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Left Ventricular Thrombus and Subsequent Thromboembolism, Comparison of Treatment Modalities (초)
( Joo Myung Lee ),( Jin Joo Park ),( Hee Won Jung ),( Young Seok Cho ),( Il Young Oh ),( Chang Hwan Yoon ),( Jung Won Suh ),( Eun Ju Chun ),( Sang Il Choi ),( Tae Jin Youn ),( Cheong Lim ),( Goo Yeong 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1
Twenty-year incidence trend of hematologic malignancies in the Republic of Korea: 1999‒2018
Won-Ju Park,Joo-Heon Park,Seunghyeon Cho,Myung Geun Shin 대한혈액학회 2021 Blood Research Vol.56 No.4
Background In this study, we presented the national cancer statistics on the incidence of hematologic malignancies in the Republic of Korea (ROK) over a period of 20 years, from 1999 to 2018. Methods We obtained data on the incidence of hematologic malignancies using the Korean Statistical Information Service (KOSIS). For each hematologic malignancy, the number of cases, crude incidence rate, and age-standardized incidence rate were calculated, and the statistical trends were confirmed by Poisson regression and Joinpoint regression analysis. Results All the investigated hematologic malignancies showed a statistically significant increase in incidence over 20 years. The 20-year trend of the age-standardized incidence rate was as follows: non-Hodgkin lymphoma [average annual percent change (AAPC)=2.26%, P -trend <0.05], leukemia (AAPC=0.94%, P -trend <0.05), myeloid leukemia (AAPC=1.44%, P -trend <0.05), multiple myeloma (AAPC=3.05%, P -trend <0.05), myeloproliferative disorders (AAPC=9.87%, P -trend <0.05), myelodysplastic syndrome (AAPC=7.59%, P -trend <0.05), malignant immunoproliferative diseases (AAPC=11.82%, P -trend <0.05), lymphoid leukemia (AAPC=2.21%, P -trend <0.05), and Hodgkin lymphoma (AAPC=4.04%, P <0.05). Conclusion It was confirmed that the incidence of hematologic malignancies has increased significantly in the ROK over the past 20 years. This study can be used as foundational data source for future studies. In addition, it can aid in the necessary actions of predicting future incidences and establishing future healthcare policies.
( Joo Kyung Park ),( Ji Won Yoo ),( Sang Myung Woo ),( Jung Kyun Seo ),( Ki Young Yang ),( Ji Kon Ryu ),( Yong Tae Kim ),( Yong Bum Yoon ),( Jun Kyu Lee ),( Won Jae Yoon ),( Sang Hyub Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: The serum of cancer patients often harbors increased free DNA levels, which can potentially be used for cancer detection. Recently, several genes (including NPTX2) have been discovered to be aberrantly methylated in primary pancreatic cancer tissue. The aim of study was to investigate possibility of differential diagnostic method in high risk group of pancreatic cancer such as chronic pancreatitis based on epigenetic characteristics. Methods: We enrolled 33 pancreatic cancer and 22 benign pancreaticobiliary disease patients. ERCP guided pancreatic duct brush cytology samples were obtained. After that, we enrolled 104 pancreatic cancer, 60 chronic pancreatitis and 5 benign biliary tract stone disease patients. We collected blood samples before surgery or any kind of treatment. DNA was extracted and NPTX2 CpG island hypermethylation was examined quantitatively by real-time PCR amplification after chemical modification. Results: There were 104 pancreatic cancers and their AJCC stages were as followed; 3 in stage I, 21 in II, 43 in III, 37 in IV. We could see statistically significant higher levels of NPTX2 hypermethylation compared to chronic pancreatitis (p=0.016). From ROC curve, we could get 79% sensitivity and 75% specificity (cut off=0.015%). NPTX2 methylation appeared in all stages of pancreatic cancer, but it got significantly higher as AJCC stages progress. This was in contrast to the fact that there were statistically significant higher levels of NPTX2 hypermethylation compared to chronic pancreatitis but there were no significant difference among the stages in cytology samples of pancreatic cancer. Conclusions: The quantitative analysis revealed that aberrantly hypermethylated NPTX2 gene could be detected from the plasma and cytology samples of pancreatic cancer and it was significantly higher compared to chronic pancreatitis. Therefore, aberrantly methylated NPTX2 gene may help differentiate from chronic pancreatitis with conventional diagnostic tools.
( Won Kee Choi ),( Myung Rae Cho ),( Joo Hwan Lee ) 대한고관절학회 2014 Hip and Pelvis Vol.26 No.4
Purpose: We evaluate the clinical and radiographic midterm results of primary total hip arthroplasty (THA) using a 36 mm diameter femoral head on highly cross-linked polyethylene (minimum 7-year follow-up). Materials and Methods: We retrospectively reviewed 73 patients (74 hips) that underwent primary THA with a 36 mm diameter femoral head on highly cross-linked polyethylene between July 2004 and February 2007. Clinical follow-ups included specific measurements like modified Harris hip scores (HHS) and Merle d``Aubigne and Postel score. For radiologic evaluations, together with position of acetabular cup at 6 weeks later of postoperation, we separately calculated the penentrations of femoral heads into polyethylene liners during postoperation and one year later check-ups, and during one year later check-ups and final check-ups. Results: There were no complications except for one case of dislocation. Average modified HHS at final followup was 88±7.5 (range, 81-96), and Merle d``Aubigne and Postel scores were more than 15 (range, 15-18). Mean acetabular cup inclination and anteversion were 50.1。(range, 35。-58。) and 23.6。(range, 5。-38。), respectively. Average femoral head penetration during the first postoperative year was 0.071±0.034 mm/year, and steady-state wear rate determined using radiographs taken at one-year postoperatively and at latest follow-up was 0.051± 0.022 mm/year. Average femoral head penetration during entire follow-ups was 0.058±0.013 mm/year. Conclusion: Primary THA with a large diameter femoral head on highly cross-linked polyethylene was found to produce the results comparable to previous in vitro laboratory hip simulation studies. And we also find out good scores in terms of patient``s functionality.