exclusion chromatography. Our results demonstrate that GLIP1-elicited systemic resistance is dependent on ethylene signaling and provide evidence that GLIP1 may mediate the production of a systemic signaling molecule(s).</P>