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Eom, Jung-Seop,Cho, Eun-Jung,Baek, Dong-Hoon,Lee, Kyung-Nam,Shin, Kyung-Hwa,Kim, Mi-Hyun,Lee, Kwang-Ha,Kim, Ki-Uk,Park, Hye-Kyung,Kim, Yun-Sung,Park, Soon-Kew,Cha, Seong-Heon,Lee, Min-Ki The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.72 No.1
Background: The survival of non-small cell lung cancer (NSCLC) patients with brain metastases is reported to be 3~6 months even with aggressive treatment. Some patients have very short survival after aggressive treatment and reliable prognostic scoring systems for patients with cancer have a strong correlation with outcome, often supporting decision making and treatment recommendations. Methods: A total of one hundred twenty two NSCLC patients with brain metastases who received gamma knife radiosurgery (GKRS) were analyzed. Survival analysis was calculated in all patients for thirteen available prognostic factors and four prognostic scoring systems: score index for radiosurgery (SIR), recursive partitioning analysis (RPA), graded prognostic assessment (GPA), and basic score for brain metastases (BSBM). Results: Age, Karnofsky performance status, largest brain lesion volume, systemic chemotherapy, primary tumor control, and medication of epidermal growth factor receptor tyrosine kinase inhibitor were statistically independent prognostic factors for survival. A multivariate model of SIR and RPA identified significant differences between each group of scores. We found that three-tiered indices such as SIR and RPA are more useful than four-tiered scoring systems (GPA and BSBM). Conclusion: There is little value of RPA class III (most unfavorable group) for the same results of 6-month and 1-year survival rate. Thus, SIR is the most useful index to sort out patients with poorer prognosis. Further prospective trials should be performed to develop a new molecular- and gene-based prognostic index model.
Recent Advances in Adjuvant Therapy for Non–Small-Cell Lung Cancer
Jung Seop Eom, M.D., Ph.D.,Mi-Hyun Kim, M.D., Ph.D.,Soo Han Kim, M.D., Ph.D.,Min Ki Lee, M.D., Ph.D. 대한결핵및호흡기학회 2024 Tuberculosis and Respiratory Diseases Vol.87 No.1
After the successful development of targeted therapy and immunotherapy for the treatmentof advanced-stage non-small cell lung cancer (NSCLC), these innovative treatmentoptions are rapidly being applied in the adjuvant setting for early-stage NSCLC. Some adjuvants that have recently been approved include osimertinib for epidermalgrowth factor receptor-mutated tumors and atezolizumab and pembrolizumab forselected patients with resectable NSCLC. Numerous studies on various targeted therapiesand immunotherapy with or without chemotherapy are currently ongoing in theadjuvant setting. However, several questions regarding optimal strategies for adjuvanttreatment remain unanswered. The present review summarizes the available literature,focusing on recent advances and ongoing trials with targeted therapy and immunotherapyin the adjuvant treatment of early-stage NSCLC.
엄중섭 ( Jung Seop Eom ),김광하 ( Gwang Ha Kim ),송근암 ( Geun Am Song ),백동훈 ( Dong Hoon Baek ),류광덕 ( Kwang Duck Ryu ),이경남 ( Kyung Nam Lee ),박도윤 ( Do Youn Park ) 대한소화기학회 2011 대한소화기학회지 Vol.58 No.6
Duplication cysts are uncommon congenital malformations that may occur anywhere throughout the alimentary tract. The stomach is an extremely rare site of occurrence. Here, we report a case of gastric duplication cyst initially presenting with a gastric submucosal tumor. A 28-year-old man complained of dyspepsia lasting 1 year and upper endoscopy revealed an ellipsoid submucosal tumor at the greater curvature of the antrum. We intended to use the injection-and-cut technique: however, after saline injection, the lesion was dented and impossible to grasp with a snare. Therefore, we decided to perform endoscopic submucosal dissection and removed the tumor without complication. Histopathology revealed a 0.6×0.6 cm-sized duplication cyst, and there has been no recurrence in 2 years. (Korean J Gastroenterol 2011;58:346-349)
고정희 ( Jung Hee Koh ),엄중섭 ( Jung Seop Eom ),김정섭 ( Jung Sub Kim ),송상헌 ( Sang Heon Song ),곽임수 ( Im Soo Kwak ),성은영 ( Eun Young Seong ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.1
Emphysematous pyelonephritis is an unusual, severe gas-forming infection of renal parenchyma and its surrounding areas. It is a rare cause of septic pulmonary embolism. We report on a case of emphysematous pyelonephritis complicated with renal vein thrombosis and septic pulmonary embolism with review of the literature. A 51-year-old diabetic woman was admitted to our hospital with symptoms of fever, diffuse abdominal pain and nausea. Her initial laboratory findings showed pyuria and leukocytosis. She was diagnosed with acute pyelonephritis with abscess formation on contrast enhanced abdominal CT. She was treated with antibiotics and percutaneous abscess aspiration, but progressed to emphysematous pyelonephritis complicated with renal vein thrombosis and septic pulmonary embolism. Finally she underwent the left total nephrectomy.
( Hae Jung Na ),( Jung Seop Eom ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: According to guidelines established by the American College of Chest Physicians and the American Association for Bronchology, the use of a fit-tested N95 particulate respirator or a higher-grade respiratory precaution during bronchoscopy are recommended when mycobacterial infection is suspected. However, previous guideline is limited in areas with low tuberculosis prevalence. Although pulmonary tuberculosis was not suspected initially, finally there was some cases to be diagnosed to pulmonary tuberculosis. The objective of our study was to verify the incidence of exposure to Mycobacterium tuberculosis in patients unsuspected pulmonary tuberculosis during fiexible bronchoscopy. Methods: A retrospective study was conducted in the Pusan National University Hospital between 2011 and 2013. Total of 1810 patients who performed bronchoscopy for suspicious respiratory disease other than pulmonary tuberculosis were included. All patients underwent a bronchoscopy with bronchial washing. The findings for acid-fast bacillus (AFB) staining and culture were reviewed in bronchial washing and post-bronchoscopic sputum. Results: Of the 1810 patients who was not suspected pulmonary tuberculosis as initial impression, 55 patients were con. rmed as having pulmonary tuberculosis. The incidence of tuberculosis in routine bronchoscopy was 3.03%. Of the 55 patients who con. rmed pulmonary tuberculosis, 10 (18.1%) were diagnosed with tuberculosis based on the analysis of bronchial washing, 13 (23.6%) were diagnosed on post-bronchoscopy sputum and 32 (58.1%) were diagnosed on both. The most common radiologic findings in the patients with diagnosed pulmonary tuberculosis were lung nodule in 39 (70.9%) and lung mass in 13 (23.6%). Conclusions: During routine bronchoscopy, we suggest that a fit-tested N95 particulate respirator or a higher-grade respiratory precaution is necessary to prevent of occupational tuberculosis in area with intermediate tuberculosis prevalence.