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KU, Bok-Kyung,KIM, Soon-Bok,MOON, Oun-Kyeong,LEE, Sang-Jin,LEE, Jong-Hwan,LYOO, Young-Soo,KIM, Hee-Jung,SUR, Jung-Hyang Japanese Society of Veterinary Science 2005 The Journal of veterinary medical science Vol.67 No.11
<P>In this study, we performed experiments to evaluate the extend of the process of apoptotic cell death by foot-and-mouth disease virus (FMDV). Apoptosis can also occur in some virus-infected cells, and ability of viruses to either inhibit or promote apoptosis may influence the pathologic outcome of infection. In this study, to determine if apoptosis plays a role in the outcome of FMDV infection in swine, we evaluated apoptosis in diseased tissues collected from pigs inoculated with two different stains of FMDV (O1 Campos and O Taiwan). And host cell DNA fragmentation in diseased tissue from animals which were infected with either virus was evaluated by occurrence of a laddering pattern characteristic of apoptosis. Infection of cultured keratinocytes from swine tongue failed to demonstrate apoptosis in the first few hours of infection, suggesting that cell-to-cell correlation between viral antigen and apoptotic changes, e.g. cytokine secretions by immune system cells, could be critical to initiating apoptosis. Consistent with this finding, we were able to detect the pro-inflammatory cytokine TNF-α in diseased tissues. A clear difference in the pathogenicity of the two different FMDV isolates to pigs was not demonstrated in our study.</P>
윤순식,이경현,배유찬,문운경,권용국,한홍율,Yoon, Soon-Seek,Lee, Kyeong-Hyun,Bae, You-Chan,Moon, Oun-Kyong,Kwon, Yong-Kuk,Han, Hong-Ryul 대한수의학회 2005 大韓獸醫學會誌 Vol.45 No.3
Porcine juvenile pustular psoriasiform dermatitis (PJPPD) is a disease of young pigs and characterized by nonpruritic round eruption of skin. The cause of this disease is yet undetermined but is presumed to be genetic predisposition. There may be few opportunities for veterinarian to detect this disease compared with actual situation in field because these lesions resolve spontaneously in two months. The authors detected spontaneous PJPPD case and performed clinical and pathological studies on three pigs from one farm. The specific skin lesions were observed in the forty-day old pigs of mixed breed, which were produced by the sows received semen from the same boar, restrictively. However, there was no skin lesion of pigs in suckling or fattening periods. Grossly, lesions were commonly found on the ventral abdominal part as a papule and were spreaded to the skin of whole body. With the spreading of lesions centrifugally, skin was showed as a umbilicated plaques or mosaic pattern with a few pustules or crusts. Microscopically, the most prominent lesion was the psoriasiform hyperplasia with acanthosis, down growth of rete ridges, exocytosis of eosinophils and neutrophils, ballooning degeneration of superficial epidermis, and koilocytic degeneration of keratinocytes. Additionally, there were moderate dermal edema and severe mixed cellular infiltration, especially eosinophils. No infectious agent which can cause the skin lesion, was detected or cultured, and no lesion caused by infectious agents was also observed, pathologically. With pathological results of this study, it is supposed that pathogenesis or severity of PJPPD may be related to the infiltration of eosinophil or hypersensitivity.
전산유체역학 기법을 이용한 돈사 내 습식 공기 정화기의 적정 위치 설계
권경석,이인복,황현섭,홍세운,서일환,최지선,송상현,문운경,Kwon, Kyeong-Seok,Lee, In-Bok,Hwang, Hyun-Seob,Bitog, Jessie.P.,Hong, Se-Woon,Seo, Il-Hwan,Choi, Ji-Sun,Song, Sang-Hyeon,Moon, Oun-Kyung 한국농공학회 2010 한국농공학회논문집 Vol.52 No.3
In South Korea, as the living standard has been getting higher, meat consumption is steadily increasing. To meet the country's demand, livestock houses become larger and wider with increased raising density. In larger livestock houses, pollutants such as flake of pig skin, excrement, odor, various dusts and noxious gas like ammonia are excessively accumulated inside the facility. These will cause weak immunity for the pigs, diminution of productivity and degeneration of working condition. These problems can be solved through the ventilation performance of the facility. In the winter time, ventilation must be controlled to minimum to maintain a suitable thermal condition. However, this affects the other internal environmental condition because of the minimum ventilation. The installation of "wet air cleaner" especially in the winter time can be an alternative solution. For efficient application of this machine, there is a need to understand the existing ventilation condition and analyze the interaction of existing ventilation system with the wet air cleaner considering its appropriate location. In this study, the existing ventilation system as well as the internal environmental condition negatively inside the facility with the wet air cleaner has been studied using CFD technology. The CFD simulation model was validated from the study conducted by Seo et al. (2008). Results show that the elimination rate of ammonia was 39.4 % and stability could be improved to 35.1 % (Comparing case 5 to 1 where wet air cleaner machine was not used). It can therefore be concluded that case 5 shows the optimum location of a wet air cleaner in the livestock house.
양돈장의 소모성질병 확산 분석을 위한 현장 모니터링 및 공기유동학적 분석
서일환,이인복,문운경,권경석,Seo, Il-Hwan,Lee, In-Bok,Moon, Oun-Kyung,Kwon, Kyeong-Seok 한국농공학회 2014 한국농공학회논문집 Vol.56 No.1
Pig chronic wasting disease, including porcine reproductive and respiratory syndrome (PRRS) and postweaning multisystemic wasting syndrome (PMWS), have made a continuous economic damage in pig farms. Airborne spread of livestock viruses are an important spread factor which is difficult to analyze due to invisible airflow and limitation of measurement. The objective of this study is to analyze airborne disease spread between buildings in the experimental pig farm by means of field experiment and computational fluid dynamics (CFD). The field experiments were conducted to capture airborne virus using air sampler and teflon filter along multi points in the experimental pig farm. The samples were tested in terms of virus detection resulting in positive reaction for PRRS and PCV-2 viruses, which can be a firm evidence of airborne virus spread. The CFD simulation model was developed by considering complex topography, wind conditions, building arrangement, and ventilation systems and was used to analyze airborne virus spread according to different wind conditions. The CFD computed result showed a possibility of airborne virus spread via livestock aerosol from infected pig house to neighboring pig houses according to wind directions. The CFD simulation technique is expected to provide significant data for estimating and making a counterplan against airborne disease spread.
고병원성 조류인플루엔자 (HPAI)의 에어로졸을 통한 공기 전파 예측을 위한 공기유동학적 확산 모델 연구
서일환,이인복,문운경,홍세운,황현섭,권경석,김기연,Seo, Il-Hwan,Lee, In-Bok,Moon, Oun-Kyung,Hong, Se-Woon,Hwnag, Hyun-Seob,Bitog, J.P.,Kwon, Kyeong-Seok,Kim, Ki-Youn 한국농공학회 2011 한국농공학회논문집 Vol.53 No.1
HPAI (High pathogenic avian influenza) which is a disease legally designated as an epidemic generally shows rapid spread of disease resulting in high mortality rate as well as severe economic damages. Because Korea is contiguous with China and southeast Asia where HPAI have occurred frequently, there is a high risk for HPAI outbreak. A prompt treatment against epidemics is most important for prevention of disease spread. The spread of HPAI should be considered by both direct and indirect contact as well as various spread factors including airborne spread. There are high risk of rapid propagation of HPAI flowing through the air because of collective farms mostly in Korea. Field experiments for the mechanism of disease spread have limitations such as unstable weather condition and difficulties in maintaining experimental conditions. In this study, therefore, computational fluid dynamics which has been actively used for mass transfer modeling were adapted. Korea has complex terrains and many livestock farms are located in the mountain regions. GIS numerical map was used to estimate spreads of virus attached aerosol by means of designing three dimensional complicated geometry including farm location, road network, related facilities. This can be used as back data in order to take preventive measures against HPAI occurrence and spread.
송상현,이인복,권경석,하태환,홍세운,서일환,문운경,김연주,최은진,Song, Sang-Hyeon,Lee, In-Bok,Kwon, Kyeong-Seok,Ha, Tae-Hwan,Bitog, Jessie P.,Hong, Se-Woon,Seo, Il-Hwan,Moon, Oun-Kyeong,Kim, Yeon-Joo,Choi, Eun-Jin 한국농공학회 2012 한국농공학회논문집 Vol.54 No.3
Recently, the livestock industry in Korea was heavily affected by the outbreak of official livestock diseases such as foot and mouse disease, high pathogenic avian influenza, swine influenza, and so on. It has been established that these diseases are being spread through direct contact, droplet and airborne transmission. Among these transmissions, airborne transmission is very complex in conducting field investigation due to the invisibility of the pathogens and unstable weather conditions. In this study, the airborne transmission was thoroughly investigated inside a pig house by conducting tracer gas ($CO_2$) experiment because experiment with real pathogen is limited and dangerous. This is possible as it can be assumed that the flow is similar pattern very fine particles and gas. In the experiment, the ventilation structure as well as the location of gas emission were varied. The $CO_2$ detection sensors were installed at 0.5 and 1.3 m height from the floor surface. The tracer gas level was measured every second. Results revealed that the direction of spread can be determined by the response time. Response time refers to the time to reach 150 ppm from the gas emission source at each measuring points. The location of the main flow as well as the gas emission was also found to be very important factor causing the spread.
2003년 한국의 돼지콜레라 전국적 확산에 대한 기술역학
박최규,이은섭,윤하정,위성환,송재영,문운경,최은진,김현수,이주호,안수환,Park, Choi-Kyu,Lee, Eune-Sub,Yoon, Hachung,Wee, Sung-Hwan,Song, Jae-Young,Moon, Oun-Kyeong,Choi, Eun-Jin,Kim, Hyun-Soo,Lee, Joo-Ho,An, Su-Hwan 대한수의학회 2006 大韓獸醫學會誌 Vol.46 No.3
In March 2003, classical swine fever (CSF) infection was reported in a piggery located at Iksan city, Jeollabuk-do in Korea. Subsequently, a total of 72 infected farms were confirmed between March and December, 2003. Based on epidemiological investigation of the earlier confirmed infected farms, the source of infection was shown to be from a breeding farm. Targeted surveillance of 82 piggeries that had acquired pigs from this breeding farm showed 44 piggeries were infected with CSF virus. CSF virus was introduced into this breeding farm by movement of selected breeder pigs from its 12 contracted farms which were located in areas that had been affected by CSF epidemic in late 2002. CSF had then spread through out the country mainly by direct transmission through the sale and movement of pigs from this breeding farm. Consequently, 47 (62%) among 72 CSF affected farms were associated, directly and indirectly, with this breeding farm. This study showed that inadequate control for breeding farms and transport restriction in CSF outbreak areas resulted in the nationwide spread of CSF and the failure of the eradication campaign that has been underway for several years by the Korean animal hygiene authority as well as the fanners. Improvements of control policy through further research of the 2003 CSF epidemic will be needed to reestablish the Korean CSF eradication program in the future.