와동 세척제가 상아질 결합제의 결합에 미치는 영향

송승호,박호원,,이주현 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.4

와동 형성시 박테리아에 감염된 상아질이나 법랑질을 완전히 제거하지 않는 것은 수복학적 측면에서 볼 때 잠재적 문제점이 된다. 수복물 하방에서의 박테리아의 활동에 의해 술후 과민반응, 치수의 염증, 이차 우식 등이 진행될 수 있다. 와동 세척제는 와동 형성 후 잔존 박테리아의 제거를 위해 효과적으로 사용될 수 있지만 상아세관에 잔유물을 남겨 상아질 결합제와 치질간의 긴밀한 결합을 방해하여 미세누출을 증가시키고 결합강도를 약화시킬 가능성이 있다. 본 연구는 2% 클로르헥시딘을 함유하는 와동 세척제인 Consepsis(Ultradent. USA)가 Adper Scotchbond MultiPurpose(3M ESPE, USA), Adper Single Bond(3M ESPE, USA), Adper prompt L-Pop (3M ESPE, USA)의 결합에 미치는 영향을 평가하기 위하여 발거된 제 3대구치 120개를 이용하여 Consepsis 와동 세척제를 사용한 군과 사용하지 않은 군으로 나누어 전단결합강도 측정과 수복물 변연에 나타나는 미세누출 정도를 색소 침투 평가 방법으로 분석함으로써 다음과 같은 결론을 얻었다. 1.Comsepsis 와동 세척제의 사용 유무는 Adper Scotchbond Multi-Purpose, Adper, Single Bond, Adper Prompt L-Pop 의 미세누출 양상에 있어 통계학적으로 유의한 차이를 보이지 않았다.(p>0.05). Incomplete removal of bacteria contaminated dentin or enamel associated with caries is a potential problem in restorative dentistry. Secondary or residual caries, pulpal inflammation and hypersensitivity may result from bacteria left after the initial preparation, especially if an adequate seal against microleakage is not obtained. A possible solution to eliminate residual bacteria left in a cavity preparation would be to treat the cavity with cavity disinfectant wash. But a potential problem with using a cavity disinfectant with dentin bonding agents could be their interference with the ability of the resin to bond to the tooth micromechanically. The purpose of this study was to ecaluate the effect of 2% chlorhexidine containing cavity disinfectant(consepsis) on shear bond strength and microleakage of dentin bonding agents, Adper Scotchbond MultiPurpose. Adper Single Bond and Adper Prompt L-Pop. Sixty and sixty sound human third molar teeth, respectively, were used for shear bond strength and microleakage test. For experimental group, cavity disnfectant was applied before dentin bonding agents, and was not applied for the control group. The result from the this study can be summarized as follows; 1. Use of 2% chlorhexidine containing cavity disinfectant(Consepsis) does not significantly affect the shear bond strength of dentin bonding agents. 2. Use of 2% chlorhexidine containing cavity disinfectant(Consepsis) dese significantly affect the microleakage of dentin bonding agents.

數種植物의 生長에 미치는 機械的 刺戟의 影響

宋承達,柳勝元 慶北大學校 自然科學大學 1987 自然科學論文集 Vol.5 No.-

An investigation was carried on the effect of mechanical stimulus on the stem elongation, leaf area growth and chlorophyll content of several annual and perennial plants. Mechanical stimulus was treated with different frequencies of 0, 10, 30, 60, 90, 120 and 150 times every day by touching and pressing on the stems and leaves. All the plants showed a gradual inhibition for the stem elongation, leaf area expansion and chlorophyll synthesis by the increased treatment. Herbaceous plants of Glycine max and Commelina communis, showed the most sensitivity for the treatments and died with treatment of 120 and 150 stimuli per day in the later growth period. but C. communis showed an enhancement of growth in the treatment of 10 stimuli per day. Forsythia koreana, a perennial woody plant showed more tolerance for the treatments than Vitis vinifera, a climbing plant. The main factor of the effect seemed to be ethylene synthesized during the treatment of mechanical stimulus.

미성숙 치근의 수직 파절과 수평 파절의 치험례 : A CASE REPORT

송승호,박호원 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.1

청소년기에는 두개악안면부위의 외상성 손상이 흔하다. 그러나 상아질, 백악질, 치수를 포함하는 치아파절로 정의 되는 치 근파절을 비교적 드물다. 성장기 아동에 있어서 외상으로 인한 손상은 심리적인 위축감, 안모에 대한 열등감 등의 정서적인 문제와 치조골과 안모의 성장이나 치간 간격의 유지에 영향을 미치는 등의 지장을 초래하기 때문에 보존적인 치료가 요구된다. 첫 번째 증례는 9세의 남아로 상악 우측 중절치의 치수노출을 동반한 치관파절과 치근단부위에 치근의 수평 파절이 관찰되어 치관부 파절편 치수만 제거하고 수산화칼슘을 이용하여 충전하였다. 6개월 후 방사선 사진에서 dentinal bridge의 형성을 이 완료된 것을 확인하여 gutta percha를 이용하여 영구 충전을 시행하였다. 두 번째 증례는 7세의 여아로 상악 우측 중절치의 치수 노출을 동반한 치근의 수직 파절이 관찰되어 인위적 발거 후 레진 시멘트를 이용하여 파절편 부착 후 재식하였다. 술 후 8개월 동안의 관찰결과 특이한 임상적 증상은 나타나지 않았다. 이상의 증례에서 치근 파절이 발생한 치아에서 보존적 치료를 시행하였고 이에 양호한 결과를 얻었기에 보고하는 바이다. Traumatic injuries in the young permanent dentition are common, but root fractures, defined as fractures involving dentin, cementum and pulp, are relatively uncommon. Case 1 is a 9-year-old boy who had a horizontal root fracture of his maxillary right central incisor in the apical third. Root canal therapy was performed in coronal segment and calcium hydroxide therapy war, initiated. Six months after treatment, a periapical radiograph showed calcific tissue formation and normal root development. 1 year and 3 months later, the canal was permanently obturated with gutta-percha. Case 2 is a 7-year-old girl who had a vertical root fracture of her maxillary right central incisor. Fractured tooth was intentionally extracted atraumatically, and then the separated fragments are bonded with resin cement the restored tooth was replanted into the original socket. Recalls up to 8 months showed normal mobility and no periapical pathosis. In these cases, we performed conservative treatment. Clinical and radiographic examination showed no pathosis or abnormality of the teeth and periodontal tissue.

Azospirillum amazonense Y1의 窒素固定活性의 調節

宋承達,柳勝元 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

A. amazonese Y1의 질소고정효소활성에 대하여 산소, 암모니움 그리고 MSX의 조절기작을 고찰하였다. 질소고정효소활성의 최대치는 0.2Kpa의 산소농도에서 있었고, 혐기상태나 고농도의 산소조건에서는 저해를 받아 8Kpa의 산소농도까지 점차적으로 감소하였으며, 이때 다시 저농도의 산소를 유지하면 가역적으로 높은 활성을 나타내었다. 암모니움에 의한 질소고정효소활성의 억제는 350m mole 농도까지 점차로 부분적 억제를 보였으나 산소소모량에는 영향이 없었다. 질소고정효소활성을 조절하는 GS의 저해제인 MSX는 in vitro에서 1m mole에 의해 GS를 33%로 감소시켰으나, in vivo에서는 MSX의 흡수가 잘 일어나지 않으므로 0.1m mole에 의해 92%를 유지하는 부분적 억제를 보였다. 암모니움의 처리전과 1m mole처리후의 Fe단백질은 SDS-PAGE에 의해 modification이 없는 2개의 밀접된 서브유닛트를 나타내었다. Regulation and mechanism of the nitrogenase activity of Azospirillum amazonense Y1 were investigated with various concentrations of oxygen, ammonium and MSX. The maximum nitrogenase activity was obtained with 0.2 Kpa oxygen, and a reversible inhibition of the nitrogenase activity appeared with high concentration of oxygen(8 Kpa). Ammonium caused a gradual inhibition of the nitrogenase activity up to 350 mmole of NH_4Cl, but showed little effect on oxygen consumption. The glutamine synthetase inhibitor MSX caused 67% decrease of the in vitro GS by 1m mole, but only 8% decrease of the in vivo GS. The inhibition of nitrogenase activity by ammonium was only partial, and no transition period could be observed. The in vitro nitrogenase activity of ammonium treated cells was not decreased and no evidence for a modified Fe protein subunit was found. Nitrogenase extracts were active and had a Fe protein that migrated as a close double band on SDS-polyacrylamide gel electrophoresis.

연마방법에 따른 탄성의치의 표면거칠기와 Candida albicans의 부착율 변화

오주원,서재민,안승근,박주미,강철균,송광엽 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.2

연구 목적: 본 연구는 탄성의치 제작 시 주로 사용되는 polyamide를 수종의 연마방법을 사용하여 처리 후 Candida albicans의 부착정도와 표면거칠기를 비교하고자 하였다. 연구 재료 및 방법: 25×15×2 mm 크기의 polyamide 시편을 4군으로 나누어 연마재를 사용하여 기공용 lathe 연마하는 방법(기공실내 연마방법)과 각기 다른 2종의 실리콘 포인트로 진료실내 연마하는 방법, 그리고 실리콘포인트 연마 후 pumice로 연마하는 방법으로 처리하였다. C. albicans의 부착성을 평가하기 위해 5×106 CFU/ml의 C. albicans 현탁액에 시편을 2시간 동안 침적하였고 5회 수세처리 후 한천배지에서 배양하였다. 그리고 주사전자 현미경(JSM-5900, JEOL LTd., Tokyo, Japan) 촬영을 시행하였다. Profilometer (Surf-pak; Kawasaki, Japan)를 이용하여 표면거칠기를 측정하였고 통계처리를 위하여 SPSS 18.0 프로그램을 사용하였다. 일원변량분석으로 비교 분석하였고 사후검증은 C. albicans의 부착성 검증을 위해 Scheffe test를 시행하였으며 표면조도검증을 위해 Tamhane’s T2 test를 시행하였다(α=.01). 결과: 최대 거칠기 값을 보인 군은 2단계의 연마용 버를 사용한 것으로 0.32 ㎛±0.10 값을 나타냈으며, 가장 낮은 거칠기 값을 보인 것은 tungsten carbide를 사용하지 않고 기공용 lathe로만 연마를 한 군으로 0.02 ㎛±0.00의 거칠기 값을 나타냈다. C. albicans 부착 실험에서는 기공용 lathe만을 이용한 연마방법이 가장 적은 부착수를 보였으며 다른 세 군과 유의한 차이가 발견되었다(P<.01). 결론: 표면거칠기 및 미생물 부착능 실험 결과 기공실 연마만을 시행한 경우 유의하게 낮은 거칠기 값과 부착율을 보였다. Pumice로 추가 연마한 군은 진료실연마를 시행한 군에 비해 낮은 거칠기 값을 보였으나 C. albicans 부착에 있어서는 유의한 차이를 보이지 않았다(P>.01). Purpose: The purpose of this study was to compare the effect of 3 chairside polishing methods and laboratory polishing methods on surface roughness and C. albicans adhesion of polyamide denture base. Materials and methods: Using contact profilometer, the surface of polyamide specimens (25×15×2 mm) was studied after conventional polishing without finishing and after chiarside polishing with 2 chiarside polishing kits and chairside-pumice polishing following finishing with tungsten carbide bur. To evaluate the adhesion of C. albicans, C. albicans suspension was overlayed on the test specimen. And the specimens were incubated for 2 hours. Imprint culture method was achieved and counted the colony on the agar plate. Polished polyamide were evaluated using a scanning electron microscope. The statistics were conducted using one-way ANOVA and in case of difference, Scheffe test and Tamhane’s T2 test were used. Results: Surface roughness (Ra) of surfaces polished with 2 chairside polishing kits had higher than conventional polishing and pumice polishing. The highest roughness value was 0.32 ± 0.10 ㎛, and the lowest was 0.02 ± 0.00 ㎛. The adhesion of C. albicans on the specimens polished with chairside polishing group and pumice polishing group were increased than conventional polishing group (P<.01). Conclusion: Conventional laboratory polishing was found to produce the smoothest surface and the lowest adhesion of C. albicans. Two groups polished with Chairside polishing kits were similar with respect to surface roughness. Surface of the specimen polished with pumice is significantly smoother than 2 chairside polishing groups, but the result of C. albicans adhesion is that group polished with pumice was similar with 2 chairside polishing groups (P>.01).

관동맥연축의 비침습적 진단에 있어 Ergonovine Echocardiogrpahy의 유용성

송재관,박성욱,김재중,두영철,김원호,박승정,이종구 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1

관동맥연축의 비침습적인 진단방법의 확립은 침습적인 관동맥조영술 및 연축유발검사에 비해 반복적용이 가능한 이론적인 장점이 있어 선별검사(screening test)로서의 기능뿐만 아니라 치료로 이용되는 약물의 효과비교 및 추적검사를 통한 관동맥연축의 임상ㄹ활동도 평가등에 손쉽게 이용될 수 있으라라 예상된다. 이에 저자들은 ergonovine 투여시 기록된 좌심실벽운동장애 유무가 갖는 관동맥연축에 의한 심근허혈의 진단적 가치를 평가하기 위해 Beside Ergonovine Echocardiography Test를 시행하였다. 관동맥조영술 및 연축유발검사에서 변이형협심증으로 증명된 30명(남자 27명, 평균연령 54세)과 비특이적인 흉통질환군 20명(여자 12명, 평균연령 55세)을 대상으로 관동맥조영술 다음날 ergonovine test를 시행하였다. 운동부하검사가 음성인 환자들을 대상으로 6시간 공복시킨 뒤 앙와위에서 상지정맥을 통하여 25-50microgram(이하 mcg)을 5뷴 간격으로 투여하여 흉통의 유무, 심전도 및 이면성심초음파를 5분마다 기록하였으며 총투여량이 350mcg에 도달하거나 양성반응을 보이는 경우 nitroglycerin 250mcg 정주 및 설하투여로 종료하였다. 좌심실벽운동의 분석은 side-by-side continuous cine-loop display가 가능한 QUAD screen 방법으로 판별하였다. 가역적인 심전도 변화나 국소적인 심실벽운동장애가 유발되는 경우를 양성으로 판정하였다. Ergonovine Echocardiography의 전체 민감도는 90%, 특이도는 100%로 동시에 기록된 심전도 변화의 민감도(73%)보다 높았으며 특히 흉통이 있으나 심전도 변화가 전혀 없었던 5례 모두에서 좌심실벽운동장애가 관찰되어 본 검사법의 우월성을 확인할 수 있었다. 양성반응을 보인 ergonovine 평균 투여량이 173±95mcg 이었으며 흉통발작의 빈도를 기준으로한 임상활동도가 높은 경우 활동도가 낮은 군에 비해 양성반응을 의한 총 ergonovine 투여량이 적었으며(123±86 vs 213±83mcg, p<0.01) 관동맥협착이 연축에 동반되어 있는 경우 정상 관동맥에 연축이 있는 경우보다 민감도가 더 높았다(100% va 60%, P=0.02). Ergonovine 투여로 혈압은 기저치 보다 약 17%정도 증가되었으나 맥박수는 큰 변화를 나타내지 않아 안전하게 시행될수 있었으며 오심, 두통, 견갑부통증, 심실기외수축, 방실차단 등이 소수례에서 관찰되었으나 검사로 인한 사망례는 없었다. Ergonovine 주입후 기록된 좌심실벽운동동장애는 심전도 변화보다 더 민감하게 관동맥연축에 의한 심근허혈을 진단할 수 있었으며 Ergonovine Echocardiography는 운동부하검사 등으로 심한 관동맥협착이 배제된 선별된 흉통환자들에서 관동맥연축의 진단에 안전하게 시행될 수 있는 민감하고 특이도가 높은 검사방법이며 변이형협심증의 임상활동도와 관동맥협착의 동반유무가 본 검사법의 결과에 영향을 미칠 수 있으리라 사료된다. The purpose of this study was to evaluate the clinical feasibility of bedside intravenous ergonovine test with echocardiography as a noninvasive diagnostic method for coronary vasospasm. Bedside ergonovine test was performed in 50 patients with chest pain one day after coronary angiography with spasm provocation test;30 patients showed positive results of provocation test while in 20 patients there was no evidence of coronary vasospasm. A bolus of ergonovine maleate(.025 or .05mg) was injected at 5 min intervals up to total cumulative dosage of 0.35mg, and 12-leads ECG and 2-D Echo were recorded every 3min after each injection. Left ventricular wall motion was analyzed with a commercially available ' QUAD' system. The positive criteria of beside ergonovine test included reversible ST segment elevation or depression, T wave changes in ECG(ECG criteria) and reversible regional wall motion abnormalities(RWMA) in Echo(Echo criteria). The overall sensitivity and specificity of ECG criteria were 73%(22/30) and 100% respectively ; The sensitivity of Echo criteria increased up to 90%(27/30) without the change of the specificity. Among 22 patients with reversible ECG changes only 73%(16/22) showed typical ST segment elevation while ST depression was recorded in 2 patients(9%) and minor T wave peaking or flattening without ST segment displacement in 4 patients(18%). Concomitant fixed coronary lesion does increase the sensitivity of the test compared to pure coronary vasospasm with ECG criteria(100% vs 60%, p<0.05). Mean does of ergonovine with positive results was 173±95 microgram(mcg) and the amount of does of ergonovine for positive result was significantly larger in patients with low disease activity (chest pain <5times/자) than those with high disease activity(213±83 vs 123±86mcg, p<0.01). There was no procedure related mortality or fatal arrhythmias. Ergonovine echocardiography is a highly sensitive and specific test for coronary vasospasm and is safe in selected patients in whom the exercise test is negative and severe fixed coronary artery disease has been excluded. Presence of concomitant fixed coronary artery disease and the degree of clinical activity of coronary vasospasm may influence the results of this test.

진균성 부비동염의 임상적 고찰

이승원,김장욱,박영진,송태현,이병돈,장혁순 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

The fungal sinusitis is relatively rare and mainly develops in immunocompromised hosts, but is sporadically appears in the immunocompetent patients, where its incidence tends to be increasing. Because the clinical features of this disease are similar to those of chronic suppurative sinusitis, this entity may be overlooked. We analysed thirteen fungal sinusitis from January 1997 through December 1999 based on clinical features, laboratory characteristics and operative findings. The results are as follows. 1)Fungal sinusitis occurred 3.3 times as frequently in female patients as in male patients and the peak age groups are 4th and 5th decades. 2) The time intervals between the onset of symptoms and the first hospital visit were as follows: 5 cases within 3 months, 1 case between 4 and 6 months, 3 cases between 7 and 12 months, and 4 cases over 1 year. 3) The chief complaints were nasal obstruction, postnasal drip, rhinorrhea, cheek pain, headache, ocular pain, sneezing. 4) The characteristic computerized tomographic findings were hyperattenuated lesions in the maxillary sinus and in the nasal cavity near the natural ostium. 5) The most common pathogen was Aspergillus(92.3%) 6) We performed Caldwell-Luc's operation only in 4 cases, Caldwell-Luc's operation with intranasal ethmoidectomy in 3 cases, Caldwell-Luc's operation with endoscopic sinus surgery in 3 cases and endoscopic sinus sugery only in 3 cases. 7) Most of the gross specimens revealed a fungus ball containing a black-brown necrotic debris or caseous material.

Pristinamycin(Pyostacine®)의 methicillin-resistant Staphylococcus aureus,Penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae 임상균주에 대한 시험관내 항균력

박정원,송준영,김철현,정희진,김우주,김민자,박승철 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.4

목적 : 국내 및 전세계적으로 methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae(PRSP), β-lactamase 생성 H. influenzae 등의 항균제 내성 감염증이 증가되고, 이에 대한 효과적인 항생제 요법에 대한 필요성이 증가되고 있다. Streptogramin 계열의 경구 항생제인 pristinamycin의 임상검체에서 분리된 균주에 대한 시험관내 항균력을 검사함으로서 이러한 감염증에 대한 임상적 사용의 유용성여부를 알아보고자 하였다. 방법 : 1999년 8월1일부터 2000년 1월 1일까지 호흡기 감염, 피부 및 연조직 감염환자로부터 분리된 MRSA 60주, PRSP 50주, H. influenzae 40주를 대상으로 pristinamycin을 비롯한 8-9종 항생제의 시험관내 항균제 감수성을 측정하였다. 결과 : Pristinamycin은 MRSA에 대한 MIC 범위가 0.125-1㎎/L로서 100%의 감수성을, PRSP에 대한 MIC 범위가 0.125-1㎎/L로서 100%의 감수성을, β-lactamase를 생성하는 H. influenzae에 대해서도 MIC 범위가 0.25-2㎎/L, 96% 감수성으로서 다른 항생제들에 비하여 우수한 시험관내 항균력을 나타내었다. 결론 : 국내에서 문제가 되고 있는 MRSA, PRSP, β-lactamase 생성 H. influenzae에 대하여 pristinamycin은 우수한 시험관내 항균력을 나타내어, 이들 항생제 내성균들에 의한 감염증의 치료에 효과적으로 사용될 수 있을 것으로 생각된다. Background: Pristinamycin(Pyostacine®) is a natural antibacterial combination of compounds Produced by Streptomyces pristinaespiralis. It has been marketed in European countries over 30 years as an oral anti-stphyhcoocal agent. Because of the increasing prevalence microorganisms that are resistant to multiple antimicrobial agents in Korea. there are demand of noble antibiotics like pristinamycin against these resistant organissms. Methods The one-hundred and fifity bacterial strains which were collected from Korea University Guro hospital included sixty methicillin-resistant S. aurous (MRSA) , fifty penicillin-resistant S. pneumoniae (PRSP) and forty H. infuenzae clinical isolates. Using an microbroth dilution or agar dilution technique, we compared the antimicrobial activities of pristinamycin and other usual antibiotics against the studmicroorganisms. Results: All sixty MRSA strains were multiply resistant to other antimicrobial agents, but 100% of MRSA strains were susceptible to pristinamycin (MIC range: 0.125-1㎎/L). All of fifty PRSP strains were multiple resistant to other antimicrobial agents but 100% PRSP strains were susceptible to pristinamycin (MIC range: 0.125-1㎎/L). Twenty-seven strains of forty H. influenzae strains were β-lactamase positive, and 95% (38/40) of H. influenzae strains were susceptible to prisitinamycin (MICrange : 0.015-4㎎/L) . Conclusion : Pristinamycin demonstrated the highly active. in vitro antimicrobial activities against MRSA. PRSP. and H.influenzae isolated so it might be an effective oral therapeutic agent for treating patients with mild infection due to those organisms or on the outpatient setting.

장기 이식 환자에서 Voriconazole 과 Cyclosporine 또는 Tacrolimus의 상호작용

한혜원,김재연,송영천,김승은,유성길 한국병원약사회 2009 병원약사회지 Vol.26 No.1

Abstract: In organ transplant patients, the opportunity of fungi infections such as invasive aspergillosis increase by use of immunosuppresant drugs and voriconazole is recommended as primary treatment drug. When voriconazole is administered with cyclosporine(CsA) or tacrolimus(FK506), caution about increment of blood CsA or FK506 concentrations that caused by the change of CYP3A4 activity is required but few domestic cases of interaction were reported yet, The purpose of this study was to assess the effect of voriconazole on the blood CsA or FK506 concentrations in transplant recipients and the factors of recipients that have an effect on the results. 25 transplant recipients who were administered voriconazole with CsA or FK506 from January 1 of 2006 to August 17 of 2008 in Asan Medical Center were objects (12 patients on CsA coadministration arm - 9 males, 3 females; 41~62years;2 liver, 2 kidney, 3 bone marrow, 5 heart transplant recipients, and 13 on FK506 coadministration arm - 7 males, 6 females;26~65years; 10 liver, 2 kidney, 1 heart transplant recipients). Blood CsA or FK506 concentrations before and after coadministration of voriconazole, and maximum concentration in one month from the first day of coadministration were monitored retrospectively. In most cases CsA or FK506 were administered as recommended doses regardless of coadministration of voriconazole, and blood concentration increased from 239.42±126. 77ng/ml to maximum 411.92±225. 76ng/ml in CsA coadministration arm(p=0.003), and from 7.72±2.79ng/ml to maximum 19.16±9.35ng/ml in FK506 coadministration arm(p=0.003). Gender, age, and the kind of transplant organ did not affect to the change of blood concentration in both two arms. In consequences, administration of voriconazole could affect on the blood CsA or FK506 concentration, and in cases of administra tion of voriconazole in transplant recipients treated with CsA or FK506, close monitoring and dose adjustment is needed.

한국산 육서사류(陸棲蛇類)의 조충류 감염상태

조승열,송기원,이순형 중앙대학교 의과대학 의과학연구소 1982 中央醫大誌 Vol.7 No.4

One hundred Korean terrestial snakes,i.e.,7 Elaphe rufodorsata,17 E. dione, 10 Dinodon rufozonatum rufozatum,37 Natrix tigrina lateralis,21 Agkistrodon blomhoffii brevicaudus,6A.calibinosus and 2A. saxatiilis were examined from June 17, 1981 to Jun 1, 1982, to observe the fauna of Korean cestode parasities. They were collected from 13 localities of southern Korea: i.e., Chunseong Gun, Hong-cheon Gun, Hoengseong Gun, Weonseong Gun, Samcheog Gun, Gangweon Do; Namyangju Gun, PAju Gun, Ganghwa Gun, Gyeonggi Do; Youngdong Gun, Jeweon Gun, Chungcheongbug Do; Jangheung Gun, Jeonlanam Do; Sancheong Gun, Gyeongsangam Do and Bugjeju Gun, Jeju Do respectively. The results could be summarized as follows: 1. A total of 61 snakes was found to be infected withsparganum larvae of Spirometra mansoni out of 100 examined. Snakes from 11 localities were infected. By species of snake, N.t. lateralis and A.b. brevicaudus showed the higher infection rates. The mean density was 11.0 per examined snake and 18.1 per infected snake respectively. A. caliginosus and A. saxatilis were new hosts of spatganum in Korea. 2. Trtrathyridium of Mesocestoides sp. was found in one snake, Elaphe rufodorsala collected from ChunSeong Gun, Gangweon Do. A total of 16 tetrathyridia was found at serosa and mesemtery of the snake. The morphology of the larvae was described. This was thr first record of recovery of thtrathyridia in any vertebrate intermediate host in Korea. Elaphe rufodorsata was a new host. 3. proteocephalus japonensis(Yamaguti, 1935) n.comb.(syn.: Ophiotaenia Japonensis Yamaguti, 1935) were found in 10 snakes which were collected from Hongcheon Gun, Weonseong Gun, Namyangju Gun, Paju Gun, Jeweon Gun, and Sancheong Gun repectively. The infected snakes were Agkistrodon blomhoffii brevicaudus, A. caliginosus, A. saxatilis and Natrix tigrina lateralis. The habit was small instetine. The measurement data and morpholigy were described. The preaently observed worms were longer than those of original description and was a difference in mumber of uteerine branches. A. blomhoffii brevicaudus, A. caliginosus, A. saxatilis were new hosts for this protecephalid cestode. Korea was added to list of the locality.